Published in Genomics on April 01, 2003
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nat Rev Neurosci (2011) 2.30
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol (2006) 2.18
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. Proc Natl Acad Sci U S A (2005) 2.12
Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol (2004) 2.10
Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners. Hum Mol Genet (2005) 2.01
Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron (2013) 1.83
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. J Cell Biol (2005) 1.80
ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia. Am J Hum Genet (2006) 1.59
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance. Proc Natl Acad Sci U S A (2006) 1.56
Disease-related phenotypes in a Drosophila model of hereditary spastic paraplegia are ameliorated by treatment with vinblastine. J Clin Invest (2005) 1.39
Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking. Mol Biol Cell (2007) 1.36
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. J Cell Biol (2009) 1.30
SPG20 protein spartin is recruited to midbodies by ESCRT-III protein Ist1 and participates in cytokinesis. Mol Biol Cell (2010) 1.20
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein. Neurogenetics (2006) 1.15
Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets. BMC Biol (2010) 1.14
Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta (2011) 1.07
SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis. Oncogene (2011) 1.06
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity. J Cell Biol (2013) 1.04
Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway. Eukaryot Cell (2007) 1.03
Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs. PLoS Pathog (2010) 1.00
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem (2012) 0.99
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. J Biol Chem (2010) 0.92
Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling. Hum Mol Genet (2012) 0.92
Identification of the Drosophila melanogaster homolog of the human spastin gene. Dev Genes Evol (2003) 0.91
The PRESAT-vector: asymmetric T-vector for high-throughput screening of soluble protein domains for structural proteomics. Protein Sci (2004) 0.89
Subcellular localization of spastin: implications for the pathogenesis of hereditary spastic paraplegia. Neurogenetics (2005) 0.89
Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element. J Biol Chem (2013) 0.88
SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis. PLoS One (2011) 0.88
Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. J Biol Chem (2015) 0.83
The role of spartin and its novel ubiquitin binding region in DALIS occurrence. Mol Biol Cell (2014) 0.83
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol (2015) 0.82
Subunit Interactions and cooperativity in the microtubule-severing AAA ATPase spastin. J Biol Chem (2012) 0.82
Crystal structure of the human spastin AAA domain. J Struct Biol (2012) 0.82
Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis. J Biol Chem (2014) 0.82
Narrowing of the critical region in autosomal recessive spastic paraplegia linked to the SPG5 locus. Neurogenetics (2003) 0.80
Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9). BMC Genomics (2008) 0.79
BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS. Front Biol (Beijing) (2015) 0.77
Fine-tuning of protein domain boundary by minimizing potential coiled coil regions. J Biomol NMR (2006) 0.77
Oxidative Stress in Caenorhabditis elegans: Protective Effects of Spartin. PLoS One (2015) 0.75
Strumpellin and Spartin, Hereditary Spastic Paraplegia Proteins, are Binding Partners. J Exp Neurosci (2015) 0.75
Detection of SPG20 gene promoter-methylated DNA, as a novel epigenetic biomarker, in plasma for colorectal cancer diagnosis using the MethyLight method. Oncol Lett (2017) 0.75
Structural characterization of a putative chitin synthase gene in Phytophthora spp. and analysis of its transcriptional activity during pathogenesis on potato and soybean plants. Curr Genet (2017) 0.75
Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15
A method and server for predicting damaging missense mutations. Nat Methods (2010) 78.53
Human non-synonymous SNPs: server and survey. Nucleic Acids Res (2002) 50.45
Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature (2002) 45.19
A human gut microbial gene catalogue established by metagenomic sequencing. Nature (2010) 43.63
Comparative metagenomics of microbial communities. Science (2005) 25.88
InterPro: the integrative protein signature database. Nucleic Acids Res (2008) 25.07
Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res (2002) 25.06
The InterPro Database, 2003 brings increased coverage and new features. Nucleic Acids Res (2003) 24.72
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Enterotypes of the human gut microbiome. Nature (2011) 24.36
Comparative assessment of large-scale data sets of protein-protein interactions. Nature (2002) 24.25
Proteome survey reveals modularity of the yeast cell machinery. Nature (2006) 20.77
STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res (2008) 20.62
The genome sequence of the malaria mosquito Anopheles gambiae. Science (2002) 20.36
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res (2010) 18.73
STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res (2012) 18.26
InterPro, progress and status in 2005. Nucleic Acids Res (2005) 17.53
SMART 5: domains in the context of genomes and networks. Nucleic Acids Res (2006) 17.13
The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data. Nat Biotechnol (2004) 16.08
Interactive Tree Of Life (iTOL): an online tool for phylogenetic tree display and annotation. Bioinformatics (2006) 14.96
Toward automatic reconstruction of a highly resolved tree of life. Science (2006) 14.96
InterPro in 2011: new developments in the family and domain prediction database. Nucleic Acids Res (2011) 13.45
New developments in the InterPro database. Nucleic Acids Res (2007) 12.49
STRING 7--recent developments in the integration and prediction of protein interactions. Nucleic Acids Res (2006) 12.16
Interactive Tree Of Life v2: online annotation and display of phylogenetic trees made easy. Nucleic Acids Res (2011) 10.82
STRING: known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res (2005) 10.44
SMART 6: recent updates and new developments. Nucleic Acids Res (2008) 9.80
STRING: a database of predicted functional associations between proteins. Nucleic Acids Res (2003) 9.45
Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science (2002) 9.43
Drug target identification using side-effect similarity. Science (2008) 9.24
SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res (2011) 9.15
Bioinformatics in the post-sequence era. Nat Genet (2003) 8.83
mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev (2006) 8.78
PAL2NAL: robust conversion of protein sequence alignments into the corresponding codon alignments. Nucleic Acids Res (2006) 8.36
Literature mining for the biologist: from information retrieval to biological discovery. Nat Rev Genet (2006) 8.23
Protein disorder prediction: implications for structural proteomics. Structure (2003) 7.93
Minimum information about a marker gene sequence (MIMARKS) and minimum information about any (x) sequence (MIxS) specifications. Nat Biotechnol (2011) 7.53
Alternative splicing and genome complexity. Nat Genet (2001) 7.30
The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc Natl Acad Sci U S A (2002) 7.21
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
Richness of human gut microbiome correlates with metabolic markers. Nature (2013) 6.93
ELM server: A new resource for investigating short functional sites in modular eukaryotic proteins. Nucleic Acids Res (2003) 6.86
A side effect resource to capture phenotypic effects of drugs. Mol Syst Biol (2010) 6.75
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans. Nature (2008) 6.69
The ecoresponsive genome of Daphnia pulex. Science (2011) 6.55
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
Association of genes to genetically inherited diseases using data mining. Nat Genet (2002) 5.78
Functional and evolutionary insights from the genomes of three parasitoid Nasonia species. Science (2010) 5.56
Immunity-related genes and gene families in Anopheles gambiae. Science (2002) 5.47
Dynamic complex formation during the yeast cell cycle. Science (2005) 5.11
STITCH: interaction networks of chemicals and proteins. Nucleic Acids Res (2007) 4.88
Genomes in flux: the evolution of archaeal and proteobacterial gene content. Genome Res (2002) 4.85
eggNOG: automated construction and annotation of orthologous groups of genes. Nucleic Acids Res (2007) 4.84
Transcriptome complexity in a genome-reduced bacterium. Science (2009) 4.64
Update on XplorMed: A web server for exploring scientific literature. Nucleic Acids Res (2003) 4.42
Genomic variation landscape of the human gut microbiome. Nature (2012) 4.38
Genome-wide experimental determination of barriers to horizontal gene transfer. Science (2007) 4.37
A genome-wide survey of human pseudogenes. Genome Res (2003) 4.34
KEGG Atlas mapping for global analysis of metabolic pathways. Nucleic Acids Res (2008) 4.14
iPath: interactive exploration of biochemical pathways and networks. Trends Biochem Sci (2008) 4.03
Proteome organization in a genome-reduced bacterium. Science (2009) 3.97
Molecular eco-systems biology: towards an understanding of community function. Nat Rev Microbiol (2008) 3.95
eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges. Nucleic Acids Res (2011) 3.94
Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev (2007) 3.92
SuperTarget and Matador: resources for exploring drug-target relationships. Nucleic Acids Res (2007) 3.82
eggNOG v4.0: nested orthology inference across 3686 organisms. Nucleic Acids Res (2013) 3.77
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Medusa: a simple tool for interaction graph analysis. Bioinformatics (2005) 3.74
Prediction of effective genome size in metagenomic samples. Genome Biol (2007) 3.73
Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways. EMBO J (2003) 3.68
Systematic identification of novel protein domain families associated with nuclear functions. Genome Res (2002) 3.50
Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms. Lancet Neurol (2008) 3.49
SmashCommunity: a metagenomic annotation and analysis tool. Bioinformatics (2010) 3.48
Derivation and feeder-free propagation of human embryonic stem cells under xeno-free conditions. Cytotherapy (2011) 3.47
Function prediction and protein networks. Curr Opin Cell Biol (2003) 3.46
Impact of genome reduction on bacterial metabolism and its regulation. Science (2009) 3.45
Extraction of regulatory gene/protein networks from Medline. Bioinformatics (2005) 3.43
A temporal map of transcription factor activity: mef2 directly regulates target genes at all stages of muscle development. Dev Cell (2006) 3.29
Co-evolution of transcriptional and post-translational cell-cycle regulation. Nature (2006) 3.28
The DNA sequence of human chromosome 7. Nature (2003) 3.18
Get the most out of your metagenome: computational analysis of environmental sequence data. Curr Opin Microbiol (2007) 3.15
Accurate and universal delineation of prokaryotic species. Nat Methods (2013) 3.14
STITCH 2: an interaction network database for small molecules and proteins. Nucleic Acids Res (2009) 3.06
Environments shape the nucleotide composition of genomes. EMBO Rep (2005) 2.96
Structure-based assembly of protein complexes in yeast. Science (2004) 2.89
Quantifying environmental adaptation of metabolic pathways in metagenomics. Proc Natl Acad Sci U S A (2009) 2.89
Comparison of computational methods for the identification of cell cycle-regulated genes. Bioinformatics (2004) 2.83
Analysis of genomic context: prediction of functional associations from conserved bidirectionally transcribed gene pairs. Nat Biotechnol (2004) 2.83
PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. Am J Hum Genet (2002) 2.81
SHOT: a web server for the construction of genome phylogenies. Trends Genet (2002) 2.79
ASTD: The Alternative Splicing and Transcript Diversity database. Genomics (2008) 2.72
A holistic approach to marine eco-systems biology. PLoS Biol (2011) 2.71
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
InterPro: an integrated documentation resource for protein families, domains and functional sites. Brief Bioinform (2002) 2.66
Information extraction from full text scientific articles: where are the keywords? BMC Bioinformatics (2003) 2.64
Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. RNA (2005) 2.59
The identification of functional modules from the genomic association of genes. Proc Natl Acad Sci U S A (2002) 2.59