Published in Diabetes on April 01, 2003
AMPK and PPARdelta agonists are exercise mimetics. Cell (2008) 6.39
AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab (2010) 2.40
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
AMPK inhibition in health and disease. Crit Rev Biochem Mol Biol (2010) 1.93
Subunit composition of AMPK trimers present in the cytokinetic apparatus: Implications for drug target identification. Cell Cycle (2012) 1.57
Exercise-induced histone modifications in human skeletal muscle. J Physiol (2009) 1.36
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol (2003) 1.11
Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase. Mol Biol Cell (2010) 1.10
Targeting AMPK for cardiac protection: opportunities and challenges. J Mol Cell Cardiol (2010) 1.04
Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation. PLoS One (2011) 1.03
Epigenetics and obesity: the devil is in the details. BMC Med (2010) 0.99
Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations. Rev Diabet Stud (2009) 0.98
Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. Trends Pharmacol Sci (2015) 0.96
The AMPK β2 subunit is required for energy homeostasis during metabolic stress. Mol Cell Biol (2012) 0.90
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy. Diabetologia (2011) 0.90
AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol (2013) 0.89
Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes. Am J Physiol Cell Physiol (2010) 0.89
Alpha-adrenergic signalling activates protein kinase D and causes nuclear efflux of the transcriptional repressor HDAC5 in cultured adult mouse soleus skeletal muscle fibres. J Physiol (2009) 0.89
Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo. Int J Obes (Lond) (2010) 0.85
Activation of an AMP-activated protein kinase is involved in post-diapause development of Artemia franciscana encysted embryos. BMC Dev Biol (2009) 0.83
Physiological and molecular responses to an acute bout of reduced-exertion high-intensity interval training (REHIT). Eur J Appl Physiol (2015) 0.82
The SNF1 Kinase Ubiquitin-associated Domain Restrains Its Activation, Activity, and the Yeast Life Span. J Biol Chem (2015) 0.81
Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
Perturbing microtubule integrity blocks AMP-activated protein kinase-induced meiotic resumption in cultured mouse oocytes. Zygote (2012) 0.78
Regulation of PGC-1α Isoform Expression in Skeletal Muscles. Acta Naturae (2015) 0.77
CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models. Cardiovasc Diabetol (2014) 0.77
Intense Resistance Exercise Promotes the Acute and Transient Nuclear Translocation of Small Ubiquitin-Related Modifier (SUMO)-1 in Human Myofibres. Int J Mol Sci (2016) 0.76
Chronic Exercise Training Improved Aortic Endothelial and Mitochondrial Function via an AMPKα2-Dependent Manner. Front Physiol (2016) 0.75
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLoS One (2017) 0.75
How to explain exercise-induced phenotype from molecular data: rethink and reconstruction based on AMPK and mTOR signaling. Springerplus (2013) 0.75
Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia (2014) 0.75
AMPK in Health and Disease. Physiol Rev (2009) 6.38
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab (2008) 3.04
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol (2006) 2.94
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells (2003) 2.62
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes (2008) 2.13
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation (2009) 2.00
Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev (2013) 1.98
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A (2011) 1.96
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem (2006) 1.93
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol (2008) 1.93
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
Real-time RT-PCR analysis of housekeeping genes in human skeletal muscle following acute exercise. Physiol Genomics (2004) 1.87
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
'Systems biology' in human exercise physiology: is it something different from integrative physiology? J Physiol (2011) 1.73
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol (1985) (2008) 1.69
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci (2005) 1.59
Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes (2003) 1.58
Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem (2002) 1.56
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol (2002) 1.56
Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease. Circulation (2005) 1.55
A reservoir of brown adipocyte progenitors in human skeletal muscle. Stem Cells (2008) 1.51
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance. Proc Natl Acad Sci U S A (2008) 1.51
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.51
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.48
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab (2005) 1.45
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
Increase in S6K1 phosphorylation in human skeletal muscle following resistance exercise occurs mainly in type II muscle fibers. Am J Physiol Endocrinol Metab (2006) 1.44
IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.43
Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol (2002) 1.43
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.39
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J Biol Chem (2005) 1.39
A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr (2003) 1.36
Exercise-induced histone modifications in human skeletal muscle. J Physiol (2009) 1.36
Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury. Am J Physiol Regul Integr Comp Physiol (2010) 1.34
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes (2007) 1.32
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. Biochem Biophys Res Commun (2002) 1.29
AMPK and transcriptional regulation. Front Biosci (2008) 1.26
Docosapentaenoic acid (22:5n-3): a review of its biological effects. Prog Lipid Res (2010) 1.26
Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol (2005) 1.25
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.25
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes (2004) 1.24
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK). Biochem J (2007) 1.24
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation. Proc Natl Acad Sci U S A (2004) 1.23
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
Glucose ingestion attenuates interleukin-6 release from contracting skeletal muscle in humans. J Physiol (2003) 1.22
Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations. AIDS (2004) 1.22
Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem (2002) 1.21
Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. J Biol Chem (2005) 1.20
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes (2003) 1.15
Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol (2004) 1.13
AMPK structure and regulation from three angles. Structure (2007) 1.13
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab (2006) 1.13
Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol (2006) 1.13
Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol (2003) 1.11
Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res (2009) 1.11
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.10
5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB. Immunol Cell Biol (2010) 1.09
Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. FASEB J (2004) 1.09
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology (2009) 1.09
Effect of AICAR treatment on glycogen metabolism in skeletal muscle. Diabetes (2002) 1.09
Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pharmacol Physiol (2006) 1.08
STAT3 signaling is activated in human skeletal muscle following acute resistance exercise. J Appl Physiol (1985) (2007) 1.08
Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. Am J Physiol Renal Physiol (2005) 1.08
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics (2008) 1.07
Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke (2005) 1.07
Impaired expression of Notch signaling genes in aged human skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 1.07
Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment. Am J Physiol Regul Integr Comp Physiol (2013) 1.05
NDRG2, a novel regulator of myoblast proliferation, is regulated by anabolic and catabolic factors. J Physiol (2009) 1.05
Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. Int J Biochem Cell Biol (2009) 1.05
AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost (2003) 1.04
Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue. Obesity (Silver Spring) (2013) 1.04
AMPK-mediated regulation of transcription in skeletal muscle. Clin Sci (Lond) (2010) 1.04
Acute activation and phosphorylation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Am J Physiol Heart Circ Physiol (2004) 1.04
Sustained weight loss in obese subjects has benefits that are independent of attained weight. Obes Res (2004) 1.03