Published in J Cell Biol on August 01, 1994
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A (1996) 4.16
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci (2008) 1.65
Role of phosphorylation on the structural dynamics and function of types III and IV intermediate filaments. Exp Cell Res (2007) 1.52
Rostrocaudal analysis of corpus callosum demyelination and axon damage across disease stages refines diffusion tensor imaging correlations with pathological features. J Neuropathol Exp Neurol (2010) 1.50
Subunit composition of neurofilaments specifies axonal diameter. J Cell Biol (1996) 1.39
Purkinje cell injury, structural plasticity and fusion in patients with Friedreich's ataxia. Acta Neuropathol Commun (2016) 1.38
Glutamate slows axonal transport of neurofilaments in transfected neurons. J Cell Biol (2000) 1.33
Requirement of heavy neurofilament subunit in the development of axons with large calibers. J Cell Biol (1998) 1.32
Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J Neurosci (1996) 1.28
GDNF-enhanced axonal regeneration and myelination following spinal cord injury is mediated by primary effects on neurons. Glia (2009) 1.26
Increasing neurofilament subunit NF-M expression reduces axonal NF-H, inhibits radial growth, and results in neurofilamentous accumulation in motor neurons. J Cell Biol (1995) 1.25
Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J Cell Biol (2000) 1.22
Neurofilament subunit NF-H modulates axonal diameter by selectively slowing neurofilament transport. J Cell Biol (1996) 1.20
Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J Cell Biol (1995) 1.17
Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation. J Cell Biol (1998) 1.16
Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci (2008) 1.15
Disruption of the NF-H gene increases axonal microtubule content and velocity of neurofilament transport: relief of axonopathy resulting from the toxin beta,beta'-iminodipropionitrile. J Cell Biol (1998) 1.14
Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. J Clin Invest (2003) 1.14
Gene replacement in mice reveals that the heavily phosphorylated tail of neurofilament heavy subunit does not affect axonal caliber or the transit of cargoes in slow axonal transport. J Cell Biol (2002) 1.11
Relating interactions between neurofilaments to the structure of axonal neurofilament distributions through polymer brush models. Biophys J (2002) 1.08
The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate. J Cell Biol (2003) 1.07
Neurofilaments at a glance. J Cell Sci (2012) 1.06
Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin-dependent radial axonal growth. J Neurosci (2009) 1.04
Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses. J Neurosci (2009) 1.01
Pharmacological induction of the heat shock response improves myelination in a neuropathic model. Neurobiol Dis (2008) 1.00
Neurofilaments form a highly stable stationary cytoskeleton after reaching a critical level in axons. J Neurosci (2009) 0.98
Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. Mol Biol Cell (2007) 0.94
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat. Brain Res (2009) 0.91
Psychosine induces the dephosphorylation of neurofilaments by deregulation of PP1 and PP2A phosphatases. Neurobiol Dis (2012) 0.90
A dynamical system model of neurofilament transport in axons. J Theor Biol (2005) 0.90
Axonal pathology precedes demyelination in a mouse model of X-linked demyelinating/type I Charcot-Marie Tooth neuropathy. J Neuropathol Exp Neurol (2010) 0.89
Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments. Neurobiol Aging (2009) 0.87
M-phase-specific phosphorylation and structural rearrangement of the cytoplasmic cross-linking protein plectin involve p34cdc2 kinase. Mol Biol Cell (1996) 0.86
Physical model for the width distribution of axons. Eur Phys J E Soft Matter (2009) 0.86
Preventing flow-metabolism uncoupling acutely reduces axonal injury after traumatic brain injury. J Neurotrauma (2012) 0.84
Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. J Biol Chem (2008) 0.84
Role of cyclins in neuronal differentiation of immortalized hippocampal cells. Mol Cell Biol (1997) 0.84
Dynamic changes of neuroskeletal proteins in DRGs underlie impaired axonal maturation and progressive axonal degeneration in type 1 diabetes. Exp Diabetes Res (2009) 0.83
Differential effects of FK506 on structural and functional axonal deficits after diffuse brain injury in the immature rat. J Neuropathol Exp Neurol (2012) 0.83
Gene targeting studies begin to reveal the function of neurofilament proteins. J Cell Biol (1998) 0.82
Axon diameter and axonal transport: In vivo and in vitro effects of androgens. Neuroimage (2015) 0.80
Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments. Front Cell Neurosci (2014) 0.80
Neurofilament Phosphorylation during Development and Disease: Which Came First, the Phosphorylation or the Accumulation? J Amino Acids (2012) 0.79
Hyperphosphorylation and accumulation of neurofilament proteins in transgenic mice with Alzheimer presenilin 1 mutation. Cell Mol Neurobiol (2009) 0.78
The C-terminal domains of NF-H and NF-M subunits maintain axonal neurofilament content by blocking turnover of the stationary neurofilament network. PLoS One (2012) 0.78
Local regulation of neurofilament transport by myelinating cells. J Neurosci (2014) 0.78
Signaling mechanisms and disrupted cytoskeleton in the diphenyl ditelluride neurotoxicity. Oxid Med Cell Longev (2014) 0.77
Modulation of phosphorylation of neuronal cytoskeletal proteins by neuronal depolarization. Cell Mol Neurobiol (1997) 0.77
Conformational properties of interacting neurofilaments: Monte Carlo simulations of cylindrically grafted apposing neurofilament brushes. J Biol Phys (2012) 0.77
Human intraretinal myelination: axon diameters and axon/myelin thickness ratios. Indian J Ophthalmol (2013) 0.76
Human retinal astroglia. A comparative study of adult and the 18 month postnatal developmental stage. J Anat (2000) 0.76
The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair. Sci Rep (2016) 0.75
Cytoskeleton as a potential target in the neuropathology of maple syrup urine disease: insight from animal studies. J Inherit Metab Dis (2007) 0.75
Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma. Front Neurosci (2016) 0.75
Changes in Neurofilament and Microtubule Distribution following Focal Axon Compression. PLoS One (2015) 0.75
Dissociation of Axonal Neurofilament Content from Its Transport Rate. PLoS One (2015) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem (1981) 38.93
Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci U S A (1983) 6.14
Molecular and cellular biology of intermediate filaments. Annu Rev Biochem (1988) 5.48
Monoclonal antibodies show that neurofibrillary tangles and neurofilaments share antigenic determinants. Nature (1982) 4.93
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons. J Cell Biol (1975) 4.70
Intermediate filaments: a chemically heterogeneous, developmentally regulated class of proteins. Annu Rev Biochem (1982) 4.54
Intermediate filaments in nervous tissues. J Cell Biol (1978) 3.51
Aberrant neurofilament phosphorylation in Alzheimer disease. Proc Natl Acad Sci U S A (1985) 2.96
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells. Cell (1992) 2.80
Neurofilament architecture combines structural principles of intermediate filaments with carboxy-terminal extensions increasing in size between triplet proteins. EMBO J (1983) 2.64
Slow components of axonal transport: two cytoskeletal networks. J Cell Biol (1980) 2.43
Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton. J Cell Biol (1984) 2.41
Neurofilament gene expression: a major determinant of axonal caliber. Proc Natl Acad Sci U S A (1987) 2.36
The structure and organization of the human heavy neurofilament subunit (NF-H) and the gene encoding it. EMBO J (1988) 2.21
Two-stage expression of neurofilament polypeptides during rat neurogenesis with early establishment of adult phosphorylation patterns. J Neurosci (1987) 2.15
Antibody decoration of neurofilaments. J Cell Biol (1981) 2.12
Interactions between neurofilaments and microtubule-associated proteins: a possible mechanism for intraorganellar bridging. J Cell Biol (1982) 2.11
Control of axonal caliber by neurofilament transport. J Cell Biol (1984) 2.03
Identification of the major multiphosphorylation site in mammalian neurofilaments. Proc Natl Acad Sci U S A (1988) 1.87
Purification of individual components of the neurofilament triplet: filament assembly from the 70 000-dalton subunit. Biochemistry (1982) 1.75
The structure, biochemical properties, and immunogenicity of neurofilament peripheral regions are determined by phosphorylation state. J Biol Chem (1985) 1.75
The distribution of phosphorylation sites among identified proteolytic fragments of mammalian neurofilaments. J Biol Chem (1983) 1.68
Immunoelectronmicroscopical localization of the three neurofilament triplet proteins along neurofilaments of cultured dorsal root ganglion neurones. Exp Cell Res (1982) 1.64
Ganglion cell distribution in the retina of the mouse. Invest Ophthalmol Vis Sci (1981) 1.64
Changes in neurofilament transport coincide temporally with alterations in the caliber of axons in regenerating motor fibers. J Cell Biol (1985) 1.55
Turnover of fluorescently labelled tubulin and actin in the axon. Nature (1990) 1.45
Neurofilament phosphorylation: a new look at regulation and function. Trends Neurosci (1991) 1.43
Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J Neurosci (1986) 1.42
Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons. J Cell Biol (1986) 1.40
Structure of the peripheral domains of neurofilaments revealed by low angle rotary shadowing. J Mol Biol (1988) 1.39
Novel monoclonal antibodies provide evidence for the in situ existence of a nonphosphorylated form of the largest neurofilament subunit. J Neurosci (1986) 1.38
Modulations of neurofilament axonal transport during the development of rabbit retinal ganglion cells. Cell (1983) 1.35
Assembly properties of dominant and recessive mutations in the small mouse neurofilament (NF-L) subunit. J Cell Biol (1990) 1.34
Antibodies against filamentous components in discrete cell types of the mouse retina. J Neurosci (1984) 1.30
Recent insights into the assembly, dynamics, and function of intermediate filament networks. Cell Motil Cytoskeleton (1991) 1.30
Cloning and developmental expression of the murine neurofilament gene family. Brain Res (1986) 1.28
Expression of NF-L in both neuronal and nonneuronal cells of transgenic mice: increased neurofilament density in axons without affecting caliber. J Cell Biol (1990) 1.24
Molecular biology of neuronal geometry: expression of neurofilament genes influences axonal diameter. Cold Spring Harb Symp Quant Biol (1983) 1.23
Location and sequence characterization of the major phosphorylation sites of the high molecular mass neurofilament proteins M and H. FEBS Lett (1987) 1.23
Two novel kinases phosphorylate tau and the KSP site of heavy neurofilament subunits in high stoichiometric ratios. J Neurosci (1991) 1.21
Regional specificity in anatomy at the lamina cribrosa. Arch Ophthalmol (1981) 1.19
Bulk preparation of CNS cytoskeleton and the separation of individual neurofilament proteins by gel filtration: dye-binding characteristics and amino acid compositions. J Neurochem (1982) 1.19
Early posttranslational modifications of the three neurofilament subunits in mouse retinal ganglion cells: neuronal sites and time course in relation to subunit polymerization and axonal transport. Brain Res Mol Brain Res (1989) 1.19
Neurofilament protein is phosphorylated in the squid giant axon. J Cell Biol (1978) 1.13
Slow axonal transport mechanisms move neurofilaments relentlessly in mouse optic axons. J Cell Biol (1992) 1.13
Slowing of neurofilament transport and the radial growth of developing nerve fibers. J Neurosci (1985) 1.12
A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M and NF-H. J Neurosci Res (1991) 1.07
Posttranslational modification of a neurofilament protein during axoplasmic transport: implications for regional specialization of CNS axons. J Cell Biol (1982) 1.07
Posttranslational modification of neurofilament proteins by phosphate during axoplasmic transport in retinal ganglion cell neurons. J Neurosci (1987) 1.07
Intracellular control of axial shape in non-uniform neurites: a serial electron microscopic analysis of organelles and microtubules in AI and AII retinal amacrine neurites. J Cell Biol (1984) 1.06
Dynamics of the neuronal intermediate filaments. J Cell Biol (1993) 1.05
The regulation of neurofilament protein dynamics by phosphorylation: clues to neurofibrillary pathobiology. Brain Pathol (1993) 1.04
Neurofilament and tubulin expression recapitulates the developmental program during axonal regeneration: induction of a specific beta-tubulin isotype. Proc Natl Acad Sci U S A (1988) 1.03
Differential turnover of phosphate groups on neurofilament subunits in mammalian neurons in vivo. J Biol Chem (1986) 0.99
Do photobleached fluorescent microtubules move?: re-evaluation of fluorescence laser photobleaching both in vitro and in growing Xenopus axon. J Cell Biol (1993) 0.98
Cytotypic differences in the protein composition of the axonally transported cytoskeleton in mammalian neurons. J Neurosci (1987) 0.97
Neurofilament monoclonal antibodies RT97 and 8D8 recognize different modified epitopes in paired helical filament-tau in Alzheimer's disease. J Neurochem (1993) 0.97
Slow posttranslational modification of a neurofilament protein. J Cell Biol (1985) 0.96
Protein degradation in the mouse visual system. I. Degradation of axonally transported and retinal proteins. Brain Res (1980) 0.96
Influence of the phosphorylation state of neurofilament proteins on the interactions between purified filaments in vitro. Biochem J (1988) 0.95
Posttranslational modification of neurofilament polypeptides in rabbit retina. J Neurobiol (1987) 0.95
Phosphorylation of the amino-terminal head domain of the middle molecular mass 145-kDa subunit of neurofilaments. Evidence for regulation by second messenger-dependent protein kinases. J Biol Chem (1990) 0.95
Effects of phosphorylation of the neurofilament L protein on filamentous structures. Cell Regul (1990) 0.94
Slow axonal transport. Curr Opin Cell Biol (1992) 0.93
Masking of epitopes in tissue sections. A study of glial fibrillary acidic (GFA) protein with antisera and monoclonal antibodies. Histochemistry (1984) 0.92
Phosphorylation-dependent neurofilament epitopes are reduced at the node of Ranvier. J Neurocytol (1992) 0.92
Identification of Ser-55 as a major protein kinase A phosphorylation site on the 70-kDa subunit of neurofilaments. Early turnover during axonal transport. J Biol Chem (1991) 0.91
In vivo phosphorylation of distinct domains of the 70-kilodalton neurofilament subunit involves different protein kinases. J Biol Chem (1989) 0.91
Axonal cytoskeleton at the nodes of Ranvier. J Neurocytol (1991) 0.90
Synthesis, axonal transport, and turnover of the high molecular weight microtubule-associated protein MAP 1A in mouse retinal ganglion cells: tubulin and MAP 1A display distinct transport kinetics. J Cell Biol (1990) 0.89
Varying degrees of phosphorylation determine microheterogeneity of the heavy neurofilament polypeptide (Nf-H). J Neuroimmunol (1987) 0.89
Biosynthesis of heterogeneous forms of mammalian brain tubulin subunits by multiple messenger RNAs. J Neurochem (1979) 0.88
Dynamics of mammalian high-molecular-weight neurofilament subunit phosphorylation in cultured rat sympathetic neurons. J Neurosci Res (1991) 0.87
Phosphate-dependent monoclonal antibodies to neurofilaments and Alzheimer neurofibrillary tangles recognize a synthetic phosphopeptide. J Neurochem (1990) 0.85
Neurofilament phosphorylation in development. A sign of axonal maturation? Exp Cell Res (1986) 0.85
Axotomy-induced alterations in the synthesis and transport of neurofilaments and microtubules in dorsal root ganglion cells. J Neurosci (1988) 0.85
Cloning of a cDNA encoding the rat high molecular weight neurofilament peptide (NF-H): developmental and tissue expression in the rat, and mapping of its human homologue to chromosomes 1 and 22. Proc Natl Acad Sci U S A (1989) 0.84
Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma. J Neurochem (1990) 0.83
Growth of adult rat retinal ganglion cell neurites on astrocytes. Glia (1990) 0.83
Effect of phosphorylation on 68 KDa neurofilament subunit protein assembly by the cyclic AMP dependent protein kinase in vitro. Biochem Biophys Res Commun (1990) 0.83
Simultaneous up-regulation of neurofilament proteins during the postnatal development of the rat nervous system. J Neurosci Res (1990) 0.83
Phosphorylation-related immunoreactivity and the rate of transport of neurofilaments in chronic 2,5-hexanedione intoxication. Brain Res (1991) 0.82
Squid neurofilaments. Phosphorylation and Ca2+-dependent proteolysis in situ. Biochem J (1986) 0.81
Temporal and topographic relationships between the phosphorylated and nonphosphorylated epitopes of the 200 kDa neurofilament protein during development in vitro. J Neurosci (1987) 0.81
Changing interactions between astrocytes and neurons during CNS maturation. Dev Biol (1991) 0.80
Temporal and spatial modulation of a cytoskeletal antigen during peripheral axonal pathfinding. Neuron (1992) 0.80
pros-methylimidazoleacetic acid in rat brain: its regional distribution and relationship to metabolic pathways of histamine. J Neurochem (1989) 0.79
Delayed phosphorylation of the largest neurofilament protein in rat optic nerve development. J Neurosci Res (1986) 0.79
Immunoassay and activity of calcium-activated neutral proteinase (mCANP): distribution in soluble and membrane-associated fractions in human and mouse brain. J Neurochem (1992) 0.79
Slow transport of freely movable cytoskeletal components shown by beading partition of nerve fibers in the cat. Neuroscience (1989) 0.77
Differential distribution of phosphorylated and non-phosphorylated neurofilaments within the retina and optic nerve of hamsters. Brain Res (1987) 0.76
cDNA coding for the tail region of the high molecular weight rabbit neurofilament protein NF-H. J Neurosci Res (1988) 0.76
Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci (1996) 2.14
Neurofilament phosphorylation: a new look at regulation and function. Trends Neurosci (1991) 1.43
Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology (1991) 1.30
Oligodendroglia regulate the regional expansion of axon caliber and local accumulation of neurofilaments during development independently of myelin formation. J Neurosci (1996) 1.28
Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus. J Neuropathol Exp Neurol (1991) 1.27
Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. Proc Natl Acad Sci U S A (1991) 1.23
Local control of neurofilament accumulation during radial growth of myelinating axons in vivo. Selective role of site-specific phosphorylation. J Cell Biol (2000) 1.22
Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin. Brain Res (1990) 1.18
The effects of haloperidol on synaptic patterns in the rat striatum. Brain Res (1985) 1.05
The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Ann N Y Acad Sci (1992) 0.96
Perturbation of the aminoacyl-tRNA synthetase complex by salts and detergents. Importance of hydrophobic interactions and possible involvement of lipids. J Biol Chem (1983) 0.96
Comparison of the complexed and free forms of rat liver arginyl-tRNA synthetase and origin of the free form. J Biol Chem (1985) 0.94
Haloperidol-induced plasticity of axon terminals in rat substantia nigra. Science (1983) 0.92
Synaptic rearrangements in medial prefrontal cortex of haloperidol-treated rats. Brain Res (1985) 0.90
Abnormalities of the endosomal-lysosomal system in Alzheimer's disease: relationship to disease pathogenesis. Adv Exp Med Biol (1996) 0.88
The protein phosphatase inhibitor okadaic acid increases axonal neurofilaments and neurite caliber, and decreases axonal microtubules in NB2a/d1 cells. J Neurosci Res (1993) 0.86
Regulation of nitrate reductase level in pea: in vivo stability by ammonium. Biochem Biophys Res Commun (1978) 0.85
Dynamics of phosphorylation and assembly of the high molecular weight neurofilament subunit in NB2a/d1 neuroblastoma. J Neurochem (1990) 0.83
[32P]orthophosphate and [35S]methionine label separate pools of neurofilaments with markedly different axonal transport kinetics in mouse retinal ganglion cells in vivo. Neurochem Res (1994) 0.81
The cytology of dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area of the rat: a light- and electron-microscopic study. Neuroscience (1983) 0.81
Neurofilament triplet proteins of NB2a/d1 neuroblastoma: posttranslational modification and incorporation into the cytoskeleton during differentiation. Brain Res (1988) 0.77
Aluminum salts induce the accumulation of neurofilaments in perikarya of NB2a/dl neuroblastoma. Brain Res (1989) 0.77
Gene transfer into hippocampal slice cultures with an adenovirus vector driven by cytomegalovirus promoter: stable co-expression of green fluorescent protein and lacZ genes. Brain Res Bull (2000) 0.75
The small nuclear ribonucleoproteins that react with anti-Sm and anti-RNP antibodies. Biochem Biophys Res Commun (1984) 0.75