Published in J Biol Chem on April 07, 2003
How addictive drugs disrupt presynaptic dopamine neurotransmission. Neuron (2011) 2.50
Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis. Mol Psychiatry (2013) 1.86
The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet (2005) 1.70
Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nat Neurosci (2005) 1.68
Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein. BMC Cell Biol (2005) 1.53
Neurotoxic profiles of HIV, psychostimulant drugs of abuse, and their concerted effect on the brain: current status of dopamine system vulnerability in NeuroAIDS. Neurosci Biobehav Rev (2008) 1.52
Three ubiquitin conjugation sites in the amino terminus of the dopamine transporter mediate protein kinase C-dependent endocytosis of the transporter. Mol Biol Cell (2006) 1.50
A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters. Mol Neurobiol (2009) 1.45
Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor. EMBO J (2007) 1.44
Organic anion transporter OAT1 undergoes constitutive and protein kinase C-regulated trafficking through a dynamin- and clathrin-dependent pathway. J Biol Chem (2008) 1.34
Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology (2007) 1.33
Protein kinase Cbeta is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice. J Pharmacol Exp Ther (2008) 1.31
Mechanisms of dopamine transporter regulation in normal and disease states. Trends Pharmacol Sci (2013) 1.25
Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (2008) 1.25
Dieldrin exposure induces oxidative damage in the mouse nigrostriatal dopamine system. Exp Neurol (2007) 1.24
Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization. Mol Cell Neurosci (2008) 1.18
Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. J Biol Chem (2010) 1.17
Negative regulation of dopamine transporter endocytosis by membrane-proximal N-terminal residues. J Neurosci (2009) 1.16
Dopamine and amphetamine rapidly increase dopamine transporter trafficking to the surface: live-cell imaging using total internal reflection fluorescence microscopy. J Neurosci (2009) 1.14
Attention deficit/hyperactivity disorder-derived coding variation in the dopamine transporter disrupts microdomain targeting and trafficking regulation. J Neurosci (2012) 1.14
Trafficking of dopamine transporters in psychostimulant actions. Semin Cell Dev Biol (2009) 1.11
GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET. J Gen Physiol (2009) 1.10
Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons. Mol Cell Neurosci (2010) 1.04
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Role of the dopamine transporter in the action of psychostimulants, nicotine, and other drugs of abuse. CNS Neurol Disord Drug Targets (2008) 1.03
Substrates dissociate dopamine transporter oligomers. J Neurochem (2007) 1.02
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Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. J Neurosci (2010) 1.01
Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants. AAPS J (2005) 1.01
The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci (2011) 1.00
SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking. Transl Psychiatry (2014) 1.00
Angiotensin II inhibits activity of human organic anion transporter 3 through activation of protein kinase Calpha: accelerating endocytosis of the transporter. Eur J Pharmacol (2009) 1.00
Proline-directed phosphorylation of the dopamine transporter N-terminal domain. Biochemistry (2009) 0.99
Internalization and degradation of the glutamate transporter GLT-1 in response to phorbol ester. Neurochem Int (2007) 0.96
Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner. J Biol Chem (2009) 0.96
Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons. FASEB J (2012) 0.95
Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression. Neuroscience (2010) 0.95
Manganese accumulates primarily in nuclei of cultured brain cells. Neurotoxicology (2008) 0.94
Estradiol effects on the dopamine transporter - protein levels, subcellular location, and function. J Mol Signal (2006) 0.94
Protein kinase Cβ is a modulator of the dopamine D2 autoreceptor-activated trafficking of the dopamine transporter. J Neurochem (2013) 0.91
Regulation of human organic anion transporter 1 by ANG II: involvement of protein kinase Calpha. Am J Physiol Endocrinol Metab (2008) 0.90
Nicotine increases dopamine transporter function in rat striatum through a trafficking-independent mechanism. Eur J Pharmacol (2006) 0.90
Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. J Neurosci (2013) 0.89
Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. Am J Physiol Gastrointest Liver Physiol (2012) 0.89
A functional fast scan cyclic voltammetry assay to characterize dopamine D2 and D3 autoreceptors in the mouse striatum. ACS Chem Neurosci (2010) 0.89
Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology (2014) 0.88
Dopamine transporter trafficking: rapid response on demand. Future Neurol (2010) 0.88
Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease. Pharmacol Rev (2015) 0.88
Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci (2011) 0.87
Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells. Neurosci Lett (2009) 0.87
Palmitoylation controls dopamine transporter kinetics, degradation, and protein kinase C-dependent regulation. J Biol Chem (2010) 0.87
Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons. FASEB J (2013) 0.87
SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2011) 0.85
Mechanism of Mn(II)-mediated dysregulation of glutamine-glutamate cycle: focus on glutamate turnover. J Neurochem (2012) 0.84
Monoamine transporter inhibitors and substrates as treatments for stimulant abuse. Adv Pharmacol (2014) 0.84
Regulation of human organic anion transporter 4 by protein kinase C and NHERF-1: altering the endocytosis of the transporter. Pharm Res (2010) 0.83
Time-of-day differences in dopamine clearance in the rat medial prefrontal cortex and nucleus accumbens. Synapse (2008) 0.82
Measuring plasma membrane protein endocytic rates by reversible biotinylation. J Vis Exp (2009) 0.82
The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem (2012) 0.82
Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. Br J Pharmacol (2009) 0.81
The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. J Biol Chem (2014) 0.80
Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. J Biol Chem (2015) 0.79
Is slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications. Neuropsychopharmacology (2010) 0.79
Chronic Ritalin administration during adulthood increases serotonin pool in rat medial frontal cortex. Iran Biomed J (2013) 0.78
Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proc Natl Acad Sci U S A (2015) 0.78
Ethanol alters endosomal recycling of human dopamine transporters. J Biol Chem (2010) 0.78
Regulation of genes involved in dopamine transporter modulation by acute cocaine in rat striatum. Neurosci Lett (2006) 0.78
Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters. Pharmacol Rev (2016) 0.78
Short-term regulation of organic anion transporters. Pharmacol Ther (2009) 0.78
Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci (2015) 0.77
Melittin initiates dopamine transporter internalization and recycling in transfected HEK-293 cells. Eur J Pharmacol (2012) 0.77
Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Front Behav Neurosci (2014) 0.77
Identification of Heat Shock Protein 60 as a Regulator of Neutral Sphingomyelinase 2 and Its Role in Dopamine Uptake. PLoS One (2013) 0.77
Dopamine Transporter Amino- and Carboxy-Termini Synergistically Contribute to Substrate and Inhibitor Affinities. J Biol Chem (2016) 0.77
Brain slice biotinylation: an ex vivo approach to measure region-specific plasma membrane protein trafficking in adult neurons. J Vis Exp (2014) 0.77
Endocytosis as a mode to regulate functional expression of two-pore domain potassium (K₂p) channels. Pflugers Arch (2014) 0.76
Differential Internalization Rates and Postendocytic Sorting of the Norepinephrine and Dopamine Transporters Are Controlled by Structural Elements in the N Termini. J Biol Chem (2016) 0.76
In vitro study methodologies to investigate genetic aspects and effects of drugs used in attention-deficit hyperactivity disorder. J Neural Transm (Vienna) (2012) 0.75
Insights in how amphetamine ROCKs (Rho-associated containing kinase) membrane protein trafficking. Proc Natl Acad Sci U S A (2015) 0.75
Molecular mechanism: the human dopamine transporter histidine 547 regulates basal and HIV-1 Tat protein-inhibited dopamine transport. Sci Rep (2016) 0.75
Insertion of tetracysteine motifs into dopamine transporter extracellular domains. PLoS One (2010) 0.75
Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells. Korean J Physiol Pharmacol (2011) 0.75
The Dopamine Transporter Recycles Via A Retromer-Dependent Post-Endocytic Mechanism: Tracking Studies Using A Novel Fluorophore-Coupling Approach. J Neurosci (2017) 0.75
AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci (2002) 13.09
Acidification of the endocytic and exocytic pathways. Annu Rev Biochem (1986) 10.90
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature (1996) 7.26
Reinsertion or degradation of AMPA receptors determined by activity-dependent endocytic sorting. Neuron (2000) 7.15
Rapid spine delivery and redistribution of AMPA receptors after synaptic NMDA receptor activation. Science (1999) 6.77
Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell (2001) 6.00
Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol (1995) 3.92
Dynamin:GTP controls the formation of constricted coated pits, the rate limiting step in clathrin-mediated endocytosis. J Cell Biol (2000) 3.30
Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry (2001) 3.19
Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A (1998) 3.12
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Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter. J Neurosci (1998) 2.72
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron (2001) 2.51
An endocytosed TGN38 chimeric protein is delivered to the TGN after trafficking through the endocytic recycling compartment in CHO cells. J Cell Biol (1998) 2.43
Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend (1998) 2.28
Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism. Proc Natl Acad Sci U S A (2000) 2.27
Schizophrenia: diverse approaches to a complex disease. Science (2002) 2.20
Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci (2001) 2.19
Dendrodendritic inhibition through reversal of dopamine transport. Science (2001) 2.08
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Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters. J Biol Chem (1999) 1.99
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Computational perspectives on dopamine function in prefrontal cortex. Curr Opin Neurobiol (2002) 1.88
Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron (2001) 1.87
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Cocaine, reward, movement and monoamine transporters. Mol Psychiatry (2002) 1.59
Rab11a and myosin Vb regulate recycling of the M4 muscarinic acetylcholine receptor. J Neurosci (2002) 1.54
Regulation of endosome sorting by a specific PP2A isoform. J Cell Biol (1998) 1.51
Cocaine increases dopamine uptake and cell surface expression of dopamine transporters. Biochem Biophys Res Commun (2002) 1.49
Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. J Biol Chem (1999) 1.46
Protein kinase C regulates endocytosis and recycling of E-cadherin. Am J Physiol Cell Physiol (2002) 1.44
Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor. J Cell Biol (1997) 1.44
Protein kinase C-mediated phosphorylation and functional regulation of dopamine transporters in striatal synaptosomes. J Biol Chem (1997) 1.44
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Cocaine induction of dopamine transporter trafficking to the plasma membrane. Mol Pharmacol (2002) 1.37
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A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity. J Neurosci (2003) 1.35
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The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. J Neurosci (2002) 1.15
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Trafficking-dependent and -independent pathways of neurotransmitter transporter regulation differentially involving p38 mitogen-activated protein kinase revealed in studies of insulin modulation of norepinephrine transport in SK-N-SH cells. J Pharmacol Exp Ther (2001) 1.10
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Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator. Biochem J (2001) 1.04
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Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nat Neurosci (2005) 1.68
Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology (2007) 1.33
Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization. Mol Cell Neurosci (2008) 1.18
The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. J Neurosci (2011) 1.00
Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. J Neurosci (2013) 0.89
The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. J Biol Chem (2012) 0.82
Insertion of tetracysteine motifs into dopamine transporter extracellular domains. PLoS One (2010) 0.75