Published in Proc Natl Acad Sci U S A on April 12, 2010
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood (2011) 2.42
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell (2011) 1.91
Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development. Nature (2012) 1.75
Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis. Genes Dev (2010) 1.42
ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood (2015) 1.39
Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. Blood (2010) 1.30
Update on fetal hemoglobin gene regulation in hemoglobinopathies. Curr Opin Pediatr (2011) 1.24
Fetal liver hematopoietic stem cell niches associate with portal vessels. Science (2015) 1.09
ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica (2015) 1.00
LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo. Blood (2013) 1.00
Myeloid leukemia in Down syndrome. Crit Rev Oncog (2011) 0.99
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Res C Embryo Today (2010) 0.84
Human CD34(lo)CD133(lo) fetal liver cells support the expansion of human CD34(hi)CD133(hi) hematopoietic stem cells. Cell Mol Immunol (2015) 0.82
Embryonic regulation of the mouse hematopoietic niche. ScientificWorldJournal (2011) 0.80
Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int (2015) 0.80
Increased Haematopoietic Supportive Function of USSC from Umbilical Cord Blood Compared to CB MSC and Possible Role of DLK-1. Stem Cells Int (2013) 0.80
Fetal hepatic progenitors support long-term expansion of hematopoietic stem cells. Exp Hematol (2013) 0.78
Angiopoietin-like protein 3 promotes preservation of stemness during ex vivo expansion of murine hematopoietic stem cells. PLoS One (2014) 0.78
Low-dose insulin-like growth factor binding proteins 1 and 2 and angiopoietin-like protein 3 coordinately stimulate ex vivo expansion of human umbilical cord blood hematopoietic stem cells as assayed in NOD/SCID gamma null mice. Stem Cell Res Ther (2014) 0.77
The role of CD44 in fetal and adult hematopoietic stem cell regulation. Haematologica (2015) 0.77
In vitro large scale production of human mature red blood cells from hematopoietic stem cells by coculturing with human fetal liver stromal cells. Biomed Res Int (2013) 0.77
Optimizing autologous cell grafts to improve stem cell gene therapy. Exp Hematol (2016) 0.76
Localized SCF and IGF-1 secretion enhances erythropoiesis in the spleen of murine embryos. Biol Open (2015) 0.76
The impact of trisomy 21 on foetal haematopoiesis. Blood Cells Mol Dis (2013) 0.76
Hepatocellular Carcinoma-propagating Cells are Detectable by Side Population Analysis and Possess an Expression Profile Reflective of a Primitive Origin. Sci Rep (2016) 0.75
Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases. Wiley Interdiscip Rev Dev Biol (2017) 0.75
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Osteoblastic cells regulate the haematopoietic stem cell niche. Nature (2003) 19.60
Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity (2006) 11.28
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
Bone-marrow haematopoietic-stem-cell niches. Nat Rev Immunol (2006) 7.20
Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell (1990) 3.98
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 3.39
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med (2006) 3.09
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. J Exp Med (2002) 2.96
Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche. Blood (2004) 2.80
Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood (2008) 2.79
Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood (2006) 2.67
Hematopoietic cytokines. Blood (2008) 2.45
Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood (2003) 2.42
Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci (2003) 2.38
The hematopoietic stem cell and its niche: a comparative view. Genes Dev (2007) 2.15
Purification and characterization of heterogeneous pluripotent hematopoietic stem cell populations expressing high levels of c-kit receptor. Blood (1993) 1.62
Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol (2008) 1.54
Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci U S A (1997) 1.41
Hepatic stem cells: from inside and outside the liver? Cell Prolif (2004) 1.37
Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells (2008) 1.36
Tg(Afp-GFP) expression marks primitive and definitive endoderm lineages during mouse development. Dev Dyn (2006) 1.30
Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition. Blood (2002) 1.26
Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation. Oncogene (2005) 1.25
Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver. Gastroenterology (2008) 1.21
Long-term culture of hepatic progenitors derived from mouse Dlk+ hepatoblasts. J Cell Sci (2004) 1.14
Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand. Blood (1992) 0.93
The role of the liver in the production of thrombopoietin compared with erythropoietin. Eur J Gastroenterol Hepatol (2001) 0.92
MicroRNAs modulate hematopoietic lineage differentiation. Science (2003) 30.05
JAK2 exon 12 mutations in polycythemia vera and idiopathic erythrocytosis. N Engl J Med (2007) 8.18
Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A (2006) 6.19
Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood (2003) 4.91
MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43
Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A (2002) 4.40
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc Natl Acad Sci U S A (2007) 4.15
T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci U S A (2004) 3.90
Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells. Nat Med (2006) 3.09
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity. Diabetes (2009) 3.02
Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation. Blood (2008) 2.79
MicroRNAs as regulators of mammalian hematopoiesis. Semin Immunol (2005) 2.62
Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2. Nat Cell Biol (2008) 2.50
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells. Blood (2003) 2.42
From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood (2011) 2.42
ACRP30, a new hormone controlling fat and glucose metabolism. Eur J Pharmacol (2002) 2.31
Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem (2003) 2.29
MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A (2010) 2.29
Oligomerization state-dependent activation of NF-kappa B signaling pathway by adipocyte complement-related protein of 30 kDa (Acrp30). J Biol Chem (2002) 2.20
Mir193b-365 is essential for brown fat differentiation. Nat Cell Biol (2011) 2.20
Lnk inhibits erythropoiesis and Epo-dependent JAK2 activation and downstream signaling pathways. Blood (2005) 2.17
Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest (2004) 2.12
Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Blood (2013) 2.12
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells. Proc Natl Acad Sci U S A (2002) 2.08
MicroRNA-125b promotes neuronal differentiation in human cells by repressing multiple targets. Mol Cell Biol (2009) 2.08
Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes Dev (2011) 2.06
A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A (2004) 2.06
Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion. Blood (2005) 2.05
Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis. J Exp Med (2004) 1.98
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-alpha. Cytokine Growth Factor Rev (2003) 1.96
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A (2006) 1.92
Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci U S A (2013) 1.90
Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking. Nature (2003) 1.88
Regulation of mammalian cell differentiation by long non-coding RNAs. EMBO Rep (2012) 1.82
Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. Am J Physiol Endocrinol Metab (2002) 1.82
Cytokines and BCR-ABL mediate suppression of TRAIL-induced apoptosis through inhibition of forkhead FOXO3a transcription factor. Proc Natl Acad Sci U S A (2003) 1.80
Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase). Biochem J (2002) 1.79
Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J (2008) 1.77
Troglitazone antagonizes tumor necrosis factor-alpha-induced reprogramming of adipocyte gene expression by inhibiting the transcriptional regulatory functions of NF-kappaB. J Biol Chem (2003) 1.67
Insulin causes fatty acid transport protein translocation and enhanced fatty acid uptake in adipocytes. Dev Cell (2002) 1.67
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood (2005) 1.63
HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. Blood (2010) 1.63
A proteomic approach for identification of secreted proteins during the differentiation of 3T3-L1 preadipocytes to adipocytes. Mol Cell Proteomics (2002) 1.61
Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. J Biol Chem (2002) 1.58
Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. Annu Rev Cell Dev Biol (2005) 1.55
Conserved regulation of p53 network dosage by microRNA-125b occurs through evolving miRNA-target gene pairs. PLoS Genet (2011) 1.55
Dimerization by a cytokine receptor is necessary for constitutive activation of JAK2V617F. J Biol Chem (2007) 1.55
MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci U S A (2011) 1.54
Cytokines regulating hematopoietic stem cell function. Curr Opin Hematol (2008) 1.54
Standard isolation of primary adipose cells from mouse epididymal fat pads induces inflammatory mediators and down-regulates adipocyte genes. J Biol Chem (2003) 1.45
Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood (2011) 1.43
The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells. Immunity (2003) 1.42
Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem (2006) 1.37
Insulin-like growth factor-binding protein 2 secreted by a tumorigenic cell line supports ex vivo expansion of mouse hematopoietic stem cells. Stem Cells (2008) 1.36
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. J Cell Biol (2007) 1.35
Distinct roles for miR-1 and miR-133a in the proliferation and differentiation of rhabdomyosarcoma cells. FASEB J (2010) 1.32
Mesenchymal stem cells secreting angiopoietin-like-5 support efficient expansion of human hematopoietic stem cells without compromising their repopulating potential. Stem Cells Dev (2011) 1.32
Down-regulation of Myc is essential for terminal erythroid maturation. J Biol Chem (2010) 1.30
An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene (2003) 1.29
Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes (2002) 1.29
Cellular trafficking and degradation of erythropoietin and novel erythropoiesis stimulating protein (NESP). J Biol Chem (2005) 1.29
Characterization of a heart-specific fatty acid transport protein. J Biol Chem (2003) 1.28
Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood (2004) 1.28
Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol (2011) 1.28
Targeted deletion of fatty acid transport protein-4 results in early embryonic lethality. J Biol Chem (2003) 1.26
Medicine. Visfatin: a new adipokine. Science (2004) 1.26
Histone deacetylase 2 is required for chromatin condensation and subsequent enucleation of cultured mouse fetal erythroblasts. Haematologica (2010) 1.25
AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation. Blood (2005) 1.25
Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes Dev (2012) 1.23
miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev (2010) 1.23
A "classical" homodimeric erythropoietin receptor is essential for the antiapoptotic effects of erythropoietin on differentiated neuroblastoma SH-SY5Y and pheochromocytoma PC-12 cells. Cell Signal (2006) 1.20
The role of the adipocyte hormone adiponectin in cardiovascular disease. Curr Opin Pharmacol (2005) 1.19
Small interfering RNA production by enzymatic engineering of DNA (SPEED). Proc Natl Acad Sci U S A (2004) 1.17
Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity. Gastroenterology (2006) 1.16
Targeting microRNAs in obesity. Expert Opin Ther Targets (2009) 1.14
Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood (2010) 1.12
Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A (2005) 1.12
Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. J Biol Chem (2004) 1.12
miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221. Blood (2009) 1.11
Adiponectin regulates expression of hepatic genes critical for glucose and lipid metabolism. Proc Natl Acad Sci U S A (2012) 1.10
ID1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signaling. Blood (2009) 1.09
Pathogenesis of the erythroid failure in Diamond Blackfan anaemia. Br J Haematol (2009) 1.08
ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature (2013) 1.08
Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. J Biol Chem (2005) 1.08
Endogenous K-ras signaling in erythroid differentiation. Cell Cycle (2007) 1.08
Expansion of human cord blood hematopoietic stem cells for transplantation. Cell Stem Cell (2010) 1.08
Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. J Biol Chem (2006) 1.07
Signals emanating from the membrane proximal region of the thrombopoietin receptor (mpl) support hematopoietic stem cell self-renewal. Exp Hematol (2007) 1.07
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Transcriptional divergence and conservation of human and mouse erythropoiesis. Proc Natl Acad Sci U S A (2014) 1.05
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene (2002) 1.00
Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex. Mol Cell (2009) 1.00
Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Curr Opin Lipidol (2004) 0.99
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells. Cell Cycle (2010) 0.99