Published in Oncogene on February 03, 2005
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc Natl Acad Sci U S A (2007) 3.24
A Wnt survival guide: from flies to human disease. J Invest Dermatol (2009) 2.91
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood (2009) 2.61
Wnt 5a signaling is critical for macrophage-induced invasion of breast cancer cell lines. Proc Natl Acad Sci U S A (2006) 2.60
The role of Dickkopf-1 in bone development, homeostasis, and disease. Blood (2008) 2.05
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res (2010) 2.05
Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb Perspect Biol (2013) 2.01
S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells. Mol Biol Cell (2011) 1.71
The Wnt pathway regulator DKK1 is preferentially expressed in hormone-resistant breast tumours and in some common cancer types. Br J Cancer (2007) 1.70
Wnt/β-catenin signalling in prostate cancer. Nat Rev Urol (2012) 1.52
Emerging therapeutic opportunities for skeletal restoration. Nat Rev Drug Discov (2011) 1.48
VDR/RXR and TCF4/β-catenin cistromes in colonic cells of colorectal tumor origin: impact on c-FOS and c-MYC gene expression. Mol Endocrinol (2011) 1.46
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. Mol Endocrinol (2006) 1.44
Wnt signaling and colon carcinogenesis: beyond APC. J Carcinog (2011) 1.44
Dickkopf-1 expression increases early in prostate cancer development and decreases during progression from primary tumor to metastasis. Prostate (2008) 1.37
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood (2007) 1.33
Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells. J Biol Chem (2009) 1.26
Profiling gene expression in human placentae of different gestational ages: an OPRU Network and UW SCOR Study. Reprod Sci (2008) 1.25
Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases. Int J Cancer (2008) 1.19
Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease. Br J Haematol (2007) 1.19
The internally truncated LRP5 receptor presents a therapeutic target in breast cancer. PLoS One (2009) 1.12
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Mol Psychiatry (2012) 1.11
Dickkopf-1 promotes hyperglycemia-induced accumulation of mesangial matrix and renal dysfunction. J Am Soc Nephrol (2009) 1.11
Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer. World J Gastroenterol (2008) 1.11
DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway. Mol Cancer (2013) 1.11
The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers. Mol Cell Biol (2010) 1.10
Dkk-1 inhibits intestinal epithelial cell migration by attenuating directional polarization of leading edge cells. Mol Biol Cell (2009) 1.08
A positive feedback loop regulates the expression of polycomb group protein BMI1 via WNT signaling pathway. J Biol Chem (2012) 1.07
Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem Biophys Res Commun (2010) 1.07
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
Dickkopf1: a tumor suppressor or metastasis promoter? Int J Cancer (2011) 1.03
Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate beta-catenin activity in colon cancer cells. Mol Carcinog (2010) 1.03
The Wnt signalling pathway is upregulated in an in vitro model of acquired tamoxifen resistant breast cancer. BMC Cancer (2013) 1.02
Cross-Regulation Between Wnt and NF-κB Signaling Pathways. For Immunopathol Dis Therap (2010) 1.01
Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas. EMBO Mol Med (2010) 1.01
The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. Br J Cancer (2006) 1.00
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
Olig2-induced neural stem cell differentiation involves downregulation of Wnt signaling and induction of Dickkopf-1 expression. PLoS One (2008) 0.96
Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy. Carcinogenesis (2011) 0.95
Networking of differentially expressed genes in human cancer cells resistant to methotrexate. Genome Med (2009) 0.95
Multispecies model of cell lineages and feedback control in solid tumors. J Theor Biol (2012) 0.95
Microbioreactor arrays for full factorial screening of exogenous and paracrine factors in human embryonic stem cell differentiation. PLoS One (2012) 0.95
Dickkopfs and Wnt/β-catenin signalling in liver cancer. World J Clin Oncol (2011) 0.94
Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line. PLoS One (2012) 0.93
Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells. Cancers (Basel) (2013) 0.93
Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/beta-catenin signaling. Acta Pharmacol Sin (2010) 0.92
Lysine-specific demethylase 1 (LSD1/KDM1A) contributes to colorectal tumorigenesis via activation of the Wnt/β-catenin pathway by down-regulating Dickkopf-1 (DKK1) [corrected]. PLoS One (2013) 0.92
SFRP-4 abrogates Wnt-3a-induced beta-catenin and Akt/PKB signalling and reverses a Wnt-3a-imposed inhibition of in vitro mammary differentiation. J Mol Signal (2008) 0.91
Engrailed-1 negatively regulates beta-catenin transcriptional activity by destabilizing beta-catenin via a glycogen synthase kinase-3beta-independent pathway. Mol Biol Cell (2006) 0.90
Transformation of epithelial cells through recruitment leads to polyclonal intestinal tumors. Proc Natl Acad Sci U S A (2013) 0.90
Elevated expression of Dickkopf-1 increases the sensitivity of human glioma cell line SHG44 to BCNU. J Exp Clin Cancer Res (2010) 0.90
Nkd1 functions as a passive antagonist of Wnt signaling. PLoS One (2013) 0.89
The archaic distinction between functioning and nonfunctioning neuroendocrine neoplasms is no longer clinically relevant. Langenbecks Arch Surg (2011) 0.89
Serum dickkopf-1 is a novel serological biomarker for the diagnosis and prognosis of pancreatic cancer. Oncotarget (2015) 0.89
Serum level of DKK-1 and its prognostic potential in non-small cell lung cancer. Diagn Pathol (2014) 0.88
Regulation of breast cancer-induced bone lesions by β-catenin protein signaling. J Biol Chem (2011) 0.88
Epigenetic regulation of wnt pathway antagonists in human glioblastoma multiforme. Genes Cancer (2010) 0.87
Aberrant activation of the WNT/β-catenin signaling pathway in lupus nephritis. PLoS One (2014) 0.87
Analysis of the expression profile of Dickkopf-1 gene in human glioma and the association with tumor malignancy. J Exp Clin Cancer Res (2010) 0.87
Cell adhesion and signal transduction in cancer. Conference on cadherins, catenins and cancer. EMBO Rep (2005) 0.87
Involvement of Wnt signaling in dermal fibroblasts. Am J Pathol (2009) 0.86
Overexpression of Dickkopf 3 in hepatoblastomas and hepatocellular carcinomas. Virchows Arch (2009) 0.86
Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PLoS One (2014) 0.85
Dickkopf-1 is oncogenic and involved in invasive growth in non small cell lung cancer. PLoS One (2013) 0.85
Identification of mesenchymal stem cells in perinodular fat and skin in Dupuytren's disease: a potential source of myofibroblasts with implications for pathogenesis and therapy. Stem Cells Dev (2011) 0.85
Role of Epiprofin, a zinc-finger transcription factor, in limb development. Dev Biol (2009) 0.85
Dickkopf-1 is involved in invasive growth of esophageal cancer cells. J Mol Histol (2011) 0.84
Dickkopf-1 is frequently overexpressed in ovarian serous carcinoma and involved in tumor invasion. Clin Exp Metastasis (2011) 0.84
Dkk1, -2, and -3 expression in mouse craniofacial development. J Mol Histol (2005) 0.84
Analysis of cellular changes resulting from forced expression of Dickkopf-1 in hepatocellular carcinoma cells. Cancer Res Treat (2007) 0.83
Using components of the vitamin D pathway to prevent and treat colon cancer. Nutr Rev (2012) 0.83
DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity. Biochem J (2012) 0.83
Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. PLoS One (2014) 0.83
Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival. Oncotarget (2015) 0.83
Wnt/β-catenin signaling regulated SATB1 promotes colorectal cancer tumorigenesis and progression. Oncogene (2015) 0.82
Dickkopf-1 expression is a novel prognostic marker for gastric cancer. J Biomed Biotechnol (2012) 0.82
Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer. Oncotarget (2015) 0.81
Serum Dickkopf-1 as a Biomarker for the Diagnosis of Hepatocellular Carcinoma. Yonsei Med J (2015) 0.80
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression. J Clin Invest (2016) 0.80
Pathophysiology of the chronic kidney disease-mineral bone disorder. Curr Opin Nephrol Hypertens (2015) 0.80
Casein kinase 1 α phosphorylates the Wnt regulator Jade-1 and modulates its activity. J Biol Chem (2014) 0.80
Beta-catenin signalling in mesenchymal islet-derived precursor cells. Cell Prolif (2008) 0.80
IFNγ-induced suppression of β-catenin signaling: evidence for roles of Akt and 14.3.3ζ. Mol Biol Cell (2014) 0.80
Dkk1 regulates ventral midbrain dopaminergic differentiation and morphogenesis. PLoS One (2011) 0.80
The role for dickkopf-homolog-1 in the pathogenesis of Crohn's disease-associated fistulae. PLoS One (2013) 0.79
Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours. BMC Cancer (2009) 0.79
Protective effect of Huang Gan formula in 5/6 nephrectomized rats by depressing the Wnt/β-catenin signaling pathway. Drug Des Devel Ther (2015) 0.78
Dickkopf1--a new player in modelling the Wnt pathway. PLoS One (2011) 0.78
Combined detection of serum Dickkopf-1 and its autoantibodies to diagnose esophageal squamous cell carcinoma. Cancer Med (2016) 0.78
Serum Dickkopf-1 expression level positively correlates with a poor prognosis in breast cancer. Diagn Pathol (2014) 0.78
Thrombin promotes epithelial ovarian cancer cell invasion by inducing epithelial-mesenchymal transition. J Gynecol Oncol (2013) 0.77
Mammary Development and Breast Cancer: A Wnt Perspective. Cancers (Basel) (2016) 0.77
Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation. Biochim Biophys Acta (2011) 0.77
FoxM1 transactivates PTTG1 and promotes colorectal cancer cell migration and invasion. BMC Med Genomics (2015) 0.77
RNA interference-mediated targeting of DKK1 gene expression in Ishikawa endometrial carcinoma cells causes increased tumor cell invasion and migration. Oncol Lett (2013) 0.77
Modulating Dickkopf-1: A Strategy to Monitor or Treat Cancer? Cancers (Basel) (2016) 0.77
Serum Dickkopf-1 (DKK1) is significantly lower in patients with lung cancer but is rapidly normalized after treatment. Am J Transl Res (2014) 0.77
Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation. Cancer Biol Ther (2016) 0.76
SOST Inhibits Prostate Cancer Invasion. PLoS One (2015) 0.76
DKK1 is a potential novel mediator of cisplatin-refractoriness in non-small cell lung cancer cell lines. BMC Cancer (2015) 0.76
Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat Rev Neurosci (2008) 8.14
A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev (2008) 3.85
p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction. Mol Cell Biol (2003) 2.58
Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor. Mol Cell Biol (2008) 2.57
Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol Cell Biol (2003) 2.46
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene (2004) 2.44
Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins. J Biol Chem (2002) 2.31
Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun (2004) 2.13
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat Med (2004) 2.11
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun (2002) 2.09
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene (2002) 2.09
β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med (2012) 2.02
Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proc Natl Acad Sci U S A (2006) 1.98
E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum Mol Genet (2005) 1.95
Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes. Mol Cell Biol (2003) 1.93
The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Int J Cancer (2006) 1.91
DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1. J Clin Oncol (2005) 1.88
Promoter methylation of the PTEN gene is a common molecular change in breast cancer. Genes Chromosomes Cancer (2004) 1.82
Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res (2006) 1.80
Deregulated expression of miR-106a predicts survival in human colon cancer patients. Genes Chromosomes Cancer (2008) 1.75
Retracted Lysyl oxidase-like 2 deaminates lysine 4 in histone H3. Mol Cell (2012) 1.74
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells. Mol Cancer Ther (2003) 1.61
Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA. Mol Cell Biol (2006) 1.50
Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft. J Biol Chem (2004) 1.46
Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells. Cancer Res (2003) 1.46
Intratumoral heterogeneity in microsatellite alterations in BRCA1 and PTEN regions in sporadic colorectal cancer. Ann Surg Oncol (2003) 1.45
E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression. J Cell Sci (2008) 1.44
The transcriptional factor Tcf-4 contains different binding sites for beta-catenin and plakoglobin. J Biol Chem (2001) 1.35
The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. J Biol Chem (2009) 1.35
Extracellular plasma RNA from colon cancer patients is confined in a vesicle-like structure and is mRNA-enriched. RNA (2008) 1.35
Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol Cell Biol (2003) 1.33
Epigenetics and environment: a complex relationship. J Appl Physiol (1985) (2010) 1.32
Double bouquet cell in the human cerebral cortex and a comparison with other mammals. J Comp Neurol (2005) 1.32
Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood (2005) 1.32
The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells. Carcinogenesis (2007) 1.27
MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Hum Mol Genet (2012) 1.26
Snail-dependent and -independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J Histochem Cytochem (2006) 1.25
Implication of polycomb members Bmi-1, Mel-18, and Hpc-2 in the regulation of p16INK4a, p14ARF, h-TERT, and c-Myc expression in primary breast carcinomas. Clin Cancer Res (2006) 1.23
Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer. Carcinogenesis (2009) 1.20
Vitamin D and colon cancer. Endocr Relat Cancer (2012) 1.20
Vitamin D regulates the phenotype of human breast cancer cells. Differentiation (2006) 1.20
Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes. Anticancer Res (2008) 1.19
Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells. J Clin Invest (2009) 1.19
Vitamin D and cancer: an update of in vitro and in vivo data. Front Biosci (2005) 1.19
Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. PLoS One (2011) 1.17
Thyroid hormone receptors/THR genes in human cancer. Cancer Lett (2003) 1.17
Proteome profiling of cancer-associated fibroblasts identifies novel proinflammatory signatures and prognostic markers for colorectal cancer. Clin Cancer Res (2013) 1.17
Snail1 protein in the stroma as a new putative prognosis marker for colon tumours. PLoS One (2009) 1.16
Retracted Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin. J Biol Chem (2002) 1.16
Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer. Oncogene (2002) 1.15
Targeting epithelial-to-mesenchymal transition with Met inhibitors reverts chemoresistance in small cell lung cancer. Clin Cancer Res (2013) 1.15
Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients. Cancer Sci (2013) 1.14
Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Hum Mutat (2011) 1.14
Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain. J Biol Chem (2003) 1.14
The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci (2007) 1.13
Identification and rational design of novel antimicrobial peptides for plant protection. Annu Rev Phytopathol (2008) 1.13
Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J (2003) 1.11
In-depth characterization of the secretome of colorectal cancer metastatic cells identifies key proteins in cell adhesion, migration, and invasion. Mol Cell Proteomics (2013) 1.11
Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer. Cancer Res (2010) 1.11
Deregulation of miR-200b, miR-200c and miR-429 indicates its potential relevant role in patients with colorectal cancer liver metastasis. J Surg Oncol (2014) 1.10
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer. Cancer Res (2009) 1.10
KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells. Hum Mol Genet (2011) 1.10
Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta. Oncogene (2002) 1.09
Clinical significance of miR-126 in colorectal cancer. Genes Chromosomes Cancer (2014) 1.09
Free circulating mRNA in plasma from breast cancer patients and clinical outcome. Cancer Lett (2008) 1.09
JNK activation is critical for Aplidin-induced apoptosis. Oncogene (2004) 1.08