Published in Biotechnol Bioeng on April 20, 2003
Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb Cell Fact (2005) 1.47
The role of tRNA and ribosome competition in coupling the expression of different mRNAs in Saccharomyces cerevisiae. Nucleic Acids Res (2011) 1.07
Suppression of metabolic defects of yeast isocitrate dehydrogenase and aconitase mutants by loss of citrate synthase. Arch Biochem Biophys (2008) 0.87
The number of catalytic elements is crucial for the emergence of metabolic cores. PLoS One (2009) 0.87
The yin and yang of yeast transcription: elements of a global feedback system between metabolism and chromatin. PLoS One (2012) 0.86
Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast. J Mol Evol (2009) 0.86
Global self-organization of the cellular metabolic structure. PLoS One (2008) 0.85
Structural basis for L-lysine feedback inhibition of homocitrate synthase. J Biol Chem (2010) 0.83
Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability. J Biol Chem (2012) 0.83
Elements of the cellular metabolic structure. Front Mol Biosci (2015) 0.83
Global self-regulation of the cellular metabolic structure. PLoS One (2010) 0.80
The metabolic core and catalytic switches are fundamental elements in the self-regulation of the systemic metabolic structure of cells. PLoS One (2011) 0.79
Quantitative analysis of cellular metabolic dissipative, self-organized structures. Int J Mol Sci (2010) 0.78
On the dynamics of the adenylate energy system: homeorhesis vs homeostasis. PLoS One (2014) 0.77
Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus. J Biol Chem (2011) 0.76
Role of phosphatidylserine synthase in shaping the phospholipidome of Candida albicans. FEMS Yeast Res (2017) 0.75
(1)H NMR metabolomic study of auxotrophic starvation in yeast using Multivariate Curve Resolution-Alternating Least Squares for Pathway Analysis. Sci Rep (2016) 0.75
Diversification of the kinetic properties of yeast NADP-glutamate-dehydrogenase isozymes proceeds independently of their evolutionary origin. Microbiologyopen (2016) 0.75
Complete genome sequence of the myxobacterium Sorangium cellulosum. Nat Biotechnol (2007) 2.43
Correcting mass isotopomer distributions for naturally occurring isotopes. Biotechnol Bioeng (2002) 1.90
Sampling for metabolome analysis of microorganisms. Anal Chem (2007) 1.89
Identification and quantification of feathers, down, and hair of avian and mammalian origin using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Chem (2002) 1.67
The yeast Kluyveromyces marxianus and its biotechnological potential. Appl Microbiol Biotechnol (2008) 1.61
OpenFLUX: efficient modelling software for 13C-based metabolic flux analysis. Microb Cell Fact (2009) 1.61
Genealogy profiling through strain improvement by using metabolic network analysis: metabolic flux genealogy of several generations of lysine-producing corynebacteria. Appl Environ Microbiol (2002) 1.58
Impact of the cold shock phenomenon on quantification of intracellular metabolites in bacteria. Anal Biochem (2004) 1.55
Comparative metabolic flux analysis of lysine-producing Corynebacterium glutamicum cultured on glucose or fructose. Appl Environ Microbiol (2004) 1.50
Systems metabolic engineering of xylose-utilizing Corynebacterium glutamicum for production of 1,5-diaminopentane. Biotechnol J (2013) 1.50
From zero to hero--design-based systems metabolic engineering of Corynebacterium glutamicum for L-lysine production. Metab Eng (2011) 1.47
Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative 13C flux analysis. Microb Cell Fact (2005) 1.47
Amplified expression of fructose 1,6-bisphosphatase in Corynebacterium glutamicum increases in vivo flux through the pentose phosphate pathway and lysine production on different carbon sources. Appl Environ Microbiol (2005) 1.44
Bio-based production of chemicals, materials and fuels -Corynebacterium glutamicum as versatile cell factory. Curr Opin Biotechnol (2011) 1.43
Integrated optical sensing of dissolved oxygen in microtiter plates: a novel tool for microbial cultivation. Biotechnol Bioeng (2003) 1.41
Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. Bioprocess Biosyst Eng (2010) 1.40
In vivo analysis of intracellular amino acid labelings by GC/MS. Anal Biochem (2002) 1.37
Minibioreactors. Biotechnol Lett (2004) 1.37
In-depth profiling of lysine-producing Corynebacterium glutamicum by combined analysis of the transcriptome, metabolome, and fluxome. J Bacteriol (2004) 1.32
In vivo quantification of intracellular amino acids and intermediates of the methionine pathway in Corynebacterium glutamicum. Anal Biochem (2005) 1.23
Industrial biotechnology of Pseudomonas putida and related species. Appl Microbiol Biotechnol (2012) 1.20
Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane. Metab Eng (2010) 1.17
Characterization and application of an optical sensor for quantification of dissolved O2 in shake-flasks. Biotechnol Lett (2003) 1.15
Selective permeabilization for the high-throughput measurement of compartmented enzyme activities in mammalian cells. Anal Biochem (2011) 1.14
Two-dimensional reversed-phase x ion-pair reversed-phase HPLC: an alternative approach to high-resolution peptide separation for shotgun proteome analysis. J Proteome Res (2007) 1.13
Metabolic flux analysis in eukaryotes. Curr Opin Biotechnol (2010) 1.13
Metabolic flux engineering of L-lysine production in Corynebacterium glutamicum--over expression and modification of G6P dehydrogenase. J Biotechnol (2007) 1.12
Characterization and control of fungal morphology for improved production performance in biotechnology. J Biotechnol (2012) 1.09
Systems and synthetic metabolic engineering for amino acid production - the heartbeat of industrial strain development. Curr Opin Biotechnol (2012) 1.09
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicol Appl Pharmacol (2009) 1.07
Metabolic flux analysis in systems biology of mammalian cells. Adv Biochem Eng Biotechnol (2012) 1.07
Isotope labeling experiments in metabolomics and fluxomics. Wiley Interdiscip Rev Syst Biol Med (2012) 1.06
On-line oxygen uptake rate and culture viability measurement of animal cell culture using microplates with integrated oxygen sensors. Biotechnol Lett (2004) 1.05
Transcriptional and metabolic responses of Bacillus subtilis to the availability of organic acids: transcription regulation is important but not sufficient to account for metabolic adaptation. Appl Environ Microbiol (2006) 1.05
Ionic (liquid) matrices for matrix-assisted laser desorption/ionization mass spectrometry-applications and perspectives. Anal Bioanal Chem (2006) 1.02
Metabolic network analysis of lysine producing Corynebacterium glutamicum at a miniaturized scale. Biotechnol Bioeng (2004) 1.02
Response of the central metabolism of Escherichia coli to modified expression of the gene encoding the glucose-6-phosphate dehydrogenase. FEBS Lett (2007) 1.01
3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies. Toxicol Sci (2013) 1.01
Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli. Microb Cell Fact (2012) 1.01
Optical device for parallel online measurement of dissolved oxygen and pH in shake flask cultures. Bioprocess Biosyst Eng (2009) 1.00
Getting the big beast to work--systems biotechnology of Bacillus megaterium for novel high-value proteins. J Biotechnol (2012) 1.00
Theoretical aspects of 13C metabolic flux analysis with sole quantification of carbon dioxide labeling. Comput Biol Chem (2005) 1.00
Morphology engineering of Aspergillus niger for improved enzyme production. Biotechnol Bioeng (2010) 1.00
Metabolic fluxes in the central carbon metabolism of Dinoroseobacter shibae and Phaeobacter gallaeciensis, two members of the marine Roseobacter clade. BMC Microbiol (2009) 0.99
Metabolic pathway analysis for rational design of L-methionine production by Escherichia coli and Corynebacterium glutamicum. Metab Eng (2006) 0.99
Metabolic responses to pyruvate kinase deletion in lysine producing Corynebacterium glutamicum. Microb Cell Fact (2008) 0.98
Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein. Metab Eng (2013) 0.97
Improved enzyme production by bio-pellets of Aspergillus niger: targeted morphology engineering using titanate microparticles. Biotechnol Bioeng (2011) 0.97
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry combined with multidimensional scaling, binary hierarchical cluster tree and selected diagnostic masses improves species identification of Neolithic keratin sequences from furs of the Tyrolean Iceman Oetzi. Rapid Commun Mass Spectrom (2012) 0.96
Species identification of Oetzi's clothing with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry based on peptide pattern similarities of hair digests. Rapid Commun Mass Spectrom (2008) 0.96
Physiology of the yeast Kluyveromyces marxianus during batch and chemostat cultures with glucose as the sole carbon source. FEMS Yeast Res (2007) 0.95
Metabolic engineering of cellular transport for overproduction of the platform chemical 1,5-diaminopentane in Corynebacterium glutamicum. Metab Eng (2011) 0.95
Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol (2011) 0.95
Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions--targeted precursor feeding designed from metabolomics. Biotechnol Bioeng (2012) 0.94
Hybrid optimization for 13C metabolic flux analysis using systems parametrized by compactification. BMC Syst Biol (2008) 0.94
Modeling of mixing in 96-well microplates observed with fluorescence indicators. Biotechnol Prog (2002) 0.94
Flux Design: In silico design of cell factories based on correlation of pathway fluxes to desired properties. BMC Syst Biol (2009) 0.93
Microbial production of the drugs violacein and deoxyviolacein: analytical development and strain comparison. Biotechnol Lett (2011) 0.93
Identification and elimination of the competing N-acetyldiaminopentane pathway for improved production of diaminopentane by Corynebacterium glutamicum. Appl Environ Microbiol (2010) 0.93
Microplates with integrated oxygen sensing for medium optimization in animal cell culture. Cytotechnology (2005) 0.93
Microparticle based morphology engineering of filamentous microorganisms for industrial bio-production. Biotechnol Lett (2012) 0.92
Systems biology of recombinant protein production using Bacillus megaterium. Methods Enzymol (2011) 0.92
Integration of in vivo and in silico metabolic fluxes for improvement of recombinant protein production. Metab Eng (2011) 0.92
Appropriate sampling for intracellular amino acid analysis in five phylogenetically different yeasts. Biotechnol Lett (2008) 0.92
Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling. Biotechnol J (2009) 0.91
Metabolic network simulation using logical loop algorithm and Jacobian matrix. Metab Eng (2004) 0.91
PH-sensing 96-well microtitre plates for the characterization of acid production by dairy starter cultures. J Dairy Res (2003) 0.91
Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products. Angew Chem Int Ed Engl (2015) 0.90
Filamentous fungi in good shape: microparticles for tailor-made fungal morphology and enhanced enzyme production. Bioeng Bugs (2011) 0.90
Doxorubicin increases oxidative metabolism in HL-1 cardiomyocytes as shown by 13C metabolic flux analysis. Toxicol Sci (2011) 0.90
Comparative study on central metabolic fluxes of Bacillus megaterium strains in continuous culture using 13C labelled substrates. Bioprocess Biosyst Eng (2006) 0.90
Metabolic engineering of industrial platform microorganisms for biorefinery applications--optimization of substrate spectrum and process robustness by rational and evolutive strategies. Bioresour Technol (2012) 0.89
Optimized bioprocess for production of fructofuranosidase by recombinant Aspergillus niger. Appl Microbiol Biotechnol (2010) 0.89
Metabolic fluxes and beyond-systems biology understanding and engineering of microbial metabolism. Appl Microbiol Biotechnol (2010) 0.89
An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells. Toxicol Appl Pharmacol (2009) 0.88
In-silico-driven metabolic engineering of Pseudomonas putida for enhanced production of poly-hydroxyalkanoates. Metab Eng (2012) 0.88
Numerical bias estimation for mass spectrometric mass isotopomer analysis. Anal Biochem (2009) 0.88
Reconciling in vivo and in silico key biological parameters of Pseudomonas putida KT2440 during growth on glucose under carbon-limited condition. BMC Biotechnol (2013) 0.88
Metabolic engineering of Corynebacterium glutamicum for production of 1,5-diaminopentane from hemicellulose. Biotechnol J (2011) 0.87
Bio-based production of the platform chemical 1,5-diaminopentane. Appl Microbiol Biotechnol (2011) 0.87
Qualitative and quantitative analysis of low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry using ionic liquid matrices. Rapid Commun Mass Spectrom (2004) 0.86
Metabolic engineering of the tricarboxylic acid cycle for improved lysine production by Corynebacterium glutamicum. Appl Environ Microbiol (2009) 0.86
Primary metabolism in the new human cell line AGE1.HN at various substrate levels: increased metabolic efficiency and α1-antitrypsin production at reduced pyruvate load. Appl Microbiol Biotechnol (2011) 0.86
Engineering the supply chain for protein production/secretion in yeasts and mammalian cells. J Ind Microbiol Biotechnol (2015) 0.85
Eukaryotic metabolism: measuring compartment fluxes. Biotechnol J (2011) 0.85
In-depth physiological characterization of primary human hepatocytes in a 3D hollow-fiber bioreactor. J Tissue Eng Regen Med (2011) 0.85
Derivatization of small biomolecules for optimized matrix-assisted laser desorption/ionization mass spectrometry. J Mass Spectrom (2002) 0.85