Published in Biochim Biophys Acta on January 26, 2008
Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients. Mech Ageing Dev (2009) 1.78
Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A (2011) 1.58
Mucolipins: Intracellular TRPML1-3 channels. FEBS Lett (2010) 1.49
Chemical screening identifies ATM as a target for alleviating senescence. Nat Chem Biol (2017) 1.39
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34
Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurol (2008) 1.31
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation. Front Cell Neurosci (2013) 1.20
Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biol Chem (2009) 1.17
Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol Cell Biol (2011) 1.14
Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol (2012) 1.08
Status of mTOR activity may phenotypically differentiate senescence and quiescence. Mol Cells (2012) 1.00
Low concentrations of diindolylmethane, a metabolite of indole-3-carbinol, protect against oxidative stress in a BRCA1-dependent manner. Cancer Res (2009) 1.00
Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress. Invest Ophthalmol Vis Sci (2010) 0.97
Sterol regulatory element-binding protein (SREBP)-1-mediated lipogenesis is involved in cell senescence. J Biol Chem (2010) 0.96
A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. Carcinogenesis (2014) 0.96
A central role for dityrosine crosslinking of Amyloid-β in Alzheimer's disease. Acta Neuropathol Commun (2013) 0.94
Role of endolysosomes in HIV-1 Tat-induced neurotoxicity. ASN Neuro (2012) 0.92
mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics (2008) 0.91
Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide. Free Radic Biol Med (2013) 0.91
Nanopreparations for organelle-specific delivery in cancer. Adv Drug Deliv Rev (2013) 0.90
Cysteine cathepsin proteases: regulators of cancer progression and therapeutic response. Nat Rev Cancer (2015) 0.89
Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox. Front Aging Neurosci (2010) 0.89
MCOLN1 is a ROS sensor in lysosomes that regulates autophagy. Nat Commun (2016) 0.89
Protein oxidation and peroxidation. Biochem J (2016) 0.88
Synergistic effect of co-exposure to carbon black and Fe2O3 nanoparticles on oxidative stress in cultured lung epithelial cells. Part Fibre Toxicol (2009) 0.87
Aluminum-induced entropy in biological systems: implications for neurological disease. J Toxicol (2014) 0.84
Inducible hsp70 in the regulation of cancer cell survival: analysis of chaperone induction, expression and activity. Cancers (Basel) (2011) 0.83
Antioxidant and free radical scavenging potential of yakuchinone B derivatives in reduction of lipofuscin formation using H2O2-treated neuroblastoma cells. Iran Biomed J (2011) 0.82
The mRNA level of the galectin-10 of Angiostrongylus cantonensis induced by reactive oxygen stress. Parasitol Res (2012) 0.81
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev (2016) 0.80
Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity. Cell Death Dis (2014) 0.80
Autophagic Killing Effects against Mycobacterium tuberculosis by Alveolar Macrophages from Young and Aged Rhesus Macaques. PLoS One (2013) 0.79
Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells. Dis Model Mech (2014) 0.78
Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet (2013) 0.78
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition. Biosci Rep (2014) 0.78
High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy. Physiol Rep (2015) 0.78
Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D. Molecules (2014) 0.78
Aggregatibacter actinomycetemcomitans leukotoxin induces cytosol acidification in LFA-1 expressing immune cells. Mol Oral Microbiol (2015) 0.77
Inhibition of TRPML1 by lysosomal adenosine involved in severe combined immunodeficiency diseases. J Biol Chem (2017) 0.75
Age-dependent development of liver fibrosis in Glmp (gt/gt) mice. Fibrogenesis Tissue Repair (2016) 0.75
Iron-Mediated Lysosomal Membrane Permeabilization in Ethanol-Induced Hepatic Oxidative Damage and Apoptosis: Protective Effects of Quercetin. Oxid Med Cell Longev (2015) 0.75
The crucial impact of lysosomes in aging and longevity. Ageing Res Rev (2016) 0.75
Biphasic ROS production, p53 and BIK dictate the mode of cell death in response to DNA damage in colon cancer cells. PLoS One (2017) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Autophagy and aging: the importance of maintaining "clean" cells. Autophagy (2005) 4.61
Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med (2002) 3.09
The mitochondrial-lysosomal axis theory of aging: accumulation of damaged mitochondria as a result of imperfect autophagocytosis. Eur J Biochem (2002) 2.67
Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res (2005) 1.76
Lipofuscin. Int J Biochem Cell Biol (2004) 1.75
Oxidative stress, accumulation of biological 'garbage', and aging. Antioxid Redox Signal (2006) 1.74
What does the commonly used DCF test for oxidative stress really show? Biochem J (2010) 1.67
Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal (2010) 1.64
Lysosomes in iron metabolism, ageing and apoptosis. Histochem Cell Biol (2008) 1.60
Lysosomal destabilization in p53-induced apoptosis. Proc Natl Acad Sci U S A (2002) 1.54
Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material. Eur J Cell Biol (2004) 1.45
Intralysosomal iron chelation protects against oxidative stress-induced cellular damage. FEBS J (2006) 1.43
The lysosomal-mitochondrial axis theory of postmitotic aging and cell death. Chem Biol Interact (2006) 1.38
Lysosomal enzymes promote mitochondrial oxidant production, cytochrome c release and apoptosis. Eur J Biochem (2003) 1.35
Intralysosomal iron: a major determinant of oxidant-induced cell death. Free Radic Biol Med (2003) 1.33
Prevention of oxidant-induced cell death by lysosomotropic iron chelators. Free Radic Biol Med (2003) 1.31
Autophagy, ageing and apoptosis: the role of oxidative stress and lysosomal iron. Arch Biochem Biophys (2007) 1.28
Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res (2011) 1.28
Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover. Ann N Y Acad Sci (2004) 1.17
Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp Gerontol (2003) 1.13
Myocyte aging and mitochondrial turnover. Exp Gerontol (2004) 1.09
Giant mitochondria do not fuse and exchange their contents with normal mitochondria. Exp Cell Res (2007) 1.09
Different effects of chloroquine and hydroxychloroquine on lysosomal function in cultured retinal pigment epithelial cells. APMIS (2002) 1.09
Metallothionein protects against oxidative stress-induced lysosomal destabilization. Biochem J (2006) 1.09
Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. Clin Cancer Res (2009) 1.09
Oxidized proteins: mechanisms of removal and consequences of accumulation. IUBMB Life (2009) 1.08
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res (2002) 1.07
Endosomal and lysosomal effects of desferrioxamine: protection of HeLa cells from hydrogen peroxide-induced DNA damage and induction of cell-cycle arrest. Free Radic Biol Med (2003) 1.04
The role of lysosomes in iron metabolism and recycling. Int J Biochem Cell Biol (2011) 1.04
Activation of the p38 MAP kinase pathway is required for foam cell formation from macrophages exposed to oxidized LDL. APMIS (2002) 1.03
Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry (2003) 1.02
Mitochondrial damage and intralysosomal degradation in cellular aging. Mol Aspects Med (2006) 1.01
Does the calcein-AM method assay the total cellular 'labile iron pool' or only a fraction of it? Biochem J (2007) 0.99
Relocalized redox-active lysosomal iron is an important mediator of oxidative-stress-induced DNA damage. Biochem J (2004) 0.98
The aging myocardium: roles of mitochondrial damage and lysosomal degradation. Heart Lung Circ (2005) 0.97
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy. Biogerontology (2005) 0.97
ARPE-19 retinal pigment epithelial cells are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron. Autophagy (2009) 0.96
Aging of cultured retinal pigment epithelial cells: oxidative reactions, lipofuscin formation and blue light damage. Doc Ophthalmol (2003) 0.95
3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin. Biochem J (2003) 0.95
Polydatin, a natural polyphenol, protects arterial smooth muscle cells against mitochondrial dysfunction and lysosomal destabilization following hemorrhagic shock. Am J Physiol Regul Integr Comp Physiol (2012) 0.94
Oxidative stress induces macroautophagy of amyloid beta-protein and ensuing apoptosis. Free Radic Biol Med (2008) 0.93
Chelation of lysosomal iron protects against ionizing radiation. Biochem J (2010) 0.92
Redox activity within the lysosomal compartment: implications for aging and apoptosis. Antioxid Redox Signal (2010) 0.92
Cytocidal effects of atheromatous plaque components: the death zone revisited. FASEB J (2006) 0.91
Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. Biochem J (2002) 0.91
Radiation-induced cell death: importance of lysosomal destabilization. Biochem J (2005) 0.89
Biochemotherapy of metastatic malignant melanoma. On down-regulation of CD28. Cancer Immunol Immunother (2002) 0.89
The involvement of lysosomes in myocardial aging and disease. Curr Cardiol Rev (2008) 0.88
Cell sensitivity to oxidative stress is influenced by ferritin autophagy. Free Radic Biol Med (2011) 0.88
Sphingosine mediates TNFα-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells. J Lipid Res (2012) 0.87
Down-regulation of the CD3-zeta chain in sentinel node biopsies from breast cancer patients. Breast Cancer Res Treat (2002) 0.87
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells. Autophagy (2011) 0.86
Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form. Autophagy (2009) 0.86
Human neuroblastoma (SH-SY5Y) cells are highly sensitive to the lysosomotropic aldehyde 3-aminopropanal. Brain Res (2004) 0.86
Aging as a catabolic malfunction. Int J Biochem Cell Biol (2004) 0.86
Decreased apoptotic response of inclusion-cell disease fibroblasts: a consequence of lysosomal enzyme missorting? Exp Cell Res (2002) 0.86
Oxidative stress induces intralysosomal accumulation of Alzheimer amyloid beta-protein in cultured neuroblastoma cells. Ann N Y Acad Sci (2006) 0.84
Fenton chemistry and iron chelation under physiologically relevant conditions: Electrochemistry and kinetics. Chem Res Toxicol (2006) 0.84
Autophagy of amyloid beta-protein in differentiated neuroblastoma cells exposed to oxidative stress. Neurosci Lett (2005) 0.84
Proteins containing oxidized amino acids induce apoptosis in human monocytes. Biochem J (2011) 0.83
Preoperative interleukin-6 production by mononuclear blood cells predicts survival after radical surgery for colorectal carcinoma. Cancer (2007) 0.83
Cyclooxygenase-2 expression in lung cancer cells evaluated by immunocytochemistry. Diagn Cytopathol (2011) 0.83
Roles of mitogen-activated protein kinases in the modulation of endothelial cell function following thermal injury. Shock (2011) 0.81
Heterogeneous expression of apolipoprotein-E by human macrophages. Immunology (2004) 0.81
3-Aminopropanal is a lysosomotropic aldehyde that causes oxidative stress and apoptosis by rupturing lysosomes. APMIS (2003) 0.81
Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system. Transl Neurodegener (2012) 0.81
Induction of fibroblast apolipoprotein E expression during apoptosis, starvation-induced growth arrest and mitosis. Biochem J (2004) 0.81
Intracellular localization of amyloid-β peptide in SH-SY5Y neuroblastoma cells. J Alzheimers Dis (2013) 0.80
Divergent pathways for TNF and C(2)-ceramide toxicity in HTC hepatoma cells. Biochim Biophys Acta (2009) 0.80
Oxidative stress and Alzheimer disease: the autophagy connection? Autophagy (2006) 0.80
Retracted Advanced glycation end products induce actin rearrangement and subsequent hyperpermeability of endothelial cells. APMIS (2006) 0.80
Ascorbate and endocytosed Motexafin gadolinium induce lysosomal rupture. Cancer Lett (2011) 0.79
Foam cell death induced by 7beta-hydroxycholesterol is mediated by labile iron-driven oxidative injury: mechanisms underlying induction of ferritin in human atheroma. Free Radic Biol Med (2005) 0.79
How useful are housekeeping genes? Variable expression in melanoma metastases. Clin Chem Lab Med (2007) 0.79
Heparan sulphate epitope-expression is associated with the inflammatory response in metastatic malignant melanoma. Cancer Immunol Immunother (2003) 0.79
Autophagy of iron-binding proteins may contribute to the oxidative stress resistance of ARPE-19 cells. Exp Eye Res (2013) 0.79
Local thermal injury induces general endothelial cell contraction through p38 MAP kinase activation. APMIS (2014) 0.79
Lysosomal redox-active iron is important for oxidative stress-induced DNA damage. Ann N Y Acad Sci (2004) 0.78
Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia. Pediatr Hematol Oncol (2009) 0.78
Age-related lysosomal dysfunction: an unrecognized roadblock for cobalamin trafficking? Cell Mol Life Sci (2011) 0.78
The P38alpha and P38delta MAP kinases may be gene therapy targets in the future treatment of severe burns. Shock (2010) 0.77