Published in J Biol Chem on April 08, 2003
International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28
ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc Natl Acad Sci U S A (2008) 3.00
Nucleotide release provides a mechanism for airway surface liquid homeostasis. J Biol Chem (2004) 2.41
Physiological regulation of ATP release at the apical surface of human airway epithelia. J Biol Chem (2006) 2.04
Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal (2010) 1.91
Role of astrocytes in cerebrovascular regulation. J Appl Physiol (1985) (2006) 1.82
ATP release from non-excitable cells. Purinergic Signal (2009) 1.78
Extracellular ATP induces the accumulation of superoxide via NADPH oxidases in Arabidopsis. Plant Physiol (2006) 1.58
Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell (2005) 1.58
Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. J Cereb Blood Flow Metab (2007) 1.48
Evidence of a novel cell signaling role for extracellular adenosine triphosphates and diphosphates in Arabidopsis. Plant Cell (2004) 1.44
Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels. Neuroscience (2008) 1.31
Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways. J Biol Chem (2009) 1.27
Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol (2003) 1.25
Regulation of renal NaCl and water transport by the ATP/UTP/P2Y2 receptor system. Am J Physiol Renal Physiol (2011) 1.25
PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine. Mol Pain (2011) 1.18
Neurons respond directly to mechanical deformation with pannexin-mediated ATP release and autostimulation of P2X7 receptors. J Physiol (2012) 1.17
Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus. Am J Respir Crit Care Med (2005) 1.16
ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation. Cell Death Dis (2012) 1.13
Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes. Am J Physiol Cell Physiol (2008) 1.13
P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation. Proc Natl Acad Sci U S A (2005) 1.12
Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation. Br J Pharmacol (2004) 1.11
Touch induces ATP release in Arabidopsis roots that is modulated by the heterotrimeric G-protein complex. FEBS Lett (2009) 1.09
The detection of micromolar pericellular ATP pool on lymphocyte surface by using lymphoid ecto-adenylate kinase as intrinsic ATP sensor. Mol Biol Cell (2006) 1.08
Thrombin-promoted release of UDP-glucose from human astrocytoma cells. Br J Pharmacol (2008) 1.08
Homeostasis of extracellular ATP in human erythrocytes. J Biol Chem (2011) 1.04
Signalling and pharmacological properties of the P2Y receptor. Acta Physiol (Oxf) (2010) 1.03
Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death. Am J Pathol (2011) 1.02
Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium. J Physiol (2004) 0.98
Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats. Mol Pain (2008) 0.97
A quantitative model of purinergic junctional transmission of calcium waves in astrocyte networks. Biophys J (2005) 0.95
Purinergic mechanisms in gliovascular coupling. Semin Cell Dev Biol (2011) 0.94
Glutamate acts at NMDA receptors on fresh bovine and on cultured human retinal pigment epithelial cells to trigger release of ATP. J Physiol (2006) 0.94
Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells. Am J Physiol Cell Physiol (2009) 0.93
Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells. Am J Physiol Cell Physiol (2009) 0.92
Release and extracellular metabolism of ATP by ecto-nucleotidase eNTPDase 1-3 in hypothalamic and pituitary cells. Purinergic Signal (2005) 0.92
The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis (2015) 0.92
GPR80/99, proposed to be the P2Y(15) receptor activated by adenosine and AMP, is not a P2Y receptor. Purinergic Signal (2004) 0.91
Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE. Purinergic Signal (2007) 0.89
Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells. Mol Vis (2007) 0.89
Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae. Immunology (2011) 0.89
Identification of hydrolytically stable and selective P2Y(1) receptor agonists. Eur J Med Chem (2008) 0.87
Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Pflugers Arch (2006) 0.85
The ecto-nucleotidase NTPDase1 differentially regulates P2Y1 and P2Y2 receptor-dependent vasorelaxation. Br J Pharmacol (2010) 0.85
Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca(2+) signaling. Front Cell Neurosci (2015) 0.84
Signaling by purinergic receptors and channels in the pituitary gland. Mol Cell Endocrinol (2009) 0.84
Purinergic signalling in the kidney in health and disease. Purinergic Signal (2013) 0.84
Cell volume changes regulate slick (Slo2.1), but not slack (Slo2.2) K+ channels. PLoS One (2014) 0.83
Inflammation, pain, and pressure--purinergic signaling in oral tissues. J Dent Res (2012) 0.82
Quantification of extracellular UDP-galactose. Anal Biochem (2009) 0.82
Kinetics of ATP release following compression injury of a peripheral nerve trunk. Purinergic Signal (2006) 0.82
Plant responses to extracellular nucleotides: Cellular processes and biological effects. Purinergic Signal (2006) 0.81
Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca(2+) signals and an IL-6 autocrine loop. Am J Physiol Endocrinol Metab (2014) 0.80
ATP induces synaptic gene expressions in cortical neurons: transduction and transcription control via P2Y1 receptors. Mol Pharmacol (2010) 0.79
Cell-surface sensors: lighting the cellular environment. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2012) 0.79
P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differently. Pflugers Arch (2005) 0.79
Spatiotemporal characteristics of calcium dynamics in astrocytes. Chaos (2009) 0.79
IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signal (2014) 0.78
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther (2013) 0.78
Fluorescent probes for monitoring regulated secretion. Curr Opin Chem Biol (2013) 0.77
Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal (2006) 0.75
Cell culture: complications due to mechanical release of ATP and activation of purinoceptors. Cell Tissue Res (2017) 0.75
How Energy Metabolism Supports Cerebral Function: Insights from (13)C Magnetic Resonance Studies In vivo. Front Neurosci (2017) 0.75
Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J Biol Chem (2007) 4.27
Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity (2008) 3.36
Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J Immunol (2007) 3.06
Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation. J Immunol (2011) 2.67
Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release. Am J Physiol Cell Physiol (2003) 2.61
Potentiation of caspase-1 activation by the P2X7 receptor is dependent on TLR signals and requires NF-kappaB-driven protein synthesis. J Immunol (2005) 2.49
Intracellular calcium changes trigger connexin 32 hemichannel opening. EMBO J (2005) 1.69
Cutting edge: human beta defensin 3--a novel antagonist of the HIV-1 coreceptor CXCR4. J Immunol (2006) 1.67
P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release. J Immunol (2003) 1.52
Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am J Physiol Cell Physiol (2003) 1.45
Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2. EMBO J (2009) 1.42
Metabolic control of oocyte apoptosis mediated by 14-3-3zeta-regulated dephosphorylation of caspase-2. Dev Cell (2009) 1.41
Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1β via caspase-8 in dendritic cells. J Immunol (2013) 1.28
Oxidized ATP (oATP) attenuates proinflammatory signaling via P2 receptor-independent mechanisms. Br J Pharmacol (2003) 1.25
P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J Immunol (2009) 1.25
Inhibitory effects of chloride on the activation of caspase-1, IL-1beta secretion, and cytolysis by the P2X7 receptor. J Immunol (2005) 1.14
Rho-family GTPases modulate Ca(2+) -dependent ATP release from astrocytes. Am J Physiol Cell Physiol (2008) 1.13
Methylene ATP analogs as modulators of extracellular ATP metabolism and accumulation. Br J Pharmacol (2004) 1.11
Mutation of a dibasic amino acid motif within the C terminus of the P2X7 nucleotide receptor results in trafficking defects and impaired function. J Immunol (2003) 1.10
Both sides now: multiple interactions of ATP with pannexin-1 hemichannels. Focus on "A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP". Am J Physiol Cell Physiol (2009) 1.06
Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle. Am J Physiol Heart Circ Physiol (2011) 1.05
Differing caspase-1 activation states in monocyte versus macrophage models of IL-1beta processing and release. J Leukoc Biol (2004) 1.04
P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways. Purinergic Signal (2009) 1.02
Enhanced activation of Akt and extracellular-regulated kinase pathways by simultaneous occupancy of Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT7A receptors in PC12 cells. J Neurochem (2005) 1.02
Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. Infect Immun (2010) 0.99
Regulation of vascular smooth muscle cell calcification by extracellular pyrophosphate homeostasis: synergistic modulation by cyclic AMP and hyperphosphatemia. Am J Physiol Cell Physiol (2009) 0.98
Maitotoxin induces biphasic interleukin-1beta secretion and membrane blebbing in murine macrophages. Mol Pharmacol (2004) 0.98
Calcium-independent phospholipase A2 beta is dispensable in inflammasome activation and its inhibition by bromoenol lactone. J Innate Immun (2009) 0.97
Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells. J Immunol (2009) 0.95
Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages. J Immunol (2007) 0.94
Autocrine ATP release coupled to extracellular pyrophosphate accumulation in vascular smooth muscle cells. Am J Physiol Cell Physiol (2009) 0.93
Extracellular osmolarity modulates G protein-coupled receptor-dependent ATP release from 1321N1 astrocytoma cells. Am J Physiol Cell Physiol (2009) 0.92
Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis. Carcinogenesis (2005) 0.90
ATP and control of intracellular growth of mycobacteria by T cells. Infect Immun (2002) 0.88
The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation. Purinergic Signal (2008) 0.87
Sulfated signal from ASJ sensory neurons modulates stomatin-dependent coordination in Caenorhabditis elegans. J Biol Chem (2006) 0.84
Functionalized congeners of tyrosine-based P2X(7) receptor antagonists: probing multiple sites for linking and dimerization. Bioconjug Chem (2002) 0.83
Purinergic regulation of high-glucose-induced caspase-1 activation in the rat retinal Müller cell line rMC-1. Am J Physiol Cell Physiol (2011) 0.83
The progressive ankylosis gene product ANK regulates extracellular ATP levels in primary articular chondrocytes. Arthritis Res Ther (2013) 0.78
Human β-defensin-3 structure motifs that are important in CXCR4 antagonism. FEBS J (2013) 0.77
Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes. Purinergic Signal (2009) 0.77
Focus on "extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells". Am J Physiol Cell Physiol (2002) 0.76
Dueling nucleosides: cross-regulation of extracellular adenosine by guanosine. Focus on "Extracellular guanosine regulates extracellular adenosine levels". Am J Physiol Cell Physiol (2013) 0.76
Function without form: an ongoing search for maxi-anion channel proteins. Focus on "Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells". Am J Physiol Cell Physiol (2012) 0.76
Charge of the mito brigade. Focus on "Changes in mitochondrial surface charge mediate recruitment of signaling molecules during apoptosis". Am J Physiol Cell Physiol (2010) 0.75