Published in Diabetes on January 09, 2008
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 8.43
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism. Nat Cell Biol (2011) 6.83
AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev (2011) 5.26
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell (2011) 3.64
Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes (2009) 2.96
AMP-activated protein kinase and its downstream transcriptional pathways. Cell Mol Life Sci (2010) 1.95
Bioinformatic and experimental survey of 14-3-3-binding sites. Biochem J (2010) 1.73
AMPK: a target for drugs and natural products with effects on both diabetes and cancer. Diabetes (2013) 1.58
Post-translational modifications regulate class IIa histone deacetylase (HDAC) function in health and disease. Mol Cell Proteomics (2015) 1.49
SnRK2 protein kinases--key regulators of plant response to abiotic stresses. OMICS (2011) 1.40
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: a reevaluation. PLoS Biol (2013) 1.40
Exercise-induced histone modifications in human skeletal muscle. J Physiol (2009) 1.36
Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus. Mol Med (2011) 1.34
AMP-activated protein kinase regulation and biological actions in the heart. Circ Res (2012) 1.33
AMP-activated protein kinase, stress responses and cardiovascular diseases. Clin Sci (Lond) (2012) 1.29
Epigenetic regulation of ageing: linking environmental inputs to genomic stability. Nat Rev Mol Cell Biol (2015) 1.24
The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev (2011) 1.17
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. J Physiol (2009) 1.11
Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). J Biol Chem (2014) 1.09
The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases. J Biol Chem (2013) 1.08
Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J Biol Chem (2011) 1.07
Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes (2010) 1.05
Nutrition, epigenetics, and metabolic syndrome. Antioxid Redox Signal (2012) 1.04
Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice. J Appl Physiol (1985) (2010) 1.02
HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication. PLoS Pathog (2012) 1.02
Adiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk. Cell Metab (2016) 1.00
Epigenetics and obesity: the devil is in the details. BMC Med (2010) 0.99
AMP-activated protein kinase regulates E3 ligases in rodent heart. Circ Res (2011) 0.99
Functional interaction of regulatory factors with the Pgc-1alpha promoter in response to exercise by in vivo imaging. Am J Physiol Cell Physiol (2008) 0.99
Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab (2012) 0.98
AMP-activated protein kinase regulates beta-catenin transcription via histone deacetylase 5. J Biol Chem (2011) 0.97
Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning. Br J Pharmacol (2015) 0.96
Transcriptional coregulators: fine-tuning metabolism. Cell Metab (2014) 0.93
Viperin regulates cellular lipid metabolism during human cytomegalovirus infection. PLoS Pathog (2013) 0.91
Myocyte enhancer factor 2C regulation of hepatocellular carcinoma via vascular endothelial growth factor and Wnt/β-catenin signaling. Oncogene (2014) 0.90
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy. Diabetologia (2011) 0.90
Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. Mol Endocrinol (2012) 0.90
Epigenetic regulation of muscle phenotype and adaptation: a potential role in COPD muscle dysfunction. J Appl Physiol (1985) (2013) 0.88
Differential effects of calorie restriction and exercise on the adipose transcriptome in diet-induced obese mice. J Obes (2011) 0.88
Exercise attenuates the major hallmarks of aging. Rejuvenation Res (2015) 0.87
Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo. Int J Obes (Lond) (2010) 0.85
Nutrition and the adaptation to endurance training. Sports Med (2014) 0.83
Roles and post-translational regulation of cardiac class IIa histone deacetylase isoforms. J Physiol (2014) 0.82
Protein kinase D controls voluntary-running-induced skeletal muscle remodelling. Biochem J (2011) 0.82
Multi-omic integrated networks connect DNA methylation and miRNA with skeletal muscle plasticity to chronic exercise in Type 2 diabetic obesity. Physiol Genomics (2014) 0.81
NOX2-dependent ROS is required for HDAC5 nuclear efflux and contributes to HDAC4 nuclear efflux during intense repetitive activity of fast skeletal muscle fibers. Am J Physiol Cell Physiol (2012) 0.81
Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation. Arterioscler Thromb Vasc Biol (2013) 0.81
The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice. PLoS One (2015) 0.80
Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis (2014) 0.80
AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol. Cell Cycle (2015) 0.80
Both HDAC5 and HDAC6 are required for the proliferation and metastasis of melanoma cells. J Transl Med (2016) 0.80
AMP-activated protein kinase mediates myogenin expression and myogenesis via histone deacetylase 5. Am J Physiol Cell Physiol (2013) 0.79
Elevated levels of TWEAK in skeletal muscle promote visceral obesity, insulin resistance, and metabolic dysfunction. FASEB J (2014) 0.79
Defect of mitochondrial respiratory chain is a mechanism of ROS overproduction in a rat model of alcoholic liver disease: role of zinc deficiency. Am J Physiol Gastrointest Liver Physiol (2015) 0.79
Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1. J Biol Chem (2014) 0.78
Abnormal unsaturated fatty acid metabolism in cystic fibrosis: biochemical mechanisms and clinical implications. Int J Mol Sci (2014) 0.78
AMPK activation--protean potential for boosting healthspan. Age (Dordr) (2013) 0.78
Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Sci Rep (2015) 0.78
Reconstruction of protein-protein interaction network of insulin signaling in Homo sapiens. J Biomed Biotechnol (2010) 0.77
Abnormal n-6 fatty acid metabolism in cystic fibrosis is caused by activation of AMP-activated protein kinase. J Lipid Res (2014) 0.77
Rethinking cardiac metabolism: metabolic cycles to refuel and rebuild the failing heart. F1000Prime Rep (2014) 0.77
Regulation of GLUT4 expression in denervated skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2009) 0.77
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med (2016) 0.77
An expanded role for AMP-activated protein kinase: regulator of myocardial protein degradation. Trends Cardiovasc Med (2011) 0.77
Regulation of GLUT4 and Insulin-Dependent Glucose Flux. ISRN Mol Biol (2012) 0.76
AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy. Cardiovasc Pharm Open Access (2015) 0.76
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice. Mol Metab (2015) 0.76
Coregulator-mediated control of skeletal muscle plasticity - a mini-review. Biochimie (2017) 0.76
Histone Deacetylases and Cardiometabolic Diseases. Arterioscler Thromb Vasc Biol (2015) 0.75
Adiponectin is not required for exercise training-induced improvements in glucose and insulin tolerance in mice. Physiol Rep (2014) 0.75
Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle (2016) 0.75
Signalling GLUTtony keeps the sugar coming through glucose transporter expression. J Physiol (2009) 0.75
Systemic Regulators of Skeletal Muscle Regeneration in Obesity. Front Endocrinol (Lausanne) (2017) 0.75
Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy. Inflammopharmacology (2016) 0.75
When food meets man: the contribution of epigenetics to health. Nutrients (2010) 0.75
Erythropoietin ameliorates hyperglycemia in type 1-like diabetic rats. Drug Des Devel Ther (2016) 0.75
HAT inhibitors antagonize AMPK in postmortem glycolysis. Asian-Australas J Anim Sci (2016) 0.75
Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. PLoS One (2014) 0.75
Emerging roles for histone deacetylases in age-related muscle atrophy. Nutr Healthy Aging (2016) 0.75
Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep (2016) 0.75
Alterations to mTORC1 signaling in the skeletal muscle differentially affect whole-body metabolism. Skelet Muscle (2016) 0.75
Increased Skeletal Muscle GLUT4 Expression in Obese Mice After Voluntary Wheel Running Exercise Is Posttranscriptional. Diabetes (2016) 0.75
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. Circ Res (2017) 0.75
AMPK in Health and Disease. Physiol Rev (2009) 6.38
The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases. J Biol Chem (2005) 6.27
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab (2010) 4.08
The ancient drug salicylate directly activates AMP-activated protein kinase. Science (2012) 3.77
AMPK is a direct adenylate charge-regulated protein kinase. Science (2011) 3.58
CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med (2006) 3.11
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab (2008) 3.04
Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol (2006) 2.94
Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes (2006) 2.80
A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells (2003) 2.62
Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling. Cell Metab (2006) 2.43
Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. J Clin Invest (2011) 2.34
β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK). Proc Natl Acad Sci U S A (2010) 2.28
AMPK beta subunit targets metabolic stress sensing to glycogen. Curr Biol (2003) 2.19
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy. Nature (2012) 2.04
High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation (2009) 2.00
Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. J Biol Chem (2003) 1.98
Exercise, GLUT4, and skeletal muscle glucose uptake. Physiol Rev (2013) 1.98
AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise. Proc Natl Acad Sci U S A (2011) 1.96
Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP. J Biol Chem (2006) 1.93
Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes. Chem Biol (2008) 1.93
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin. Nat Med (2013) 1.91
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. J Biol Chem (2003) 1.75
'Systems biology' in human exercise physiology: is it something different from integrative physiology? J Physiol (2011) 1.73
Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol (1985) (2008) 1.69
Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab (2007) 1.69
Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness. Biogerontology (2008) 1.67
Chutes and Ladders: the search for protein kinases that act on AMPK. Trends Biochem Sci (2005) 1.59
Effect of exercise intensity on skeletal muscle AMPK signaling in humans. Diabetes (2003) 1.58
Identification of regulatory sites of phosphorylation of the bovine endothelial nitric-oxide synthase at serine 617 and serine 635. J Biol Chem (2002) 1.56
Shear stress stimulates phosphorylation of eNOS at Ser(635) by a protein kinase A-dependent mechanism. Am J Physiol Heart Circ Physiol (2002) 1.56
Prediction of myocardial infarction by N-terminal-pro-B-type natriuretic peptide, C-reactive protein, and renin in subjects with cerebrovascular disease. Circulation (2005) 1.55
Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. J Biol Chem (2001) 1.51
Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.51
Structural basis for glycogen recognition by AMP-activated protein kinase. Structure (2005) 1.50
AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem (2009) 1.49
Regulation of HSL serine phosphorylation in skeletal muscle and adipose tissue. Am J Physiol Endocrinol Metab (2005) 1.48
Impaired activation of AMP-kinase and fatty acid oxidation by globular adiponectin in cultured human skeletal muscle of obese type 2 diabetics. J Clin Endocrinol Metab (2005) 1.45
AMPK functions as an adenylate charge-regulated protein kinase. Trends Endocrinol Metab (2012) 1.44
Impaired cardiac contractility response to hemodynamic stress in S100A1-deficient mice. Mol Cell Biol (2002) 1.43
Intrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory site. Protein Sci (2004) 1.41
Exercise increases nuclear AMPK alpha2 in human skeletal muscle. Diabetes (2003) 1.40
Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.39
AMP-activated protein kinase beta subunit tethers alpha and gamma subunits via its C-terminal sequence (186-270). J Biol Chem (2005) 1.39
A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr (2003) 1.36
Exercise-induced histone modifications in human skeletal muscle. J Physiol (2009) 1.36
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Diabetes (2007) 1.32
Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity. J Biol Chem (2010) 1.30
AMP-activated protein kinase kinase: detection with recombinant AMPK alpha1 subunit. Biochem Biophys Res Commun (2002) 1.29
Therapeutic approaches for muscle wasting disorders. Pharmacol Ther (2006) 1.28
AMPK and transcriptional regulation. Front Biosci (2008) 1.26
Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol (2005) 1.25
Reduced plasma FFA availability increases net triacylglycerol degradation, but not GPAT or HSL activity, in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 1.25
Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle. Diabetes (2004) 1.24
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK). Biochem J (2007) 1.24
AMP-activated protein kinase impairs endothelial actin cytoskeleton assembly by phosphorylating vasodilator-stimulated phosphoprotein. J Biol Chem (2006) 1.23
High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation. Proc Natl Acad Sci U S A (2004) 1.23
AMPK-independent pathways regulate skeletal muscle fatty acid oxidation. J Physiol (2008) 1.23
Incidence immunoassay for distinguishing recent from established HIV-1 infection in therapy-naive populations. AIDS (2004) 1.22
Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem (2002) 1.21
Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity. Diabetes (2012) 1.20
Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. J Biol Chem (2005) 1.20
Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue. Neuromuscul Disord (2006) 1.16
Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radic Biol Med (2003) 1.16
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. Diabetes (2003) 1.15
Regulation of the energy sensor AMP-activated protein kinase in the kidney by dietary salt intake and osmolality. Am J Physiol Renal Physiol (2004) 1.13
AMPK structure and regulation from three angles. Structure (2007) 1.13
The suppressor of cytokine signaling 3 inhibits leptin activation of AMP-kinase in cultured skeletal muscle of obese humans. J Clin Endocrinol Metab (2006) 1.13
Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells. Arch Physiol Biochem (2009) 1.13
Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol (2006) 1.13
Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol (2003) 1.11
Interleukin-15 administration improves diaphragm muscle pathology and function in dystrophic mdx mice. Am J Pathol (2005) 1.10
Effect of AICAR treatment on glycogen metabolism in skeletal muscle. Diabetes (2002) 1.09
Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling. FASEB J (2004) 1.09
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology (2009) 1.09
5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB. Immunol Cell Biol (2010) 1.09
Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp Pharmacol Physiol (2006) 1.08
Acute renal ischemia rapidly activates the energy sensor AMPK but does not increase phosphorylation of eNOS-Ser1177. Am J Physiol Renal Physiol (2005) 1.08
Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice. J Physiol (2006) 1.08
Associations of inflammatory and hemostatic variables with the risk of recurrent stroke. Stroke (2005) 1.07
Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites. BMC Bioinformatics (2008) 1.07
Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase. Int J Biochem Cell Biol (2009) 1.05
AMP-activated protein kinase (AMPK) regulates the insulin-induced activation of the nitric oxide synthase in human platelets. Thromb Haemost (2003) 1.04