Published in Proc Natl Acad Sci U S A on February 06, 2003
Synthesis of programmable integrases. Proc Natl Acad Sci U S A (2009) 1.94
Zinc-finger nucleases as a novel therapeutic strategy for targeting hepatitis B virus DNAs. Mol Ther (2010) 1.61
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
Rationalizing the development of live attenuated virus vaccines. Nat Biotechnol (2010) 1.26
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.21
Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A (2009) 1.15
Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA. Nat Protoc (2010) 0.99
Transport and self-organization across different length scales powered by motor proteins and programmed by DNA. Nat Nanotechnol (2013) 0.91
Inhibition of DNA replication of human papillomavirus by artificial zinc finger proteins. J Virol (2006) 0.82
The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. J Virol (2007) 0.81
Tailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae. PLoS One (2007) 0.81
Epigenetic manipulation of gene expression: a toolkit for cell biologists. J Cell Biol (2005) 0.81
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol (1974) 26.25
Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol (1985) 25.52
A short amino acid sequence able to specify nuclear location. Cell (1984) 21.17
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. Cell (1981) 11.62
Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J Mol Biol (1984) 8.87
Design and selection of novel Cys2His2 zinc finger proteins. Annu Rev Biochem (2001) 7.79
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO J (1984) 7.33
Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc Natl Acad Sci U S A (1998) 5.46
A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science (1997) 4.93
Krüppel-associated boxes are potent transcriptional repression domains. Proc Natl Acad Sci U S A (1994) 4.84
Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol Cell Biol (1985) 4.74
Herpes simplex virus infections. Lancet (2001) 4.41
Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol (2002) 4.40
Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions. Proc Natl Acad Sci U S A (1994) 4.12
Positive and negative regulation of endogenous genes by designed transcription factors. Proc Natl Acad Sci U S A (2000) 3.92
The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition. Nature (1993) 3.82
Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression. J Virol (1984) 3.76
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J Biol Chem (2001) 3.38
Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors. J Biol Chem (2001) 3.35
In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence. Nature (1994) 3.31
A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter. Nat Biotechnol (2001) 3.12
Building zinc fingers by selection: toward a therapeutic application. Proc Natl Acad Sci U S A (1995) 2.92
Induction of angiogenesis in a mouse model using engineered transcription factors. Nat Med (2002) 2.81
Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc Natl Acad Sci U S A (1998) 2.51
Tetracycline-reversible silencing of eukaryotic promoters. Mol Cell Biol (1995) 2.48
The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression. Proc Natl Acad Sci U S A (1994) 2.46
Comparison of upstream sequence requirements for positive and negative regulation of a herpes simplex virus immediate-early gene by three virus-encoded trans-acting factors. J Virol (1987) 2.27
Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units. Proc Natl Acad Sci U S A (2001) 2.13
Design of polyzinc finger peptides with structured linkers. Proc Natl Acad Sci U S A (2001) 1.88
The virtuoso of versatility: POU proteins that flex to fit. J Mol Biol (2000) 1.79
POU-domain proteins: structure and function of developmental regulators. Curr Opin Cell Biol (1993) 1.79
Repression of transcriptional activity by heterologous KRAB domains present in zinc finger proteins. FEBS Lett (1995) 1.62
Rapid, high-throughput engineering of sequence-specific zinc finger DNA-binding proteins. Methods Enzymol (2001) 1.49
Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J (1993) 1.35
The herpes simplex virus VP16-induced complex: mechanisms of combinatorial transcriptional regulation. Cold Spring Harb Symp Quant Biol (1998) 1.28
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.21
Advances in zinc finger engineering. Curr Opin Struct Biol (2000) 1.11
Regulation of endogenous gene expression with a small-molecule dimerizer. Nat Biotechnol (2002) 1.08
Regulation of transgene expression in plants with polydactyl zinc finger transcription factors. Proc Natl Acad Sci U S A (2002) 0.96
A ribozyme derived from the catalytic subunit of RNase P from Escherichia coli is highly effective in inhibiting replication of herpes simplex virus 1. J Mol Biol (2000) 0.93
Inhibition of herpes simplex virus replication by antisense oligo-2'-O-methylribonucleoside methylphosphonates. Biochemistry (1995) 0.89
Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme. Nucleic Acids Res (2001) 0.89
From repression domains to designer zinc finger proteins: a novel strategy of intracellular immunization against HIV. Gene Expr (1996) 0.87
Herpes simplex virus-mediated activation of human immunodeficiency virus is inhibited by oligonucleoside methylphosphonates that target immediate-early mRNAs 1 and 3. Antisense Nucleic Acid Drug Dev (1996) 0.79
Inhibition of HSV-1 proliferation by decoy phosphodiester oligonucleotides containing ICP4 recognition sequences. Gene Expr (1995) 0.78
Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases. Proc Natl Acad Sci U S A (2008) 6.59
Information leaflet and antibiotic prescribing strategies for acute lower respiratory tract infection: a randomized controlled trial. JAMA (2005) 6.33
Management of depression in UK general practice in relation to scores on depression severity questionnaires: analysis of medical record data. BMJ (2009) 4.93
Amoxicillin for acute lower-respiratory-tract infection in primary care when pneumonia is not suspected: a 12-country, randomised, placebo-controlled trial. Lancet Infect Dis (2012) 4.62
Antibiotics and topical nasal steroid for treatment of acute maxillary sinusitis: a randomized controlled trial. JAMA (2007) 4.39
Cryptococcal infection in a cohort of HIV-1-infected Ugandan adults. AIDS (2002) 3.99
Predictors of poor outcome and benefits from antibiotics in children with acute otitis media: pragmatic randomised trial. BMJ (2002) 2.63
Delayed antibiotic prescribing strategies for respiratory tract infections in primary care: pragmatic, factorial, randomised controlled trial. BMJ (2014) 2.46
Predictors of suppurative complications for acute sore throat in primary care: prospective clinical cohort study. BMJ (2013) 2.41
Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A (2003) 2.24
Randomised controlled trial of effect of leaflets to empower patients in consultations in primary care. BMJ (2004) 1.74
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences. Nucleic Acids Res (2008) 1.74
Developing clinical rules to predict urinary tract infection in primary care settings: sensitivity and specificity of near patient tests (dipsticks) and clinical scores. Br J Gen Pract (2006) 1.73
A randomized controlled trial of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving decitabine. Leuk Lymphoma (2012) 1.57
Crystal structure of a zinc-finger-RNA complex reveals two modes of molecular recognition. Nature (2003) 1.54
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol (2005) 1.52
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52
Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. BMJ (2013) 1.51
Implementing early infant diagnosis of HIV infection at the primary care level: experiences and challenges in Malawi. Bull World Health Organ (2012) 1.48
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA. Nucleic Acids Res (2008) 1.48
The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism. J Biol Chem (2002) 1.46
Designer zinc-finger proteins and their applications. Gene (2005) 1.33
Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nat Genet (2013) 1.30
Text-messaging-enhanced HIV intervention for African American adolescents: a feasibility study. J Assoc Nurses AIDS Care (2012) 1.28
Demographic Change, Social Security Systems, and Savings. J Monet Econ (2007) 1.27
ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. Am J Hum Genet (2013) 1.27
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
Human polynucleotide phosphorylase, hPNPase, is localized in mitochondria. J Mol Biol (2003) 1.22
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.21
PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Res (2011) 1.18
Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues. J Med Chem (2003) 1.15
The post-transcriptional life of mammalian mitochondrial RNA. Biochem J (2012) 1.14
Does a slower treatment rate impact the efficacy of extracorporeal shock wave lithotripsy for solitary kidney or ureteral stones? J Urol (2006) 1.14
A randomised controlled trial of three pragmatic approaches to initiate increased physical activity in sedentary patients with risk factors for cardiovascular disease. Br J Gen Pract (2004) 1.11
C7orf30 is necessary for biogenesis of the large subunit of the mitochondrial ribosome. Nucleic Acids Res (2012) 1.10
Tau protein, the paired helical filament and Alzheimer's disease. J Alzheimers Dis (2006) 1.10
Effects of volume and site of blood draw on blood culture results. J Clin Microbiol (2009) 1.09
European Antibiotic Awareness Day 2012: TARGET antibiotics through guidance, education, and tools. Br J Gen Pract (2012) 1.09
An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Mol Cell Biol (2010) 1.07
Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice. Proc Natl Acad Sci U S A (2012) 1.06
p53 Gene repair with zinc finger nucleases optimised by yeast 1-hybrid and validated by Solexa sequencing. PLoS One (2011) 1.04
Identification of the lumbar interspinous spaces: palpation versus ultrasound. Anesth Analg (2008) 1.04
Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations. EMBO Mol Med (2014) 1.02
The Ime2 protein kinase enhances the disassociation of the Sum1 repressor from middle meiotic promoters. Mol Cell Biol (2009) 1.00
Striking association between urinary cadmium level and albuminuria among Torres Strait Islander people with diabetes. Environ Res (2007) 1.00
Validating the prediction of lower urinary tract infection in primary care: sensitivity and specificity of urinary dipsticks and clinical scores in women. Br J Gen Pract (2010) 0.98
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes. Biochemistry (2004) 0.98
Antibiotics: time to act. Br J Gen Pract (2013) 0.97
Nasal self-swabbing for estimating the prevalence of Staphylococcus aureus in the community. J Med Microbiol (2012) 0.96
VARS2 and TARS2 mutations in patients with mitochondrial encephalomyopathies. Hum Mutat (2014) 0.96
Longer term outcomes from a randomised trial of prescribing strategies in otitis media. Br J Gen Pract (2006) 0.94
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry. J Am Chem Soc (2006) 0.93
Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev (2014) 0.93
Point of care testing for urinary tract infection in primary care (POETIC): protocol for a randomised controlled trial of the clinical and cost effectiveness of FLEXICULT™ informed management of uncomplicated UTI in primary care. BMC Fam Pract (2014) 0.92
Engineering prokaryotic gene circuits. FEMS Microbiol Rev (2008) 0.91
Building synthetic gene circuits from combinatorial libraries: screening and selection strategies. Mol Biosyst (2013) 0.91
Safety of antidepressants in adults aged under 65: protocol for a cohort study using a large primary care database. BMC Psychiatry (2013) 0.91
Practitioner-supported delivery of internet-based cognitive behaviour therapy: evaluation of the feasibility of conducting a cluster randomised trial. Med J Aust (2010) 0.90
Does a high UV environment ensure adequate vitamin D status? J Photochem Photobiol B (2007) 0.90
Genetically encoded sender-receiver system in 3D mammalian cell culture. ACS Synth Biol (2013) 0.90
Cell-free selection of zinc finger DNA-binding proteins using in vitro compartmentalization. J Mol Biol (2005) 0.90
Regulation of gene expression in Arabidopsis thaliana by artificial zinc finger chimeras. Plant Cell Physiol (2002) 0.90
A case-control study to investigate serological correlates of clinical failure of 23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults. J Infect Dis (2004) 0.89
Mortality trends of stranded marine mammals on Cape Cod and southeastern Massachusetts, USA, 2000 to 2006. Dis Aquat Organ (2010) 0.89
Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Res (2012) 0.89
Occurrence and patterns of antibiotic resistance in vertebrates off the Northeastern United States coast. FEMS Microbiol Ecol (2009) 0.89
The BREATHE study: Breathing REtraining for Asthma--Trial of Home Exercises. a protocol summary of a randomised controlled trial. Prim Care Respir J (2013) 0.88
Genetic characterization and phylogenetic analysis of skunk-associated rabies viruses in North America with special emphasis on the central plains. Virus Res (2013) 0.87
Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2). Hum Mutat (2015) 0.87
Mitochondrial transcript maturation and its disorders. J Inherit Metab Dis (2015) 0.87
General practice: professional preparation for a pandemic. Med J Aust (2006) 0.87
Mitochondria: mitochondrial RNA metabolism and human disease. Int J Biochem Cell Biol (2013) 0.87
Decongestants and antihistamines for acute otitis media in children. Cochrane Database Syst Rev (2008) 0.86
A biobrick library for cloning custom eukaryotic plasmids. PLoS One (2011) 0.86
Feasibility of detection and intervention for alcohol-related liver disease in the community: the Alcohol and Liver Disease Detection study (ALDDeS). Br J Gen Pract (2013) 0.85
Correlates of cytochrome P450 1A1 expression in bottlenose dolphin (Tursiops truncatus) integument biopsies. Toxicol Sci (2007) 0.85
Exploring potential dietary contributions including traditional seafood and other determinants of urinary cadmium levels among indigenous women of a Torres Strait Island (Australia). J Expo Sci Environ Epidemiol (2007) 0.85
Distal radius osteotomy in the elderly patient using angular stable implants and Norian bone cement. J Hand Surg Am (2007) 0.84
Are patient beliefs important in determining adherence to treatment and outcome for depression? Development of the beliefs about depression questionnaire. J Affect Disord (2011) 0.84
Effect of carbon starvation on p-nitrophenol degradation by a Moraxella strain in buffer and river water. FEMS Microbiol Ecol (2005) 0.83
How do primary health-care practitioners identify and manage communication impairments in preschool children? Aust J Prim Health (2015) 0.83
Regulation of Arabidopsis thaliana 4-coumarate:coenzyme-A ligase-1 expression by artificial zinc finger chimeras. Plant Biotechnol J (2006) 0.83
Public say food regulatory policies to improve health in Western Australia are important: population survey results. Aust N Z J Public Health (2013) 0.83
The PLOS ONE synthetic biology collection: six years and counting. PLoS One (2012) 0.83
Cooperativity to increase Turing pattern space for synthetic biology. ACS Synth Biol (2014) 0.83
Routine use of patient reported outcome measures (PROMs) for improving treatment of common mental health disorders in adults. Cochrane Database Syst Rev (2016) 0.82
Outcomes of a laparoscopic approach for total abdominal colectomy and proctocolectomy. Am J Surg (2006) 0.82
Corticosteroids for acute and subacute cough following respiratory tract infection: a systematic review. Fam Pract (2013) 0.82
Comparison of intravenous sedation versus general anesthesia on the efficacy of the Doli 50 lithotriptor. J Urol (2002) 0.82
Tailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae. PLoS One (2007) 0.81