Published in Am J Physiol Endocrinol Metab on January 28, 2004
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Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J Appl Physiol (1985) (2010) 1.26
Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise. J Physiol (2006) 1.17
Regulation and limitations to fatty acid oxidation during exercise. J Physiol (2012) 1.08
Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise. J Physiol (2004) 1.07
Exercise in the fasted state facilitates fibre type-specific intramyocellular lipid breakdown and stimulates glycogen resynthesis in humans. J Physiol (2005) 0.99
In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation. J Biol Chem (2012) 0.98
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Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab (2011) 0.94
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Carbohydrate supplementation during prolonged cycling exercise spares muscle glycogen but does not affect intramyocellular lipid use. Pflugers Arch (2007) 0.87
The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding. Diabetol Metab Syndr (2013) 0.83
Intramyocellular lipid stores increase markedly in athletes after 1.5 days lipid supplementation and are utilized during exercise in proportion to their content. Eur J Appl Physiol (2006) 0.82
High muscle lipid content in obesity is not due to enhanced activation of key triglyceride esterification enzymes or the suppression of lipolytic proteins. Am J Physiol Endocrinol Metab (2011) 0.82
Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. J Lipid Res (2014) 0.82
A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology (2012) 0.81
Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B. Am J Physiol Endocrinol Metab (2014) 0.81
The effect of age and unilateral leg immobilization for 2 weeks on substrate utilization during moderate-intensity exercise in human skeletal muscle. J Physiol (2016) 0.80
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Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice. Am J Physiol Endocrinol Metab (2014) 0.79
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AMPK in Health and Disease. Physiol Rev (2009) 6.38
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Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest (2007) 4.86
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab (2008) 3.04
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol (2006) 2.94
Interleukin-6 stimulates lipolysis and fat oxidation in humans. J Clin Endocrinol Metab (2003) 2.90
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
Reactive oxygen species enhance insulin sensitivity. Cell Metab (2009) 2.77
Exosome-dependent trafficking of HSP70: a novel secretory pathway for cellular stress proteins. J Biol Chem (2005) 2.64
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells (2003) 2.62
HSP72 protects against obesity-induced insulin resistance. Proc Natl Acad Sci U S A (2008) 2.52
The transcription factor IRF4 is essential for TCR affinity-mediated metabolic programming and clonal expansion of T cells. Nat Immunol (2013) 2.48
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J (2004) 2.37
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes (2008) 2.14
AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes (2008) 2.13
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues. Endocrinology (2006) 2.01
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation (2009) 2.00
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A (2011) 1.96
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem (2006) 1.93
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol (2008) 1.93
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol (1985) (2005) 1.88
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65
Glycogen availability does not affect the TCA cycle or TAN pools during prolonged, fatiguing exercise. J Appl Physiol (1985) (2002) 1.60
Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci (2005) 1.59
Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes (2003) 1.58
Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem (2002) 1.56
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol (2002) 1.56
Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease. Circulation (2005) 1.55
Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development. Proc Natl Acad Sci U S A (2011) 1.52
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.51
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.48
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab (2005) 1.45
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.43
Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol (2002) 1.43
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Regulation and function of triacylglycerol lipases in cellular metabolism. Biochem J (2008) 1.41
Exercise increases nuclear AMPK alpha2 in human skeletal muscle. Diabetes (2003) 1.40
Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance. Am J Physiol Endocrinol Metab (2006) 1.39
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J Biol Chem (2005) 1.39
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology (2010) 1.32
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes (2007) 1.32
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
Skeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity. FASEB J (2004) 1.29
AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. Biochem Biophys Res Commun (2002) 1.29
Plasma lysophosphatidylcholine levels are reduced in obesity and type 2 diabetes. PLoS One (2012) 1.28
Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol (2005) 1.25
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK). Biochem J (2007) 1.24
PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA. Arterioscler Thromb Vasc Biol (2010) 1.24
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation. Proc Natl Acad Sci U S A (2004) 1.23
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
Deletion of macrophage migration inhibitory factor protects the heart from severe ischemia-reperfusion injury: a predominant role of anti-inflammation. J Mol Cell Cardiol (2011) 1.22
Role of exercise-induced brain-derived neurotrophic factor production in the regulation of energy homeostasis in mammals. Exp Physiol (2009) 1.22
Retracted FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signaling in mammalian skeletal muscle. J Biol Chem (2007) 1.22
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: implications for obesity. Mol Cell Endocrinol (2012) 1.22