Published in J Lipid Res on December 01, 2002
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med (2010) 6.84
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology (2010) 5.35
Molecular biology of PCSK9: its role in LDL metabolism. Trends Biochem Sci (2007) 3.59
Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL. Magn Reson Med (2008) 2.27
Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut (2005) 1.99
Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res (2010) 1.67
Genetic determinants of hepatic steatosis in man. J Lipid Res (2011) 1.52
Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet. PLoS One (2015) 1.47
Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring) (2009) 1.33
Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterology (2010) 1.27
Hypobetalipoproteinemia and abetalipoproteinemia. Curr Opin Lipidol (2014) 1.19
Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia. Diabetologia (2011) 1.17
Whole-body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes (2006) 1.14
Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia. J Lipid Res (2009) 1.13
Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization. J Clin Endocrinol Metab (2012) 1.03
Exercise training augments the peripheral insulin-sensitizing effects of pioglitazone in HIV-infected adults with insulin resistance and central adiposity. Am J Physiol Endocrinol Metab (2010) 1.03
Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB). J Biol Chem (2010) 0.95
Hepatic Steatosis as a Marker of Metabolic Dysfunction. Nutrients (2015) 0.92
Common and rare gene variants affecting plasma LDL cholesterol. Clin Biochem Rev (2008) 0.89
A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia. Arterioscler Thromb Vasc Biol (2013) 0.89
Fatty liver and insulin resistance: not always linked. Trans Am Clin Climatol Assoc (2008) 0.87
Clinical characteristics and plasma lipids in subjects with familial combined hypolipidemia: a pooled analysis. J Lipid Res (2013) 0.86
Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. Am J Physiol Endocrinol Metab (2010) 0.81
Insights from human congenital disorders of intestinal lipid metabolism. J Lipid Res (2014) 0.81
Clinical utility gene card for: Familial hypobetalipoproteinaemia (APOB)--Update 2014. Eur J Hum Genet (2014) 0.77
Clinical utility gene card for: Familial Hypobetalipoproteinaemia (APOB). Eur J Hum Genet (2012) 0.77
The PNPLA3 Variant Associated with Fatty Liver Disease (I148M) Accumulates on Lipid Droplets by Evading Ubiquitylation. Hepatology (2017) 0.75
Quantitative study of liver magnetic resonance spectroscopy quality at 3T using body and phased array coils with physical analysis and clinical evaluation. PLoS One (2015) 0.75
Lipoproteins: When size really matters. Curr Opin Colloid Interface Sci (2006) 0.75
Familial hypobetalipoproteinemia-induced nonalcoholic steatohepatitis. Case Rep Gastroenterol (2012) 0.75
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia. N Engl J Med (2010) 6.84
Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med (2004) 6.12
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med (2015) 5.59
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med (2011) 4.07
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J (2013) 3.58
Evidence for adult lung growth in humans. N Engl J Med (2012) 2.80
Quantitative BOLD: mapping of human cerebral deoxygenated blood volume and oxygen extraction fraction: default state. Magn Reson Med (2007) 2.55
Biophysical mechanisms of phase contrast in gradient echo MRI. Proc Natl Acad Sci U S A (2009) 2.49
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology (2007) 2.29
Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr (2012) 2.23
Gastric bypass and banding equally improve insulin sensitivity and β cell function. J Clin Invest (2012) 2.19
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes (2009) 1.83
Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema. Magn Reson Med (2006) 1.76
Modeling dendrite density from magnetic resonance diffusion measurements. Neuroimage (2006) 1.74
Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr (2012) 1.71
Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover. J Lipid Res (2002) 1.67
Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care (2013) 1.63
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? Diabetes (2003) 1.56
Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemia. Atherosclerosis (2004) 1.54
WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab (2013) 1.51
Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity. J Lipid Res (2004) 1.50
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr (2003) 1.48
Role of collateral paths in long-range diffusion in lungs. J Appl Physiol (1985) (2008) 1.47
On the role of neuronal magnetic susceptibility and structure symmetry on gradient echo MR signal formation. Magn Reson Med (2013) 1.46
Validation of oxygen extraction fraction measurement by qBOLD technique. Magn Reson Med (2008) 1.44
Commentaries on viewpoint: unresolved mysteries. J Appl Physiol (1985) (2012) 1.42
A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. JAMA (2004) 1.40
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med (2013) 1.38
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics. J Lipid Res (2007) 1.37
Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Am J Physiol Endocrinol Metab (2005) 1.34
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am J Physiol Endocrinol Metab (2002) 1.34
Effects of restricted diffusion on MR signal formation. J Magn Reson (2002) 1.32
Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab (2007) 1.31
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab (2004) 1.29
On the nature of the NAA diffusion attenuated MR signal in the central nervous system. Magn Reson Med (2004) 1.28
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology (2012) 1.27
Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia. Gastroenterology (2010) 1.27
Long-range diffusion of hyperpolarized 3He in explanted normal and emphysematous human lungs via magnetization tagging. J Appl Physiol (1985) (2005) 1.26
Molecular diagnosis of hypobetalipoproteinemia: an ENID review. Atherosclerosis (2007) 1.25
Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes (2009) 1.24
Plasma free fatty acid storage in subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes (2008) 1.22
Protein-induced water 1H MR frequency shifts: contributions from magnetic susceptibility and exchange effects. J Magn Reson (2009) 1.22
In vivo lung morphometry with hyperpolarized 3He diffusion MRI in canines with induced emphysema: disease progression and comparison with computed tomography. J Appl Physiol (1985) (2006) 1.21
Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J Clin Endocrinol Metab (2010) 1.21
Multiorgan insulin sensitivity in lean and obese subjects. Diabetes Care (2012) 1.20
A genetic variant of the atrial natriuretic peptide gene is associated with cardiometabolic protection in the general community. J Am Coll Cardiol (2011) 1.20
Natural linewidth chemical shift imaging (NL-CSI). Magn Reson Med (2006) 1.19
Hyperpolarized 3He MR imaging: physiologic monitoring observations and safety considerations in 100 consecutive subjects. Radiology (2008) 1.19
Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring) (2008) 1.18
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology (2012) 1.18
Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril (2011) 1.18
Metabolically normal obese people are protected from adverse effects following weight gain. J Clin Invest (2015) 1.17
Hepatic fatty acid synthesis is suppressed in mice with fatty livers due to targeted apolipoprotein B38.9 mutation. Arterioscler Thromb Vasc Biol (2002) 1.15
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am J Physiol Endocrinol Metab (2002) 1.15
No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Am J Physiol Endocrinol Metab (2006) 1.14
Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring) (2010) 1.14
Whole-body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes (2006) 1.14
Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. Diabetes Care (2012) 1.14
Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes (2013) 1.12
Magnetization tagging decay to measure long-range (3)He diffusion in healthy and emphysematous canine lungs. Magn Reson Med (2004) 1.12
Hepatic triglyceride contents are genetically determined in mice: results of a strain survey. Am J Physiol Gastrointest Liver Physiol (2004) 1.12
3He diffusion MRI of the lung. Acad Radiol (2005) 1.11
In vivo detection of acinar microstructural changes in early emphysema with (3)He lung morphometry. Radiology (2011) 1.11
Hypobetalipoproteinemia: genetics, biochemistry, and clinical spectrum. Adv Clin Chem (2011) 1.07
Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian families. J Lipid Res (2007) 1.05
How accurately can the parameters from a model of anisotropic 3He gas diffusion in lung acinar airways be estimated? Bayesian view. J Magn Reson (2006) 1.05
On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans. Am J Physiol Endocrinol Metab (2005) 1.04
Additive effect of mutations in LDLR and PCSK9 genes on the phenotype of familial hypercholesterolemia. Atherosclerosis (2005) 1.04
Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes (2011) 1.03
Acute pancreatitis and upper gastrointestinal bleeding as presenting symptoms of duodenal Brunner's gland hamartoma. Can J Gastroenterol (2006) 1.03
Optimal decay rate constant estimates from phased array data utilizing joint Bayesian analysis. J Magn Reson (2009) 1.03
A novel loss of function mutation of PCSK9 gene in white subjects with low-plasma low-density lipoprotein cholesterol. Arterioscler Thromb Vasc Biol (2006) 1.03
Levofloxacin-induced delirium. Neurol Sci (2009) 1.02
Gradient echo plural contrast imaging--signal model and derived contrasts: T2*, T1, phase, SWI, T1f, FST2*and T2*-SWI. Neuroimage (2012) 1.02
Gaussian approximation in the theory of MR signal formation in the presence of structure-specific magnetic field inhomogeneities. J Magn Reson (2003) 1.01
Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans. Circulation (2008) 1.01
Theoretical model of temperature regulation in the brain during changes in functional activity. Proc Natl Acad Sci U S A (2006) 1.01
Imaging lung microstructure in mice with hyperpolarized 3He diffusion MRI. Magn Reson Med (2010) 1.00
Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis (2009) 0.99
How the body controls brain temperature: the temperature shielding effect of cerebral blood flow. J Appl Physiol (1985) (2006) 0.99
A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men. Am J Physiol Endocrinol Metab (2007) 0.98
Mutations in MTP gene in abeta- and hypobeta-lipoproteinemia. Atherosclerosis (2005) 0.97
In vivo quantitative evaluation of brain tissue damage in multiple sclerosis using gradient echo plural contrast imaging technique. Neuroimage (2010) 0.97
Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care (2011) 0.97
Prevalence of ANGPTL3 and APOB gene mutations in subjects with combined hypolipidemia. Arterioscler Thromb Vasc Biol (2012) 0.97
Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals. Atherosclerosis (2005) 0.95
Effects of diffusion time on short-range hyperpolarized (3)He diffusivity measurements in emphysema. J Magn Reson Imaging (2009) 0.95
Triglyceride-rich lipoprotein-associated apolipoprotein C-III production is stimulated by plasma free fatty acids in humans. Arterioscler Thromb Vasc Biol (2008) 0.95
Gaussian approximation in the theory of MR signal formation in the presence of structure-specific magnetic field inhomogeneities. Effects of impermeable susceptibility inclusions. J Magn Reson (2004) 0.95
Insulin sensitivity is not associated with palmitoleate availability in obese humans. J Lipid Res (2011) 0.95
Diurnal variation in insulin sensitivity of glucose metabolism is associated with diurnal variations in whole-body and cellular fatty acid metabolism in metabolically normal women. J Clin Endocrinol Metab (2014) 0.95
Amyloid-β efflux from the central nervous system into the plasma. Ann Neurol (2014) 0.94
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem (2013) 0.93
19F MR imaging of ventilation and diffusion in excised lungs. Magn Reson Med (2005) 0.93