Published in Proc Natl Acad Sci U S A on September 20, 2005
The ESCRT complexes: structure and mechanism of a membrane-trafficking network. Annu Rev Biophys Biomol Struct (2006) 5.21
Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66
Biogenesis and function of multivesicular bodies. Annu Rev Cell Dev Biol (2007) 4.08
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology (2007) 2.68
Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. Proc Natl Acad Sci U S A (2006) 2.63
Structural and mechanistic studies of VPS4 proteins. EMBO J (2005) 2.58
Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomes. J Cell Biol (2006) 2.24
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Interactions between Nef and AIP1 proliferate multivesicular bodies and facilitate egress of HIV-1. Retrovirology (2006) 1.71
Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell (2008) 1.71
The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING PROTEIN5. Plant Cell (2007) 1.70
Ist1 regulates Vps4 localization and assembly. Mol Biol Cell (2007) 1.68
Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A (2006) 1.66
Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell (2007) 1.63
Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell (2009) 1.57
The nucleocapsid region of HIV-1 Gag cooperates with the PTAP and LYPXnL late domains to recruit the cellular machinery necessary for viral budding. PLoS Pathog (2009) 1.55
Evolution of diverse cell division and vesicle formation systems in Archaea. Nat Rev Microbiol (2010) 1.55
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Exploring the ESCRTing machinery in eukaryotes. Trends Plant Sci (2006) 1.47
Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell (2008) 1.46
Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol Biol Cell (2010) 1.43
The ESCRT-related CHMP1A and B proteins mediate multivesicular body sorting of auxin carriers in Arabidopsis and are required for plant development. Plant Cell (2009) 1.39
Troyer syndrome protein spartin is mono-ubiquitinated and functions in EGF receptor trafficking. Mol Biol Cell (2007) 1.36
Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33
A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover. J Cell Biol (2009) 1.30
Establishment of the ambient pH signaling complex in Aspergillus nidulans: PalI assists plasma membrane localization of PalH. Eukaryot Cell (2007) 1.15
Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
PalC, one of two Bro1 domain proteins in the fungal pH signalling pathway, localizes to cortical structures and binds Vps32. Traffic (2007) 1.11
Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol (2007) 1.11
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition. J Biol Chem (2010) 1.08
Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta (2011) 1.07
Coordination of substrate binding and ATP hydrolysis in Vps4-mediated ESCRT-III disassembly. Mol Biol Cell (2010) 1.06
Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation. J Cell Biol (2014) 1.05
Regulation of Vps4 during MVB sorting and cytokinesis. Traffic (2011) 1.04
Physiological involvement in pH signaling of Vps24-mediated recruitment of Aspergillus PalB cysteine protease to ESCRT-III. J Biol Chem (2008) 1.04
Further characterization of the signaling proteolysis step in the Aspergillus nidulans pH signal transduction pathway. Eukaryot Cell (2007) 1.03
Structural role of the Vps4-Vta1 interface in ESCRT-III recycling. Structure (2010) 1.03
Chitin synthases from Saprolegnia are involved in tip growth and represent a potential target for anti-oomycete drugs. PLoS Pathog (2010) 1.00
Structural basis for ESCRT-III CHMP3 recruitment of AMSH. Structure (2011) 1.00
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem (2012) 0.99
The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity. Mol Biol Cell (2011) 0.98
The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol (2013) 0.95
Membrane protein targeting to the MVB/lysosome. Chem Rev (2009) 0.95
LIP5 interacts with aquaporin 2 and facilitates its lysosomal degradation. J Am Soc Nephrol (2009) 0.94
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. J Biol Chem (2010) 0.92
Mutational analysis of Candida albicans SNF7 reveals genetically separable Rim101 and ESCRT functions and demonstrates divergence in bro1-domain protein interactions. Genetics (2009) 0.90
Assembly and disassembly of the ESCRT-III membrane scission complex. FEBS Lett (2011) 0.89
Relief of autoinhibition enhances Vta1 activation of Vps4 via the Vps4 stimulatory element. J Biol Chem (2013) 0.88
Regulation of Vps4 ATPase activity by ESCRT-III. Biochem Soc Trans (2009) 0.84
Distinct mechanisms of recognizing endosomal sorting complex required for transport III (ESCRT-III) protein IST1 by different microtubule interacting and trafficking (MIT) domains. J Biol Chem (2015) 0.83
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem (2015) 0.83
Where do they come from and where do they go: candidates for regulating extracellular vesicle formation in fungi. Int J Mol Sci (2013) 0.83
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol (2015) 0.82
The linker region plays a regulatory role in assembly and activity of the Vps4 AAA ATPase. J Biol Chem (2013) 0.82
Vps4 stimulatory element of the cofactor Vta1 contacts the ATPase Vps4 α7 and α9 to stimulate ATP hydrolysis. J Biol Chem (2014) 0.82
Vfa1 binds to the N-terminal microtubule-interacting and trafficking (MIT) domain of Vps4 and stimulates its ATPase activity. J Biol Chem (2014) 0.81
ESCRT requirements for EIAV budding. Retrovirology (2013) 0.80
Gene organization, evolution and expression of the microtubule-associated protein ASAP (MAP9). BMC Genomics (2008) 0.79
Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife (2017) 0.79
Origin of a folded repeat protein from an intrinsically disordered ancestor. Elife (2016) 0.78
Fine-tuning of protein domain boundary by minimizing potential coiled coil regions. J Biomol NMR (2006) 0.77
Conformational Changes in the Endosomal Sorting Complex Required for the Transport III Subunit Ist1 Lead to Distinct Modes of ATPase Vps4 Regulation. J Biol Chem (2015) 0.76
Secreted Glioblastoma Nanovesicles Contain Intracellular Signaling Proteins and Active Ras Incorporated in a Farnesylation-dependent Manner. J Biol Chem (2016) 0.75
Improved tools for biological sequence comparison. Proc Natl Acad Sci U S A (1988) 193.60
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR (1996) 29.55
Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
Dali: a network tool for protein structure comparison. Trends Biochem Sci (1995) 14.13
Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell (2001) 12.00
Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol (2002) 10.12
Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell (1992) 9.63
Automated NMR structure calculation with CYANA. Methods Mol Biol (2004) 9.31
The protein network of HIV budding. Cell (2003) 7.82
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
TPR proteins: the versatile helix. Trends Biochem Sci (2003) 7.37
Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell (2002) 7.32
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
The biogenesis of multivesicular endosomes. Nat Rev Mol Cell Biol (2004) 6.31
MultiCoil: a program for predicting two- and three-stranded coiled coils. Protein Sci (1997) 5.92
Improving biosensor analysis. J Mol Recognit (2000) 4.83
Functional surfaces of the human immunodeficiency virus type 1 capsid protein. J Virol (2003) 4.47
The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells. Mol Biol Cell (2000) 4.22
Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Proc Natl Acad Sci U S A (2003) 4.21
Retrovirus budding. Virus Res (2004) 3.66
ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol Biol Cell (2000) 2.92
The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. Genomics (2003) 2.69
Socket: a program for identifying and analysing coiled-coil motifs within protein structures. J Mol Biol (2001) 2.57
Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. J Biol Chem (2005) 2.50
SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. Nat Genet (2002) 2.27
A software tool for the prediction of Xaa-Pro peptide bond conformations in proteins based on 13C chemical shift statistics. J Biomol NMR (2002) 2.21
Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. Hum Mol Genet (2002) 2.20
AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett (2002) 2.10
CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. J Cell Sci (2001) 2.10
The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Curr Biol (2004) 2.06
The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum Mol Genet (2004) 1.77
Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae. J Cell Sci (2003) 1.73
The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment. Curr Genet (1997) 1.38
Exosome secretion: the art of reutilizing nonrecycled proteins? Traffic (2004) 1.37
Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. J Cell Sci (2004) 1.27
Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. J Biol Chem (2000) 1.24
Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. J Mol Biol (2001) 1.22
The plasticity of multivesicular bodies and the regulation of antigen presentation. Semin Cell Dev Biol (2002) 1.12
The protein network of HIV budding. Cell (2003) 7.82
Intrinsic dynamics of an enzyme underlies catalysis. Nature (2005) 7.32
Retrovirus budding. Annu Rev Cell Dev Biol (2004) 7.16
Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci U S A (2006) 6.82
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. EMBO J (2007) 5.31
Formation of a human immunodeficiency virus type 1 core of optimal stability is crucial for viral replication. J Virol (2002) 5.20
Functional surfaces of the human immunodeficiency virus type 1 capsid protein. J Virol (2003) 4.47
An interferon-alpha-induced tethering mechanism inhibits HIV-1 and Ebola virus particle release but is counteracted by the HIV-1 Vpu protein. Cell Host Microbe (2007) 4.17
X-ray structures of the hexameric building block of the HIV capsid. Cell (2009) 4.08
The structural biology of HIV assembly. Curr Opin Struct Biol (2008) 3.71
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
ESCRT-III recognition by VPS4 ATPases. Nature (2007) 3.64
Mechanisms of enveloped RNA virus budding. Trends Cell Biol (2002) 3.36
Electron cryotomography of immature HIV-1 virions reveals the structure of the CA and SP1 Gag shells. EMBO J (2007) 3.17
Assembly properties of the human immunodeficiency virus type 1 CA protein. J Virol (2004) 3.09
Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding. Cell (2007) 3.06
The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell (2007) 2.99
Ubiquitin interactions of NZF zinc fingers. EMBO J (2004) 2.72
Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nat Struct Biol (2002) 2.66
ESCRT-III protein requirements for HIV-1 budding. Cell Host Microbe (2011) 2.61
Structural and mechanistic studies of VPS4 proteins. EMBO J (2005) 2.58
Structure and functional interactions of the Tsg101 UEV domain. EMBO J (2002) 2.40
Hexagonal assembly of a restricting TRIM5alpha protein. Proc Natl Acad Sci U S A (2010) 2.40
HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. J Cell Biol (2003) 2.38
Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid. J Virol (2004) 2.37
Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. J Virol (2008) 2.30
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A. Proc Natl Acad Sci U S A (2002) 2.19
Structure and ubiquitin binding of the ubiquitin-interacting motif. J Biol Chem (2003) 2.19
Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Cell Host Microbe (2007) 2.18
Three-dimensional structure of HIV-1 virus-like particles by electron cryotomography. J Mol Biol (2004) 2.10
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. J Virol (2006) 2.06
Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol (2009) 1.98
The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. J Biol Chem (2004) 1.92
ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A (2008) 1.91
Membrane fission reactions of the mammalian ESCRT pathway. Annu Rev Biochem (2013) 1.91
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance. Proc Natl Acad Sci U S A (2010) 1.89
Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus. J Virol (2005) 1.88
Yeast frataxin solution structure, iron binding, and ferrochelatase interaction. Biochemistry (2004) 1.80
Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein. J Mol Biol (2007) 1.78
Structural insights into the catalytic mechanism of cyclophilin A. Nat Struct Biol (2003) 1.78
Structural and functional studies of ALIX interactions with YPX(n)L late domains of HIV-1 and EIAV. Nat Struct Mol Biol (2007) 1.76
The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. J Biol Chem (2005) 1.73
Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem (2003) 1.72
Virus budding and the ESCRT pathway. Cell Host Microbe (2013) 1.70
NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol (2008) 1.60
Three-dimensional structure of the M-MuLV CA protein on a lipid monolayer: a general model for retroviral capsid assembly. EMBO J (2003) 1.58
Biochemical analyses of human IST1 and its function in cytokinesis. Mol Biol Cell (2009) 1.57
Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278). Biochemistry (2006) 1.41
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain. Nat Struct Mol Biol (2006) 1.41
Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33
Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. Proc Natl Acad Sci U S A (2010) 1.29
The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A (2014) 1.27
Function of dynein in budding yeast: mitotic spindle positioning in a polarized cell. Cell Motil Cytoskeleton (2009) 1.19
Discovery of novel small-molecule HIV-1 replication inhibitors that stabilize capsid complexes. Antimicrob Agents Chemother (2013) 1.18
Distinct effects of two HIV-1 capsid assembly inhibitor families that bind the same site within the N-terminal domain of the viral CA protein. J Virol (2012) 1.17
The Polycomb-associated protein Rybp is a ubiquitin binding protein. FEBS Lett (2006) 1.16
Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15
Good to CU. Nature (2003) 1.13
Inhibitor-induced structural change in the HCV IRES domain IIa RNA. Proc Natl Acad Sci U S A (2010) 1.10
Intrinsic domain and loop dynamics commensurate with catalytic turnover in an induced-fit enzyme. Structure (2009) 1.09
Integrated oxidative folding of cysteine/selenocysteine containing peptides: improving chemical synthesis of conotoxins. Angew Chem Int Ed Engl (2009) 1.08
Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. J Virol (2010) 1.06
ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding. Dev Cell (2012) 1.01
Arginine kinase: joint crystallographic and NMR RDC analyses link substrate-associated motions to intrinsic flexibility. J Mol Biol (2010) 1.00
Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport. J Biol Chem (2012) 0.99
Theopapuamide, a cyclic depsipeptide from a Papua New Guinea lithistid sponge Theonella swinhoei. J Nat Prod (2006) 0.98
NMR spectroscopy of RNA duplexes containing pseudouridine in supercooled water. RNA (2005) 0.98
Activation of the retroviral budding factor ALIX. J Virol (2011) 0.97
Role of hydroxyprolines in the in vitro oxidative folding and biological activity of conotoxins. Biochemistry (2008) 0.96
NMR-based mapping of disulfide bridges in cysteine-rich peptides: application to the mu-conotoxin SxIIIA. J Am Chem Soc (2008) 0.95
Molecular characterization of the Ran-binding zinc finger domain of Nup153. J Biol Chem (2007) 0.94
ESCRT-III CHMP2A and CHMP3 form variable helical polymers in vitro and act synergistically during HIV-1 budding. Cell Microbiol (2012) 0.92
Araiosamines A-D: tris-bromoindole cyclic guanidine alkaloids from the marine sponge Clathria (Thalysias) araiosa. J Org Chem (2011) 0.91
Main chain 1H, 13C, and 15N resonance assignments of the 42-kDa enzyme arginine kinase. J Biomol NMR (2005) 0.91
Rate-limiting domain and loop motions in arginine kinase. Biochemistry (2011) 0.91
Site-specific effects of diselenide bridges on the oxidative folding of a cystine knot peptide, omega-selenoconotoxin GVIA. Biochemistry (2010) 0.88
Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry. Carbohydr Res (2010) 0.83
Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding. PLoS One (2011) 0.83
How HIV finds the door. Proc Natl Acad Sci U S A (2012) 0.82
Attenuated protein expression vectors for use in siRNA rescue experiments. Biotechniques (2012) 0.81
Two new structures of Ub-receptor complexes. U2. Nat Struct Mol Biol (2006) 0.81
ESCRT requirements for EIAV budding. Retrovirology (2013) 0.80
Chemical transformation of prostaglandin-A2: a novel series of C-10 halogenated, C-12 hydroxylated prostaglandin-A2 analogues. Org Lett (2006) 0.78
Structural biology: ESCRT service. Nature (2007) 0.78
Resonance assignments for the 21 kDa engineered fluorescein-binding lipocalin FluA. J Biomol NMR (2003) 0.77