Published in EMBO J on April 15, 2003
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron (2008) 1.97
The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A (2006) 1.61
BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol (2004) 1.35
Soluble adenylyl cyclase mediates nerve growth factor-induced activation of Rap1. J Biol Chem (2006) 1.30
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. J Cell Biol (2007) 1.30
Multi-tasking by the p75 neurotrophin receptor: sortilin things out? EMBO Rep (2004) 1.04
Synaptic membrane rafts: traffic lights for local neurotrophin signaling? Front Synaptic Neurosci (2013) 0.89
Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/⁻ mice. J Neurophysiol (2010) 0.86
Regulation of TrkB receptor translocation to lipid rafts by adenosine A(2A) receptors and its functional implications for BDNF-induced regulation of synaptic plasticity. Purinergic Signal (2013) 0.86
Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes. Pediatr Res (2013) 0.85
G-patch domain and KOW motifs-containing protein, GPKOW; a nuclear RNA-binding protein regulated by protein kinase A. J Mol Signal (2011) 0.85
Protein kinase A catalytic subunit interacts and phosphorylates members of trans-sialidase super-family in Trypanosoma cruzi. Microbes Infect (2010) 0.83
Fates of neurotrophins after retrograde axonal transport: phosphorylation of p75NTR is a sorting signal for delayed degradation. J Neurosci (2009) 0.83
NGF causes TrkA to specifically attract microtubules to lipid rafts. PLoS One (2012) 0.83
Pan-neuronal maturation but not neuronal subtype differentiation of adult neural stem cells is mechanosensitive. Sci Rep (2013) 0.81
The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA. BMC Biochem (2011) 0.80
Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. PLoS One (2013) 0.80
Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice. Biol Psychiatry (2015) 0.80
PRKACB is downregulated in non-small cell lung cancer and exogenous PRKACB inhibits proliferation and invasion of LTEP-A2 cells. Oncol Lett (2013) 0.79
Nerve growth factor/p75 neurotrophin receptor-mediated sensitization of rat sensory neurons depends on membrane cholesterol. Neuroscience (2013) 0.77
Dependence receptors: mechanisms of an announced death. Cell Cycle (2010) 0.76
Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75(NTR) and sortillin. Neuroscience (2013) 0.76
Glioma invasion mediated by the p75 neurotrophin receptor (p75(NTR)/CD271) requires regulated interaction with PDLIM1. Oncogene (2015) 0.76
A cellular genetics approach identifies gene-drug interactions and pinpoints drug toxicity pathway nodes. Front Genet (2014) 0.75
Functional cooperation of of IL-1β and RGS4 in the brachial plexus avulsion mediated brain reorganization. J Brachial Plex Peripher Nerve Inj (2010) 0.75
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. PLoS One (2017) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J (1999) 9.76
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J Biol Chem (1977) 4.87
Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol (1997) 3.77
Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth. Neuron (1994) 3.57
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron (1994) 3.57
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem Biophys Res Commun (1987) 3.46
Emerging themes in lipid rafts and caveolae. Cell (2001) 3.09
Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes. EMBO J (1996) 2.94
cAMP-induced switching in turning direction of nerve growth cones. Nature (1997) 2.90
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA. Front Biosci (2000) 2.70
Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci (2001) 2.31
Neurotrophin binding to the p75 receptor modulates Rho activity and axonal outgrowth. Neuron (1999) 2.26
Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron (1999) 2.16
Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75. Science (1996) 2.15
Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature (1996) 2.14
The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol (2002) 2.08
Rho GTPases in growth cone guidance. Curr Opin Neurobiol (2001) 1.90
Ceramide enables fas to cap and kill. J Biol Chem (2001) 1.88
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science (1994) 1.71
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J (1999) 1.70
Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol Cell Biol (2000) 1.63
GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. Neuron (2000) 1.56
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis. J Neurosci (2002) 1.49
Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation. J Cell Biol (2001) 1.46
Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron (1994) 1.43
p75 is important for axon growth and schwann cell migration during development. J Neurosci (2000) 1.39
p53 is essential for developmental neuron death as regulated by the TrkA and p75 neurotrophin receptors. J Cell Biol (1998) 1.36
Nerve growth factor and its low-affinity receptor promote Schwann cell migration. Proc Natl Acad Sci U S A (1994) 1.32
GM3-enriched microdomain involved in cell adhesion and signal transduction through carbohydrate-carbohydrate interaction in mouse melanoma B16 cells. J Biol Chem (1998) 1.27
Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons. J Neurosci (1999) 1.24
Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts. J Neurosci (2002) 1.17
Membrane compartmentation and the response to antigen. Curr Opin Immunol (1999) 1.15
The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem (2002) 1.11
Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase. J Biol Chem (1997) 1.10
Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae. J Biol Chem (1997) 1.09
The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem (2001) 1.06
Characterization of the human melanoma nerve growth factor receptor. J Biol Chem (1985) 1.05
Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptors. J Biol Chem (1996) 1.05
Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. Eur J Biochem (2001) 0.98
The low-affinity neurotrophin receptor p75 regulates the function but not the selective survival of specific subpopulations of sensory neurons. J Neurosci (1997) 0.93
Phosphorylation of nerve growth factor receptor proteins in sympathetic neurons and PC12 cells. In vitro phosphorylation by the cAMP-independent protein kinase FA/GSK-3. J Biol Chem (1986) 0.87
Neurotrophin induced cAMP and IP3 responses in PC12 cells. Different pathways. FEBS Lett (1993) 0.86
Phosphorylation of the common neurotrophin receptor p75 by p38beta2 kinase affects NF-kappaB and AP-1 activities. J Mol Neurosci (2000) 0.83
Promoter of the gene encoding the bovine catalytic subunit of cAMP-dependent protein kinase isoform C beta 2. Biochim Biophys Acta (1996) 0.83
Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR). FEBS Lett (1999) 0.81
Nerve growth factor (NGF)-induced calcium influx and intracellular calcium mobilization in 3T3 cells expressing NGF receptors. J Biol Chem (1999) 0.77
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85
The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat Neurosci (2003) 3.20
Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature (2006) 2.82
C5 palsy after decompression surgery for cervical myelopathy: review of the literature. Spine (Phila Pa 1976) (2003) 2.26
The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho. J Cell Biol (2002) 2.08
Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/stromal cell-derived factor-1 pathway. Stem Cells (2007) 1.92
Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J (2004) 1.82
Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun (2005) 1.80
Measurements of pelvic flexion angle using three-dimensional computed tomography. Clin Orthop Relat Res (2003) 1.79
Randomized Teriparatide [human parathyroid hormone (PTH) 1-34] Once-Weekly Efficacy Research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk. J Clin Endocrinol Metab (2012) 1.74
RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis. Nat Med (2011) 1.71
Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci (2013) 1.70
Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653. Arthritis Rheum (2003) 1.65
Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases. Cancer Res (2012) 1.65
Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism. J Neurosci (2002) 1.64
Keratan sulfate restricts neural plasticity after spinal cord injury. J Neurosci (2011) 1.63
miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression. Nat Neurosci (2011) 1.57
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone development. J Bone Miner Res (2006) 1.56
RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J Cell Biol (2006) 1.55
Cytoplasmic p21(Cip1/WAF1) regulates neurite remodeling by inhibiting Rho-kinase activity. J Cell Biol (2002) 1.54
Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 2: Advantages of anterior decompression and fusion over laminoplasty. Spine (Phila Pa 1976) (2007) 1.54
Extraskeletal myxoid chondrosarcoma: a Multi-Institutional Study of 42 Cases in Japan. Cancer (2003) 1.53
Does alendronate prevent collapse in osteonecrosis of the femoral head? Clin Orthop Relat Res (2006) 1.53
Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia. FEBS Lett (2002) 1.51
A clinical comparative study of the direct anterior with mini-posterior approach: two consecutive series. J Arthroplasty (2008) 1.50
Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 1: Clinical results and limitations of laminoplasty. Spine (Phila Pa 1976) (2007) 1.46
Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo. J Biomed Mater Res (2002) 1.45
Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors. J Clin Invest (2011) 1.45
Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. Neurosci Lett (2004) 1.43
Verification of the Robin and Graham classification system of hip disease in cerebral palsy using three-dimensional computed tomography. Dev Med Child Neurol (2011) 1.42
The vascular network in the femoral head and neck after hip resurfacing. J Arthroplasty (2008) 1.42
Scapulohumeral rhythm: relationship between motion velocity and rhythm. Clin Orthop Relat Res (2002) 1.42
Induction of neuronal death by ER stress in Alzheimer's disease. J Chem Neuroanat (2004) 1.42
Angiotensin II accelerates osteoporosis by activating osteoclasts. FASEB J (2008) 1.42
Synovial sarcoma is a stem cell malignancy. Stem Cells (2010) 1.42
Oxygen tension regulates chondrocyte differentiation and function during endochondral ossification. J Biol Chem (2006) 1.41
Interosseous membrane of the forearm: an anatomical study of ligament attachment locations. J Hand Surg Am (2009) 1.41
Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci (2003) 1.40
Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis. J Bone Miner Res (2002) 1.39
Continuous inhibition of MAPK signaling promotes the early osteoblastic differentiation and mineralization of the extracellular matrix. J Bone Miner Res (2002) 1.37
Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice. PLoS One (2012) 1.36
Unc5B associates with LARG to mediate the action of repulsive guidance molecule. J Cell Biol (2009) 1.35
Oxygen tension is an important mediator of the transformation of osteoblasts to osteocytes. J Bone Miner Metab (2007) 1.34
Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. J Cell Biol (2002) 1.33
Bone marrow-derived osteoblast progenitor cells in circulating blood contribute to ectopic bone formation in mice. Biochem Biophys Res Commun (2007) 1.32
Mechanical stress-induced apoptosis of endplate chondrocytes in organ-cultured mouse intervertebral discs: an ex vivo study. Spine (Phila Pa 1976) (2003) 1.32
VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line. Jpn J Cancer Res (2002) 1.31
Three-dimensional corrective osteotomy of malunited fractures of the upper extremity with use of a computer simulation system. J Bone Joint Surg Am (2008) 1.31
Differential and collaborative actions of Rad51 paralog proteins in cellular response to DNA damage. Nucleic Acids Res (2005) 1.30
Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development (2011) 1.30
Long-term results of surgery for forearm deformities in patients with multiple cartilaginous exostoses. J Bone Joint Surg Am (2007) 1.27
Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line. Cancer Lett (2005) 1.26
Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritis. Arthritis Rheum (2002) 1.25
Leptin regulates chondrocyte differentiation and matrix maturation during endochondral ossification. Bone (2005) 1.24
Radiographic predictors for the development of myelopathy in patients with ossification of the posterior longitudinal ligament: a multicenter cohort study. Spine (Phila Pa 1976) (2008) 1.24
A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci (2002) 1.24
bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing. PLoS One (2010) 1.23
Methylcobalamin increases Erk1/2 and Akt activities through the methylation cycle and promotes nerve regeneration in a rat sciatic nerve injury model. Exp Neurol (2010) 1.23
JAB1 participates in unfolded protein responses by association and dissociation with IRE1. Neurochem Int (2004) 1.21
Myelin suppresses axon regeneration by PIR-B/SHP-mediated inhibition of Trk activity. EMBO J (2011) 1.20
Cadherin-11-mediated interactions with bone marrow stromal/osteoblastic cells support selective colonization of breast cancer cells in bone. Int J Oncol (2008) 1.20
Change in knee cartilage T2 in response to mechanical loading. J Magn Reson Imaging (2008) 1.20
Change in the length of the ulnocarpal ligaments during radiocarpal motion: possible impact on triangular fibrocartilage complex foveal tears. J Hand Surg Am (2008) 1.20
Role of Herp in the endoplasmic reticulum stress response. Genes Cells (2004) 1.19
The source of axial pain after cervical laminoplasty-C7 is more crucial than deep extensor muscles. Spine (Phila Pa 1976) (2007) 1.19
CARM1 regulates proliferation of PC12 cells by methylating HuD. Mol Cell Biol (2006) 1.19
Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopenia. J Cell Biol (2004) 1.19
An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease. EMBO J (2004) 1.18
Matrix extracellular phosphoglycoprotein (MEPE) is highly expressed in osteocytes in human bone. J Bone Miner Metab (2004) 1.18
Migration of EndoButton after anatomic double-bundle anterior cruciate ligament reconstruction. Arthroscopy (2011) 1.17
Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia. J Biol Chem (2001) 1.16
Mouse Prickle1 and Prickle2 are expressed in postmitotic neurons and promote neurite outgrowth. FEBS Lett (2007) 1.15
Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury. Brain (2012) 1.15
BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. J Neurochem (2008) 1.15
Wnt-Ryk signaling mediates axon growth inhibition and limits functional recovery after spinal cord injury. J Neurotrauma (2009) 1.13
Capillary vessel network integration by inserting a vascular pedicle enhances bone formation in tissue-engineered bone using interconnected porous hydroxyapatite ceramics. Tissue Eng (2004) 1.13
Engulfment of axon debris by microglia requires p38 MAPK activity. J Biol Chem (2009) 1.13
Parthenolide, a natural inhibitor of Nuclear Factor-kappaB, inhibits lung colonization of murine osteosarcoma cells. Clin Cancer Res (2007) 1.13
Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res (2006) 1.12
The role of bone morphogenetic proteins in endochondral bone formation. Cytokine Growth Factor Rev (2005) 1.12
Eleven cases of cardiac metastases from soft-tissue sarcomas. Jpn J Clin Oncol (2011) 1.12
Kinematics of the upper cervical spine in rotation: in vivo three-dimensional analysis. Spine (Phila Pa 1976) (2004) 1.12
Pericentrin, a centrosomal protein related to microcephalic primordial dwarfism, is required for olfactory cilia assembly in mice. FASEB J (2009) 1.11
Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells. Biomaterials (2007) 1.11
Unusual skeletal metastases from myxoid liposarcoma only detectable by MR imaging. Eur Radiol (2003) 1.11
Gender differences in 3D morphology and bony impingement of human hips. J Orthop Res (2010) 1.11
FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons. EMBO J (2011) 1.11
FDG-PET imaging for chronic expanding hematoma in pelvis with massive bone destruction. Skeletal Radiol (2005) 1.11
Influence of component positions on dislocation: computed tomographic evaluations in a consecutive series of total hip arthroplasty. J Arthroplasty (2004) 1.11
Outcome of total en bloc spondylectomy for solitary metastasis of the thoracolumbar spine. J Spinal Disord Tech (2004) 1.10
Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays. J Neurochem (2002) 1.10
Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction. Clin Rheumatol (2008) 1.09
Clinical implications of serum C-reactive protein levels in malignant fibrous histiocytoma. Int J Cancer (2002) 1.09