Published in JAMA on April 16, 2003
Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury. Transfusion (2011) 1.87
Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation. Blood (2008) 1.55
Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model. Blood (2009) 1.49
Reducing noninfectious risks of blood transfusion. Anesthesiology (2011) 1.30
Transfusion-transmitted parasitic infections. Asian J Transfus Sci (2010) 1.27
Transfusion-related acute lung injury (TRALI): a clinical review with emphasis on the critically ill. Br J Haematol (2009) 1.23
Anemia and red blood cell transfusion in neurocritical care. Crit Care (2009) 1.23
Transfusion immunomodulation--the case for leukoreduced and (perhaps) washed transfusions. Blood Cells Mol Dis (2012) 1.22
Red blood cell transfusions and the risk of acute respiratory distress syndrome among the critically ill: a cohort study. Crit Care (2007) 1.14
Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo. Blood (2014) 1.11
Red cell transfusion triggers in critically ill patients: time for some new TRICCs? Crit Care (2010) 1.08
Anemia and blood transfusion in a surgical intensive care unit. Crit Care (2010) 1.06
Differential effects of plasma and red blood cell transfusions on acute lung injury and infection risk following liver transplantation. Liver Transpl (2011) 1.06
Red blood cell transfusion in the critically ill patient. Ann Intensive Care (2011) 1.04
Proteomic analysis of the supernatant of red blood cell units: the effects of storage and leucoreduction. Vox Sang (2013) 1.02
Effects of transfusion with red cells filtered to remove leucocytes: randomised controlled trial in patients undergoing major surgery. BMJ (2004) 1.01
The effect of age and clinical circumstances on the outcome of red blood cell transfusion in critically ill patients. Crit Care (2014) 0.98
Clinical evidence of blood transfusion effectiveness. Blood Transfus (2009) 0.96
To filter blood or universal leukoreduction: what is the answer? Crit Care (2004) 0.96
Prestorage leukoreduction ameliorates the effects of aging on banked blood. J Trauma (2010) 0.95
Restrictive vs liberal blood transfusion for acute upper gastrointestinal bleeding: rationale and protocol for a cluster randomized feasibility trial. Transfus Med Rev (2013) 0.95
Leucoreduction of blood components: an effective way to increase blood safety? Blood Transfus (2015) 0.94
Leukoreduced blood components: Advantages and strategies for its implementation in developing countries. Asian J Transfus Sci (2010) 0.94
Treating critical illness: the importance of first doing no harm. PLoS Med (2005) 0.94
Infectious and immunologic consequences of blood transfusion. Crit Care (2004) 0.93
Transfusion trigger: when to transfuse? Crit Care (2004) 0.92
The association of early transfusion with acute lung injury in patients with severe injury. J Trauma Acute Care Surg (2012) 0.89
Neutrophils release extracellular DNA traps during storage of red blood cell units. Transfusion (2013) 0.87
Red blood cell transfusion in septic shock - clinical characteristics and outcome of unselected patients in a prospective, multicentre cohort. Scand J Trauma Resusc Emerg Med (2014) 0.86
Is the current management of severe sepsis and septic shock really evidence based? PLoS Med (2006) 0.86
Lack of evidence of CD40 ligand involvement in transfusion-related acute lung injury. Clin Exp Immunol (2011) 0.85
Effect of a restrictive transfusion strategy on transfusion-attributable severe acute complications and costs in the US ICUs: a model simulation. BMC Health Serv Res (2007) 0.82
Use of leukoreduced blood does not reduce infection, organ failure, or mortality following trauma. World J Surg (2009) 0.81
Red Blood Cell Transfusions Impact Pneumonia Rates After Coronary Artery Bypass Grafting. Ann Thorac Surg (2015) 0.81
Influence of storage time and amount of red blood cell transfusion on postoperative renal function: an observational cohort study. Heart Lung Vessel (2013) 0.79
Red blood cell transfusion in the neurological ICU. Neurotherapeutics (2012) 0.77
Transfusion trigger in critically ill patients: has the puzzle been completed? Crit Care (2007) 0.77
Impact of transfusion on patients with sepsis admitted in intensive care unit: a systematic review and meta-analysis. Ann Intensive Care (2017) 0.77
Is leukoreduction of blood components for everyone? JAMA (2003) 0.76
Factors Affecting Tissue Oxygenation in Erythrocyte Transfusions. Turk J Anaesthesiol Reanim (2014) 0.75
8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada. Crit Care (2004) 0.75
Leukoreduction vs buffy-coat depletion and the safety of blood transfusion. JAMA (2003) 0.75
The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration. Blood Transfus (2017) 0.75
Blood management in intensive care medicine: CRIT and ABC--what can we learn? Crit Care (2004) 0.75
Pulmonary complications of transfused blood components. Crit Care Nurs Clin North Am (2012) 0.75
Balance Between the Proinflammatory and Anti-Inflammatory Immune Responses with Blood Transfusion in Sepsis. Crit Care Nurs Clin North Am (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol (2007) 13.46
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25
Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med (2010) 8.28
Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med (2007) 7.99
Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59
Screening for Occult Cancer in Unprovoked Venous Thromboembolism. N Engl J Med (2015) 7.39
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
Pacemaker or defibrillator surgery without interruption of anticoagulation. N Engl J Med (2013) 6.40
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31
Randomized trial of long-term follow-up for early-stage breast cancer: a comparison of family physician versus specialist care. J Clin Oncol (2006) 6.24
Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 6.10
AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol (2009) 6.00
Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2007) 5.51
A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med (2008) 5.20
High risk clinical characteristics for subarachnoid haemorrhage in patients with acute headache: prospective cohort study. BMJ (2010) 4.65
The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr (2006) 4.63
Host and pathogen factors for Clostridium difficile infection and colonization. N Engl J Med (2011) 4.62
The Canadian C-spine rule versus the NEXUS low-risk criteria in patients with trauma. N Engl J Med (2003) 4.48
Does this patient have deep vein thrombosis? JAMA (2006) 4.44
Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial. Lancet (2012) 4.36
Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury. JAMA (2005) 4.35
Clinical decision rules to rule out subarachnoid hemorrhage for acute headache. JAMA (2013) 4.34
Family caregiver burden: results of a longitudinal study of breast cancer patients and their principal caregivers. CMAJ (2004) 4.13
Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes. Ann Emerg Med (2004) 4.12
Advanced cardiac life support in out-of-hospital cardiac arrest. N Engl J Med (2004) 4.09
CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. CMAJ (2010) 4.03
Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med (2005) 3.84
Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials. CMAJ (2007) 3.77
CONSORT 2010 changes and testing blindness in RCTs. Lancet (2010) 3.68
Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57
Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med (2008) 3.56
Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev (2011) 3.44
A citywide protocol for primary PCI in ST-segment elevation myocardial infarction. N Engl J Med (2008) 3.44
Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene (2003) 3.32
Effect of fresh red blood cell transfusions on clinical outcomes in premature, very low-birth-weight infants: the ARIPI randomized trial. JAMA (2012) 3.26
Overdiagnosis of asthma in obese and nonobese adults. CMAJ (2008) 3.23
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet (2010) 3.15
The Canadian C-spine rule performs better than unstructured physician judgment. Ann Emerg Med (2003) 3.12
Rocuronium versus succinylcholine for rapid sequence induction intubation. Cochrane Database Syst Rev (2008) 3.08
Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol (2003) 3.07
Gene dosage of the common variant 9p21 predicts severity of coronary artery disease. J Am Coll Cardiol (2010) 3.07
Effects of red-cell storage duration on patients undergoing cardiac surgery. N Engl J Med (2015) 3.03
Bacterial contamination in platelets: incremental improvements drive down but do not eliminate risk. Transfusion (2011) 3.00
Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82
BIPHASIC Trial: a randomized comparison of fixed lower versus escalating higher energy levels for defibrillation in out-of-hospital cardiac arrest. Circulation (2007) 2.80
Effect of study setting on anticoagulation control: a systematic review and metaregression. Chest (2006) 2.79
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75
Time-dependent bias was common in survival analyses published in leading clinical journals. J Clin Epidemiol (2004) 2.70
Cost-effectiveness of self-monitoring of blood glucose in patients with type 2 diabetes mellitus managed without insulin. CMAJ (2009) 2.70
Transfusion-related immunomodulation (TRIM): an update. Blood Rev (2007) 2.69
Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst Rev (2009) 2.61
Implementation of the Canadian C-Spine Rule: prospective 12 centre cluster randomised trial. BMJ (2009) 2.58
Age of transfused blood in critically ill adults. N Engl J Med (2015) 2.52
The OPALS Major Trauma Study: impact of advanced life-support on survival and morbidity. CMAJ (2008) 2.51
Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial. Circulation (2010) 2.51
Many faces of the minimal clinically important difference (MCID): a literature review and directions for future research. Curr Opin Rheumatol (2002) 2.47
Prospective validation of the ABCD2 score for patients in the emergency department with transient ischemic attack. CMAJ (2011) 2.45
Variation in management of recent-onset atrial fibrillation and flutter among academic hospital emergency departments. Ann Emerg Med (2010) 2.44
Preservation of renal function following partial or radical nephrectomy using 24-hour creatinine clearance. Eur Urol (2008) 2.43
Optimal defibrillation response intervals for maximum out-of-hospital cardiac arrest survival rates. Ann Emerg Med (2003) 2.42
Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest (2004) 2.35
Early intravenous unfractionated heparin and mortality in septic shock. Crit Care Med (2008) 2.35
Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis. Stroke (2008) 2.23
Prognostic value of 64-slice cardiac computed tomography severity of coronary artery disease, coronary atherosclerosis, and left ventricular ejection fraction. J Am Coll Cardiol (2010) 2.21
Transfusion-related mortality: the ongoing risks of allogeneic blood transfusion and the available strategies for their prevention. Blood (2009) 2.21
Shelter-based managed alcohol administration to chronically homeless people addicted to alcohol. CMAJ (2006) 2.20
Association of diagnostic radiation exposure and second abdominal-pelvic malignancies after testicular cancer. J Clin Oncol (2011) 2.18
The out-of-hospital validation of the Canadian C-Spine Rule by paramedics. Ann Emerg Med (2009) 2.17
Diagnostic accuracy and impact of computed tomographic coronary angiography on utilization of invasive coronary angiography. Circ Cardiovasc Imaging (2009) 2.16
Retrospective application of the NEXUS low-risk criteria for cervical spine radiography in Canadian emergency departments. Ann Emerg Med (2004) 2.15
Cardiac resynchronization therapy in patients with permanent atrial fibrillation: results from the Resynchronization for Ambulatory Heart Failure Trial (RAFT). Circ Heart Fail (2012) 2.13
Addressing the risk of bacterial contamination of platelets within the United States: a history to help illuminate the future. Transfusion (2012) 2.10
Prognostic value of CT angiography in coronary bypass patients. JACC Cardiovasc Imaging (2011) 2.10
The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis. Am J Kidney Dis (2008) 2.09
Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1. EMBO J (2009) 2.08
Bivalirudin for primary percutaneous coronary interventions: outcome assessment in the Ottawa STEMI registry. Circ Cardiovasc Interv (2012) 2.07
Multicentre prospective validation of use of the Canadian C-Spine Rule by triage nurses in the emergency department. CMAJ (2010) 2.07
Asking questions changes behavior: mere measurement effects on frequency of blood donation. Health Psychol (2008) 2.04
A clinical prediction rule to identify patients with atrial fibrillation and a low risk for stroke while taking aspirin. Arch Intern Med (2003) 2.04
A prospective cohort study of patients with transient ischemic attack to identify high-risk clinical characteristics. Stroke (2013) 2.03
Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis. CMAJ (2008) 2.02
Donor exposures in recipients of pooled platelet concentrates. N Engl J Med (2013) 2.01
A randomized controlled trial comparing the frequency of acute reactions to plasma-removed platelets and prestorage WBC-reduced platelets. Transfusion (2002) 1.98
Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol (2008) 1.96
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med (2013) 1.92
Proceedings of a consensus conference: towards an understanding of TRALI. Transfus Med Rev (2005) 1.91
Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study). J Am Coll Cardiol (2005) 1.90
Equivalence study of a topical diclofenac solution (pennsaid) compared with oral diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. J Rheumatol (2004) 1.90
Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations. Pain (2012) 1.88
A novel equation to estimate glomerular filtration rate using beta-trace protein. Clin Chem (2007) 1.85
Development of a clinical prediction rule for 30-day cardiac events in emergency department patients with chest pain and possible acute coronary syndrome. Ann Emerg Med (2011) 1.78
Understanding and improving low bystander CPR rates: a systematic review of the literature. CJEM (2008) 1.77
A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview. CMAJ (2009) 1.76
The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev (2011) 1.71