Published in J Biol Chem on March 07, 2003
Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics (2010) 1.60
Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol (2004) 1.47
Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes. BMC Genomics (2008) 1.24
Transgenic models of Alzheimer's disease: learning from animals. NeuroRx (2005) 1.21
Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression. J Mammary Gland Biol Neoplasia (2009) 1.15
Translational regulation of BACE-1 expression in neuronal and non-neuronal cells. Nucleic Acids Res (2004) 1.05
Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription. Biochem J (2004) 1.04
MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. J Biol Chem (2012) 1.03
Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim Biophys Acta (2008) 1.01
Aβ internalization by neurons and glia. Int J Alzheimers Dis (2011) 0.99
Brain injury-associated biomarkers of TGF-beta1, S100B, GFAP, NF-L, tTG, AbetaPP, and tau were concomitantly enhanced and the UPS was impaired during acute brain injury caused by Toxocara canis in mice. BMC Infect Dis (2008) 0.98
Astrocytes as a source for extracellular matrix molecules and cytokines. Front Pharmacol (2012) 0.96
Assessment of allele-specific gene silencing by RNA interference with mutant and wild-type reporter alleles. J RNAi Gene Silencing (2006) 0.94
Modelling neuroinflammatory phenotypes in vivo. J Neuroinflammation (2004) 0.91
Neuroinflammation in autism spectrum disorders. J Neuroinflammation (2012) 0.91
Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol Cell Biol (2005) 0.90
Transgenic mice overexpressing APP and transforming growth factor-beta1 feature cognitive and vascular hallmarks of Alzheimer's disease. Am J Pathol (2010) 0.86
Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression. Glia (2010) 0.85
Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised. J Neuroinflammation (2004) 0.83
TGF-β1 protection against Aβ1-42-induced neuroinflammation and neurodegeneration in rats. Int J Mol Sci (2014) 0.82
PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE). BMC Genomics (2013) 0.82
Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation. Brain Behav Immun (2013) 0.81
Role of the Transforming-Growth-Factor-β1 Gene in Late-Onset Alzheimer's Disease: Implications for the Treatment. Curr Genomics (2013) 0.81
The TGF-beta1/upstream stimulatory factor-regulated PAI-1 gene: potential involvement and a therapeutic target in Alzheimer's disease. J Biomed Biotechnol (2006) 0.81
TGF beta2-induced changes in LRP-1/T beta R-V and the impact on lysosomal A beta uptake and neurotoxicity. Brain Res (2008) 0.80
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. Acta Neuropathol (2008) 0.80
Association of a polymorphism of the transforming growth factor-beta1 gene with cerebral amyloid angiopathy. J Neurol Neurosurg Psychiatry (2005) 0.79
Interleukin17A Promotes Postoperative Cognitive Dysfunction by Triggering β-Amyloid Accumulation via the Transforming Growth Factor-β (TGFβ)/Smad Signaling Pathway. PLoS One (2015) 0.79
Novel Combinatorial Therapeutic Targeting of PAI-1 (SERPINE1) Gene Expression in Alzheimer's Disease. Mol Med Ther (2012) 0.78
Role of TGFβ signaling in the pathogenesis of Alzheimer's disease. Front Cell Neurosci (2015) 0.77
Icariin ameliorates neuropathological changes, TGF-β1 accumulation and behavioral deficits in a mouse model of cerebral amyloidosis. PLoS One (2014) 0.77
Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease. Mol Neurodegener (2016) 0.76
Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease. J Neurochem (2015) 0.75
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol (2007) 18.62
Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurol (2010) 8.74
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A (2008) 5.24
Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment. Anesthesiology (2012) 2.87
The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (2009) 2.35
Vesicular glycolysis provides on-board energy for fast axonal transport. Cell (2013) 2.33
Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis (2008) 2.26
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15
Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol (2004) 2.15
Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J (2008) 2.03
An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem (2002) 2.00
Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic. Trends Neurosci (2008) 1.97
Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci (2008) 1.92
MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis (2008) 1.89
Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain. J Cereb Blood Flow Metab (2002) 1.88
Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet (2010) 1.83
Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Invest (2011) 1.79
Stroke and the immune system: from pathophysiology to new therapeutic strategies. Lancet Neurol (2011) 1.77
Stroke research priorities for the next decade--A representative view of the European scientific community. Cerebrovasc Dis (2006) 1.75
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am J Pathol (2006) 1.68
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proc Natl Acad Sci U S A (2005) 1.61
Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron (2008) 1.59
Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB J (2004) 1.56
Epigenetics, oxidative stress, and Alzheimer disease. Free Radic Biol Med (2009) 1.56
Thrombotic stroke in the anesthetized monkey (Macaca mulatta): characterization by MRI--a pilot study. Cerebrovasc Dis (2012) 1.52
Nuclear tau, a key player in neuronal DNA protection. J Biol Chem (2010) 1.47
Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease. Neuromolecular Med (2002) 1.46
Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha. Nat Cell Biol (2003) 1.46
The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain. J Neurosci (2005) 1.46
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron. J Neurosci Res (2003) 1.45
Mouse model of in situ thromboembolic stroke and reperfusion. Stroke (2007) 1.45
NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. J Neurosci (2005) 1.44
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells. J Pharmacol Exp Ther (2002) 1.43
Truncated beta-amyloid peptide species in pre-clinical Alzheimer's disease as new targets for the vaccination approach. J Neurochem (2003) 1.40
Endovascular treatment for acute ischemic stroke. N Engl J Med (2013) 1.39
Global analysis of Smad2/3-dependent TGF-beta signaling in living mice reveals prominent tissue-specific responses to injury. J Immunol (2005) 1.39
GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease. J Alzheimers Dis (2010) 1.36
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. J Biol Chem (2007) 1.35
Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis. Circulation (2005) 1.32
PART is part of Alzheimer disease. Acta Neuropathol (2015) 1.31
Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proc Natl Acad Sci U S A (2007) 1.30
Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism. J Affect Disord (2007) 1.30
Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons. Hum Mol Genet (2008) 1.28
Cytokines in neuroinflammation and Alzheimer's disease. Curr Drug Targets (2004) 1.26
Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production. J Neurosci (2010) 1.26
Early axonopathy preceding neurofibrillary tangles in mutant tau transgenic mice. Am J Pathol (2007) 1.26
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients. J Clin Endocrinol Metab (2002) 1.25
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res (2005) 1.25
Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins--a role in nuclear localization. Biochim Biophys Acta (2003) 1.24
Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol Ther (2009) 1.23
Neuroprotection and stroke: time for a compromise. J Neurochem (2007) 1.23
Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. FASEB J (2006) 1.22
MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochem Biophys Res Commun (2010) 1.21
Tau protein as a differential biomarker of tauopathies. Biochim Biophys Acta (2005) 1.21
Biochemistry of Tau in Alzheimer's disease and related neurological disorders. Expert Rev Proteomics (2008) 1.21
N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Curr Alzheimer Res (2012) 1.20
Activation of cannabinoid CB2 receptor negatively regulates IL-12p40 production in murine macrophages: role of IL-10 and ERK1/2 kinase signaling. Br J Pharmacol (2005) 1.20
A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis. Curr Alzheimer Res (2006) 1.18
High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. J Child Neurol (2006) 1.18
Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process. Stroke (2005) 1.18
Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis. Haematologica (2012) 1.16
Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling. J Biol Chem (2004) 1.16
Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model. J Neurochem (2011) 1.15
p25/Cdk5-mediated retinoblastoma phosphorylation is an early event in neuronal cell death. J Cell Sci (2005) 1.15
Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease. J Alzheimers Dis (2011) 1.14
Age-related changes in murine CNS mRNA gene expression are modulated by dietary melatonin. J Pineal Res (2004) 1.13
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation (2012) 1.13
Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis. FASEB J (2011) 1.12
Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain. Ann Neurol (2012) 1.12
CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury. FASEB J (2003) 1.11
MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy. Hum Mol Genet (2011) 1.11
Transforming growth factor-beta and ischemic brain injury. Cell Mol Neurobiol (2003) 1.10
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex. J Biol Chem (2003) 1.10
Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol (2009) 1.10
The endocannabinoid system is modulated in response to spinal cord injury in rats. Neurobiol Dis (2008) 1.10
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies. Acta Neuropathol Commun (2014) 1.09
Reduction of ischemic brain damage by nitrous oxide and xenon. J Cereb Blood Flow Metab (2003) 1.08
Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice. J Neurosci Res (2010) 1.08
Apoptotic and behavioral sequelae of mild brain trauma in mice. J Neurosci Res (2007) 1.07
Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. J Neurosci (2012) 1.06
Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One (2011) 1.06
Targets for AD treatment: conflicting messages from γ-secretase inhibitors. J Neurochem (2011) 1.05
TGFbeta1 regulates the inflammatory response during chronic neurodegeneration. Neurobiol Dis (2006) 1.05
Equivocal roles of tissue-type plasminogen activator in stroke-induced injury. Trends Neurosci (2004) 1.05
Potential contribution of exosomes to the prion-like propagation of lesions in Alzheimer's disease. Front Physiol (2012) 1.05
Cell-derived microparticles: a new challenge in neuroscience. J Neurochem (2009) 1.05