Published in Br J Pharmacol on April 01, 2003
Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans. Genes Dev (2006) 1.29
Modulation of neurotransmitter release by the second messenger-activated protein kinases: implications for presynaptic plasticity. Pharmacol Ther (2005) 1.26
Wealth of opportunity - the C1 domain as a target for drug development. Curr Drug Targets (2008) 1.21
Modular architecture of Munc13/calmodulin complexes: dual regulation by Ca2+ and possible function in short-term synaptic plasticity. EMBO J (2009) 1.09
Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings. J Physiol (2003) 0.94
Characterization of the interaction of phorbol esters with the C1 domain of MRCK (myotonic dystrophy kinase-related Cdc42 binding kinase) alpha/beta. J Biol Chem (2008) 0.93
A system for performing high throughput assays of synaptic function. PLoS One (2011) 0.91
Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia. Learn Mem (2005) 0.89
Regulation of Weibel-Palade body exocytosis by alpha-synuclein in endothelial cells. J Biol Chem (2010) 0.87
Rapid activation of dormant presynaptic terminals by phorbol esters. J Neurosci (2010) 0.84
Mechanisms of neuromodulation as dissected using Sr2+ at motor nerve endings. J Neurophysiol (2008) 0.81
DAG tales: the multiple faces of diacylglycerol--stereochemistry, metabolism, and signaling. Cell Mol Life Sci (2015) 0.80
Modulation of Ca(2+)-dependent and Ca(2+)-independent miniature endplate potentials by phorbol ester and adenosine in frog. Br J Pharmacol (2005) 0.80
Persistent posttetanic depression at cerebellar parallel fiber to Purkinje cell synapses. PLoS One (2013) 0.78
Modulation of purinergic neuromuscular transmission by phorbol dibutyrate is independent of protein kinase C in murine urinary bladder. J Pharmacol Exp Ther (2012) 0.77
PKC-induced sensitization of Ca2+-dependent exocytosis is mediated by reducing the Ca2+ cooperativity in pituitary gonadotropes. J Gen Physiol (2005) 0.77
The mechanism for prejunctional enhancement of neuromuscular transmission by ethanol in the mouse. J Pharmacol Exp Ther (2010) 0.76
Phorbol ester modulation of Ca2+ channels mediates nociceptive transmission in dorsal horn neurones. Pharmaceuticals (Basel) (2013) 0.75
Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorg Med Chem (2014) 0.75
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP. Bioorg Med Chem (2017) 0.75
The genetics of Caenorhabditis elegans. Genetics (1974) 102.14
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution. Nature (1998) 15.80
The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (1988) 14.43
The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature (1995) 7.48
Membrane fusion and exocytosis. Annu Rev Biochem (1999) 7.35
Protein kinase C: structure, function, and regulation. J Biol Chem (1995) 5.55
UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat Neurosci (1999) 4.39
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
Implications of the SNARE hypothesis for intracellular membrane topology and dynamics. Curr Biol (1994) 4.16
Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell (1995) 3.94
Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles. Nature (1999) 3.65
A post-docking role for active zone protein Rim. Nat Neurosci (2001) 3.40
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature (2001) 3.18
Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester. Cell (1995) 3.08
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A (2002) 2.91
The protein kinase C family: heterogeneity and its implications. Annu Rev Biochem (1989) 2.70
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron (1998) 2.68
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. J Biol Chem (1995) 2.68
Mechanisms of synaptic vesicle exocytosis. Annu Rev Cell Dev Biol (2000) 2.66
A phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc Natl Acad Sci U S A (1991) 2.65
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo. Nature (2002) 2.60
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron (2002) 2.52
Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming. Neuron (2001) 2.49
Drosophila UNC-13 is essential for synaptic transmission. Nat Neurosci (1999) 2.33
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
How does calcium trigger neurotransmitter release? Curr Opin Neurobiol (2001) 2.30
Folding intermediates of SNARE complex assembly. Nat Struct Biol (1999) 2.27
Exocytosis: a molecular and physiological perspective. Neuron (1996) 2.25
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci (2002) 2.22
Synaptotagmins: C2-domain proteins that regulate membrane traffic. Neuron (1996) 2.14
Protein kinase C isozymes and substrates. Curr Opin Cell Biol (1996) 2.12
Regulation of retrograde signaling at neuromuscular junctions by the novel C2 domain protein AEX-1. Neuron (2002) 2.00
Regulation of the readily releasable vesicle pool by protein kinase C. Neuron (1998) 1.88
Regulation of transmitter release by Unc-13 and its homologues. Curr Opin Neurobiol (2000) 1.83
SNAREs and SNARE regulators in membrane fusion and exocytosis. Cell Mol Life Sci (1999) 1.82
RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. Annu Rev Neurosci (1998) 1.76
The biophysical pharmacology of calcium-dependent acetylcholine secretion. Pharmacol Rev (1985) 1.71
Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol Pharmacol (2002) 1.66
Activation of protein kinase C augments evoked transmitter release. Nature (1987) 1.64
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin. J Biol Chem (1993) 1.60
Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform. Biochem J (2000) 1.48
Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13. J Neurosci (1999) 1.32
Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci (2002) 1.32
Presynaptic mechanism for phorbol ester-induced synaptic potentiation. J Neurosci (1999) 1.32
Docking and fusion in neurosecretion. Curr Opin Cell Biol (1998) 1.32
Solution structure of a cysteine rich domain of rat protein kinase C. Nat Struct Biol (1994) 1.25
Molecular genetic analysis of the regulatory and catalytic domains of protein kinase C. J Biol Chem (1989) 1.24
Protein kinase C potentiates transmitter release from the chick ciliary presynaptic terminal by increasing the exocytotic fusion probability. J Physiol (1999) 1.21
A novel brain-specific isoform of beta spectrin: isolation and its interaction with Munc13. Biochem Biophys Res Commun (1998) 1.09
Phosphorylation regulates spontaneous and evoked transmitter release at a giant terminal in the rat auditory brainstem. J Physiol (2000) 0.98
Export of protein from the endoplasmic reticulum is regulated by a diacylglycerol/phorbol ester binding protein. J Biol Chem (1994) 0.93
Opposing effects of phorbol esters on transmitter release and calcium currents at frog motor nerve endings. J Physiol (1997) 0.91
Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings. J Physiol (2002) 0.89
Calcium-independent receptor for alpha-latrotoxin and neurexin 1alpha [corrected] facilitate toxin-induced channel formation: evidence that channel formation results from tethering of toxin to membrane. Mol Pharmacol (2000) 0.88
Evidence for two distinct processes in the final stages of neurotransmitter release as detected by binomial analysis in calcium and strontium solutions. J Physiol (2002) 0.88
Increases in acetylcholine release produced by phorbol esters are not mediated by protein kinase C at motor nerve endings. J Pharmacol Exp Ther (1998) 0.88
Alpha-latrotoxin: from structure to some functions. Toxicon (2002) 0.87
On the simultaneous electrophysiological measurements of neurotransmitter release and perineural calcium currents from frog motor nerve endings. J Neurosci Methods (1995) 0.86
Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin. Cancer Res (1979) 0.85
Re-evaluation of phorbol ester-induced potentiation of transmitter release from mossy fibre terminals of the mouse hippocampus. J Physiol (2000) 0.84
Regulation of synaptic vesicle fusion by protein kinase C. J Physiol (1999) 0.82
UNC-13 and neurotransmitter release. Nat Neurosci (1999) 0.82
A phorbol diester-induced enhancement of synaptic transmission in olfactory cortex. Br J Pharmacol (1989) 0.81
Direct interaction between the ARF-specific guanine nucleotide exchange factor msec7-1 and presynaptic Munc13-1. Eur J Cell Biol (1999) 0.81