Published in Diabetes on June 02, 2009
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes (2009) 1.83
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet. J Physiol (2010) 1.55
Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy. Cell Metab (2014) 1.45
K(ATP) channels and islet hormone secretion: new insights and controversies. Nat Rev Endocrinol (2013) 1.33
KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res (2013) 1.23
Acute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes. Diabetes (2011) 1.12
Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice. Cell Metab (2009) 1.06
KATP channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response. Hum Genet (2009) 0.92
The ATP-sensitive K(+) channel ABCC8 S1369A type 2 diabetes risk variant increases MgATPase activity. Diabetes (2012) 0.90
Moderate effect of duodenal-jejunal bypass surgery on glucose homeostasis in patients with type 2 diabetes. Obesity (Silver Spring) (2012) 0.89
Pharmacogenetics and personalized treatment of type 2 diabetes. Biochem Med (Zagreb) (2013) 0.89
Evidence for central regulation of glucose metabolism. J Biol Chem (2013) 0.85
Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends Endocrinol Metab (2011) 0.84
HMR 1098 is not an SUR isotype specific inhibitor of heterologous or sarcolemmal K ATP channels. J Mol Cell Cardiol (2010) 0.84
Modeling K,ATP--dependent excitability in pancreatic islets. Biophys J (2014) 0.81
Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk. Diabetologia (2016) 0.80
Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes. Diabetologia (2013) 0.79
K(ATP) channelopathies in the pancreas. Pflugers Arch (2009) 0.78
Effect of genetic polymorphisms on the development of secondary failure to sulfonylurea in egyptian patients with type 2 diabetes. Ther Adv Endocrinol Metab (2011) 0.77
Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders. Acta Pharmacol Sin (2011) 0.77
Snapshot Hyperspectral Light-Sheet Imaging of Signal Transduction in Live Pancreatic Islets. Biophys J (2016) 0.77
Molecular determinants of ATP-sensitive potassium channel MgATPase activity: diabetes risk variants and diazoxide sensitivity. Biosci Rep (2015) 0.75
Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. PLoS Comput Biol (2016) 0.75
Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel. J Gen Physiol (2016) 0.75
KCNJ11, ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients with type 2 diabetes: a bioinformatics assessment. BMC Med Genet (2017) 0.75
Sulfonylurea treatment in an infant with transient neonatal diabetes mellitus caused by an adenosine triphosphate binding cassette subfamily C member 8 gene mutation. Clin Pediatr Endocrinol (2017) 0.75
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science (2007) 32.97
Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care (1999) 26.39
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet (2007) 13.28
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med (2006) 10.97
The variance of sodium current fluctuations at the node of Ranvier. J Physiol (1980) 9.29
Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med (2004) 8.62
Conductance fluctuations and ionic pores in membranes. Annu Rev Biophys Bioeng (1977) 7.60
Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med (2004) 6.12
Hypothalamic K(ATP) channels control hepatic glucose production. Nature (2005) 4.56
Estimation of insulin secretion rates from C-peptide levels. Comparison of individual and standard kinetic parameters for C-peptide clearance. Diabetes (1992) 4.47
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice. Proc Natl Acad Sci U S A (1998) 3.11
Oral glucose tolerance test minimal model indexes of beta-cell function and insulin sensitivity. Diabetes (2001) 3.05
Haplotype structure and genotype-phenotype correlations of the sulfonylurea receptor and the islet ATP-sensitive potassium channel gene region. Diabetes (2004) 2.52
Binding and degradation of 125I-insulin by rat hepatocytes. J Biol Chem (1975) 2.46
The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes (2003) 2.41
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding. Biophys J (2000) 2.19
Update of mutations in the genes encoding the pancreatic beta-cell K(ATP) channel subunits Kir6.2 (KCNJ11) and sulfonylurea receptor 1 (ABCC8) in diabetes mellitus and hyperinsulinism. Hum Mutat (2009) 2.07
The use of areas under curves in diabetes research. Diabetes Care (1995) 2.07
Minimal model estimation of glucose absorption and insulin sensitivity from oral test: validation with a tracer method. Am J Physiol Endocrinol Metab (2004) 2.04
The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng (2002) 1.88
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J Clin Invest (1994) 1.82
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features. Proc Natl Acad Sci U S A (2004) 1.72
K(IR)6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K(+) channels. Diabetes (2002) 1.59
Relapsing diabetes can result from moderately activating mutations in KCNJ11. Hum Mol Genet (2005) 1.52
Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Diabetes (2007) 1.51
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. Diabetes (2005) 1.45
Nonalcoholic fatty liver disease is associated with hepatic and skeletal muscle insulin resistance in overweight adolescents. Am J Clin Nutr (2008) 1.44
New gene variants alter type 2 diabetes risk predominantly through reduced beta-cell function. Curr Opin Clin Nutr Metab Care (2008) 1.43
The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes. J Clin Endocrinol Metab (2006) 1.36
Dose-dependent effects of oral and intravenous glucose on insulin secretion and clearance in normal humans. Am J Physiol (1988) 1.25
Alterations in liver, muscle, and adipose tissue insulin sensitivity in men with HIV infection and dyslipidemia. Am J Physiol Endocrinol Metab (2005) 1.21
Kir6.2 polymorphisms sensitize beta-cell ATP-sensitive potassium channels to activation by acyl CoAs: a possible cellular mechanism for increased susceptibility to type 2 diabetes? Diabetes (2003) 1.18
Beta-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1alpha mutation carriers. Diabetes Care (2005) 1.14
Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Hum Genet (2004) 1.10
Insulin secretion and clearance during low-dose graded glucose infusion. Am J Physiol (1995) 1.06
Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in while Caucasian subjects or evidence of abnormal function when expressed in vitro. Diabetologia (1996) 0.99
Hepatic metabolism of insulin. Am J Med (1988) 0.97
The E23K variant of KCNJ11 and the risk for severe sulfonylurea-induced hypoglycemia in patients with type 2 diabetes. Horm Metab Res (2009) 0.93
Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: The Hisayama Study. Diabetes (2007) 0.90
Clinical presentation and early course of type 1 diabetes in patients with and without thyroid autoimmunity. Diabetes Care (1999) 0.90
Nucleotide sensitivity of pancreatic ATP-sensitive potassium channels and type 2 diabetes. Diabetes (2002) 0.90
Genetic variations in the pancreatic ATP-sensitive potassium channel, beta-cell dysfunction, and susceptibility to type 2 diabetes. Acta Diabetol (2008) 0.90
Serum tolbutamide and chlorpropamide concentrations in patients with diabetes mellitus. Br Med J (1978) 0.88
Association of the Kir6.2 E23K variant with reduced acute insulin response in African-Americans. J Clin Endocrinol Metab (2008) 0.87
International trial of the Edmonton protocol for islet transplantation. N Engl J Med (2006) 13.43
Control of pancreas and liver gene expression by HNF transcription factors. Science (2004) 12.05
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39
Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease. N Engl J Med (2004) 6.12
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A (2009) 5.64
Transgenic mice with green fluorescent protein-labeled pancreatic beta -cells. Am J Physiol Endocrinol Metab (2002) 4.45
C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes (2004) 4.44
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13
Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci Transl Med (2011) 4.07
Insulin gene mutations as a cause of permanent neonatal diabetes. Proc Natl Acad Sci U S A (2007) 3.77
Core transcriptional regulatory circuitry in human hepatocytes. Mol Syst Biol (2006) 3.15
To nap or not to nap? Residents' work hours revisited. N Engl J Med (2009) 2.93
Identification of type 2 diabetes genes in Mexican Americans through genome-wide association studies. Diabetes (2007) 2.91
Increased islet apoptosis in Pdx1+/- mice. J Clin Invest (2003) 2.91
Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab (2009) 2.83
Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes (2002) 2.64
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology (2007) 2.29
Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease. J Pediatr (2012) 2.23
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity. J Clin Invest (2003) 2.23
Critical role of gap junction coupled KATP channel activity for regulated insulin secretion. PLoS Biol (2006) 2.20
Gastric bypass and banding equally improve insulin sensitivity and β cell function. J Clin Invest (2012) 2.19
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology (2009) 2.19
Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes. Diabetes (2008) 2.15
Permanent neonatal diabetes due to mutations in KCNJ11 encoding Kir6.2: patient characteristics and initial response to sulfonylurea therapy. Diabetes (2004) 2.10
Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes (2010) 2.10
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest (2004) 2.09
Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev (2010) 2.06
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat Commun (2012) 2.01
Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1. Circ Res (2008) 1.98
Fatty liver in familial hypobetalipoproteinemia: triglyceride assembly into VLDL particles is affected by the extent of hepatic steatosis. J Lipid Res (2002) 1.97
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab (2012) 1.93
Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan. J Clin Endocrinol Metab (2008) 1.91
In vitro processing and secretion of mutant insulin proteins that cause permanent neonatal diabetes. Am J Physiol Endocrinol Metab (2009) 1.88
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes (2009) 1.83
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
Molecular basis of ion selectivity, block, and rectification of the inward rectifier Kir3.1/Kir3.4 K(+) channel. J Biol Chem (2003) 1.79
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. J Clin Invest (2003) 1.73
Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Am J Clin Nutr (2012) 1.71
Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab (2003) 1.68
Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J Biol Chem (2003) 1.65
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pharmacol Rev (2005) 1.63
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci U S A (2006) 1.63
Sucralose affects glycemic and hormonal responses to an oral glucose load. Diabetes Care (2013) 1.63
Two-hour seven-sample oral glucose tolerance test and meal protocol: minimal model assessment of beta-cell responsivity and insulin sensitivity in nondiabetic individuals. Diabetes (2005) 1.62
Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am J Hum Genet (2002) 1.61
Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births. Acta Diabetol (2011) 1.59
Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice. PLoS One (2010) 1.58
GEL: a novel genotype calling algorithm using empirical likelihood. Bioinformatics (2006) 1.58
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 1.57
What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? Diabetes (2003) 1.56
Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice. Am J Physiol Heart Circ Physiol (2009) 1.56
Diagnosis and treatment of neonatal diabetes: a United States experience. Pediatr Diabetes (2008) 1.55
Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatment. Curr Diab Rep (2011) 1.52
Portal vein thrombosis complicating islet transplantation in a recipient with the Factor V Leiden mutation. Transplantation (2004) 1.51
WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation. Cell Metab (2013) 1.51
Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Res (2011) 1.50
Insulin sensitivity by oral glucose minimal models: validation against clamp. Am J Physiol Endocrinol Metab (2005) 1.50
Autophagy regulates pancreatic beta cell death in response to Pdx1 deficiency and nutrient deprivation. J Biol Chem (2009) 1.48
Effect of sex and obesity on basal VLDL-triacylglycerol kinetics. Am J Clin Nutr (2003) 1.48
Structure and transcription of the human m3 muscarinic receptor gene. Am J Respir Cell Mol Biol (2002) 1.47
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy. Diabetes (2005) 1.45
Heterogeneity and function of K(ATP) channels in canine hearts. Heart Rhythm (2013) 1.45
Direct modulation of Kir channel gating by membrane phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2005) 1.43
Optical imaging of pancreatic beta cells in living mice expressing a mouse insulin I promoter-firefly luciferase transgene. Genesis (2005) 1.42
MODY: history, genetics, pathophysiology, and clinical decision making. Diabetes Care (2011) 1.42
The physician scientist training program in internal medicine at Washington University School of Medicine. Acad Med (2009) 1.41
Ca2+ controls slow NAD(P)H oscillations in glucose-stimulated mouse pancreatic islets. J Physiol (2006) 1.41
Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis. Proc Natl Acad Sci U S A (2008) 1.39
Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Sci Transl Med (2013) 1.38
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics. J Lipid Res (2007) 1.37
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem (2004) 1.37
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. Cell Metab (2009) 1.36
Standardization of C-peptide measurements. Clin Chem (2008) 1.36
Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men. Am J Physiol Endocrinol Metab (2005) 1.34
Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts. J Mol Cell Cardiol (2011) 1.34
Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am J Physiol Endocrinol Metab (2002) 1.34
Differential nucleotide regulation of KATP channels by SUR1 and SUR2A. J Mol Cell Cardiol (2005) 1.32
Targeted ablation of glucose-dependent insulinotropic polypeptide-producing cells in transgenic mice reduces obesity and insulin resistance induced by a high fat diet. J Biol Chem (2008) 1.31
Women produce fewer but triglyceride-richer very low-density lipoproteins than men. J Clin Endocrinol Metab (2007) 1.31
An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes. Diabetes (2007) 1.30
Gating dependence of inner pore access in inward rectifier K(+) channels. Neuron (2003) 1.29
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab (2004) 1.29
The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy. J Clin Endocrinol Metab (2007) 1.28
Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Proc Natl Acad Sci U S A (2009) 1.28
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology (2012) 1.27
Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis. J Gen Physiol (2004) 1.27