Published in Nature on May 12, 2010
Systems biology approach in Chlamydomonas reveals connections between copper nutrition and multiple metabolic steps. Plant Cell (2011) 1.74
Methanobactin reverses acute liver failure in a rat model of Wilson disease. J Clin Invest (2016) 1.52
A four-helix bundle stores copper for methane oxidation. Nature (2015) 1.47
Unification of the copper(I) binding affinities of the metallo-chaperones Atx1, Atox1, and related proteins: detection probes and affinity standards. J Biol Chem (2011) 1.35
Charting the travels of copper in eukaryotes from yeast to mammals. Biochim Biophys Acta (2012) 1.25
Mitochondrial disulfide relay: redox-regulated protein import into the intermembrane space. J Biol Chem (2011) 1.24
A new structural paradigm in copper resistance in Streptococcus pneumoniae. Nat Chem Biol (2013) 1.17
A targetable fluorescent sensor reveals that copper-deficient SCO1 and SCO2 patient cells prioritize mitochondrial copper homeostasis. J Am Chem Soc (2011) 1.16
Copper signaling in the mammalian nervous system: synaptic effects. J Neurosci Res (2012) 1.03
Atomic-resolution monitoring of protein maturation in live human cells by NMR. Nat Chem Biol (2013) 1.01
Regulation of Cisplatin cytotoxicity by cu influx transporters. Met Based Drugs (2011) 1.00
Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro. Proc Natl Acad Sci U S A (2011) 1.00
An intercellular heme-trafficking protein delivers maternal heme to the embryo during development in C. elegans. Cell (2011) 1.00
Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases). Adv Nutr (2011) 0.99
Cellular glutathione plays a key role in copper uptake mediated by human copper transporter 1. Am J Physiol Cell Physiol (2013) 0.98
Importance of electrostatic polarizability in calculating cysteine acidity constants and copper(I) binding energy of Bacillus subtilis CopZ. J Comput Chem (2012) 0.97
Synthetic fluorescent probes for studying copper in biological systems. Chem Soc Rev (2015) 0.96
Thermodynamics of copper and zinc distribution in the cyanobacterium Synechocystis PCC 6803. Proc Natl Acad Sci U S A (2011) 0.94
Copper transport and trafficking at the host-bacterial pathogen interface. Acc Chem Res (2014) 0.93
Variations in methanobactin structure influences copper utilization by methane-oxidizing bacteria. Proc Natl Acad Sci U S A (2012) 0.91
The Menkes and Wilson disease genes counteract in copper toxicosis in Labrador retrievers: a new canine model for copper-metabolism disorders. Dis Model Mech (2016) 0.91
Copper is an endogenous modulator of neural circuit spontaneous activity. Proc Natl Acad Sci U S A (2014) 0.91
Recognition- and reactivity-based fluorescent probes for studying transition metal signaling in living systems. Acc Chem Res (2015) 0.89
Measuring copper and zinc superoxide dismutase from spinal cord tissue using electrospray mass spectrometry. Anal Biochem (2011) 0.89
Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis. Proc Natl Acad Sci U S A (2014) 0.87
Robust affinity standards for Cu(I) biochemistry. J Am Chem Soc (2013) 0.87
Copper economy in Chlamydomonas: prioritized allocation and reallocation of copper to respiration vs. photosynthesis. Proc Natl Acad Sci U S A (2015) 0.87
Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism. Sci Rep (2013) 0.85
In-cell NMR in E. coli to monitor maturation steps of hSOD1. PLoS One (2011) 0.85
Biochemical characterization of P-type copper ATPases. Biochem J (2014) 0.84
Copper starvation-inducible protein for cytochrome oxidase biogenesis in Bradyrhizobium japonicum. J Biol Chem (2012) 0.84
Structure and metal loading of a soluble periplasm cuproprotein. J Biol Chem (2010) 0.84
Role of glutaredoxin1 and glutathione in regulating the activity of the copper-transporting P-type ATPases, ATP7A and ATP7B. J Biol Chem (2010) 0.84
The ScoI homologue SenC is a copper binding protein that interacts directly with the cbb₃-type cytochrome oxidase in Rhodobacter capsulatus. Biochim Biophys Acta (2012) 0.83
Copper at the Fungal Pathogen-Host Axis. J Biol Chem (2015) 0.83
Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Mol Biol Cell (2015) 0.83
Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function. Ann N Y Acad Sci (2014) 0.83
An expanding range of functions for the copper chaperone/antioxidant protein Atox1. Antioxid Redox Signal (2013) 0.83
Probing the coordination environment of the human copper chaperone HAH1: characterization of Hg(II)-bridged homodimeric species in solution. Chemistry (2013) 0.82
Cellular transport and homeostasis of essential and nonessential metals. Metallomics (2012) 0.82
Sco proteins are involved in electron transfer processes. J Biol Inorg Chem (2010) 0.82
The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons. PLoS One (2010) 0.82
Modeling the effect of copper availability on bacterial denitrification. Microbiologyopen (2013) 0.81
Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD(G93A) mice co-expressing the Copper-Chaperone-for-SOD. Neurobiol Dis (2016) 0.81
Evolution of the genetic code by incorporation of amino acids that improved or changed protein function. J Mol Evol (2013) 0.81
Bacterial cytosolic proteins with a high capacity for Cu(I) that protect against copper toxicity. Sci Rep (2016) 0.80
Decreased copper in Alzheimer's disease brain is predominantly in the soluble extractable fraction. Int J Alzheimers Dis (2013) 0.80
Loop recognition and copper-mediated disulfide reduction underpin metal site assembly of CuA in human cytochrome oxidase. Proc Natl Acad Sci U S A (2015) 0.80
Dynamic multibody protein interactions suggest versatile pathways for copper trafficking. J Am Chem Soc (2012) 0.79
Molecular modulation of the copper and cisplatin transport function of CTR1 and its interaction with IRS-4. Biochem Pharmacol (2014) 0.79
Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains. Chem Commun (Camb) (2013) 0.79
Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun (2016) 0.78
Two metallothionein genes in Oxya chinensis: molecular characteristics, expression patterns and roles in heavy metal stress. PLoS One (2014) 0.77
Resolution of Stepwise Cooperativities of Copper Binding by the Homotetrameric Copper-Sensitive Operon Repressor (CsoR): Impact on Structure and Stability. Angew Chem Int Ed Engl (2015) 0.77
Copper Homeostasis as a Therapeutic Target in Amyotrophic Lateral Sclerosis with SOD1 Mutations. Int J Mol Sci (2016) 0.77
Metallothionein 2A affects the cell respiration by suppressing the expression of mitochondrial protein cytochrome c oxidase subunit II. J Bioenerg Biomembr (2015) 0.77
Copper regulates cyclic-AMP-dependent lipolysis. Nat Chem Biol (2016) 0.77
Single-molecule dynamics and mechanisms of metalloregulators and metallochaperones. Biochemistry (2013) 0.77
Metalloproteomics: challenges and prospective for clinical research applications. Expert Rev Proteomics (2014) 0.77
How Mammalian Cells Acquire Copper: An Essential but Potentially Toxic Metal. Biophys J (2016) 0.76
Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective. J Biol Chem (2011) 0.76
Stabilization of Cu(I) for binding and calorimetric measurements in aqueous solution. Dalton Trans (2015) 0.76
Immobilization of gold nanoclusters inside porous electrospun fibers for selective detection of Cu(II): A strategic approach to shielding pristine performance. Sci Rep (2015) 0.76
The copper transporter 1 (CTR1) is required to maintain the stability of copper transporter 2 (CTR2). Metallomics (2015) 0.76
Cooperation between two periplasmic copper chaperones is required for full activity of the cbb3 -type cytochrome c oxidase and copper homeostasis in Rhodobacter capsulatus. Mol Microbiol (2016) 0.75
Cisplatin inhibits MEK1/2. Oncotarget (2015) 0.75
Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans. Metallomics (2016) 0.75
The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution. Antioxidants (Basel) (2016) 0.75
The thermodynamics of protein interactions with essential first row transition metals. Biochim Biophys Acta (2015) 0.75
Selective cysteine modification of metal-free human metallothionein 1a and its isolated domain fragments: Solution structural properties revealed via ESI-MS. Protein Sci (2017) 0.75
Copper-Catalyzed Click Reaction on/in Live Cells. Chem Sci (2016) 0.75
Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization. J Biol Chem (2017) 0.75
Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase. Science (1999) 6.86
Transition metal speciation in the cell: insights from the chemistry of metal ion receptors. Science (2003) 5.12
Metal ion chaperone function of the soluble Cu(I) receptor Atx1. Science (1997) 4.55
Mechanisms for copper acquisition, distribution and regulation. Nat Chem Biol (2008) 4.03
Protein-folding location can regulate manganese-binding versus copper- or zinc-binding. Nature (2008) 2.81
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol (2006) 2.56
Function, structure, and mechanism of intracellular copper trafficking proteins. Annu Rev Biochem (2001) 2.33
STUDIES ON CYTOCHROME OXIDASE. VI. KINETICS OF THE AEROBIC OXIDATION OF FERROCYTOCHROME C BY CYTOCHROME OXIDASE. J Biol Chem (1965) 2.25
Monitoring disulfide bond formation in the eukaryotic cytosol. J Cell Biol (2004) 2.08
Cu(I) binding and transfer by the N terminus of the Wilson disease protein. J Biol Chem (2007) 1.52
Coordination of heavy metals by dithiothreitol, a commonly used thiol group protectant. J Inorg Biochem (2001) 1.41
Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein. J Biol Chem (2006) 1.40
Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives. J Biol Chem (1989) 1.32
Structure of the Ctr1 copper trans'PORE'ter reveals novel architecture. Trends Biochem Sci (2006) 1.28
A structural-dynamical characterization of human Cox17. J Biol Chem (2007) 1.20
Metal-binding mechanism of Cox17, a copper chaperone for cytochrome c oxidase. Biochem J (2004) 1.18
Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR. J Am Chem Soc (2001) 1.18
Thionein/metallothionein control Zn(II) availability and the activity of enzymes. J Biol Inorg Chem (2007) 1.15
Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci (2007) 1.14
Soluble CuA-binding domain from the Paracoccus cytochrome c oxidase. J Biol Chem (1993) 1.11
Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci U S A (2008) 1.11
Preferential binding of copper to the beta domain of metallothionein. J Biol Chem (1984) 1.10
Mechanism of Cu,Zn-superoxide dismutase activation by the human metallochaperone hCCS. J Biol Chem (2000) 1.09
Human Sco1 functional studies and pathological implications of the P174L mutant. Proc Natl Acad Sci U S A (2006) 1.08
The CuAsite of the caa3-type oxidase of Bacillus subtilis is a mixed-valence binuclear copper centre. FEBS Lett (1994) 1.06
Water-soluble, recombinant CuA-domain of the cytochrome ba3 subunit II from Thermus thermophilus. Biochemistry (1996) 1.05
Copper-transporting ATPases ATP7A and ATP7B: cousins, not twins. J Bioenerg Biomembr (2007) 1.02
An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein. FEBS J (2005) 1.00
Studies of energy transport in heart cells. The importance of creatine kinase localization for the coupling of mitochondrial phosphorylcreatine production to oxidative phosphorylation. J Biol Chem (1980) 0.99
Menkes copper-translocating P-type ATPase (ATP7A): biochemical and cell biology properties, and role in Menkes disease. J Bioenerg Biomembr (2002) 0.98
Copper binding to rabbit liver metallothionein. Formation of a continuum of copper(I)-thiolate stoichiometric species. Eur J Biochem (1995) 0.93
Metal acquisition and availability in the mitochondria. Chem Rev (2009) 0.93
Cooperative binding of copper(I) to the metal binding domains in Menkes disease protein. Biochim Biophys Acta (1999) 0.89
Purification of recombinant human apometallothionein-3 and reconstitution with zinc. Protein Expr Purif (2003) 0.82
Cox17, a copper chaperone for cytochrome c oxidase: expression, purification, and formation of mixed disulphide adducts with thiol reagents. Protein Expr Purif (2006) 0.81
Metal ions in biological catalysis: from enzyme databases to general principles. J Biol Inorg Chem (2008) 2.87
The Atx1-Ccc2 complex is a metal-mediated protein-protein interaction. Nat Chem Biol (2006) 2.56
Counting the zinc-proteins encoded in the human genome. J Proteome Res (2006) 2.38
Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: a possible general mechanism for familial ALS. Proc Natl Acad Sci U S A (2007) 2.16
Zinc through the three domains of life. J Proteome Res (2006) 2.11
Evidence of different metabolic phenotypes in humans. Proc Natl Acad Sci U S A (2008) 2.06
Solution structure of Sco1: a thioredoxin-like protein Involved in cytochrome c oxidase assembly. Structure (2003) 2.01
The unusually stable quaternary structure of human Cu,Zn-superoxide dismutase 1 is controlled by both metal occupancy and disulfide status. J Biol Chem (2004) 1.97
Perspectives on NMR in drug discovery: a technique comes of age. Nat Rev Drug Discov (2008) 1.95
Folding studies of Cox17 reveal an important interplay of cysteine oxidation and copper binding. Structure (2005) 1.81
Metallochaperones and metal-transporting ATPases: a comparative analysis of sequences and structures. Genome Res (2002) 1.80
MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. Nat Struct Mol Biol (2009) 1.60
Protonless NMR experiments for sequence-specific assignment of backbone nuclei in unfolded proteins. J Am Chem Soc (2006) 1.54
Metalloproteomes: a bioinformatic approach. Acc Chem Res (2009) 1.52
A copper(I) protein possibly involved in the assembly of CuA center of bacterial cytochrome c oxidase. Proc Natl Acad Sci U S A (2005) 1.52
NMR reveals pathway for ferric mineral precursors to the central cavity of ferritin. Proc Natl Acad Sci U S A (2009) 1.48
Structure of human Wilson protein domains 5 and 6 and their interplay with domain 4 and the copper chaperone HAH1 in copper uptake. Proc Natl Acad Sci U S A (2006) 1.47
A redox switch in CopC: an intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites. Proc Natl Acad Sci U S A (2003) 1.46
Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice. Gastroenterology (2010) 1.44
Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding. Biochemistry (2003) 1.44
Metabolomics: available results, current research projects in breast cancer, and future applications. J Clin Oncol (2007) 1.42
Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs. Biochemistry (2004) 1.41
A large dust/ice ratio in the nucleus of comet 9P/Tempel 1. Nature (2005) 1.40
Solution structure and intermolecular interactions of the third metal-binding domain of ATP7A, the Menkes disease protein. J Biol Chem (2006) 1.40
Italy must invest more in science and technology. Nature (2008) 1.38
Individual human phenotypes in metabolic space and time. J Proteome Res (2009) 1.29
SOD1 and amyotrophic lateral sclerosis: mutations and oligomerization. PLoS One (2008) 1.27
Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide. J Neurochem (2008) 1.27
A novel intermembrane space-targeting signal docks cysteines onto Mia40 during mitochondrial oxidative folding. J Cell Biol (2009) 1.26
A hint to search for metalloproteins in gene banks. Bioinformatics (2004) 1.25
Occurrence of copper proteins through the three domains of life: a bioinformatic approach. J Proteome Res (2007) 1.24
13C direct detection experiments on the paramagnetic oxidized monomeric copper, zinc superoxide dismutase. J Am Chem Soc (2003) 1.23
Metal-MACiE: a database of metals involved in biological catalysis. Bioinformatics (2009) 1.23
A hint for the function of human Sco1 from different structures. Proc Natl Acad Sci U S A (2006) 1.23
Complete assignment of heteronuclear protein resonances by protonless NMR spectroscopy. Angew Chem Int Ed Engl (2005) 1.22
Fast resonance assignment and fold determination of human superoxide dismutase by high-resolution proton-detected solid-state MAS NMR spectroscopy. Angew Chem Int Ed Engl (2011) 1.21
A structural-dynamical characterization of human Cox17. J Biol Chem (2007) 1.20
Cellular copper distribution: a mechanistic systems biology approach. Cell Mol Life Sci (2010) 1.18
Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1. Biochemistry (2008) 1.18
Mechanism of Cu(A) assembly. Nat Chem Biol (2008) 1.17
Solid-state NMR spectroscopy of a paramagnetic protein: assignment and study of human dimeric oxidized CuII-ZnII superoxide dismutase (SOD). Angew Chem Int Ed Engl (2007) 1.17
Molecular chaperone function of Mia40 triggers consecutive induced folding steps of the substrate in mitochondrial protein import. Proc Natl Acad Sci U S A (2010) 1.16
Solution structure of CopC: a cupredoxin-like protein involved in copper homeostasis. Structure (2002) 1.15
Paramagnetism-based restraints for Xplor-NIH. J Biomol NMR (2004) 1.15
Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks. J Biomol NMR (2011) 1.15
High-field dynamic nuclear polarization with high-spin transition metal ions. J Am Chem Soc (2011) 1.15
Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR. Proc Natl Acad Sci U S A (2011) 1.14
A method for C(alpha) direct-detection in protonless NMR. J Magn Reson (2007) 1.13
Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1. Biochemistry (2004) 1.13
Structural and dynamic aspects related to oligomerization of apo SOD1 and its mutants. Proc Natl Acad Sci U S A (2009) 1.12
Cyanobacterial metallochaperone inhibits deleterious side reactions of copper. Proc Natl Acad Sci U S A (2011) 1.12
Human SOD1 before harboring the catalytic metal: solution structure of copper-depleted, disulfide-reduced form. J Biol Chem (2005) 1.12
Structural model for an alkaline form of ferricytochrome C. J Am Chem Soc (2003) 1.11
A structural characterization of human SCO2. Structure (2007) 1.11
Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics (2011) 1.11
Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer. Proc Natl Acad Sci U S A (2008) 1.11
Structure and backbone dynamics of a microcrystalline metalloprotein by solid-state NMR. Proc Natl Acad Sci U S A (2012) 1.10
The coiled coil-helix-coiled coil-helix proteins may be redox proteins. FEBS Lett (2009) 1.09
Human Sco1 functional studies and pathological implications of the P174L mutant. Proc Natl Acad Sci U S A (2006) 1.08
Structural analysis of metal sites in proteins: non-heme iron sites as a case study. J Mol Biol (2009) 1.06
Structural characterization of CHCHD5 and CHCHD7: two atypical human twin CX9C proteins. J Struct Biol (2012) 1.06
Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution. J Biol Chem (2005) 1.05
Structure and dynamics of copper-free SOD: The protein before binding copper. Protein Sci (2002) 1.04
An NMR study of the interaction of the N-terminal cytoplasmic tail of the Wilson disease protein with copper(I)-HAH1. J Biol Chem (2009) 1.04
Paramagnetically induced residual dipolar couplings for solution structure determination of lanthanide binding proteins. J Am Chem Soc (2002) 1.04
The G-triplex DNA. Angew Chem Int Ed Engl (2013) 1.04
A docking approach to the study of copper trafficking proteins; interaction between metallochaperones and soluble domains of copper ATPases. Structure (2004) 1.03
A bioinformatics view of zinc enzymes. J Inorg Biochem (2011) 1.02
Minimal functional sites allow a classification of zinc sites in proteins. PLoS One (2011) 1.02
Understanding copper trafficking in bacteria: interaction between the copper transport protein CopZ and the N-terminal domain of the copper ATPase CopA from Bacillus subtilis. Biochemistry (2003) 1.02
Atomic-resolution monitoring of protein maturation in live human cells by NMR. Nat Chem Biol (2013) 1.01
Superoxide dismutase folding/unfolding pathway: role of the metal ions in modulating structural and dynamical features. J Mol Biol (2003) 1.01
An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein. FEBS J (2005) 1.00
Solution structures of a cyanobacterial metallochaperone: insight into an atypical copper-binding motif. J Biol Chem (2004) 1.00
Solution structure of Cox11, a novel type of beta-immunoglobulin-like fold involved in CuB site formation of cytochrome c oxidase. J Biol Chem (2004) 1.00