Rapid, high-throughput engineering of sequence-specific zinc finger DNA-binding proteins.

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol (2008) 14.75

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One (2009) 6.67

Precise genome modification in the crop species Zea mays using zinc-finger nucleases. Nature (2009) 4.71

Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection. Proc Natl Acad Sci U S A (2003) 3.29

A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR. Blood (2012) 1.61

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (2011) 1.54

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases. PLoS Pathog (2011) 1.50

Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein. BMC Bioinformatics (2005) 1.31

Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.21

Profiling the DNA-binding specificities of engineered Cys2His2 zinc finger domains using a rapid cell-based method. Nucleic Acids Res (2007) 1.17

Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors. Proc Natl Acad Sci U S A (2003) 1.10

Tailor-made zinc-finger transcription factors activate FLO11 gene expression with phenotypic consequences in the yeast Saccharomyces cerevisiae. PLoS One (2007) 0.81

Upregulation of endogenous HMOX1 expression by a computer-designed artificial transcription factor. J Biomed Biotechnol (2010) 0.75

Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci U S A (2001) 5.08

Synergy between adjacent zinc fingers in sequence-specific DNA recognition. Proc Natl Acad Sci U S A (1997) 3.32

A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter. Nat Biotechnol (2001) 3.12

Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers. Biochemistry (1998) 2.51

Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units. Proc Natl Acad Sci U S A (2001) 2.13

Design of polyzinc finger peptides with structured linkers. Proc Natl Acad Sci U S A (2001) 1.88

Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation. Biochemistry (2001) 1.19

Engineering nucleic acid-binding proteins by phage display. Methods Mol Biol (2001) 0.90

Engineered zinc finger proteins that respond to DNA modification by HaeIII and HhaI methyltransferase enzymes. J Mol Biol (2000) 0.85

Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten. Arch Pharm Res (2001) 0.82

All wrapped up. Nat Struct Biol (1998) 0.80

Histocompatibility 1991. Transfusion (1992) 0.75