Published in Biochemistry on April 22, 2003
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov (2010) 2.68
Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism. Science (2015) 2.29
Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta (2009) 1.67
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60
Structure of the mitochondrial translocator protein in complex with a diagnostic ligand. Science (2014) 1.29
Translocator protein (18 kDa) TSPO: an emerging therapeutic target in neurotrauma. Exp Neurol (2009) 1.26
Three-dimensional structure of TspO by electron cryomicroscopy of helical crystals. Structure (2010) 1.22
Protein structure. Structure and activity of tryptophan-rich TSPO proteins. Science (2015) 1.05
Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones. Mol Endocrinol (2012) 1.02
Translocator protein 2 is involved in cholesterol redistribution during erythropoiesis. J Biol Chem (2009) 1.02
Targeting and insertion of the cholesterol-binding translocator protein into the outer mitochondrial membrane. Biochemistry (2009) 0.96
Saccharomyces cerevisiae porin pore forms complexes with mitochondrial outer membrane proteins Om14p and Om45p. J Biol Chem (2012) 0.94
Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides. Biochemistry (2013) 0.92
Phorbol-12-myristate 13-acetate acting through protein kinase Cepsilon induces translocator protein (18-kDa) TSPO gene expression. Biochemistry (2008) 0.91
ABA, porphyrins and plant TSPO-related protein. Plant Signal Behav (2009) 0.88
Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO). Psychoneuroendocrinology (2013) 0.86
Minireview: translocator protein (TSPO) and steroidogenesis: a reappraisal. Mol Endocrinol (2015) 0.85
Translocator protein blockade reduces prostate tumor growth. Clin Cancer Res (2009) 0.85
Expression and modulation of translocator protein and its partners by hypoxia reoxygenation or ischemia and reperfusion in porcine renal models. Am J Physiol Renal Physiol (2009) 0.85
Aging and luteinizing hormone effects on reactive oxygen species production and DNA damage in rat Leydig cells. Biol Reprod (2013) 0.85
Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis. Mol Cell Endocrinol (2015) 0.82
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The endocrine disruptor mono-(2-ethylhexyl) phthalate affects the differentiation of human liposarcoma cells (SW 872). PLoS One (2011) 0.81
A TSPO-related protein localizes to the early secretory pathway in Arabidopsis, but is targeted to mitochondria when expressed in yeast. J Exp Bot (2010) 0.81
Bacterial ortholog of mammalian translocator protein (TSPO) with virulence regulating activity. PLoS One (2009) 0.80
Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition. Metab Brain Dis (2013) 0.79
Increased expression of peripheral benzodiazepine receptor (PBR) in dimethylbenz[a]anthracene-induced mammary tumors in rats. Glycoconj J (2006) 0.79
Functional characterization of the human translocator protein (18kDa) gene promoter in human breast cancer cell lines. Biochim Biophys Acta (2011) 0.78
Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria. Arch Biochem Biophys (2015) 0.78
Evolving understanding of translocator protein 18 kDa (TSPO). Pharmacol Res (2015) 0.77
Translocator Protein-Mediated Stabilization of Mitochondrial Architecture during Inflammation Stress in Colonic Cells. PLoS One (2016) 0.77
Structure-to-function relationships of bacterial translocator protein (TSPO): a focus on Pseudomonas. Front Microbiol (2014) 0.77
Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies. Front Endocrinol (Lausanne) (2016) 0.76
TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. Sci Rep (2016) 0.75
Toward the functional oligomerization state of tryptophan-rich sensory proteins. Protein Sci (2014) 0.75
Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure. Nat Commun (2017) 0.75
Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells. Int J Mol Sci (2016) 0.75
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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation. J Am Chem Soc (2004) 2.79
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov (2010) 2.68
AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell (2005) 2.68
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Cholesterol transport, peripheral benzodiazepine receptor, and steroidogenesis in aging Leydig cells. J Androl (2002) 2.23
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Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res (2009) 2.19
Genetic and biophysical basis of sudden unexplained nocturnal death syndrome (SUNDS), a disease allelic to Brugada syndrome. Hum Mol Genet (2002) 2.16
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Generating daily high spatial land surface temperatures by combining ASTER and MODIS land surface temperature products for environmental process monitoring. Environ Sci Process Impacts (2015) 2.03
Structural insights on the Mycobacterium tuberculosis proteasomal ATPase Mpa. Structure (2009) 1.96
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Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol (2008) 1.75
Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger. Science (2012) 1.74
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Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J (2011) 1.74
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Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochim Biophys Acta (2009) 1.67
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Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy. Mol Genet Metab (2007) 1.60
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60
Phosphatidylinositol monophosphate-binding interface in the oomycete RXLR effector AVR3a is required for its stability in host cells to modulate plant immunity. Proc Natl Acad Sci U S A (2011) 1.59
ERG oncogene modulates prostaglandin signaling in prostate cancer cells. Cancer Biol Ther (2011) 1.56
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Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther (2007) 1.55
Association between endothelin receptor B nonsynonymous variants and melanoma risk. J Natl Cancer Inst (2005) 1.51
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Characterization of the cholesterol recognition amino acid consensus sequence of the peripheral-type benzodiazepine receptor. Mol Endocrinol (2004) 1.49
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Automatic selection of tube potential for radiation dose reduction in CT: a general strategy. Med Phys (2010) 1.46
Normal mode-based fitting of atomic structure into electron density maps: application to sarcoplasmic reticulum Ca-ATPase. Biophys J (2004) 1.46
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Eur J Hum Genet (2008) 1.44
Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med (2004) 1.41
Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene. EMBO Mol Med (2009) 1.41
In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. Hum Mutat (2008) 1.39
Topography and severity of coronary artery disease in white-coat hypertension. Eur J Intern Med (2008) 1.39
Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system. JOP (2004) 1.38
Two microtubule-associated proteins of the Arabidopsis MAP65 family function differently on microtubules. Plant Physiol (2005) 1.37
mTORC2 is required for proliferation and survival of TSC2-null cells. Mol Cell Biol (2011) 1.36
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response. Curr Pharm Des (2007) 1.36
Large deletions of the PRKAR1A gene in Carney complex. Clin Cancer Res (2008) 1.36
N-terminus of M2 protein could induce antibodies with inhibitory activity against influenza virus replication. FEMS Immunol Med Microbiol (2003) 1.35
Novel regulators of Fgf23 expression and mineralization in Hyp bone. Mol Endocrinol (2009) 1.34
Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression. Neoplasia (2011) 1.34
Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria. Mol Endocrinol (2004) 1.33
Multiple polyadenylated RNA viruses detected in pooled cultivated and wild plant samples. Arch Virol (2011) 1.33
A scoring model based on neutrophil to lymphocyte ratio predicts recurrence of HBV-associated hepatocellular carcinoma after liver transplantation. PLoS One (2011) 1.32
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Cytoglobin overexpression protects against damage-induced fibrosis. Mol Ther (2006) 1.32
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. Cancer Res (2011) 1.31
Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model. Antimicrob Agents Chemother (2007) 1.30
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Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res (2011) 1.29
Protein-protein interactions mediate mitochondrial cholesterol transport and steroid biosynthesis. J Biol Chem (2006) 1.29
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Can transanal tube placement after anterior resection for rectal carcinoma reduce anastomotic leakage rate? A single-institution prospective randomized study. World J Surg (2011) 1.22
Transconformations of the SERCA1 Ca-ATPase: a normal mode study. Biophys J (2003) 1.22
Advances in liver echinococcosis: diagnosis and treatment. Clin Gastroenterol Hepatol (2006) 1.21
Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci (2006) 1.20
Flavour compounds in tomato fruits: identification of loci and potential pathways affecting volatile composition. J Exp Bot (2008) 1.20
A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model. PLoS One (2012) 1.20
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FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer. J Exp Med (2005) 1.19
Leydig cell aging and the mechanisms of reduced testosterone synthesis. Mol Cell Endocrinol (2008) 1.18
Hepatic stem cells and transforming growth factor β in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol (2012) 1.17
Differential expression patterns of the hox gene are associated with differential growth of insect hind legs. Proc Natl Acad Sci U S A (2004) 1.17
Cohesin proteins promote ribosomal RNA production and protein translation in yeast and human cells. PLoS Genet (2012) 1.17
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miR-497 induces apoptosis of breast cancer cells by targeting Bcl-w. Exp Ther Med (2011) 1.15
Diabetes gene therapy: potential and challenges. Curr Gene Ther (2003) 1.15
Reciprocal intraepithelial interactions between TP63 and hedgehog signaling regulate quiescence and activation of progenitor elaboration by mammary stem cells. Stem Cells (2008) 1.15