Published in Nat Biotechnol on February 18, 2003
A mitochondrial protein compendium elucidates complex I disease biology. Cell (2008) 13.51
Variations in DNA elucidate molecular networks that cause disease. Nature (2008) 12.04
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A (2003) 5.13
Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci U S A (2005) 4.03
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
MARCH-V is a novel mitofusin 2- and Drp1-binding protein able to change mitochondrial morphology. EMBO Rep (2006) 3.19
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High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82
The mitochondrial inner membrane protein mitofilin controls cristae morphology. Mol Biol Cell (2005) 2.53
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Mitochondrial localization of estrogen receptor beta. Proc Natl Acad Sci U S A (2004) 2.15
Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium. Biochemistry (2006) 2.06
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria. J Biol Chem (2008) 1.94
Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes. Curr Biol (2008) 1.93
Characterization of the mouse brain proteome using global proteomic analysis complemented with cysteinyl-peptide enrichment. J Proteome Res (2006) 1.93
Mitochondrial disorders: prevalence, myths and advances. J Inherit Metab Dis (2004) 1.89
Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells. Plant Cell (2003) 1.80
MitoP2: the mitochondrial proteome database--now including mouse data. Nucleic Acids Res (2006) 1.79
Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol Biol Cell (2006) 1.75
Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g. J Cell Biol (2009) 1.66
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell (2010) 1.65
Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Curr Opin Cell Biol (2011) 1.62
Glycolytic enzymes associate dynamically with mitochondria in response to respiratory demand and support substrate channeling. Plant Cell (2007) 1.62
The role of mitochondria in osteoarthritis. Nat Rev Rheumatol (2011) 1.59
MitoP2, an integrated database on mitochondrial proteins in yeast and man. Nucleic Acids Res (2004) 1.55
Evaluation of strong cation exchange versus isoelectric focusing of peptides for multidimensional liquid chromatography-tandem mass spectrometry. J Proteome Res (2008) 1.55
Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway. Mol Cell Proteomics (2009) 1.52
Systematic characterization of the murine mitochondrial proteome using functionally validated cardiac mitochondria. Proteomics (2008) 1.51
A straightforward and highly efficient precipitation/on-pellet digestion procedure coupled with a long gradient nano-LC separation and Orbitrap mass spectrometry for label-free expression profiling of the swine heart mitochondrial proteome. J Proteome Res (2009) 1.46
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem (2011) 1.46
Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria. Eur J Neurosci (2013) 1.45
A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. FASEB J (2010) 1.45
Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. J Med Genet (2005) 1.41
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TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Res (2011) 1.38
A glycolytic enzyme, enolase, is recruited as a cofactor of tRNA targeting toward mitochondria in Saccharomyces cerevisiae. Genes Dev (2006) 1.37
In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins. Am J Physiol Endocrinol Metab (2008) 1.36
Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol Cell Biol (2005) 1.34
Improved proteome coverage by using high efficiency cysteinyl peptide enrichment: the human mammary epithelial cell proteome. Proteomics (2005) 1.33
Assessing systems properties of yeast mitochondria through an interaction map of the organelle. PLoS Genet (2006) 1.31
Characterization of the human skeletal muscle proteome by one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. Mol Cell Proteomics (2007) 1.31
A transcriptomic and proteomic characterization of the Arabidopsis mitochondrial protein import apparatus and its response to mitochondrial dysfunction. Plant Physiol (2004) 1.27
ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import. Proc Natl Acad Sci U S A (2010) 1.26
A systematic characterization of mitochondrial proteome from human T leukemia cells. Mol Cell Proteomics (2004) 1.24
Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stress. Biochem Soc Trans (2008) 1.22
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase. Proc Natl Acad Sci U S A (2006) 1.22
Mdm38 interacts with ribosomes and is a component of the mitochondrial protein export machinery. J Cell Biol (2006) 1.19
MitoMiner, an integrated database for the storage and analysis of mitochondrial proteomics data. Mol Cell Proteomics (2009) 1.17
Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis. Mol Cell Proteomics (2004) 1.17
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One (2011) 1.16
Hallmarks of a new era in mitochondrial biochemistry. Genes Dev (2013) 1.15
Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem J (2004) 1.15
Mitochondria in cardiomyocyte Ca2+ signaling. Int J Biochem Cell Biol (2009) 1.14
From endosymbiont to host-controlled organelle: the hijacking of mitochondrial protein synthesis and metabolism. PLoS Comput Biol (2007) 1.13
Mitochondrial protein targets of thiol-reactive electrophiles. Chem Res Toxicol (2008) 1.12
A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell (2011) 1.12
Proteomic analysis of mitochondrial protein turnover: identification of novel substrate proteins of the matrix protease pim1. Mol Cell Biol (2006) 1.12
Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry. Biochim Biophys Acta (2007) 1.11
Domestication of the cardiac mitochondrion for energy conversion. J Mol Cell Cardiol (2009) 1.10
Definition of the mitochondrial proteome by measurement of molecular masses of membrane proteins. Proc Natl Acad Sci U S A (2006) 1.09
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. J Proteomics (2009) 1.09
The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain. J Biol Chem (2012) 1.08
HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes (2013) 1.07
Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system. BMC Genomics (2008) 1.05
'Omics' of the mitochondrion. Nat Biotechnol (2003) 1.04
Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes. Int J Mass Spectrom (2007) 1.04
Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria. Am J Nephrol (2005) 1.04
Identification of membrane proteins by tandem mass spectrometry of protein ions. Proc Natl Acad Sci U S A (2007) 1.03
Identification of phosphorylation sites in mammalian mitochondrial ribosomal protein DAP3. Protein Sci (2008) 1.03
Exercise training induces a cardioprotective phenotype and alterations in cardiac subsarcolemmal and intermyofibrillar mitochondrial proteins. Am J Physiol Heart Circ Physiol (2009) 1.02
Application of proteomic marker ensembles to subcellular organelle identification. Mol Cell Proteomics (2009) 1.00
Quantitative assessment of in-solution digestion efficiency identifies optimal protocols for unbiased protein analysis. Mol Cell Proteomics (2013) 0.99
Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease. Mol Cell (2008) 0.99
Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA. Nat Protoc (2010) 0.99
The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes. Int J Parasitol (2011) 0.98
Mitochondrial proteomics on human fibroblasts for identification of metabolic imbalance and cellular stress. Proteome Sci (2009) 0.98
LACTB is a filament-forming protein localized in mitochondria. Proc Natl Acad Sci U S A (2009) 0.97
AMPDB: the Arabidopsis Mitochondrial Protein Database. Nucleic Acids Res (2005) 0.97
Evidence for compartmentalization of mammalian carotenoid metabolism. FASEB J (2014) 0.96
Application of capillary isotachophoresis-based multidimensional separations coupled with electrospray ionization-tandem mass spectrometry for characterization of mouse brain mitochondrial proteome. Electrophoresis (2008) 0.96
Scale-free flow of life: on the biology, economics, and physics of the cell. Theor Biol Med Model (2009) 0.96
Specialized compartments of cardiac nuclei exhibit distinct proteomic anatomy. Mol Cell Proteomics (2010) 0.95
Genetic evidence for a mitochondriate ancestry in the 'amitochondriate' flagellate Trimastix pyriformis. PLoS One (2008) 0.95
Disorders of phospholipid metabolism: an emerging class of mitochondrial disease due to defects in nuclear genes. Front Genet (2015) 0.95
Divide and conquer: the application of organelle proteomics to heart failure. Circ Res (2011) 0.94
Characterization, design, and function of the mitochondrial proteome: from organs to organisms. J Proteome Res (2013) 0.94
Identification of novel proteins affected by rotenone in mitochondria of dopaminergic cells. BMC Neurosci (2007) 0.94
4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. Biochim Biophys Acta (2012) 0.94
The mitochondrial proteome: a dynamic functional program in tissues and disease states. Environ Mol Mutagen (2010) 0.93
Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia. J Theor Biol (2008) 0.92
The mitochondrial genome encodes abundant small noncoding RNAs. Cell Res (2013) 0.92
The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis. Neurobiol Dis (2007) 0.92
What makes a mitochondrion? Genome Biol (2003) 0.92
Lipid metabolism in mitochondrial membranes. J Inherit Metab Dis (2014) 0.92
Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy. BMC Evol Biol (2008) 0.92
Genomes, proteomes, and the central dogma. Circ Cardiovasc Genet (2011) 0.91
Comparative mitochondrial proteomics: perspective in human diseases. J Hematol Oncol (2012) 0.91
Integral membrane proteins and bilayer proteomics. Anal Chem (2013) 0.90
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol (2009) 9.67
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
LMSD: LIPID MAPS structure database. Nucleic Acids Res (2006) 6.21
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res (2013) 6.17
Reduced-median-network analysis of complete mitochondrial DNA coding-region sequences for the major African, Asian, and European haplogroups. Am J Hum Genet (2002) 6.02
Investigating mitochondrial redox potential with redox-sensitive green fluorescent protein indicators. J Biol Chem (2004) 5.26
Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res (2010) 4.14
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology (2009) 4.08
Cohort Profile: The China Health and Nutrition Survey--monitoring and understanding socio-economic and health change in China, 1989-2011. Int J Epidemiol (2009) 4.08
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells. Cancer Res (2004) 4.03
Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A (2011) 3.80
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res (2005) 3.78
IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering. J Proteome Res (2009) 3.72
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci (2006) 3.20
Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state. Biochem J (2002) 3.13
Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry. J Proteome Res (2010) 3.08
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J Clin Invest (2011) 2.99
High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82
The Drosophila BMP type II receptor Wishful Thinking regulates neuromuscular synapse morphology and function. Neuron (2002) 2.79
Platform-independent and label-free quantitation of proteomic data using MS1 extracted ion chromatograms in skyline: application to protein acetylation and phosphorylation. Mol Cell Proteomics (2012) 2.66
MS2Assign, automated assignment and nomenclature of tandem mass spectra of chemically crosslinked peptides. J Am Soc Mass Spectrom (2003) 2.56
MITOPRED: a genome-scale method for prediction of nucleus-encoded mitochondrial proteins. Bioinformatics (2004) 2.52
Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance. Mol Cell Proteomics (2009) 2.39
Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell (2012) 2.38
MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A (2007) 2.28
MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A (2007) 2.19
A mouse macrophage lipidome. J Biol Chem (2010) 2.14
Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol (2004) 2.10
Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses. Mol Cell Proteomics (2009) 2.09
Global organellar proteomics. Trends Biotechnol (2003) 2.09
Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. Blood (2006) 2.06
Polycomb repressive complex 2 regulates normal development of the mouse heart. Circ Res (2011) 2.05
Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A (2013) 2.01
Parkin protein deficiency exacerbates cardiac injury and reduces survival following myocardial infarction. J Biol Chem (2012) 1.98
N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature (2011) 1.97
Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis. Cell Metab (2011) 1.97
The lipid maps initiative in lipidomics. Methods Enzymol (2007) 1.93
Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metab (2012) 1.92
Novel modification of lipid A of Francisella tularensis. Infect Immun (2004) 1.91
ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. J Biol Chem (2010) 1.91
Global analysis of protein damage by the lipid electrophile 4-hydroxy-2-nonenal. Mol Cell Proteomics (2008) 1.89
Eighteen year weight trajectories and metabolic markers of diabetes in modernising China. Diabetologia (2014) 1.81
Sweetening the pot: adding glycosylation to the biomarker discovery equation. Clin Chem (2009) 1.81
Microarray analysis of chitin elicitation in Arabidopsis thaliana. Mol Plant Pathol (2002) 1.80
A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansing. Am J Gastroenterol (2007) 1.74
The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem (2007) 1.72
A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema. Am J Respir Crit Care Med (2006) 1.72
Diet and nutrient intakes and risk of non-Hodgkin's lymphoma in Connecticut women. Am J Epidemiol (2004) 1.71
The Streptococcus gordonii platelet binding protein GspB undergoes glycosylation independently of export. J Bacteriol (2004) 1.71
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets. Genes Dev (2002) 1.66
Protein identification using customized protein sequence databases derived from RNA-Seq data. J Proteome Res (2011) 1.62
Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol (2003) 1.60
Haemophilus influenzae type b strain A2 has multiple sialyltransferases involved in lipooligosaccharide sialylation. J Biol Chem (2002) 1.60
Community proteogenomics highlights microbial strain-variant protein expression within activated sludge performing enhanced biological phosphorus removal. ISME J (2008) 1.60
Prior medical conditions and medication use and risk of non-Hodgkin lymphoma in Connecticut United States women. Cancer Causes Control (2004) 1.59
Gene expression profiling in human preadipocytes and adipocytes by microarray analysis. J Nutr (2004) 1.57
Sodium intake from various time frames and incident hypertension among Chinese adults. Epidemiology (2013) 1.55
The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. FEBS Lett (2007) 1.53
Understanding the patterns and trends of sodium intake, potassium intake, and sodium to potassium ratio and their effect on hypertension in China. Am J Clin Nutr (2013) 1.50
Oxidative damage to mitochondrial complex I due to peroxynitrite: identification of reactive tyrosines by mass spectrometry. J Biol Chem (2003) 1.50
Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis. Eur J Haematol (2015) 1.48
The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J Biol Chem (2003) 1.48
Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem (2011) 1.47
A comparison between ribo-minus RNA-sequencing and polyA-selected RNA-sequencing. Genomics (2010) 1.47
Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma among women in Connecticut. Hum Genet (2006) 1.47
Subcellular organelle lipidomics in TLR-4-activated macrophages. J Lipid Res (2010) 1.46
Supervised principal component analysis for gene set enrichment of microarray data with continuous or survival outcomes. Bioinformatics (2008) 1.45
Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc Natl Acad Sci U S A (2013) 1.45
Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry. J Proteome Res (2004) 1.44
Steps to ensure accuracy in genotype and SNP calling from Illumina sequencing data. BMC Genomics (2012) 1.44
Panorama: a targeted proteomics knowledge base. J Proteome Res (2014) 1.43
Distinct transcriptomes define rostral and caudal serotonin neurons. J Neurosci (2010) 1.43
Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila. Development (2003) 1.42
An integrated approach for the analysis of biological pathways using mixed models. PLoS Genet (2008) 1.40
Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B. J Biol Chem (2005) 1.39
Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans. Cell Metab (2011) 1.39
MitoProteome: mitochondrial protein sequence database and annotation system. Nucleic Acids Res (2004) 1.39
Screening active anti-breast cancer compounds from Cortex Magnolia officinalis by 2D LC-MS. J Sep Sci (2013) 1.39
Monitoring phosphorylation of the pyruvate dehydrogenase complex. Anal Biochem (2009) 1.38
Environmental adaptation: genomic analysis of the piezotolerant and psychrotolerant deep-sea iron reducing bacterium Shewanella piezotolerans WP3. PLoS One (2008) 1.38
Diet-induced mouse model of fatty liver disease and nonalcoholic steatohepatitis reflecting clinical disease progression and methods of assessment. Am J Physiol Gastrointest Liver Physiol (2013) 1.37
Cell cycle dependent morphology changes and associated mitochondrial DNA redistribution in mitochondria of human cell lines. Mitochondrion (2002) 1.35
MITOPRED: a web server for the prediction of mitochondrial proteins. Nucleic Acids Res (2004) 1.35
Intracellular survival of Neisseria gonorrhoeae in male urethral epithelial cells: importance of a hexaacyl lipid A. Infect Immun (2002) 1.34
A bioinformatics workflow for variant peptide detection in shotgun proteomics. Mol Cell Proteomics (2011) 1.34
Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J Cell Biol (2014) 1.34
Co-expression module analysis reveals biological processes, genomic gain, and regulatory mechanisms associated with breast cancer progression. BMC Syst Biol (2010) 1.33
Recombinant T cell receptor ligand treats experimental stroke. Stroke (2009) 1.33