Published in Genes Dev on May 01, 2000
The epigenomics of cancer. Cell (2007) 30.91
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J (2004) 11.00
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
The acetate switch. Microbiol Mol Biol Rev (2005) 6.10
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol (2002) 5.37
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell (2008) 5.11
Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev (2004) 4.51
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
Role of oxidative carbonylation in protein quality control and senescence. EMBO J (2005) 3.59
Neural mechanisms of ageing and cognitive decline. Nature (2010) 3.59
Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet (2006) 3.54
Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A (2000) 3.46
Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell (2008) 3.32
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. PLoS Biol (2007) 3.19
Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus. Genes Dev (2002) 3.09
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93
SIRT1, is it a tumor promoter or tumor suppressor? Int J Biol Sci (2009) 2.80
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res (2002) 2.79
Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. Mol Cell Biol (2003) 2.79
Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol Cell Biol (2001) 2.64
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev (2007) 2.32
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
Retracted Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A (2007) 2.09
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol (2002) 2.08
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem (2003) 1.93
Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab (2009) 1.89
High-resolution genome-wide mapping of the primary structure of chromatin. Cell (2011) 1.89
Nucleolus: the fascinating nuclear body. Histochem Cell Biol (2007) 1.87
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest (2003) 1.84
Functional divergence between histone deacetylases in fission yeast by distinct cellular localization and in vivo specificity. Mol Cell Biol (2002) 1.84
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin. Microbiol Mol Biol Rev (2003) 1.78
Altered sirtuin expression is associated with node-positive breast cancer. Br J Cancer (2006) 1.73
Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol (2004) 1.73
The NAD(+)-dependent SIRT1 deacetylase translates a metabolic switch into regulatory epigenetics in skeletal muscle stem cells. Cell Stem Cell (2015) 1.73
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem (2009) 1.70
The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation. Mol Cell Biol (2003) 1.66
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem (2010) 1.65
The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. Genetics (2003) 1.63
A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Genetics (2002) 1.63
BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis. Genes Dev (2004) 1.62
Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics (2002) 1.60
The SirT3 divining rod points to oxidative stress. Mol Cell (2011) 1.58
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging. Genes Dev (2004) 1.57
AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res (2012) 1.52
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One (2007) 1.50
Differential localization of HDAC4 orchestrates muscle differentiation. Nucleic Acids Res (2001) 1.49
The histone deacetylase genes HDA1 and RPD3 play distinct roles in regulation of high-frequency phenotypic switching in Candida albicans. J Bacteriol (2001) 1.48
Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol (2006) 1.47
Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci U S A (2004) 1.45
Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. J Biol Chem (2010) 1.45
Nucleolus: from structure to dynamics. Histochem Cell Biol (2005) 1.44
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication. Genes Dev (2004) 1.43
Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.43
The nucleolus: a model for the organization of nuclear functions. Histochem Cell Biol (2006) 1.39
Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions. Mol Cell Biol (2004) 1.37
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence. Nucleic Acids Res (2010) 1.35
Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity. EMBO J (2003) 1.35
Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res (2002) 1.33
Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm. EMBO Rep (2004) 1.33
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A (2010) 1.30
hpr1Delta affects ribosomal DNA recombination and cell life span in Saccharomyces cerevisiae. Mol Cell Biol (2002) 1.28
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle (2008) 1.28
NF-κB in Aging and Disease. Aging Dis (2011) 1.28
Longevity and stress in Caenorhabditis elegans. Aging (Albany NY) (2011) 1.28
Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Nucleic Acids Res (2002) 1.27
Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation. PLoS Genet (2011) 1.27
Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell (2011) 1.26
SIRT1 and energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2013) 1.25
Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer. Mol Biol Cell (2006) 1.24
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis. J Cell Sci (2009) 1.22
Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22
The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases. Proc Natl Acad Sci U S A (2006) 1.21
Epigenetic memory loss in aging oligodendrocytes in the corpus callosum. Neurobiol Aging (2006) 1.21
Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Cell (2014) 1.20
SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol (2009) 1.19
p53, oxidative stress, and aging. Antioxid Redox Signal (2011) 1.18
The Sir2 protein family: A novel deacetylase for gene silencing and more. Proc Natl Acad Sci U S A (2000) 1.18
A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med (2012) 1.18
Mammalian sirtuins and energy metabolism. Int J Biol Sci (2011) 1.17
Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem (2010) 1.17
Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest (2001) 1.15
Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J Biol Chem (2008) 1.11
Considerations on temperature, longevity and aging. Cell Mol Life Sci (2008) 1.11
Mitochondrial longevity pathways. Biochim Biophys Acta (2011) 1.11
The Sgs1 helicase of Saccharomyces cerevisiae inhibits retrotransposition of Ty1 multimeric arrays. Mol Cell Biol (2001) 1.10
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis. Antioxid Redox Signal (2013) 1.09
Distinct roles for the essential MYST family HAT Esa1p in transcriptional silencing. Mol Biol Cell (2006) 1.08
G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity. PLoS Genet (2014) 1.06
Conserved locus-specific silencing functions of Schizosaccharomyces pombe sir2+. Genetics (2004) 1.06