Published in Oncogene on February 20, 2003
Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. Mol Cell Biol (2005) 1.84
Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Mol Cell Biol (2004) 1.47
The mechanism of nuclear export of Smad3 involves exportin 4 and Ran. Mol Cell Biol (2006) 1.42
Regulation of Smad activities. Biochim Biophys Acta (2006) 1.41
Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron (2007) 1.32
An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A. EMBO J (2010) 1.25
Dynamics of TGF-β signaling reveal adaptive and pulsatile behaviors reflected in the nuclear localization of transcription factor Smad4. Proc Natl Acad Sci U S A (2012) 1.23
Expanding the definition of the classical bipartite nuclear localization signal. Traffic (2009) 1.17
Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells. J Virol (2013) 1.08
Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. Biochem J (2004) 1.05
Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. Mol Cell Biol (2005) 1.00
Quantitative modeling and analysis of the transforming growth factor beta signaling pathway. Biophys J (2009) 1.00
Identification of a novel human Rad51 variant that promotes DNA strand exchange. Nucleic Acids Res (2008) 0.98
Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers. Nucleic Acids Res (2011) 0.91
Blocking of SMAD4 expression by shRNA effectively inhibits fibrogenesis of human hepatic stellate cells. Gastroenterol Hepatol Bed Bench (2015) 0.86
OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival. Eur J Immunol (2011) 0.85
PLTP is present in the nucleus, and its nuclear export is CRM1-dependent. Biochim Biophys Acta (2009) 0.84
Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J (2007) 0.82
Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS. Sci Rep (2015) 0.80
Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Mol Biol Cell (2004) 0.80
Cooperative assembly of Co-Smad4 MH1 with R-Smad1/3 MH1 on DNA: a molecular dynamics simulation study. PLoS One (2013) 0.80
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function. Front Immunol (2015) 0.79
Functional analysis of nuclear localization signals in VP1-2 homologues from all herpesvirus subfamilies. J Virol (2014) 0.79
A highly organized structure mediating nuclear localization of a Myb2 transcription factor in the protozoan parasite Trichomonas vaginalis. Eukaryot Cell (2011) 0.79
Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal. PLoS One (2013) 0.78
Reduction of invasive potential in K-ras-transformed thyroid cells by restoring of TGF-beta pathway. Clin Exp Metastasis (2006) 0.77
Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system. Cytokine (2008) 0.77
Association of v-ErbA with Smad4 disrupts TGF-beta signaling. Mol Biol Cell (2009) 0.76
αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol (2016) 0.75
Analysis of ligand-dependent nuclear accumulation of Smads in TGF-beta signaling. Methods Mol Biol (2010) 0.75
Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin. J Biol Chem (2016) 0.75
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med (2007) 8.18
Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A (2006) 6.19
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood (2003) 4.91
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A (2002) 4.40
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A (2004) 3.90
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med (2006) 3.09
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
siRNA Selection Server: an automated siRNA oligonucleotide prediction server. Nucleic Acids Res (2004) 2.91
Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood (2008) 2.79
MicroRNAs as regulators of mammalian hematopoiesis. Semin Immunol (2005) 2.62
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nat Cell Biol (2008) 2.50
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood (2003) 2.42
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood (2011) 2.42
ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol (2002) 2.31
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem (2003) 2.29
MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A (2010) 2.29
Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol (2011) 2.20
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem (2002) 2.20
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood (2005) 2.17
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest (2004) 2.12
Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood (2013) 2.12
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 2.08
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes Dev (2011) 2.06
A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A (2004) 2.06
Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood (2005) 2.05
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med (2004) 1.98
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev (2003) 1.96
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A (2006) 1.92
Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci U S A (2013) 1.90
Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature (2003) 1.88
Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep (2012) 1.82
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proc Natl Acad Sci U S A (2003) 1.80
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J (2002) 1.79
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J (2008) 1.77
Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem (2003) 1.67
Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell (2002) 1.67
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood (2005) 1.63
HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. Blood (2010) 1.63
A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics (2002) 1.61
Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. J Biol Chem (2002) 1.58
Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol (2005) 1.55
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem (2007) 1.55
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A (2011) 1.54
Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol (2008) 1.54
Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes. J Biol Chem (2003) 1.45
Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood (2011) 1.43
The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity (2003) 1.42
Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem (2006) 1.37
Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells (2008) 1.36
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol (2007) 1.35
Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J (2010) 1.32
Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev (2011) 1.32
Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem (2010) 1.30
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes (2002) 1.29
Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem (2005) 1.29
Characterization of a heart-specific fatty acid transport protein. J Biol Chem (2003) 1.28
Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol (2011) 1.28
Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood (2004) 1.28
Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem (2003) 1.26
Medicine. Visfatin: a new adipokine. Science (2004) 1.26
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Haematologica (2010) 1.25
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev (2012) 1.23
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev (2010) 1.23
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. Proc Natl Acad Sci U S A (2010) 1.22
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal (2006) 1.20
The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol (2005) 1.19
Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A (2004) 1.17
Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology (2006) 1.16
Targeting microRNAs in obesity. Expert Opin Ther Targets (2009) 1.14
Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood (2010) 1.12
Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. J Biol Chem (2004) 1.12
Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A (2005) 1.12
miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. Blood (2009) 1.11
Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proc Natl Acad Sci U S A (2012) 1.10
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood (2009) 1.09
Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. Br J Haematol (2009) 1.08
ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature (2013) 1.08
Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. J Biol Chem (2005) 1.08
Endogenous K-ras signaling in erythroid differentiation. Cell Cycle (2007) 1.08
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. J Biol Chem (2006) 1.07
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Exp Hematol (2007) 1.07
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Transcriptional divergence and conservation of human and mouse erythropoiesis. Proc Natl Acad Sci U S A (2014) 1.05
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene (2002) 1.00
Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex. Mol Cell (2009) 1.00
Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Curr Opin Lipidol (2004) 0.99
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. Cell Cycle (2010) 0.99