Published in BMC Biochem on August 03, 2011
cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse. Mol Cell Endocrinol (2013) 0.97
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA). PLoS One (2012) 0.80
Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Mol Endocrinol (2013) 0.78
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms. PLoS One (2017) 0.75
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Compensatory regulation of RIalpha protein levels in protein kinase A mutant mice. J Biol Chem (1997) 1.80
The essential role of RI alpha in the maintenance of regulated PKA activity. Ann N Y Acad Sci (2002) 1.70
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Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol Endocrinol (1990) 1.56
Sperm-specific protein kinase A catalytic subunit Calpha2 orchestrates cAMP signaling for male fertility. Proc Natl Acad Sci U S A (2004) 1.54
Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol (2002) 1.49
A-kinase-interacting protein localizes protein kinase A in the nucleus. Proc Natl Acad Sci U S A (2005) 1.43
Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes. J Biol Chem (1992) 1.37
Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry (1993) 1.33
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Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci (1997) 1.19
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci U S A (1999) 1.18
PKA phosphorylates the p75 receptor and regulates its localization to lipid rafts. EMBO J (2003) 1.17
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The catalytic subunit of the cAMP-dependent protein kinase of ovine sperm flagella has a unique amino-terminal sequence. J Biol Chem (1998) 1.10
Deletion of type IIalpha regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization. J Biol Chem (1999) 1.10
Two novel brain-specific splice variants of the murine Cbeta gene of cAMP-dependent protein kinase. J Biol Chem (1997) 1.10
Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A. Am J Physiol Cell Physiol (2001) 1.08
PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. J Biol Chem (1999) 1.07
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Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J (2008) 1.02
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Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development. Proc Natl Acad Sci U S A (2000) 1.00
Chemical tools selectively target components of the PKA system. BMC Chem Biol (2009) 1.00
Molecular basis for isoform-specific autoregulation of protein kinase A. Cell Signal (2007) 0.99
Identification of novel splice variants of the human catalytic subunit Cbeta of cAMP-dependent protein kinase. Eur J Biochem (2001) 0.98
A mutation in the catalytic subunit of protein kinase A prevents myristylation but does not inhibit biological activity. J Biol Chem (1989) 0.98
The major catalytic subunit isoforms of cAMP-dependent protein kinase have distinct biochemical properties in vitro and in vivo. J Biol Chem (1996) 0.97
Selective activation of cAMP-dependent protein kinase type I inhibits rat natural killer cell cytotoxicity. J Biol Chem (1997) 0.97
Cyclic AMP-dependent protein kinase (cAK) in human B cells: co-localization of type I cAK (RI alpha 2 C2) with the antigen receptor during anti-immunoglobulin-induced B cell activation. Eur J Immunol (1996) 0.96
Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Mol Cell Biol (2002) 0.96
Differential expression of the C(s) and Calpha1 isoforms of the catalytic subunit of cyclic 3',5'-adenosine monophosphate-dependent protein kinase testicular cells. Biol Reprod (2001) 0.93
Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit. J Biol Chem (1997) 0.93
Induction of Cbeta splice variants and formation of novel forms of protein kinase A type II holoenzymes during retinoic acid-induced differentiation of human NT2 cells. Cell Signal (2004) 0.92
A conserved deamidation site at Asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry. Protein Sci (1998) 0.92
The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. Genomics (1998) 0.92
Determination of kinetic data using surface plasmon resonance biosensors. Methods Mol Med (2004) 0.89
Identification and characterization of novel PKA holoenzymes in human T lymphocytes. FEBS J (2005) 0.88
Direct optical detection of protein-ligand interactions. Methods Mol Biol (2005) 0.86
A novel isoform of human cyclic 3',5'-adenosine monophosphate-dependent protein kinase, c alpha-s, localizes to sperm midpiece. Biol Reprod (2000) 0.86
Crystallization of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods Enzymol (1991) 0.85
Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates. FEBS J (2007) 0.84
Cellular location and age-dependent changes of the regulatory subunits of cAMP-dependent protein kinase in rat testis. J Reprod Fertil (1993) 0.82
Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. BMC Biochem (2006) 0.82
Differential expression and subcellular localization for subunits of cAMP-dependent protein kinase during ram spermatogenesis. J Cell Biol (1989) 0.82
Identification, characterization, and hormonal regulation of 3', 5'-cyclic adenosine monophosphate-dependent protein kinases in rat Sertoli cells. Endocrinology (1991) 0.81
The protein kinase A catalytic subunit Cbeta2: molecular characterization and distribution of the splice variant. Biochem J (2000) 0.81
Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cell Signal (2008) 0.81
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Differential localization of two isoforms of the regulatory subunit RII alpha of cAMP-dependent protein kinase in human sperm: biochemical and cytochemical study. Mol Reprod Dev (1994) 0.78
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome. Nat Methods (2007) 2.04
PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. J Cell Biol (2006) 1.81
Reprogramming fibroblasts to express T-cell functions using cell extracts. Nat Biotechnol (2002) 1.79
Design, synthesis and biological activity of acyl substituted 3-amino-5-methyl-1,4,5,7-tetrahydropyrazolo[3,4-b]pyridin-6-ones as potential hypnotic drugs. Eur J Med Chem (2005) 1.47
Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J Biol Chem (2004) 1.39
Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem (2011) 1.26
Inhibition of T cell activation by cyclic adenosine 5'-monophosphate requires lipid raft targeting of protein kinase A type I by the A-kinase anchoring protein ezrin. J Immunol (2007) 1.19
Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. J Biol Chem (2010) 1.18
IL-7 is expressed and secreted by human skeletal muscle cells. Am J Physiol Cell Physiol (2010) 1.17
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity. J Virol (2008) 1.12
A community standard format for the representation of protein affinity reagents. Mol Cell Proteomics (2009) 1.11
Novel, isotype-specific sensors for protein kinase A subunit interaction based on bioluminescence resonance energy transfer (BRET). Cell Signal (2006) 1.11
A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. J Microbiol Methods (2011) 1.08
High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides. Biochem J (2006) 1.04
Reprogrammed gene expression in a somatic cell-free extract. EMBO Rep (2002) 1.03
Effect of metal ions on high-affinity binding of pseudosubstrate inhibitors to PKA. Biochem J (2008) 1.02
Structural and functional analysis of phosphorylation-specific binders of the kinase ERK from designed ankyrin repeat protein libraries. Proc Natl Acad Sci U S A (2012) 1.01
Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol (2014) 1.00
Molecular basis for isoform-specific autoregulation of protein kinase A. Cell Signal (2007) 0.99
Characterization of A-kinase-anchoring disruptors using a solution-based assay. Biochem J (2006) 0.98
The chicken leukocyte receptor complex encodes a primordial, activating, high-affinity IgY Fc receptor. Proc Natl Acad Sci U S A (2007) 0.97
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Proc Natl Acad Sci U S A (2013) 0.96
Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. J Biol Chem (2009) 0.96
Merlin links to the cAMP neuronal signaling pathway by anchoring the RIbeta subunit of protein kinase A. J Biol Chem (2003) 0.95
Designed ankyrin repeat proteins (DARPins) as novel isoform-specific intracellular inhibitors of c-Jun N-terminal kinases. ACS Chem Biol (2012) 0.93
Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cell Signal (2008) 0.91
Comparative thermodynamic analysis of cyclic nucleotide binding to protein kinase A. Biol Chem (2007) 0.91
Activation of C-terminal Src kinase (Csk) by phosphorylation at serine-364 depends on the Csk-Src homology 3 domain. Biochem J (2003) 0.90
Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits. PLoS One (2013) 0.90
Determination of kinetic data using surface plasmon resonance biosensors. Methods Mol Med (2004) 0.89
The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling. PLoS One (2011) 0.88
Effects of follicle stimulating hormone on estradiol-17 beta production and P-450 aromatase (CYP19) activity and mRNA expression in brown trout vitellogenic ovarian follicles in vitro. Gen Comp Endocrinol (2004) 0.87
Application of bioluminescence resonance energy transfer (BRET) for biomolecular interaction studies. Chembiochem (2006) 0.87
Quantification of cAMP antagonist action in vitro and in living cells. Eur J Cell Biol (2006) 0.87
Biochemical characterization and cellular imaging of a novel, membrane permeable fluorescent cAMP analog. BMC Biochem (2008) 0.87
Expression of complement regulators and receptors on human NT2-N neurons--effect of hypoxia and reoxygenation. Mol Immunol (2006) 0.87
Direct optical detection of protein-ligand interactions. Methods Mol Biol (2005) 0.86
The chicken leukocyte receptor complex encodes a family of different affinity FcY receptors. J Immunol (2009) 0.86
Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. Biochem J (2014) 0.86
Analysis of posttranslational modifications exemplified using protein kinase A. Biochim Biophys Acta (2006) 0.86
Splicing factor arginine/serine-rich 17A (SFRS17A) is an A-kinase anchoring protein that targets protein kinase A to splicing factor compartments. J Biol Chem (2009) 0.86
Synthesis, pharmacology and molecular modeling of N-substituted 2-phenyl-indoles and benzimidazoles as potent GABA(A) agonists. Eur J Med Chem (2006) 0.84
Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates. FEBS J (2007) 0.84
Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop. J Biol Chem (2010) 0.82
Long-term in vitro, cell-type-specific genome-wide reprogramming of gene expression. Exp Cell Res (2005) 0.82
Identification, cloning and characterization of a novel 47 kDa murine PKA C subunit homologous to human and bovine Cbeta2. BMC Biochem (2006) 0.82
Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cell Signal (2008) 0.81
Plasma protein binding properties to immobilized heparin and heparin-albumin conjugate. Artif Organs (2007) 0.81
Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci (2013) 0.80
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA). PLoS One (2012) 0.80
Cyclic nucleotides as affinity tools: phosphorothioate cAMP analogues address specific PKA subproteomes. N Biotechnol (2010) 0.80
Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA. Biol Chem (2005) 0.80
Differential binding studies applying functional protein microarrays and surface plasmon resonance. Proteomics (2006) 0.79
Dictyostelium lipid droplets host novel proteins. Eukaryot Cell (2013) 0.79
Epidermal growth factor receptor levels are reduced in mice with targeted disruption of the protein kinase A catalytic subunit. BMC Cell Biol (2008) 0.79
The high biofilm-encoding Bee locus: a second pilus gene cluster in Enterococcus faecalis? Curr Microbiol (2009) 0.78
Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics (2010) 0.78
Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform. BMC Biochem (2011) 0.78
Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein. Genes Cancer (2011) 0.78
Activation of the cAMP-dependent protein kinase signaling pathway by luteinizing hormone in trout theca layers. Mol Cell Endocrinol (2003) 0.78
Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag. Mol Endocrinol (2013) 0.78
Surface-plasmon-resonance-based biosensor with immobilized bisubstrate analog inhibitor for the determination of affinities of ATP- and protein-competitive ligands of cAMP-dependent protein kinase. Anal Biochem (2006) 0.78
Structure and function of the human sperm-specific isoform of protein kinase A (PKA) catalytic subunit Cα2. J Struct Biol (2012) 0.77
Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity. Cardiovasc Res (2003) 0.77
Cyclic nucleotide mapping of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. ACS Chem Biol (2014) 0.77
Systematic interpretation of cyclic nucleotide binding studies using KinetXBase. Proteomics (2008) 0.77
Regulatory subunit I-controlled protein kinase A activity is required for apical bile canalicular lumen development in hepatocytes. J Biol Chem (2009) 0.75