Published in J Physiol on June 21, 2007
Acetylsalicylic Acid and Type 2 Diabetes Mellitus | NCT03341117
Reactive oxygen species enhance insulin sensitivity. Cell Metab (2009) 2.77
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
The role of mitochondria in reactive oxygen species metabolism and signaling. Ann N Y Acad Sci (2008) 2.27
SIRT1 and insulin resistance. Nat Rev Endocrinol (2009) 1.96
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest (2011) 1.80
Oxidative stress induces degradation of mitochondrial DNA. Nucleic Acids Res (2009) 1.73
Small G proteins in islet beta-cell function. Endocr Rev (2009) 1.68
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67
Cellular metabolic and autophagic pathways: traffic control by redox signaling. Free Radic Biol Med (2013) 1.46
Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line. Clin Sci (Lond) (2011) 1.44
Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. Diabetes (2010) 1.43
Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem J (2010) 1.40
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
The vitamin nicotinamide: translating nutrition into clinical care. Molecules (2009) 1.36
Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol (2010) 1.23
Oxidative stress and beta-cell dysfunction. Pflugers Arch (2010) 1.22
Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion. FEBS J (2010) 1.21
Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxid Redox Signal (2009) 1.14
The role of external and matrix pH in mitochondrial reactive oxygen species generation. J Biol Chem (2008) 1.13
The importance of mitochondria in age-related and inherited eye disorders. Ophthalmic Res (2010) 1.13
Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol (2008) 1.13
Friendly, and not so friendly, roles of Rac1 in islet β-cell function: lessons learnt from pharmacological and molecular biological approaches. Biochem Pharmacol (2011) 1.09
Erythropoietin and oxidative stress. Curr Neurovasc Res (2008) 1.07
Tiam1/Rac1 signaling pathway mediates palmitate-induced, ceramide-sensitive generation of superoxides and lipid peroxides and the loss of mitochondrial membrane potential in pancreatic beta-cells. Biochem Pharmacol (2010) 1.07
Mitochondrial flashes: new insights into mitochondrial ROS signalling and beyond. J Physiol (2014) 1.07
Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res (2010) 1.06
Triple play: promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother (2008) 1.02
EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes. Curr Neurovasc Res (2011) 1.01
Molecular mechanisms of diabetic vascular complications. J Diabetes Investig (2010) 1.01
Heat-processed Panax ginseng and diabetic renal damage: active components and action mechanism. J Ginseng Res (2013) 1.01
Oxidative stress and redox modulation potential in type 1 diabetes. Clin Dev Immunol (2011) 1.00
Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. J Clin Invest (2009) 1.00
Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E. Diabetologia (2011) 0.99
A role for aberrant protein palmitoylation in FFA-induced ER stress and β-cell death. Am J Physiol Endocrinol Metab (2012) 0.98
Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term. Domest Anim Endocrinol (2010) 0.98
Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets. J Diabetes Res (2013) 0.97
Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes. PLoS One (2011) 0.97
The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci (2009) 0.97
Redox regulation of Nox proteins. Respir Physiol Neurobiol (2010) 0.96
Cystic fibrosis-related diabetes: from CFTR dysfunction to oxidative stress. Clin Biochem Rev (2009) 0.96
Diabetes mellitus: channeling care through cellular discovery. Curr Neurovasc Res (2010) 0.93
Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PLoS One (2013) 0.92
Diabetic stress: new triumphs and challenges to maintain vascular longevity. Expert Rev Cardiovasc Ther (2008) 0.91
Imaging ROS signaling in cells and animals. J Mol Med (Berl) (2013) 0.90
Impairment of pancreatic β-cell function by chronic intermittent hypoxia. Exp Physiol (2013) 0.90
Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease. Diabetes Obes Metab (2013) 0.90
Lipotoxicity is glucose-dependent in INS-1E cells but not in human islets and MIN6 cells. Lipids Health Dis (2011) 0.89
Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? Curr Diab Rep (2014) 0.89
Selenium and diabetes--evidence from animal studies. Free Radic Biol Med (2013) 0.89
The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies. PLoS One (2015) 0.89
Erectile dysfunction in young non-obese type II diabetic Goto-Kakizaki rats is associated with decreased eNOS phosphorylation at Ser1177. J Sex Med (2010) 0.88
The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress. Biochem J (2012) 0.88
Molecular targets related to inflammation and insulin resistance and potential interventions. J Biomed Biotechnol (2012) 0.88
Nrf2 and redox status in prediabetic and diabetic patients. Int J Mol Sci (2014) 0.87
Serum malondialdehyde level: Surrogate stress marker in the Sikkimese diabetics. J Nat Sci Biol Med (2011) 0.86
Anti-inflammatory and cardioprotective effects of tadalafil in diabetic mice. PLoS One (2012) 0.86
Novel avenues of drug discovery and biomarkers for diabetes mellitus. J Clin Pharmacol (2010) 0.86
Nutritional regulation of insulin secretion: implications for diabetes. Clin Biochem Rev (2012) 0.86
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells. Apoptosis (2014) 0.85
Rhinacanthus nasutus Ameliorates Cytosolic and Mitochondrial Enzyme Levels in Streptozotocin-Induced Diabetic Rats. Evid Based Complement Alternat Med (2013) 0.85
Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and β-Cell Dysfunction. Oxid Med Cell Longev (2015) 0.84
Reactive metabolites and antioxidant gene polymorphisms in Type 2 diabetes mellitus. Redox Biol (2013) 0.84
Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes. Curr Diab Rep (2009) 0.84
Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2. Cell Metab (2014) 0.83
Impaired autophagic function in rat islets with aging. Age (Dordr) (2012) 0.82
Atorvastatin improves insulin sensitivity in mice with obesity induced by monosodium glutamate. Acta Pharmacol Sin (2009) 0.82
Redox homeostasis in pancreatic β cells. Oxid Med Cell Longev (2012) 0.82
Maternal obesity during the preconception and early life periods alters pancreatic development in early and adult life in male mouse offspring. PLoS One (2013) 0.82
Therapeutic promise and principles: metabotropic glutamate receptors. Oxid Med Cell Longev (2010) 0.82
Impact of exercise and metabolic disorders on heat shock proteins and vascular inflammation. Autoimmune Dis (2012) 0.82
Elevated glucocorticoids during ovine pregnancy increase appetite and produce glucose dysregulation and adiposity in their granddaughters in response to ad libitum feeding at 1 year of age. Am J Obstet Gynecol (2013) 0.81
Analysis of synaptic-like microvesicle exocytosis of B-cells using a live imaging technique. PLoS One (2014) 0.81
NADPH oxidase inhibition prevents beta cell dysfunction induced by prolonged elevation of oleate in rodents. Diabetologia (2013) 0.81
Biphasic response of mitochondrial biogenesis to oxidative stress in visceral fat of diet-induced obesity mice. Antioxid Redox Signal (2014) 0.81
Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes. PLoS One (2016) 0.80
Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-mβ cell death by inducing ROS generation. PLoS One (2013) 0.80
A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes. Genes Nutr (2015) 0.80
Total Antioxidant Status in Type 2 Diabetic Patients in Palestine. J Diabetes Res (2015) 0.80
Hyperglycemia / hypoglycemia-induced mitochondrial dysfunction and cerebral ischemic damage in diabetics. Metab Brain Dis (2014) 0.79
Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects. Clin Epigenetics (2012) 0.79
Hemoglobin conjugates with antioxidant enzymes (hemoglobin-superoxide dismutase-catalase) via poly(ethylene glycol) crosslinker for protection of pancreatic beta RINm5F cells in hypoxia. Tissue Eng Part A (2011) 0.79
TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS. Int J Mol Sci (2014) 0.79
Reactive metabolites and antioxidant gene polymorphisms in type 2 diabetes mellitus. Indian J Hum Genet (2014) 0.79
Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells. Redox Biol (2014) 0.79
A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity. J Biol Chem (2010) 0.79
The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus. Antioxid Redox Signal (2016) 0.78
Molecular mechanisms associated with diabetic endothelial-erectile dysfunction. Nat Rev Urol (2016) 0.78
Astaxanthin addition improves human neutrophils function: in vitro study. Eur J Nutr (2010) 0.78
The role of lipid droplet formation in the protection of unsaturated fatty acids against palmitic acid induced lipotoxicity to rat insulin-producing cells. Nutr Metab (Lond) (2016) 0.78
Exercise training enhances rat pancreatic islets anaplerotic enzymes content despite reduced insulin secretion. Eur J Appl Physiol (2011) 0.78
Liraglutide prevents fast weight gain and β-cell dysfunction in male catch-up growth rats. Exp Biol Med (Maywood) (2015) 0.78
Evaluation of Effects of Chinese Prescription Kangen-karyu on Diabetes-Induced Alterations such as Oxidative Stress and Apoptosis in the Liver of Type 2 Diabetic db/db Mice. Evid Based Complement Alternat Med (2012) 0.77
Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig (2014) 0.77
Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells? Pflugers Arch (2011) 0.77
NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction. Front Endocrinol (Lausanne) (2013) 0.77
Effect of BI-1 on insulin resistance through regulation of CYP2E1. Sci Rep (2016) 0.75
Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked? J Biomed Sci (2016) 0.75
Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells. Redox Biol (2016) 0.75
Bcl-2 maintains the mitochondrial membrane potential, but fails to affect production of reactive oxygen species and endoplasmic reticulum stress, in sodium palmitate-induced β-cell death. Ups J Med Sci (2014) 0.75
Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose. PeerJ (2016) 0.75
Biochemistry and molecular cell biology of diabetic complications. Nature (2001) 25.43
Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol (2006) 21.58
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Free radicals in the physiological control of cell function. Physiol Rev (2002) 19.62
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet (1963) 16.71
The pathobiology of diabetic complications: a unifying mechanism. Diabetes (2005) 14.96
Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26
Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73
Insulin-promoter-factor 1 is required for pancreas development in mice. Nature (1994) 10.13
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia (2003) 7.88
NADPH oxidase: an update. Blood (1999) 7.65
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab (2007) 6.83
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev (2002) 6.05
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes (1997) 5.61
Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet (1997) 5.47
IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J (1993) 5.46
beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev (1998) 5.25
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett (1997) 5.21
Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes (2002) 5.21
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem (2001) 5.12
Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem (1998) 5.09
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes (2000) 4.55
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes (2003) 4.40
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med (2000) 3.96
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes (1997) 3.86
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem (2002) 3.83
Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med (1995) 3.75
Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem (1994) 3.73
NADPH oxidase. Curr Opin Immunol (2004) 3.58
Oxidative DNA damage and disease: induction, repair and significance. Mutat Res (2004) 3.54
Diabetes mellitus and genetically programmed defects in beta-cell function. Nature (2001) 3.51
Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci U S A (2000) 3.36
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med (1996) 3.35
Mitochondrial function in normal and diabetic beta-cells. Nature (2001) 3.32
Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem (2002) 3.21
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie (2005) 3.20
Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes (2003) 2.96
IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J (1994) 2.89
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion. J Biol Chem (2002) 2.87
Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol (2006) 2.80
Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res (2000) 2.60
Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes (2007) 2.59
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest (2004) 2.56
Protein glycation, diabetes, and aging. Recent Prog Horm Res (2001) 2.51
The molecular basis for oxidative stress-induced insulin resistance. Antioxid Redox Signal (2005) 2.46
Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation. Biochemistry (2002) 2.31
Experimental conversion of liver to pancreas. Curr Biol (2003) 2.24
Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes (2001) 2.21
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol (1996) 2.14
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem (1999) 2.01
Modulation of the JNK pathway in liver affects insulin resistance status. J Biol Chem (2004) 1.99
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol (2002) 1.96
Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes. Diabetes (1999) 1.94
Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A (1999) 1.94
Oxidative stress is associated with adiposity and insulin resistance in men. J Clin Endocrinol Metab (2003) 1.92
S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes (2005) 1.91
Insulin expression in pancreatic islet cells relies on cooperative interactions between the helix loop helix factor E47 and the homeobox factor STF-1. Mol Endocrinol (1994) 1.89
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Biochem J (2004) 1.88
Reactive oxygen species mediate cytokine activation of c-Jun NH2-terminal kinases. J Biol Chem (1996) 1.85
Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. J Biol Chem (1994) 1.84
Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J Neurosci Res (1998) 1.82
Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J Biol Chem (1995) 1.82
A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc Natl Acad Sci U S A (2002) 1.79
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem (2002) 1.76
Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care (1992) 1.76
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation. J Biol Chem (2003) 1.75
Protein kinase C delta is required for p47phox phosphorylation and translocation in activated human monocytes. J Immunol (2004) 1.68
Role of oxidative stress in pancreatic beta-cell dysfunction. Ann N Y Acad Sci (2004) 1.68
PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes (2005) 1.68
Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest (1997) 1.64
Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes (2005) 1.59
Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem (1998) 1.57
Hexosamines and insulin resistance. Diabetes (1996) 1.57
Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. Proc Natl Acad Sci U S A (1994) 1.56
Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia (2002) 1.56
Regulatory factor linked to late-onset diabetes? Nature (1998) 1.55
Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res (2007) 1.48
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes (2003) 1.46
Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes (2003) 1.46
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia (2006) 1.43
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem (2001) 1.42
Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism (2002) 1.40
Nitrosative stress and pathogenesis of insulin resistance. Antioxid Redox Signal (2007) 1.38
Regulation and co-ordination of nuclear gene expression during mitochondrial biogenesis. Exp Physiol (2003) 1.36
The physiological regulation of uncoupling proteins. Biochim Biophys Acta (2006) 1.33
Palmitate induced mitochondrial deoxyribonucleic acid damage and apoptosis in l6 rat skeletal muscle cells. Endocrinology (2006) 1.31
A radical explanation for glucose-induced beta cell dysfunction. J Clin Invest (2003) 1.28
PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes (1996) 1.27
Increased glucose uptake promotes oxidative stress and PKC-delta activation in adipocytes of obese, insulin-resistant mice. Am J Physiol Endocrinol Metab (2003) 1.27
Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis. Biochem Biophys Res Commun (2003) 1.27
Effect of HIV-1 and increasing immunosuppression on malaria parasitaemia and clinical episodes in adults in rural Uganda: a cohort study. Lancet (2000) 5.93
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat Med (1998) 5.78
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature (1996) 5.50
X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet (1996) 3.90
Corrective shoes and inserts as treatment for flexible flatfoot in infants and children. J Bone Joint Surg Am (1989) 2.56
The effects of positive and negative social exchanges on aging adults. J Gerontol B Psychol Sci Soc Sci (1997) 2.40
Noninvasive pulse wave analysis for the early detection of vascular disease. Hypertension (1995) 2.36
Expression and localization of prestin and the sugar transporter GLUT-5 during development of electromotility in cochlear outer hair cells. J Neurosci (2000) 2.28
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages. Biochem J (1986) 2.21
A case control study of infection with an epidemic strain of multiresistant Salmonella typhimurium DT104 in England and Wales. Commun Dis Rep CDR Rev (1994) 2.04
Ion movement through gramicidin A channels. On the importance of the aqueous diffusion resistance and ion-water interactions. Acta Physiol Scand Suppl (1980) 1.96
Perception of emotion from dynamic point-light displays represented in dance. Perception (1996) 1.94
Differential effects of human papillomavirus type 6, 16, and 18 DNAs on immortalization and transformation of human cervical epithelial cells. Proc Natl Acad Sci U S A (1989) 1.87
Maintenance chemotherapy for anaplastic small cell carcinoma of the bronchus: a randomised, controlled trial. Cancer Chemother Pharmacol (1986) 1.87
Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice. Neurobiol Aging (2001) 1.79
The groin hernia - an ultrasound diagnosis? Ann R Coll Surg Engl (2003) 1.79
Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. Proc Natl Acad Sci U S A (1998) 1.76
Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav Genet (1999) 1.74
Radiation dose-response of human tumors. Int J Radiat Oncol Biol Phys (1995) 1.73
Effect of type 2 diabetes mellitus on left ventricular geometry and systolic function in hypertensive subjects: Hypertension Genetic Epidemiology Network (HyperGEN) study. Circulation (2001) 1.69
Causes of death in a rural, population-based human immunodeficiency virus type 1 (HIV-1) natural history cohort in Uganda. Int J Epidemiol (1998) 1.66
The risk of HIV, HBV, HCV and HTLV infection among musculoskeletal tissue donors in Australia. Am J Transplant (2007) 1.66
The first case of Lassa fever imported from Mali to the United Kingdom, February 2009. Euro Surveill (2009) 1.63
Acute orbital cellulitis due to gas-forming bacteria. Eye (Lond) (1991) 1.61
Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res (2001) 1.59
Inverse relationship between aldosterone and large artery compliance in chronically treated heart failure patients. Eur Heart J (1998) 1.59
Molecular mechanisms of glutamine action. J Cell Physiol (2005) 1.57
Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci (2003) 1.50
Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res (2007) 1.47
Transmission of multi-resistant strains of Salmonella typhimurium from cattle to man. Vet Rec (1995) 1.46
Signature patterns of DNA restriction fragments of Helicobacter pylori before and after treatment. J Clin Pathol (1990) 1.44
Estimating the balance of general practice versus family planning clinic coverage of contraception services in London. Br J Fam Plann (2000) 1.43
Detailed comparison of expressed and native voltage-gated proton channel currents. J Physiol (2008) 1.43
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line. Diabetologia (2006) 1.43
A fatal case of Lassa fever in London, January 2009. Euro Surveill (2009) 1.40
In vivo regulation of murine hair growth: insights from grafting defined cell populations onto nude mice. J Invest Dermatol (1993) 1.39
AIDS stigma in insurance market. BMJ (1989) 1.39
Histomorphometric assessment of bone mass, structure, and remodeling: a comparison between healthy black and white premenopausal women. J Bone Miner Res (1997) 1.36
Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice. Neurobiol Aging (2001) 1.35
Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. J Neuroimmunol (2001) 1.35
The gp91phox component of NADPH oxidase is not the voltage-gated proton channel in phagocytes, but it helps. J Biol Chem (2001) 1.32
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32
Amyloid-beta vaccination, but not nitro-nonsteroidal anti-inflammatory drug treatment, increases vascular amyloid and microhemorrhage while both reduce parenchymal amyloid. Neuroscience (2006) 1.31
Physical activity for the chronically ill and disabled. Sports Med (2000) 1.30
Relationship between HIV-1 Env subtypes A and D and disease progression in a rural Ugandan cohort. AIDS (2001) 1.29
An outbreak of Campylobacter jejuni enteritis associated with failed milk pasteurisation. J Infect (1995) 1.27
Glutamine and glutamate as vital metabolites. Braz J Med Biol Res (2003) 1.26
Causality in acute encephalitis: defining aetiologies. Epidemiol Infect (2010) 1.22
Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol (2001) 1.22
Pleiotropic effects of fatty acids on pancreatic beta-cells. J Cell Physiol (2003) 1.21
Frailty and injuries in later life: the FICSIT trials. J Am Geriatr Soc (1993) 1.20
Nitrofurans in the treatment of gastritis associated with Campylobacter pylori. The Gastrointestinal Physiology Working Group of Cayetano Heredia and The Johns Hopkins Universities. Gastroenterology (1988) 1.19
Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA Cell Biol (2001) 1.19
The stimulus-secretion coupling of glucose-induced insulin release. XLVI. Physiological role of L-glutamine as a fuel for pancreatic islets. Mol Cell Endocrinol (1980) 1.19
Case-control study of risk factors for incident HIV infection in rural Uganda. J Acquir Immune Defic Syndr (2000) 1.17
Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell. Diabetologia (2009) 1.17
Spontaneously productive C-type retrovirus infection of fish cell lines. J Gen Virol (1991) 1.15
Evolution of in vitro transformation and tumorigenesis of HPV16 and HPV18 immortalized primary cervical epithelial cells. Am J Pathol (1991) 1.14
BLASTOMYCOSIS. Ann Surg (1915) 1.14
Maximum activities of some key enzymes of glycolysis, glutaminolysis, Krebs cycle and fatty acid utilization in bovine pulmonary endothelial cells. FEBS Lett (1987) 1.13
Aetiology of sexually transmitted infections and response to syndromic treatment in southwest Uganda. Sex Transm Infect (2005) 1.13
Cultivation of murine hair follicles as organoids in a collagen matrix. J Invest Dermatol (1987) 1.13
Behavioural surveillance: the value of national coordination. Sex Transm Infect (2002) 1.12
Effects of dexamethasone and betamethasone on in vitro cultures from human astrocytoma. Br J Cancer (1977) 1.12
Treatment of advanced hepatocellular carcinoma with very low levels of amplitude-modulated electromagnetic fields. Br J Cancer (2011) 1.10
The stimulus-secretion coupling of amino acid-induced insulin release: metabolism and cationic effects of leucine. Diabetes (1980) 1.10
Adjuvant radiotherapy for gastrointestinal stromal tumor of the rectum. Dig Dis Sci (2001) 1.10
Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells. Endocrinology (2009) 1.09
Diabetes causes marked changes in function and metabolism of rat neutrophils. J Endocrinol (2006) 1.08
Insulinotropic effect of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in rat pancreatic islets. Cancer Res (1980) 1.08
The prognostic value of the World Health Organisation staging system for HIV infection and disease in rural Uganda. AIDS (1999) 1.07
Effects of repeated doses of ivermectin on ocular onchocerciasis: community-based trial in Sierra Leone. Lancet (1991) 1.07
Assay of anticancer drugs in tissue culture: cell cultures of biopsies from human astrocytoma. Br J Cancer (1983) 1.06
Diabetes induces apoptosis in lymphocytes. J Endocrinol (2004) 1.06
Glutamine metabolism by lymphocytes, macrophages, and neutrophils: its importance in health and disease. J Nutr Biochem (1999) 1.05
The spirochete FlaA periplasmic flagellar sheath protein impacts flagellar helicity. J Bacteriol (2000) 1.05
Ranking the toxicity of fatty acids on Jurkat and Raji cells by flow cytometric analysis. Toxicol In Vitro (2002) 1.04
Expression of interferon-beta is associated with growth arrest of murine and human epidermal cells. J Invest Dermatol (1999) 1.04
Visual loss in an onchocerciasis endemic community in Sierra Leone. Br J Ophthalmol (1993) 1.02
Repair of chronic ruptures of the distal biceps tendon using flexor carpi radialis tendon graft. Am J Sports Med (2000) 1.01
Deliberate releases of biological agents: initial lessons for Europe from events in the United States. Euro Surveill (2001) 1.01
Stimulus-secretion coupling of glucose-induced insulin release. Effect of intracellular acidification upon calcium efflux from islet cells. Metabolism (1980) 1.01
Double-stranded RNA-activated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology (2012) 1.01
L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity. Diabetologia (2007) 1.01
Interspecies generality and human behavior: An addendum to Baron and Perone. Behav Anal (1983) 1.01
Labelling and immunoprecipitation of thyroid microsomal antigen. FEBS Lett (1985) 1.01
Effect of surgical experience on results of esophagectomy for esophageal carcinoma. J Surg Oncol (1997) 1.00
Surveillance of HTLV infection in England and Wales: 1986-1992. Commun Dis Rep CDR Rev (1994) 1.00
Leiomyosarcoma of the larynx. Otolaryngol Head Neck Surg (1999) 0.99