Published in J Neurosci on October 01, 2002
The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function. Nat Struct Mol Biol (2008) 1.76
A quaternary SNARE-synaptotagmin-Ca2+-phospholipid complex in neurotransmitter release. J Mol Biol (2007) 1.73
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1. Proc Natl Acad Sci U S A (2005) 1.71
Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion. Mol Biol Cell (2005) 1.67
Formation, stabilisation and fusion of the readily releasable pool of secretory vesicles. Pflugers Arch (2004) 1.55
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J Cell Biol (2003) 1.51
Arabidopsis synaptotagmin 1 is required for the maintenance of plasma membrane integrity and cell viability. Plant Cell (2008) 1.50
Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+. J Gen Physiol (2003) 1.43
Synaptotagmin C2A loop 2 mediates Ca2+-dependent SNARE interactions essential for Ca2+-triggered vesicle exocytosis. Mol Biol Cell (2007) 1.32
Membrane-docking loops of the cPLA2 C2 domain: detailed structural analysis of the protein-membrane interface via site-directed spin-labeling. Biochemistry (2003) 1.28
Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol (2009) 1.07
Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Mol Biol Cell (2009) 1.05
Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo. J Neurosci (2011) 1.04
Phorbol esters and neurotransmitter release: more than just protein kinase C? Br J Pharmacol (2003) 1.03
Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release. J Neurosci (2013) 1.02
Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. J Neurosci (2008) 1.01
C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo. Mol Biol Cell (2006) 1.00
Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. J Neurosci (2012) 0.99
Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Mol Biol Cell (2010) 0.96
The role of synaptotagmin I C2A calcium-binding domain in synaptic vesicle clustering during synapse formation. J Physiol (2007) 0.90
Enlightening molecular mechanisms through study of protein interactions. J Mol Cell Biol (2012) 0.88
Real-time assay for monitoring membrane association of lipid-binding domains. Anal Biochem (2008) 0.86
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS One (2010) 0.85
Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy. Biochemistry (2013) 0.85
Unexpected Ca2+-binding properties of synaptotagmin 9. Proc Natl Acad Sci U S A (2004) 0.84
The cooperative response of synaptotagmin I C2A. A hypothesis for a Ca2+-driven molecular hammer. Biophys J (2006) 0.84
Reconstituting SNARE-mediated membrane fusion at the single liposome level. Methods Cell Biol (2015) 0.83
NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1). Biochim Biophys Acta (2009) 0.79
Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. Mol Biol Cell (2016) 0.78
Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission. Mol Biol Cell (2013) 0.78
Synaptotagmin function illuminated. J Gen Physiol (2003) 0.77
Upregulation of synaptotagmin IV inhibits transmitter release in PC12 cells with targeted synaptotagmin I knockdown. BMC Neurosci (2010) 0.76
Mapping of the spontaneous deletion in the Ap3d1 gene of mocha mice: fast and reliable genotyping. BMC Res Notes (2008) 0.75
Copper binding affinity of the C2B domain of synaptotagmin-1 and its potential role in the nonclassical secretion of acidic fibroblast growth factor. Biochim Biophys Acta (2014) 0.75
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature (2010) 5.11
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
Synaptic vesicle fusion. Nat Struct Mol Biol (2008) 4.22
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron (2007) 4.15
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A (2002) 2.91
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science (2012) 2.70
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. Neuron (2003) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29
Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis. Neuron (2009) 2.26
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
A shared vesicular carrier allows synaptic corelease of GABA and glycine. Neuron (2006) 2.25
Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci (2002) 2.22
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
A neural circuit for memory specificity and generalization. Science (2013) 1.96
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95