Published in Lancet on August 08, 2005
Stenotrophomonas maltophilia: an emerging global opportunistic pathogen. Clin Microbiol Rev (2012) 4.39
Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesis. Thorax (2007) 2.60
Combination therapy for treatment of infections with gram-negative bacteria. Clin Microbiol Rev (2012) 1.84
Results of antibiotic susceptibility testing do not influence clinical outcome in children with cystic fibrosis. J Cyst Fibros (2012) 1.60
Predictors of pulmonary exacerbations in patients with cystic fibrosis infected with multi-resistant bacteria. Thorax (2006) 1.11
Antimicrobial susceptibility and synergy studies of Burkholderia cepacia complex isolated from patients with cystic fibrosis. Antimicrob Agents Chemother (2006) 1.09
Combination antibiotic susceptibility of biofilm-grown Burkholderia cepacia and Pseudomonas aeruginosa isolated from patients with pulmonary exacerbations of cystic fibrosis. Eur J Clin Microbiol Infect Dis (2009) 1.00
Comparison of methods to test antibiotic combinations against heterogeneous populations of multiresistant Pseudomonas aeruginosa from patients with acute infective exacerbations in cystic fibrosis. Antimicrob Agents Chemother (2009) 0.97
Exacerbations in cystic fibrosis: 2 . prevention. Thorax (2007) 0.96
Multiple antibiotic-resistant Pseudomonas aeruginosa and lung function decline in patients with cystic fibrosis. J Cyst Fibros (2012) 0.92
When does 2 plus 2 equal 5? A review of antimicrobial synergy testing. J Clin Microbiol (2014) 0.90
Is the improvement of CF patients, hospitalized for pulmonary exacerbation, correlated to a decrease in bacterial load? PLoS One (2013) 0.84
Targeted Antibiotic Prophylaxis for Lung Transplantation in Cystic Fibrosis Patients Colonised with Pseudomonas aeruginosa Using Multiple Combination Bactericidal Testing. J Transplant (2012) 0.83
Identification and management of unusual pathogens in cystic fibrosis. J R Soc Med (2008) 0.82
Antimicrobial susceptibility and synergy studies of cystic fibrosis sputum by direct sputum sensitivity testing. Eur J Clin Microbiol Infect Dis (2012) 0.81
Pharmacokinetics and pharmacodynamics of aerosolized antibacterial agents in chronically infected cystic fibrosis patients. Clin Microbiol Rev (2014) 0.79
Pulmonary exacerbations in cystic fibrosis and bronchiectasis. Thorax (2007) 0.78
Combination antibiotic susceptibility testing in cystic fibrosis. Lancet (2005) 0.78
Multiresistant pulmonary infection in cystic fibrosis--prevention is better than cure. Lancet (2005) 0.77
Randomized trial of biofilm testing to select antibiotics for cystic fibrosis airway infection. Pediatr Pulmonol (2010) 0.77
Pseudomonas aeruginosa infection in patients with cystic fibrosis: scientific evidence regarding clinical impact, diagnosis, and treatment. J Bras Pneumol (2013) 0.76
Impact of multidrug-resistant organisms on patients considered for lung transplantation. Infect Dis Clin North Am (2013) 0.76
Colistimethate sodium for the treatment of chronic pulmonary infection in cystic fibrosis: an evidence-based review of its place in therapy. Core Evid (2014) 0.76
Lung transplantation for cystic fibrosis: results, indications, complications, and controversies. Semin Respir Crit Care Med (2015) 0.76
Deaths certified as asthma and use of medical services: a national case-control study. Thorax (2005) 0.75
Sputum DNA sequencing in cystic fibrosis: non-invasive access to the lung microbiome and to pathogen details. Microbiome (2017) 0.75
Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria. Emerg Microbes Infect (2016) 0.75
One Center's Guide to Outpatient Management of Pediatric Cystic Fibrosis Acute Pulmonary Exacerbation. Clin Med Insights Pediatr (2016) 0.75
Towards individualized diagnostics of biofilm-associated infections: a case study. NPJ Biofilms Microbiomes (2017) 0.75
Novel glycopolymer sensitizes Burkholderia cepacia complex isolates from cystic fibrosis patients to tobramycin and meropenem. PLoS One (2017) 0.75
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med (2011) 8.73
Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med (2003) 7.32
Daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol: a randomized controlled trial. JAMA (2012) 6.69
The need for an institute of continuing health education. CMAJ (2008) 6.36
Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst (2003) 6.28
Hypothermia therapy after traumatic brain injury in children. N Engl J Med (2008) 6.10
How quickly do systematic reviews go out of date? A survival analysis. Ann Intern Med (2007) 5.86
A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med (2006) 5.74
Tiotropium in combination with placebo, salmeterol, or fluticasone-salmeterol for treatment of chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2007) 5.51
Outpatient oral prednisone after emergency treatment of chronic obstructive pulmonary disease. N Engl J Med (2003) 5.12
Climate change impacts on marine ecosystems. Ann Rev Mar Sci (2012) 4.90
Association between suicide attempts and selective serotonin reuptake inhibitors: systematic review of randomised controlled trials. BMJ (2005) 4.74
Does this patient have deep vein thrombosis? JAMA (2006) 4.44
Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis. Crit Care Med (2010) 4.39
Reliability of point-of-care testing for glucose measurement in critically ill adults. Crit Care Med (2005) 3.84
Prophylactic vaccination against human papillomavirus infection and disease in women: a systematic review of randomized controlled trials. CMAJ (2007) 3.77
CONSORT 2010 changes and testing blindness in RCTs. Lancet (2010) 3.68
Clinical consequences of red cell storage in the critically ill. Transfusion (2006) 3.57
Systematic review: the Trousseau syndrome revisited: should we screen extensively for cancer in patients with venous thromboembolism? Ann Intern Med (2008) 3.56
Sarcoma derived from cultured mesenchymal stem cells. Stem Cells (2006) 3.40
Overdiagnosis of asthma in obese and nonobese adults. CMAJ (2008) 3.23
Upwelling-driven nearshore hypoxia signals ecosystem and oceanographic changes in the northeast Pacific. Nature (2004) 3.21
The Canadian C-spine rule performs better than unstructured physician judgment. Ann Emerg Med (2003) 3.12
Impact of influenza exposure on rates of hospital admissions and physician visits because of respiratory illness among pregnant women. CMAJ (2007) 3.05
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2. Nat Genet (2011) 3.02
The H1N1 vaccine race: can we beat the pandemic? CMAJ (2009) 3.01
Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection. CMAJ (2010) 2.96
Binge drinking: all too prevalent and hazardous. CMAJ (2011) 2.85
Jordan's Principle, governments' paralysis. CMAJ (2007) 2.85
Fluids after cardiac surgery: a pilot study of the use of colloids versus crystalloids. Crit Care Med (2010) 2.82
Effect of study setting on anticoagulation control: a systematic review and metaregression. Chest (2006) 2.79
Is it time for another medical curriculum revolution? CMAJ (2008) 2.76
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials. PLoS One (2012) 2.75
MicroRNA expression profiles in head and neck cancer cell lines. Biochem Biophys Res Commun (2007) 2.75
Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA (2003) 2.74
Nontuberculous mycobacterial immune reconstitution syndrome in HIV-infected patients: spectrum of disease and long-term follow-up. Clin Infect Dis (2005) 2.58
Medical education research remains the poor relation. BMJ (2007) 2.52
Preservation of renal function following partial or radical nephrectomy using 24-hour creatinine clearance. Eur Urol (2008) 2.43
Activated protein C and septic shock: a propensity-matched cohort study*. Crit Care Med (2012) 2.39
Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision. Pediatrics (2013) 2.37
Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest (2004) 2.35
Early intravenous unfractionated heparin and mortality in septic shock. Crit Care Med (2008) 2.35
Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes. Chest (2013) 2.24
Infant death among Ohio resident infants born at 32 to 41 weeks of gestation. Am J Obstet Gynecol (2010) 2.22
Delayed upwelling alters nearshore coastal ocean ecosystems in the northern California current. Proc Natl Acad Sci U S A (2007) 2.20
Association of diagnostic radiation exposure and second abdominal-pelvic malignancies after testicular cancer. J Clin Oncol (2011) 2.18
Retrospective application of the NEXUS low-risk criteria for cervical spine radiography in Canadian emergency departments. Ann Emerg Med (2004) 2.15
The effect of pentoxifylline on proteinuria in diabetic kidney disease: a meta-analysis. Am J Kidney Dis (2008) 2.09
Multiple combination bactericidal testing of staphylococcal biofilms from implant-associated infections. Antimicrob Agents Chemother (2006) 2.05
Anticoagulation intensity and outcomes among patients prescribed oral anticoagulant therapy: a systematic review and meta-analysis. CMAJ (2008) 2.02
Getting to the electronic medical record. CMAJ (2008) 2.02
Every child deserves a home. CMAJ (2009) 2.01
[A plea for clear language on vaccine safety]. CMAJ (2009) 2.01
Indole-derived arynes and their Diels-Alder reactivity with furans. Org Lett (2007) 1.94
β-adrenergic sweat secretion as a diagnostic test for cystic fibrosis. Am J Respir Crit Care Med (2012) 1.92
Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLoS Med (2013) 1.92
Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem (2003) 1.90
Adult cystic fibrosis exacerbations and new strains of Pseudomonas aeruginosa. Am J Respir Crit Care Med (2003) 1.87
A novel equation to estimate glomerular filtration rate using beta-trace protein. Clin Chem (2007) 1.85
Members' of Parliament knowledge of and attitudes toward health research and funding. CMAJ (2007) 1.85
Stenotrophomonas maltophilia in cystic fibrosis: serologic response and effect on lung disease. Am J Respir Crit Care Med (2010) 1.82
Assessment of thiopurine S-methyltransferase activity in patients prescribed thiopurines: a systematic review. Ann Intern Med (2011) 1.81
Genotype and phenotype correlations in patients with cystic fibrosis and pancreatitis. Gastroenterology (2002) 1.80
Competing interests and undergraduate medical education: time for transparency. CMAJ (2010) 1.79
Revisiting transfusion practices in critically ill patients. Crit Care Med (2005) 1.78
Experimental and theoretical investigations into the unusual regioselectivity of 4,5-, 5,6-, and 6,7-indole aryne cycloadditions. Org Lett (2010) 1.72
The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev (2011) 1.71
Clubbing of the digits. Am J Med (2007) 1.71
A statewide initiative to reduce inappropriate scheduled births at 36(0/7)-38(6/7) weeks' gestation. Am J Obstet Gynecol (2010) 1.70
Canada's pathology. CMAJ (2008) 1.70
Reducing the pain of childhood vaccination: an evidence-based clinical practice guideline. CMAJ (2010) 1.68
Driving retirement program for seniors: long overdue. CMAJ (2010) 1.68
Guide to bone health and disease in cystic fibrosis. J Clin Endocrinol Metab (2004) 1.67
Spirometry in the primary care setting: influence on clinical diagnosis and management of airflow obstruction. Chest (2005) 1.67
Cholecalciferol significantly increases 25-hydroxyvitamin D concentrations in adults with cystic fibrosis. Am J Clin Nutr (2007) 1.66
Prevalence of vertebral fractures in adults with cystic fibrosis and their relationship to bone mineral density. Chest (2006) 1.63
Insulin therapy to improve BMI in cystic fibrosis-related diabetes without fasting hyperglycemia: results of the cystic fibrosis related diabetes therapy trial. Diabetes Care (2009) 1.62
Energy starved Candidatus Pelagibacter ubique substitutes light-mediated ATP production for endogenous carbon respiration. PLoS One (2011) 1.62
Tuberculosis in Nunavut: a century of failure. CMAJ (2011) 1.61
Use of primary prevention implantable cardioverter-defibrillators in a population-based cohort is associated with a significant survival benefit. Circ Arrhythm Electrophysiol (2012) 1.60
A systematic review and meta-analysis of efficacy, cost-effectiveness, and safety of selected complementary and alternative medicine for neck and low-back pain. Evid Based Complement Alternat Med (2011) 1.59
A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg (2005) 1.59
Prevalence, risk factors, and outcomes of delirium in mechanically ventilated adults. Crit Care Med (2015) 1.58
Complex two-gene modulation of lung disease severity in children with cystic fibrosis. J Clin Invest (2008) 1.57