Published in J Mol Biol on February 21, 2003
Structural basis for converting a general transcription factor into an operon-specific virulence regulator. Mol Cell (2007) 2.56
Structural plasticity of an aminoacyl-tRNA synthetase active site. Proc Natl Acad Sci U S A (2006) 1.13
Sequence determinants of a conformational switch in a protein structure. Proc Natl Acad Sci U S A (2005) 1.08
Effects of temperature and salt concentration on the structural stability of human lymphotactin: insights from molecular simulations. J Am Chem Soc (2006) 0.88
An energetic representation of protein architecture that is independent of primary and secondary structure. Biophys J (2009) 0.80
Mutagenic dissection of the sequence determinants of protein folding, recognition, and machine function. Protein Sci (2013) 0.78
A polymetamorphic protein. Protein Sci (2013) 0.76
OMP peptide signals initiate the envelope-stress response by activating DegS protease via relief of inhibition mediated by its PDZ domain. Cell (2003) 4.21
Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol (2007) 4.09
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines. Nature (2005) 4.05
Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals. Mol Cell (2003) 3.95
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nat Struct Mol Biol (2008) 3.41
Linkage between ATP consumption and mechanical unfolding during the protein processing reactions of an AAA+ degradation machine. Cell (2003) 3.33
The tmRNA system for translational surveillance and ribosome rescue. Annu Rev Biochem (2007) 3.21
Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87
ATP-dependent proteases of bacteria: recognition logic and operating principles. Trends Biochem Sci (2006) 2.86
Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality control. Mol Cell (2003) 2.67
Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell (2011) 2.40
Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell (2005) 2.33
Allosteric activation of DegS, a stress sensor PDZ protease. Cell (2007) 2.32
Engineering controllable protein degradation. Mol Cell (2006) 2.23
ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17
Proline residues at the C terminus of nascent chains induce SsrA tagging during translation termination. J Biol Chem (2002) 2.15
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates. Genes Dev (2004) 2.11
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation. Genes Dev (2004) 2.08
Stop codons preceded by rare arginine codons are efficient determinants of SsrA tagging in Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.02
Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes. Nat Struct Mol Biol (2008) 1.95
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol Cell (2007) 1.91
Communication between ClpX and ClpP during substrate processing and degradation. Nat Struct Mol Biol (2004) 1.85
Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing. Proc Natl Acad Sci U S A (2005) 1.85
Dynamic NMR line-shape analysis demonstrates that the villin headpiece subdomain folds on the microsecond time scale. J Am Chem Soc (2003) 1.82
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
Recognition of misfolded proteins by Lon, a AAA(+) protease. Genes Dev (2008) 1.77
Crystal structure of the nickel-responsive transcription factor NikR. Nat Struct Biol (2003) 1.74
Proteomic profiling of ClpXP substrates after DNA damage reveals extensive instability within SOS regulon. Mol Cell (2006) 1.74
Ribosome rescue: tmRNA tagging activity and capacity in Escherichia coli. Mol Microbiol (2005) 1.69
Cytoplasmic degradation of ssrA-tagged proteins. Mol Microbiol (2005) 1.62
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase. Mol Microbiol (2014) 1.62
Flexible linkers leash the substrate binding domain of SspB to a peptide module that stabilizes delivery complexes with the AAA+ ClpXP protease. Mol Cell (2003) 1.61
Effects of local protein stability and the geometric position of the substrate degradation tag on the efficiency of ClpXP denaturation and degradation. J Struct Biol (2004) 1.61
Characterization of a specificity factor for an AAA+ ATPase: assembly of SspB dimers with ssrA-tagged proteins and the ClpX hexamer. Chem Biol (2002) 1.60
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag. Mol Cell (2003) 1.57
The role of aromatic residues in the hydrophobic core of the villin headpiece subdomain. Protein Sci (2002) 1.56
Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56
Design, construction and characterization of a set of insulated bacterial promoters. Nucleic Acids Res (2010) 1.55
Direct and adaptor-mediated substrate recognition by an essential AAA+ protease. Proc Natl Acad Sci U S A (2007) 1.51
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
Characterizing a partially folded intermediate of the villin headpiece domain under non-denaturing conditions: contribution of His41 to the pH-dependent stability of the N-terminal subdomain. J Mol Biol (2005) 1.47
NikR repressor: high-affinity nickel binding to the C-terminal domain regulates binding to operator DNA. Chem Biol (2002) 1.41
Energy-dependent degradation: Linkage between ClpX-catalyzed nucleotide hydrolysis and protein-substrate processing. Protein Sci (2003) 1.39
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease. Proc Natl Acad Sci U S A (2003) 1.36
Bivalent tethering of SspB to ClpXP is required for efficient substrate delivery: a protein-design study. Mol Cell (2004) 1.35
Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease. J Mol Biol (2011) 1.33
Polypeptide translocation by the AAA+ ClpXP protease machine. Chem Biol (2009) 1.32
Inhibition of regulated proteolysis by RseB. Proc Natl Acad Sci U S A (2007) 1.32
Control of Pseudomonas aeruginosa AlgW protease cleavage of MucA by peptide signals and MucB. Mol Microbiol (2009) 1.31
High-resolution crystal structures of villin headpiece and mutants with reduced F-actin binding activity. Biochemistry (2005) 1.29
Toxin-antitoxin pairs in bacteria: killers or stress regulators? Cell (2003) 1.28
Temperature-dependent dynamics of the villin headpiece helical subdomain, an unusually small thermostable protein. J Mol Biol (2002) 1.28
Degrons in protein substrates program the speed and operating efficiency of the AAA+ Lon proteolytic machine. Proc Natl Acad Sci U S A (2009) 1.27
ClpS modulates but is not essential for bacterial N-end rule degradation. Genes Dev (2007) 1.26
Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nat Struct Mol Biol (2012) 1.26
Latent ClpX-recognition signals ensure LexA destruction after DNA damage. Genes Dev (2003) 1.24
Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease. Nat Struct Mol Biol (2005) 1.22
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat Struct Mol Biol (2005) 1.22
Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Nat Struct Biol (2002) 1.20
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J Mol Biol (2010) 1.16
Asymmetric nucleotide transactions of the HslUV protease. J Mol Biol (2008) 1.16
OMP peptides modulate the activity of DegS protease by differential binding to active and inactive conformations. Mol Cell (2009) 1.14
Dual molecular signals mediate the bacterial response to outer-membrane stress. Science (2013) 1.13
SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags. Proc Natl Acad Sci U S A (2004) 1.13
Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem (2007) 1.12
Nickel coordination is regulated by the DNA-bound state of NikR. Nat Struct Biol (2003) 1.12
Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease. Proc Natl Acad Sci U S A (2009) 1.11
Altered specificity of a AAA+ protease. Mol Cell (2007) 1.10
Tuning the strength of a bacterial N-end rule degradation signal. J Biol Chem (2008) 1.08
Evolution of the ssrA degradation tag in Mycoplasma: specificity switch to a different protease. Proc Natl Acad Sci U S A (2008) 1.08
Sequence determinants of a conformational switch in a protein structure. Proc Natl Acad Sci U S A (2005) 1.08
Distinct structural elements of the adaptor ClpS are required for regulating degradation by ClpAP. Nat Struct Mol Biol (2008) 1.07
Ribosomal protein S1 binds mRNA and tmRNA similarly but plays distinct roles in translation of these molecules. Proc Natl Acad Sci U S A (2004) 1.06
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure (2009) 1.06
Molecular basis of substrate selection by the N-end rule adaptor protein ClpS. Proc Natl Acad Sci U S A (2009) 1.05
A novel nontruncating APOB gene mutation, R463W, causes familial hypobetalipoproteinemia. J Biol Chem (2003) 1.05
Unique contacts direct high-priority recognition of the tetrameric Mu transposase-DNA complex by the AAA+ unfoldase ClpX. Mol Cell (2008) 1.05
Protein unfolding and degradation by the AAA+ Lon protease. Protein Sci (2012) 1.02
Covalent linkage of distinct substrate degrons controls assembly and disassembly of DegP proteolytic cages. Cell (2011) 1.02
Signal integration by DegS and RseB governs the σ E-mediated envelope stress response in Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.02
Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J Biol Chem (2010) 1.00
Defining lipid-interacting domains in the N-terminal region of apolipoprotein B. Biochemistry (2006) 0.99
Altered tethering of the SspB adaptor to the ClpXP protease causes changes in substrate delivery. J Biol Chem (2007) 0.99
The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease. Mol Microbiol (2010) 0.98
Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. J Am Chem Soc (2014) 0.98
Molecular model of the microvillar cytoskeleton and organization of the brush border. PLoS One (2010) 0.97
Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc Natl Acad Sci U S A (2013) 0.96
The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site. J Biol Chem (2003) 0.95
The differential impact of disulfide bonds and N-linked glycosylation on the stability and function of CD14. J Biol Chem (2007) 0.95
The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol Cell (2011) 0.94
Forced extraction of targeted components from complex macromolecular assemblies. Proc Natl Acad Sci U S A (2008) 0.94
Crystal structure of a pH-stabilized mutant of villin headpiece. Biochemistry (2008) 0.93
C-terminal domain mutations in ClpX uncouple substrate binding from an engagement step required for unfolding. Mol Microbiol (2003) 0.93
Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival. Proc Natl Acad Sci U S A (2012) 0.93
Limited proteolysis and biophysical characterization of the lipovitellin homology region in apolipoprotein B. Biochemistry (2005) 0.93
Engineering synthetic adaptors and substrates for controlled ClpXP degradation. J Biol Chem (2009) 0.92
A phosphorylation-induced conformation change in dematin headpiece. Structure (2006) 0.92