Published in N Engl J Med on June 17, 2004
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab (2008) 5.07
What we talk about when we talk about fat. Cell (2014) 4.12
Fat tissue, aging, and cellular senescence. Aging Cell (2010) 3.34
Ethnic differences in hepatic steatosis: an insulin resistance paradox? Hepatology (2009) 3.08
Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab (2008) 3.05
Cardiac remodeling in obesity. Physiol Rev (2008) 2.95
Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care (2009) 2.80
Bariatric surgery: an IDF statement for obese Type 2 diabetes. Diabet Med (2011) 2.74
Adipogenesis and WNT signalling. Trends Endocrinol Metab (2008) 2.37
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Mechanisms and metabolic implications of regional differences among fat depots. Cell Metab (2013) 1.94
Influence of obesity on the risk of developing colon cancer. Gut (2005) 1.93
Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training. CMAJ (2005) 1.90
Visceral adipose tissue modulates mammalian longevity. Aging Cell (2008) 1.87
Greater omentectomy improves insulin sensitivity in nonobese dogs. Obesity (Silver Spring) (2009) 1.82
Bariatric surgery reduces visceral adipose inflammation and improves endothelial function in type 2 diabetic mice. Arterioscler Thromb Vasc Biol (2011) 1.69
Sex differences in the regulation of body weight. Physiol Behav (2009) 1.68
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol (2010) 1.56
New insights into pancreatic cancer-induced paraneoplastic diabetes. Nat Rev Gastroenterol Hepatol (2013) 1.54
The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment. J Lipid Res (2006) 1.50
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Pathological ventricular remodeling: mechanisms: part 1 of 2. Circulation (2013) 1.48
The sexual dimorphism of obesity. Mol Cell Endocrinol (2015) 1.47
Omentectomy added to Roux-en-Y gastric bypass surgery: a randomized, controlled trial. Surg Obes Relat Dis (2011) 1.45
Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes. Diabetes Care (2009) 1.43
Weight science: evaluating the evidence for a paradigm shift. Nutr J (2011) 1.42
Impact of different bariatric surgical procedures on insulin action and beta-cell function in type 2 diabetes. Diabetes Care (2009) 1.41
Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes. Diabetes (2008) 1.41
Role of visceral adipose tissue in aging. Biochim Biophys Acta (2009) 1.38
Role of a critical visceral adipose tissue threshold (CVATT) in metabolic syndrome: implications for controlling dietary carbohydrates: a review. Nutr Metab (Lond) (2004) 1.34
Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell (2011) 1.32
Improved insulin sensitivity after weight loss and exercise training is mediated by a reduction in plasma fatty acid mobilization, not enhanced oxidative capacity. J Physiol (2009) 1.31
Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes (2009) 1.24
Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology (2008) 1.19
Optimal body weight for health and longevity: bridging basic, clinical, and population research. Aging Cell (2014) 1.16
Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes? Diabetes Care (2012) 1.16
Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans. Diabetes Care (2012) 1.13
Critical role of the mesenteric depot versus other intra-abdominal adipose depots in the development of insulin resistance in young rats. Diabetes (2010) 1.08
Adverse prognosis associated with the metabolic syndrome in established coronary artery disease: data from the EUROPA trial. Heart (2007) 1.05
Neuroendocrine factors in the regulation of inflammation: excessive adiposity and calorie restriction. Exp Gerontol (2008) 1.05
Rimonabant prevents additional accumulation of visceral and subcutaneous fat during high-fat feeding in dogs. Am J Physiol Endocrinol Metab (2009) 1.01
Does insulin resistance, visceral adiposity, or a sex hormone alteration underlie the metabolic syndrome? Studies in women. Metabolism (2008) 1.00
Fat distribution and glucose intolerance among Greenland Inuit. Diabetes Care (2013) 0.95
Viewpoints on the way to the consensus session: where does insulin resistance start? The adipose tissue. Diabetes Care (2009) 0.94
Potential additional effect of omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in grade III obese patients undergoing laparoscopic Roux-en-Y gastric bypass: a randomized trial. Diabetes Care (2010) 0.94
The blind men 'see' the elephant-the many faces of fatty liver disease. World J Gastroenterol (2008) 0.94
Role of fat body lipogenesis in protection against the effects of caloric overload in Drosophila. J Biol Chem (2013) 0.93
Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy. Front Endocrinol (Lausanne) (2015) 0.93
The contribution of vitamin A to autocrine regulation of fat depots. Biochim Biophys Acta (2011) 0.93
Adiposopathy, "sick fat," Ockham's razor, and resolution of the obesity paradox. Curr Atheroscler Rep (2014) 0.90
Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial. J Clin Endocrinol Metab (2012) 0.90
Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus. Surgery (2006) 0.90
Current Treatment Options for the Metabolic Syndrome. Curr Treat Options Cardiovasc Med (2005) 0.90
Long-term effects of large-volume liposuction on metabolic risk factors for coronary heart disease. Obesity (Silver Spring) (2008) 0.90
Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity. Physiol Behav (2010) 0.89
Differential associations of abdominal visceral, subcutaneous adipose tissue with cardiometabolic risk factors between African and European Americans. Obesity (Silver Spring) (2014) 0.89
Prevention and treatment of type 2 diabetes: current role of lifestyle, natural product, and pharmacological interventions. Pharmacol Ther (2008) 0.89
Markers of inflammation and fat distribution following weight loss in African-American and white women. Obesity (Silver Spring) (2011) 0.88
The epidemiology of obesity and gastrointestinal and other diseases: an overview. Dig Dis Sci (2008) 0.88
Adipose tissue content, muscle performance and physical function in obese adults with type 2 diabetes mellitus and peripheral neuropathy. J Diabetes Complications (2014) 0.87
Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutr Metab (Lond) (2008) 0.87
Sex differences in visceral adipose tissue post-bariatric surgery compared to matched non-surgical controls. Int J Body Compos Res (2008) 0.87
A 12-week regimen of caloric restriction improves levels of adipokines and pro-inflammatory cytokines in Korean women with BMIs greater than 23 kg/m2. Inflamm Res (2009) 0.87
Metabolic effects of liposuction--yes or no? N Engl J Med (2004) 0.86
Changes in adipose tissue depots and metabolic markers following a 1-year diet and exercise intervention in overweight and obese patients with type 2 diabetes. Diabetes Care (2014) 0.85
Reductions in cardiovascular risk after bariatric surgery. Curr Opin Cardiol (2011) 0.85
Vascular dysfunction in Type 2 diabetes: emerging targets for therapy. Expert Rev Cardiovasc Ther (2009) 0.84
Little evidence of systemic and adipose tissue inflammation in overweight individuals(†). Front Genet (2012) 0.84
Metabolic alterations following visceral fat removal and expansion: Beyond anatomic location. Adipocyte (2012) 0.84
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine. Exp Gerontol (2016) 0.83
Relationships between adipose tissue and cytokine responses to a randomized controlled exercise training intervention. Metabolism (2008) 0.83
Magnetic resonance imaging determined visceral fat reduction associates with enhanced IL-10 plasma levels in calorie restricted obese subjects. PLoS One (2012) 0.82
Notch signaling pathway activation in normal and hyperglycemic rats differs in the stem cells of visceral and subcutaneous adipose tissue. Stem Cells Dev (2014) 0.82
C-reactive protein decrease after postbariatric abdominoplasty. Inflammation (2012) 0.80
Associations between body fat distribution, insulin resistance and dyslipidaemia in black and white South African women. Cardiovasc J Afr (2016) 0.80
Diabetes improvement following Roux-en-Y gastric bypass: understanding dynamic changes in insulin secretion and action. Diabetes (2014) 0.79
Sleep, sleep-disordered breathing and lipid homeostasis: translational evidence from murine models and children. Clin Lipidol (2012) 0.79
Caloric Restriction as a Strategy to Improve Vascular Dysfunction in Metabolic Disorders. Nutrients (2016) 0.79
Abdominal obesity: causal factor or simply a symptom of obesity-related health risk. Diabetes Metab Syndr Obes (2014) 0.79
Thermodynamics, liposuction, and metabolism. N Engl J Med (2004) 0.79
Obesity and preclinical changes of cardiac geometry and function. Korean Circ J (2010) 0.79
Association of in vivo β-adrenergic receptor sensitivity with inflammatory markers in healthy subjects. Psychosom Med (2012) 0.78
Cardiovascular Consequences of Obesity and Targets for Treatment. Drug Discov Today Ther Strateg (2008) 0.78
Effects and mechanism of duodenal-jejunal bypass and sleeve gastrectomy on GLUT2 and glucokinase in diabetic Goto-Kakizaki rats. Eur J Med Res (2012) 0.78
Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men. Diabetol Metab Syndr (2014) 0.78
Treatment options for nonalcoholic Fatty liver disease. Therap Adv Gastroenterol (2008) 0.77
Routine clinical measures of adiposity as predictors of visceral fat in adolescence: a population-based magnetic resonance imaging study. PLoS One (2013) 0.77
Intrauterine protein restriction combined with early postnatal overfeeding was not associated with adult-onset obesity but produced glucose intolerance by pancreatic dysfunction. Nutr Metab (Lond) (2013) 0.77
Femoral lipectomy increases postprandial lipemia in women. Am J Physiol Endocrinol Metab (2015) 0.77
Adipocytokines, metabolic syndrome, and exercise. Int J Endocrinol (2014) 0.76
Sympathetic inhibition after bariatric surgery. Hypertension (2014) 0.76
Strength training and testosterone treatment have opposing effects on migration inhibitor factor levels in ageing men. Mediators Inflamm (2013) 0.76
Effect of abdominoplasty in the lipid profile of patients with dyslipidemia. Plast Surg Int (2013) 0.76
Effects of lifestyle measures, antiobesity agents, and bariatric surgery on serological markers of inflammation in obese patients. Mediators Inflamm (2010) 0.76
The two-edged sword. Endocrinol Nutr (2009) 0.76
Strategies for reducing body fat mass: effects of liposuction and exercise on cardiovascular risk factors and adiposity. Diabetes Metab Syndr Obes (2011) 0.76
A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med (2003) 9.23
Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans. Science (2011) 8.88
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med (2011) 4.07
Weight and metabolic outcomes after 2 years on a low-carbohydrate versus low-fat diet: a randomized trial. Ann Intern Med (2010) 3.73
Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes (2008) 3.47
Long-term caloric restriction ameliorates the decline in diastolic function in humans. J Am Coll Cardiol (2006) 3.29
Anaplastic large cell lymphoma and breast implants: a systematic review. Plast Reconstr Surg (2011) 3.14
Hereditary and acquired angioedema: problems and progress: proceedings of the third C1 esterase inhibitor deficiency workshop and beyond. J Allergy Clin Immunol (2004) 3.07
Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects. Gastroenterology (2008) 3.04
Metabolic and structural effects of phosphatidylcholine and deoxycholate injections on subcutaneous fat: a randomized, controlled trial. Aesthet Surg J (2013) 3.02
Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr (2006) 2.76
Caloric restriction in humans. Exp Gerontol (2007) 2.66
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr (2006) 2.57
Anaplastic large cell lymphoma and breast implants: results from a structured expert consultation process. Plast Reconstr Surg (2011) 2.55
Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med (2006) 2.37
One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci (2006) 2.31
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology (2007) 2.29
Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr (2012) 2.23
Gastric bypass and banding equally improve insulin sensitivity and β cell function. J Clin Invest (2012) 2.19
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst (2007) 1.98
Fatty liver in familial hypobetalipoproteinemia: triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis. J Lipid Res (2002) 1.97
A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci (2015) 1.96
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes (2009) 1.83
Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 1.82
Fasting and cancer treatment in humans: A case series report. Aging (Albany NY) (2009) 1.71
Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr (2012) 1.71
Calorie restriction and prevention of age-associated chronic disease. FEBS Lett (2011) 1.69
Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol (1985) (2006) 1.68
Sub-lingual immunotherapy: World Allergy Organization Position Paper 2009. Allergy (2009) 1.65
Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr (2010) 1.63
Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care (2013) 1.63
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? Diabetes (2003) 1.56
WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab (2013) 1.51
Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell (2013) 1.48
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr (2003) 1.48
Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents. Am J Clin Nutr (2008) 1.44
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med (2013) 1.38
Relationship between body fat mass and free fatty acid kinetics in men and women. Obesity (Silver Spring) (2009) 1.37
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics. J Lipid Res (2007) 1.37
Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol (2011) 1.35
Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Am J Physiol Endocrinol Metab (2005) 1.34
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am J Physiol Endocrinol Metab (2002) 1.34
Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab (2007) 1.31
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab (2004) 1.29
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology (2012) 1.27
Alterations in fatty acid kinetics in obese adolescents with increased intrahepatic triglyceride content. Obesity (Silver Spring) (2008) 1.27
Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes (2009) 1.24
Plasma free fatty acid storage in subcutaneous and visceral adipose tissue in postabsorptive women. Diabetes (2008) 1.22
Impact of gender on the myocardial metabolic response to obesity. JACC Cardiovasc Imaging (2008) 1.22
Effect of fenofibrate and niacin on intrahepatic triglyceride content, very low-density lipoprotein kinetics, and insulin action in obese subjects with nonalcoholic fatty liver disease. J Clin Endocrinol Metab (2010) 1.21
Multiorgan insulin sensitivity in lean and obese subjects. Diabetes Care (2012) 1.20
Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring) (2008) 1.18
Fasting and differential chemotherapy protection in patients. Cell Cycle (2010) 1.18
Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology (2012) 1.18
Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization. Fertil Steril (2011) 1.18
Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women. Clin Sci (Lond) (2011) 1.17
Effect of moderate diet-induced weight loss and weight regain on cardiovascular structure and function. J Am Coll Cardiol (2009) 1.17
Trends in autologous fat grafting to the breast: a national survey of the american society of plastic surgeons. Plast Reconstr Surg (2013) 1.17
Metabolically normal obese people are protected from adverse effects following weight gain. J Clin Invest (2015) 1.17
VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity. Am J Physiol Endocrinol Metab (2002) 1.15
No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics. Am J Physiol Endocrinol Metab (2006) 1.14
Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity (Silver Spring) (2010) 1.14
Whole-body proteolysis rate is elevated in HIV-associated insulin resistance. Diabetes (2006) 1.14
Relationship of dopamine type 2 receptor binding potential with fasting neuroendocrine hormones and insulin sensitivity in human obesity. Diabetes Care (2012) 1.14
Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects. Diabetes (2013) 1.12
Interactions between hyperglycemia and hypoxia: implications for diabetic retinopathy. Diabetes (2004) 1.12
Will calorie restriction work in humans? Aging (Albany NY) (2013) 1.11
Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell (2012) 1.10
Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans. Aging (Albany NY) (2011) 1.04
On the suppression of plasma nonesterified fatty acids by insulin during enhanced intravascular lipolysis in humans. Am J Physiol Endocrinol Metab (2005) 1.04
Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes. Diabetes (2011) 1.03
Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res (2008) 1.02
Sex and type 2 diabetes: obesity-independent effects on left ventricular substrate metabolism and relaxation in humans. Obesity (Silver Spring) (2011) 1.02
Improving patient care. Group visits 101. Fam Pract Manag (2003) 1.02
Long-term effects of calorie restriction on serum sex-hormone concentrations in men. Aging Cell (2010) 1.02
Both intestinal and hepatic lipoprotein production are stimulated by an acute elevation of plasma free fatty acids in humans. Circulation (2008) 1.01
Energy requirements in nonobese men and women: results from CALERIE. Am J Clin Nutr (2013) 1.01
Favourable response to infliximab in a case of bilateral refractory Mooren's ulcer. Clin Experiment Ophthalmol (2007) 1.00
Serum insulin-like growth factor-I and platelet-derived growth factor as biomarkers of breast cancer prognosis. Cancer Epidemiol Biomarkers Prev (2008) 1.00
A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men. Am J Physiol Endocrinol Metab (2007) 0.98
No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in middle-aged adults. J Appl Physiol (1985) (2009) 0.97
Ginseng and ginsenoside Re do not improve β-cell function or insulin sensitivity in overweight and obese subjects with impaired glucose tolerance or diabetes. Diabetes Care (2011) 0.97
The need for venous thromboembolism (VTE) prophylaxis in plastic surgery. Aesthet Surg J (2009) 0.96
Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV-infected individuals. Atherosclerosis (2005) 0.95
Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition. Aging Cell (2010) 0.95