Published in J Mol Biol on April 25, 2003
Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol (2004) 3.28
Conformational changes in protein loops and helices induced by post-translational phosphorylation. PLoS Comput Biol (2006) 1.36
Structural basis for m3G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1. EMBO J (2005) 1.26
RNA binding protein/RNA element interactions and the control of translation. Curr Protein Pept Sci (2012) 1.24
Structure of a viral cap-independent translation element that functions via high affinity binding to the eIF4E subunit of eIF4F. J Biol Chem (2009) 1.13
The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond. Plant Physiol (2007) 1.10
eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition. Proc Natl Acad Sci U S A (2013) 1.09
Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency. RNA (2004) 1.04
Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein. J Virol (2004) 1.03
Binding specificities and potential roles of isoforms of eukaryotic initiation factor 4E in Leishmania. Eukaryot Cell (2006) 1.01
Weak binding affinity of human 4EHP for mRNA cap analogs. RNA (2007) 0.98
High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation. RNA (2005) 0.98
Intrinsic RNA binding by the eukaryotic initiation factor 4F depends on a minimal RNA length but not on the m7G cap. J Biol Chem (2009) 0.98
Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons. Mol Cell Biol (2006) 0.95
Structural basis for nematode eIF4E binding an m(2,2,7)G-Cap and its implications for translation initiation. Nucleic Acids Res (2011) 0.95
Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression. RNA (2012) 0.94
Cap-binding activity of an eIF4E homolog from Leishmania. RNA (2004) 0.93
Kinetic mechanism for assembly of the m7GpppG.eIF4E.eIF4G complex. J Biol Chem (2008) 0.92
Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E. J Mol Biol (2011) 0.90
Chemical synthesis and binding activity of the trypanosomatid cap-4 structure. RNA (2004) 0.89
Evolutionary conservation and diversification of the translation initiation apparatus in trypanosomatids. Comp Funct Genomics (2012) 0.84
Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH. RNA (2011) 0.83
Structural insights into parasite eIF4E binding specificity for m7G and m2,2,7G mRNA caps. J Biol Chem (2009) 0.83
Recognition of cap structure by influenza B virus RNA polymerase is less dependent on the methyl residue than recognition by influenza A virus polymerase. J Virol (2011) 0.82
The Distribution of eIF4E-Family Members across Insecta. Comp Funct Genomics (2012) 0.81
Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry. J Am Chem Soc (2014) 0.80
Kinetic mechanism for the binding of eIF4F and tobacco Etch virus internal ribosome entry site rna: effects of eIF4B and poly(A)-binding protein. J Biol Chem (2009) 0.80
Insights into the molecular determinants involved in cap recognition by the vaccinia virus D10 decapping enzyme. Nucleic Acids Res (2010) 0.79
Identification and bioinformatics characterization of translation initiation complex eIF4F components and poly(A)-binding protein from Plasmodium falciparum. Commun Integr Biol (2009) 0.78
Dynamical insight into Caenorhabditis elegans eIF4E recognition specificity for mono-and trimethylated structures of mRNA 5' cap. J Mol Model (2010) 0.78
Turnip mosaic virus genome-linked protein VPg binds C-terminal region of cap-bound initiation factor 4E orthologue without exhibiting host cellular specificity. J Biochem (2009) 0.78
Interpretation of intramolecular stacking effect on the fluorescence intensity decay of 3-methylbenzimidazolyl(5'-5')guanosine dinucleotides using a model of lifetime distribution. Eur Biophys J (2006) 0.78
The alveolate translation initiation factor 4E family reveals a custom toolkit for translational control in core dinoflagellates. BMC Evol Biol (2015) 0.77
Distinct features of cap binding by eIF4E1b proteins. J Mol Biol (2014) 0.75
Diversity of preferred nucleotide sequences around the translation initiation codon in eukaryote genomes. Nucleic Acids Res (2007) 1.52
Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium. Structure (2011) 1.46
Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion. J Biol Chem (2008) 1.38
A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist. Anal Biochem (2004) 1.29
Preparation of silk protein sericin as mitogenic factor for better mammalian cell culture. J Biosci Bioeng (2005) 1.29
Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections. BMC Microbiol (2006) 1.27
Molecular basis of the interaction of Saccharomyces cerevisiae Eaf3 chromo domain with methylated H3K36. J Biol Chem (2008) 1.26
Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Sci (2006) 1.25
Virtual screening on natural products for discovering active compounds and target information. Curr Med Chem (2003) 1.25
Dynamic evolution of translation initiation mechanisms in prokaryotes. Proc Natl Acad Sci U S A (2010) 1.20
The spike protein of severe acute respiratory syndrome (SARS) is cleaved in virus infected Vero-E6 cells. Cell Res (2004) 1.18
Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol (2005) 1.15
Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J Biol Chem (2007) 1.11
Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J Neurosci (2013) 1.10
Crystal structure of d(GCGAAAGCT) containing a parallel-stranded duplex with homo base pairs and an anti-parallel duplex with Watson-Crick base pairs. Nucleic Acids Res (2002) 1.09
pH-dependent conformational flexibility of the SARS-CoV main proteinase (M(pro)) dimer: molecular dynamics simulations and multiple X-ray structure analyses. J Mol Biol (2005) 1.09
Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods. Biochim Biophys Acta (2005) 1.09
A new dolabellane diterpenoid from the Hainan soft coral Spongodes sp. Nat Prod Res (2007) 1.09
Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum. J Biol Chem (2006) 1.09
Comparison of the diagnostic performance of FDG-PET and VBM-MRI in very mild Alzheimer's disease. Eur J Nucl Med Mol Imaging (2006) 1.08
klavier (klv), a novel hypernodulation mutant of Lotus japonicus affected in vascular tissue organization and floral induction. Plant J (2005) 1.07
Trophectoderm morphology significantly affects the rates of ongoing pregnancy and miscarriage in frozen-thawed single-blastocyst transfer cycle in vitro fertilization. Fertil Steril (2012) 1.06
Ligand-binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology-based kinetic analysis correlated with molecular dynamics simulation. Protein Sci (2005) 1.06
Crystal structure and molecular dynamics simulation of ubiquitin-like domain of murine parkin. Biochim Biophys Acta (2008) 1.05
ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. Int J Clin Exp Pathol (2013) 1.04
Malonyl-CoA: acyl carrier protein transacylase from Helicobacter pylori: Crystal structure and its interaction with acyl carrier protein. Protein Sci (2007) 1.04
Alchivemycin A, a bioactive polycyclic polyketide with an unprecedented skeleton from Streptomyces sp. Org Lett (2010) 1.03
Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Biochem Biophys Res Commun (2004) 1.03
Sericin, a protein derived from silkworms, accelerates the proliferation of several mammalian cell lines including a hybridoma. Cytotechnology (2002) 1.03
Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg Med Chem Lett (2006) 1.02
Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis. Protein Sci (2008) 1.02
Aza analogues of equol: novel ligands for estrogen receptor beta. Bioorg Med Chem (2007) 1.02
Aromaticity of planar boron clusters confirmed. J Am Chem Soc (2005) 1.02
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II. Mol Cancer Ther (2007) 1.01
Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin. Mol Pharmacol (2006) 1.01
Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J Med Chem (2009) 1.01
WT1 and WT1-AS genes are inactivated by promoter methylation in ovarian clear cell adenocarcinoma. Cancer (2005) 1.00
Antitussive effects of the H1-receptor antagonist epinastine in patients with atopic cough (eosinophilic bronchitis). Arzneimittelforschung (2004) 1.00
Polymorphisms of the CYP1B1 gene have higher risk for prostate cancer. Biochem Biophys Res Commun (2002) 0.99
Effect of the silk protein sericin on the production of adenovirus-based gene-therapy vectors. Biotechnol Appl Biochem (2006) 0.99
Structural determinants of an insect beta-N-Acetyl-D-hexosaminidase specialized as a chitinolytic enzyme. J Biol Chem (2010) 0.98
Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS J (2006) 0.98
Identification of an epitope of SARS-coronavirus nucleocapsid protein. Cell Res (2003) 0.98
Differences in cerebral metabolic impairment between early and late onset types of Alzheimer's disease. J Neurol Sci (2002) 0.98
Identification of an allele attributable to formation of cucumber-like flavor in wild tomato species (Solanum pennellii) that was inactivated during domestication. J Agric Food Chem (2007) 0.98
Conformational transition pathway in the allosteric process of human glucokinase. Proc Natl Acad Sci U S A (2006) 0.97
Gender differences in cerebral glucose metabolism: a PET study. J Neurol Sci (2002) 0.97
Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol (2010) 0.97
Activation and translocation of PKCdelta is necessary for VEGF-induced ERK activation through KDR in HEK293T cells. Biochem Biophys Res Commun (2004) 0.97
A conserved motif within the flexible C-terminus of the translational regulator 4E-BP is required for tight binding to the mRNA cap-binding protein eIF4E. Biochem J (2012) 0.97
A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. Eur J Biochem (2003) 0.96
Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. J Virol (2003) 0.96
Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha. Oncol Rep (2003) 0.96
The rare crystallographic structure of d(CGCGCG)(2): the natural spermidine molecule bound to the minor groove of left-handed Z-DNA d(CGCGCG)(2) at 10 degrees C. Biochem Biophys Res Commun (2007) 0.95
S9, a novel anticancer agent, exerts its anti-proliferative activity by interfering with both PI3K-Akt-mTOR signaling and microtubule cytoskeleton. PLoS One (2009) 0.95
Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure. Virology (2009) 0.95
Diastereoisomeric macrocyclic polydisulfides from the mangrove Bruguiera gymnorrhiza. Phytochemistry (2009) 0.95
Polymorphisms of estrogen receptor alpha in prostate cancer. Mol Carcinog (2003) 0.95
Binding analyses between Human PPARgamma-LBD and ligands. Eur J Biochem (2004) 0.95
Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney. J Biol Chem (2002) 0.94
Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci (2008) 0.94
Aggregation analysis of the microtubule binding domain in tau protein by spectroscopic methods. J Biochem (2003) 0.94
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents (2008) 0.94
Voxel-based comparison of regional cerebral glucose metabolism between PSP and corticobasal degeneration. J Neurol Sci (2002) 0.93
Consumption of a resistant protein, sericin, elevates fecal immunoglobulin A, mucins, and cecal organic acids in rats fed a high-fat diet. J Nutr (2011) 0.93
Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One (2011) 0.93
Matrix metalloproteinase-9 induces cardiac fibroblast migration, collagen and cytokine secretion: inhibition by salvianolic acid B from Salvia miltiorrhiza. Phytomedicine (2011) 0.92
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer. Biochem Biophys Res Commun (2004) 0.92
D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75. Biochem Biophys Res Commun (2008) 0.92
The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation. Chembiochem (2006) 0.92
Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening. J Med Chem (2009) 0.92
Carboxyl terminus of severe acute respiratory syndrome coronavirus nucleocapsid protein: self-association analysis and nucleic acid binding characterization. Biochemistry (2006) 0.92
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem (2010) 0.91
Identification and characterization of genes that control fat deposition in chickens. J Anim Sci Biotechnol (2013) 0.91
X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. FEBS J (2009) 0.91
Estrogen receptor alpha polymorphisms and renal cell carcinoma--a possible risk. Mol Cell Endocrinol (2003) 0.91
Quercetin regulates growth of Ishikawa cells through the suppression of EGF and cyclin D1. Int J Oncol (2003) 0.91