Manganese: recent advances in understanding its transport and neurotoxicity.

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Published in Toxicol Appl Pharmacol on March 12, 2007

Authors

Michael Aschner1, Tomás R Guilarte, Jay S Schneider, Wei Zheng

Author Affiliations

1: Department of Pediatrics, and The Kennedy Center for Research on Human Development, Vanderbilt University, School of Medicine, Nashville, TN 37232-2495, USA. michael.aschner@vanderbilt.edu

Associated clinical trials:

Manganese-Enhanced Magnetic Resonance Imaging in Healthy Volunteers and People With Multiple Sclerosis | NCT01326715

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DNA transformation. Methods Cell Biol (1995) 9.27

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Chronic manganese poisoning. Clinical picture and manganese turnover. Neurology (1967) 1.71

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Alteration of iron homeostasis following chronic exposure to manganese in rats. Brain Res (1999) 1.68

EXPERIMENTAL MANGANESE ENCEPHALOPATHY IN MONKEYS. A PRELIMINARY REPORT. J Neuropathol Exp Neurol (1963) 1.67

Transferrin and iron in normal, Alzheimer's disease, and Parkinson's disease brain regions. J Neurochem (1995) 1.65

Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices. Am J Ind Med (1987) 1.63

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Manganese intoxication during total parenteral nutrition. Lancet (1992) 1.60

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Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord (1998) 1.55

Manganese and extrapyramidal disorders (a critical review and tribute to Dr. George C. Cotzias). Neurotoxicology (1984) 1.55

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Manganese encephalopathy: utility of early magnetic resonance imaging. Br J Ind Med (1993) 1.53

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Brain magnetic resonance imaging and manganese concentrations in red blood cells of smelting workers: search for biomarkers of manganese exposure. Neurotoxicology (2006) 1.52

Human blood-brain barrier transferrin receptor. Metabolism (1987) 1.50

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Hepatic encephalopathy: An update of pathophysiologic mechanisms. Proc Soc Exp Biol Med (1999) 1.36

Transferrin receptors in rat brain: neuropeptide-like pattern and relationship to iron distribution. Proc Natl Acad Sci U S A (1985) 1.35

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Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. Brain Res (1994) 1.26

Effects of manganese oxide on monkeys as revealed by a combined neurochemical, histological and neurophysiological evaluation. Arch Toxicol (1987) 1.26

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Manganese (Mn) transport across the rat blood-brain barrier: saturable and transferrin-dependent transport mechanisms. Brain Res Bull (1994) 1.25

Chronic manganese poisoning. Clearance of tissue manganese concentrations with persistance of the neurological picture. Neurology (1968) 1.25

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Neurobehavioral effects of manganese in workers from a ferroalloy plant after temporary cessation of exposure. Scand J Work Environ Health (1995) 1.23

Modification of chronic manganese poisoning. Treatment with L-dopa or 5-OH tryptophane. N Engl J Med (1970) 1.23

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Interactions between excessive manganese exposures and dietary iron-deficiency in neurodegeneration. Environ Toxicol Pharmacol (2005) 1.22

Chronic manganese intoxication. Arch Neurol (1989) 1.22

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Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells. Brain Res (2001) 1.21

Manganese neurotoxicity and glutamate-GABA interaction. Neurochem Int (2003) 1.20

Drug "diffusion" within the brain. Ann N Y Acad Sci (1988) 1.19

Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res (1997) 1.18

Role of manganese in dystonia. Adv Neurol (1976) 1.18

Manganese intoxication and chronic liver failure. Ann Neurol (1994) 1.18

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Manganese distribution across the blood-brain barrier. I. Evidence for carrier-mediated influx of managanese citrate as well as manganese and manganese transferrin. Neurotoxicology (2003) 1.11

[18F]FDOPA PET and clinical features in parkinsonism due to manganism. Mov Disord (2005) 1.11

Idiopathic parkinsonism with superimposed manganese exposure: utility of positron emission tomography. Neurotoxicology (1999) 1.10

The chromium, manganese, and cobalt complexes of transferrin. J Biol Chem (1969) 1.10

Long-term progression in chronic manganism: ten years of follow-up. Neurology (1998) 1.09

Existing and emerging mechanisms for transport of iron and manganese to the brain. J Neurosci Res (1999) 1.08

Saturable transport of manganese(II) across the rat blood-brain barrier. J Neurochem (1991) 1.08

Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology (2004) 1.08

Neuropsychological sequelae of exposure to welding fumes in a group of occupationally exposed men. Int J Hyg Environ Health (2003) 1.07

Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography. J Cereb Blood Flow Metab (1987) 1.07

Dopamine transporter density is decreased in parkinsonian patients with a history of manganese exposure: what does it mean? Mov Disord (2002) 1.06

SLC11 family of H+-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch (2003) 1.06

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Manganese intoxication during total parenteral nutrition: report of two cases and review of the literature. J Neurol Sci (1999) 1.06

Manganese transport across the blood-brain barrier: relationship to iron homeostasis. Brain Res Bull (1990) 1.05

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Compound Management for Quantitative High-Throughput Screening. JALA Charlottesv Va (2008) 2.11

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol (2011) 2.09

A meta-analysis of bisphosphonates for periprosthetic bone loss after total joint arthroplasty. J Orthop Sci (2013) 2.09

Vanadium exposure-induced neurobehavioral alterations among Chinese workers. Neurotoxicology (2013) 2.08

Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats. Hypertension (2004) 2.05

An automated, broad-based, near real-time public health surveillance system using presentations to hospital Emergency Departments in New South Wales, Australia. BMC Public Health (2005) 1.99

Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium. PLoS Genet (2010) 1.98

Elevated blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentrations in essential tremor. Neurotoxicology (2007) 1.98

The choroid plexus removes beta-amyloid from brain cerebrospinal fluid. Exp Biol Med (Maywood) (2005) 1.97

Genome-wide association study of glioma and meta-analysis. Hum Genet (2012) 1.96

Circulating 25-hydroxyvitamin D and the risk of rarer cancers: Design and methods of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.95

Reproducibility and validity of the Shanghai Women's Health Study physical activity questionnaire. Am J Epidemiol (2003) 1.95

Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium. PLoS Genet (2011) 1.94

Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer. PLoS Genet (2012) 1.91

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet (2012) 1.90

Correlates of circulating 25-hydroxyvitamin D: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Am J Epidemiol (2010) 1.90

A robotic platform for quantitative high-throughput screening. Assay Drug Dev Technol (2008) 1.90

The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90

Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Arch Intern Med (2010) 1.88

Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study. Am J Clin Nutr (2008) 1.87

Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium. Am J Epidemiol (2009) 1.87

Evaluation of breast cancer susceptibility loci in Chinese women. Cancer Epidemiol Biomarkers Prev (2010) 1.87

Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia Cohort Consortium. Am J Epidemiol (2015) 1.87

Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer. Nat Genet (2012) 1.85

Genome-wide association study identifies a common variant associated with risk of endometrial cancer. Nat Genet (2011) 1.84

Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene. Clin Cancer Res (2009) 1.83

Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res (2010) 1.82

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82

Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4. Nat Genet (2012) 1.78

Association between body mass index and cardiovascular disease mortality in east Asians and south Asians: pooled analysis of prospective data from the Asia Cohort Consortium. BMJ (2013) 1.78

Intra-individual variation of plasma adipokine levels and utility of single measurement of these biomarkers in population-based studies. Cancer Epidemiol Biomarkers Prev (2007) 1.77

Use of complementary and alternative medicine by chinese women with breast cancer. Breast Cancer Res Treat (2004) 1.76

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73

Exome sequencing generates high quality data in non-target regions. BMC Genomics (2012) 1.72

Combined impact of lifestyle-related factors on total and cause-specific mortality among Chinese women: prospective cohort study. PLoS Med (2010) 1.71

Association of cyclin D1 genotype with breast cancer risk and survival. Cancer Epidemiol Biomarkers Prev (2005) 1.69

Lead neurotoxicity: from exposure to molecular effects. Brain Res Brain Res Rev (2005) 1.69

Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation (2012) 1.69

Genome-wide association study of survival in patients with pancreatic adenocarcinoma. Gut (2012) 1.66

Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. Nat Genet (2012) 1.64

Female protection in progressive renal disease is associated with estradiol attenuation of superoxide production. Gend Med (2007) 1.63

Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. J Clin Oncol (2006) 1.62

Genetic polymorphisms in the estrogen receptor alpha gene and risk of breast cancer: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev (2003) 1.62

Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types. Carcinogenesis (2005) 1.61

Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies. Am J Clin Nutr (2013) 1.61

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61

Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res (2003) 1.60

Evaluating cost efficiency of SNP chips in genome-wide association studies. Genet Epidemiol (2008) 1.60

Obesity and weight change in relation to breast cancer survival. Breast Cancer Res Treat (2010) 1.60

A large population of 'Lyman-break' galaxies in a protocluster at redshift z approximately 4.1. Nature (2004) 1.59