Published in Nature on April 10, 2003
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol Cell (2012) 4.32
The exocyst complex in polarized exocytosis. Curr Opin Cell Biol (2009) 3.04
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Rab11 in recycling endosomes regulates the sorting and basolateral transport of E-cadherin. Mol Biol Cell (2005) 2.74
Insulin signaling diverges into Akt-dependent and -independent signals to regulate the recruitment/docking and the fusion of GLUT4 vesicles to the plasma membrane. Mol Biol Cell (2006) 2.27
Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18
Exo70 interacts with phospholipids and mediates the targeting of the exocyst to the plasma membrane. EMBO J (2007) 2.03
ARF6 controls post-endocytic recycling through its downstream exocyst complex effector. J Cell Biol (2003) 2.02
Insulin signaling and the regulation of glucose transport. Mol Med (2006) 1.99
Insulin stimulates the halting, tethering, and fusion of mobile GLUT4 vesicles in rat adipose cells. J Cell Biol (2005) 1.93
Exorcising the exocyst complex. Traffic (2012) 1.88
GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes. Mol Biol Cell (2003) 1.83
Mechanism of recruiting Sec6/8 (exocyst) complex to the apical junctional complex during polarization of epithelial cells. J Cell Sci (2004) 1.82
Phosphatidylinositol 4,5-bisphosphate mediates the targeting of the exocyst to the plasma membrane for exocytosis in mammalian cells. Mol Biol Cell (2007) 1.77
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell (2006) 1.75
Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. EMBO J (2005) 1.75
AtEXO70A1, a member of a family of putative exocyst subunits specifically expanded in land plants, is important for polar growth and plant development. Plant J (2006) 1.71
Cellular pathways regulating responses to compatible and self-incompatible pollen in Brassica and Arabidopsis stigmas intersect at Exo70A1, a putative component of the exocyst complex. Plant Cell (2009) 1.62
Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking. Curr Opin Cell Biol (2007) 1.61
RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells. Mol Cell Biol (2004) 1.59
Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1. Mol Biol Cell (2005) 1.53
Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells. J Cell Biol (2005) 1.51
SEC8, a subunit of the putative Arabidopsis exocyst complex, facilitates pollen germination and competitive pollen tube growth. Plant Physiol (2005) 1.51
Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol (2007) 1.50
GLUT4 exocytosis. J Cell Sci (2011) 1.50
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J (2006) 1.45
Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex. EMBO J (2003) 1.43
RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization. PLoS Genet (2015) 1.43
Disruption of cortical actin in skeletal muscle demonstrates an essential role of the cytoskeleton in glucose transporter 4 translocation in insulin-sensitive tissues. J Biol Chem (2004) 1.42
An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol (2007) 1.38
Regulation of membrane trafficking, cytoskeleton dynamics, and cell polarity by ROP/RAC GTPases. Plant Physiol (2008) 1.37
Multiple roles for the actin cytoskeleton during regulated exocytosis. Cell Mol Life Sci (2012) 1.35
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab (2007) 1.35
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells. Dev Cell (2012) 1.35
The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst. J Mol Biol (2007) 1.32
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci U S A (2007) 1.25
On being the right size: scaling effects in designing a human-on-a-chip. Integr Biol (Camb) (2013) 1.23
Akt2 phosphorylates ezrin to trigger NHE3 translocation and activation. J Biol Chem (2004) 1.22
Identification of a distal GLUT4 trafficking event controlled by actin polymerization. Mol Biol Cell (2009) 1.21
Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Am J Physiol Renal Physiol (2010) 1.16
Actin cables and the exocyst form two independent morphogenesis pathways in the fission yeast. Mol Biol Cell (2010) 1.16
Protective effect of phosphatidylinositol 4,5-bisphosphate against cortical filamentous actin loss and insulin resistance induced by sustained exposure of 3T3-L1 adipocytes to insulin. J Biol Chem (2004) 1.15
Membrane organization and dynamics in cell polarity. Cold Spring Harb Perspect Biol (2009) 1.15
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell (2010) 1.13
The exocyst complex in exocytosis and cell migration. Protoplasma (2011) 1.12
Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3. Nat Struct Mol Biol (2010) 1.11
Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J Cell Biol (2005) 1.11
The ubiquitin ligase PUB22 targets a subunit of the exocyst complex required for PAMP-triggered responses in Arabidopsis. Plant Cell (2012) 1.10
Exocyst function is regulated by effector phosphorylation. Nat Cell Biol (2011) 1.08
R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol Biol Cell (2007) 1.07
The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons. J Neurosci (2009) 1.06
Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis. Trends Endocrinol Metab (2011) 1.06
Munc18c phosphorylation by the insulin receptor links cell signaling directly to SNARE exocytosis. J Cell Biol (2011) 1.05
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell (2008) 1.03
Exocyst is involved in polarized cell migration and cerebral cortical development. Proc Natl Acad Sci U S A (2009) 1.03
"Actin"g on GLUT4: membrane & cytoskeletal components of insulin action. Curr Diabetes Rev (2007) 1.02
Spatial regulation of exocytosis and cell polarity: yeast as a model for animal cells. FEBS Lett (2007) 1.00
The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol (2012) 1.00
Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. Mol Biol Cell (2013) 0.99
Evidence of recessive Alzheimer disease loci in a Caribbean Hispanic data set: genome-wide survey of runs of homozygosity. JAMA Neurol (2013) 0.99
Exo70 generates membrane curvature for morphogenesis and cell migration. Dev Cell (2013) 0.98
ERK1/2 regulate exocytosis through direct phosphorylation of the exocyst component Exo70. Dev Cell (2012) 0.98
Epithelial cell surface polarity: the early steps. Front Biosci (Landmark Ed) (2009) 0.97
Spatial control of exocytosis. Curr Opin Cell Biol (2003) 0.97
Grp1 plays a key role in linking insulin signaling to glut4 recycling. Dev Cell (2012) 0.96
Decreased insulin-dependent glucose transport by chronic ethanol feeding is associated with dysregulation of the Cbl/TC10 pathway in rat adipocytes. Am J Physiol Endocrinol Metab (2005) 0.95
Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking. Small GTPases (2014) 0.93
Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering. J Biol Chem (2009) 0.93
Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Exp Cell Res (2008) 0.92
An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization. Mol Biol Cell (2011) 0.90
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A (2015) 0.89
Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole. Mol Biol Cell (2012) 0.89
The role of Sec3p in secretory vesicle targeting and exocyst complex assembly. Mol Biol Cell (2014) 0.89
Insulin stimulates the phosphorylation of the exocyst protein Sec8 in adipocytes. Biosci Rep (2009) 0.88
Thrombospondin 1 mediates high-fat diet-induced muscle fibrosis and insulin resistance in male mice. Endocrinology (2013) 0.88
Cdc42 interacts with the exocyst complex to promote phagocytosis. J Cell Biol (2013) 0.87
SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2014) 0.87
PI(4,5)P₂-binding effector proteins for vesicle exocytosis. Biochim Biophys Acta (2014) 0.86
Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC Med Genet (2008) 0.85
The Exocyst at a Glance. J Cell Sci (2015) 0.85
De novo t(7;10)(q33;q23) translocation and closely juxtaposed microdeletion in a patient with macrocephaly and developmental delay. Hum Genet (2005) 0.84
Replication analysis for severe diabetic retinopathy. Invest Ophthalmol Vis Sci (2012) 0.84
Local translation of TC10 is required for membrane expansion during axon outgrowth. Nat Commun (2014) 0.84
GTP hydrolysis of TC10 promotes neurite outgrowth through exocytic fusion of Rab11- and L1-containing vesicles by releasing exocyst component Exo70. PLoS One (2013) 0.84
PI 4,5-P2 stimulates glucose transport activity of GLUT4 in the plasma membrane of 3T3-L1 adipocytes. Biochim Biophys Acta (2006) 0.83
Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans. PLoS One (2012) 0.83
Urothelial Defects from Targeted Inactivation of Exocyst Sec10 in Mice Cause Ureteropelvic Junction Obstructions. PLoS One (2015) 0.81
The exocyst and regulatory GTPases in urinary exosomes. Physiol Rep (2014) 0.81
RNA Silencing of Exocyst Genes in the Stigma Impairs the Acceptance of Compatible Pollen in Arabidopsis. Plant Physiol (2015) 0.81
Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. J Biol Chem (2015) 0.81
Identification of a role for CLASP2 in insulin action. J Biol Chem (2012) 0.81
Rho GTPases in insulin-stimulated glucose uptake. Small GTPases (2014) 0.80
Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing. Biochem J (2011) 0.80
Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex. Curr Opin Chem Biol (2015) 0.79
A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b. Biochem Biophys Res Commun (2015) 0.79
TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One (2012) 0.79
GIV/girdin binds exocyst subunit-Exo70 and regulates exocytosis of GLUT4 storage vesicles. Biochem Biophys Res Commun (2015) 0.79
Phosphoinositides: Key modulators of energy metabolism. Biochim Biophys Acta (2014) 0.79
Exocyst complex protein expression in the human placenta. Placenta (2014) 0.78
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Inflammatory links between obesity and metabolic disease. J Clin Invest (2011) 6.73
Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes (2007) 6.08
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 4.56
The protein kinase IKKepsilon regulates energy balance in obese mice. Cell (2009) 3.93
A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell (2006) 3.90
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15
Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J Physiol Endocrinol Metab (2006) 3.04
Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem (2004) 2.32
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett (2008) 2.28
Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18
Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem (2008) 2.07
Insulin signaling and the regulation of glucose transport. Mol Med (2006) 1.99
Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med (2007) 1.91
Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c. Dev Cell (2007) 1.88
Compartmentalization of the exocyst complex in lipid rafts controls Glut4 vesicle tethering. Mol Biol Cell (2006) 1.75
T-ing up inflammation in fat. Nat Med (2009) 1.66
Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes (2007) 1.65
APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. Mol Cell Biol (2002) 1.52
Changes in integrin expression during adipocyte differentiation. Cell Metab (2005) 1.51
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med (2009) 1.46
RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis. J Biol Chem (2006) 1.45
LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem (2005) 1.44
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. Proc Natl Acad Sci U S A (2012) 1.39
Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Mol Cell (2003) 1.38
Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes. Cell Metab (2007) 1.35
A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease. Genes Dev (2007) 1.32
PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance. J Clin Invest (2003) 1.27
Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell (2009) 1.27
Lipid phosphatases as drug discovery targets for type 2 diabetes. Nat Rev Drug Discov (2006) 1.26
Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol (2010) 1.25
Small GTP-binding protein TC10 differentially regulates two distinct populations of filamentous actin in 3T3L1 adipocytes. Mol Biol Cell (2002) 1.19
The stomatin/prohibitin/flotillin/HflK/C domain of flotillin-1 contains distinct sequences that direct plasma membrane localization and protein interactions in 3T3-L1 adipocytes. J Biol Chem (2005) 1.18
Inhibition of AMPK catabolic action by GSK3. Mol Cell (2013) 1.18
Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Biol Cell (2012) 1.17
Munc18c interaction with syntaxin 4 monomers and SNARE complex intermediates in GLUT4 vesicle trafficking. J Biol Chem (2007) 1.16
CAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motility. EMBO J (2006) 1.14
Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest. Circulation (2004) 1.13
A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Mol Biol Cell (2010) 1.13
The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A (2002) 1.12
The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1. J Biol Chem (2002) 1.11
Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation. Eukaryot Cell (2002) 1.10
Atypical protein kinase C (PKCzeta/lambda) is a convergent downstream target of the insulin-stimulated phosphatidylinositol 3-kinase and TC10 signaling pathways. J Cell Biol (2004) 1.10
The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport. J Biol Chem (2003) 1.08
Exocyst function is regulated by effector phosphorylation. Nat Cell Biol (2011) 1.08
TC10alpha is required for insulin-stimulated glucose uptake in adipocytes. Endocrinology (2006) 1.06
Cloning and functional characterization of related TC10 isoforms, a subfamily of Rho proteins involved in insulin-stimulated glucose transport. J Biol Chem (2002) 1.03
Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell (2008) 1.03
Rab5 proteins regulate activation and localization of target of rapamycin complex 1. J Biol Chem (2012) 1.02
GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell (2006) 1.00
Insulin-stimulated Interaction between insulin receptor substrate 1 and p85alpha and activation of protein kinase B/Akt require Rab5. J Biol Chem (2006) 0.98
p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. Proc Natl Acad Sci U S A (2012) 0.96
TC10 and insulin-stimulated glucose transport. Methods Enzymol (2006) 0.95
Distinct mutations in the glycogen debranching enzyme found in glycogen storage disease type III lead to impairment in diverse cellular functions. Hum Mol Genet (2009) 0.94
Roles for PI(3,5)P2 in nutrient sensing through TORC1. Mol Biol Cell (2014) 0.93
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1. Elife (2013) 0.93
TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J (2003) 0.93
The exocytotic trafficking of TC10 occurs through both classical and nonclassical secretory transport pathways in 3T3L1 adipocytes. Mol Cell Biol (2003) 0.91
Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells. Endocrinology (2006) 0.87
Identification of CAP as a costameric protein that interacts with filamin C. Mol Biol Cell (2007) 0.86
Cloning and characterization of Cbl-associated protein splicing isoforms. Mol Med (2003) 0.86
Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes. J Biol Chem (2008) 0.86
Circadian metabolic regulation through crosstalk between casein kinase 1δ and transcriptional coactivator PGC-1α. Mol Endocrinol (2011) 0.84
More TORC for the gluconeogenic engine. Bioessays (2006) 0.83
TIRFing out studies on Glut4 trafficking. Dev Cell (2007) 0.81
Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. Diabetes (2013) 0.81
Ral's engagement with the exocyst: breaking up is hard to do. Cell Cycle (2011) 0.81
Staying in SHIP shape. Nat Med (2005) 0.81
Progesterone interactions with the cervix: translational implications for term and preterm birth. Infect Dis Obstet Gynecol (2011) 0.79
TC10 is regulated by caveolin in 3T3-L1 adipocytes. PLoS One (2012) 0.79
Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest (2017) 0.79
Holding the line on hepatic fat. Cell Metab (2005) 0.78
Phosphoinositides in insulin action and diabetes. Curr Top Microbiol Immunol (2012) 0.78
Autophagy works out. Cell Metab (2012) 0.77
Negative regulation of the RalGAP complex by 14-3-3. J Biol Chem (2013) 0.77
Insulin htts on autophagy. Autophagy (2006) 0.76
Von Gierke's disease adopts an orphan (and its partner). Sci Signal (2009) 0.75
Infectious diseases and prematurity. Infect Dis Obstet Gynecol (2011) 0.75
Dilation and evacuation of a single fetus after midtrimester PROM in previable twin pregnancy. Am J Perinatol (2008) 0.75
A TUG on glucose transport. Nat Med (2003) 0.75