Published in Proc Natl Acad Sci U S A on November 06, 2007
Mechanisms of implantation: strategies for successful pregnancy. Nat Med (2012) 2.50
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res (2008) 2.15
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nat Med (2011) 1.41
Physiological and molecular determinants of embryo implantation. Mol Aspects Med (2013) 1.33
Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology (2008) 1.18
Uterine disorders and pregnancy complications: insights from mouse models. J Clin Invest (2010) 1.17
Prokineticin 1 signaling and gene regulation in early human pregnancy. Endocrinology (2008) 1.17
Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res (2009) 1.14
The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling. Mol Cell Endocrinol (2011) 1.07
HB-EGF: a unique mediator of embryo-uterine interactions during implantation. Exp Cell Res (2008) 1.05
Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol Reprod (2010) 1.03
Heparin-binding EGF-like growth factor induces heart interstitial fibrosis via an Akt/mTor/p70s6k pathway. PLoS One (2012) 0.99
Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation. J Biol Chem (2010) 0.98
Diverse functions of HBEGF during pregnancy. Mol Reprod Dev (2009) 0.94
Minireview: Steroid-regulated paracrine mechanisms controlling implantation. Mol Endocrinol (2014) 0.94
High throughput, cell type-specific analysis of key proteins in human endometrial biopsies of women from fertile and infertile couples. Hum Reprod (2012) 0.91
Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res (2014) 0.89
Function-specific intracellular signaling pathways downstream of heparin-binding EGF-like growth factor utilized by human trophoblasts. Biol Reprod (2010) 0.88
An integrated view of L-selectin and trophinin function in human embryo implantation. J Obstet Gynaecol Res (2008) 0.87
Role of uterine stromal-epithelial crosstalk in embryo implantation. Int J Dev Biol (2014) 0.85
Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors. PLoS One (2013) 0.84
The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet (2014) 0.83
Restraint stress inhibits mouse implantation: temporal window and the involvement of HB-EGF, estrogen and progesterone. PLoS One (2013) 0.82
Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization. Cell Cycle (2015) 0.79
Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor. Mamm Genome (2009) 0.79
Contraceptive vaccines targeting factors involved in establishment of pregnancy. Am J Reprod Immunol (2011) 0.78
Expression of PRB, FKBP52 and HB-EGF relating with ultrasonic evaluation of endometrial receptivity. PLoS One (2012) 0.77
Compartmentalized gene expression profiling of receptive endometrium reveals progesterone regulated ENPP3 is differentially expressed and secreted in glycosylated form. Sci Rep (2016) 0.75
Identification of Differentially Expressed Genes Associated with Litter Size in Berkshire Pig Placenta. PLoS One (2016) 0.75
Mechanisms of uterine estrogen signaling during early pregnancy in mice: an update. J Mol Endocrinol (2016) 0.75
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. EMBO J (2017) 0.75
EGF-ERBB signalling: towards the systems level. Nat Rev Mol Cell Biol (2006) 10.39
Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet (2006) 4.92
EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science (2004) 3.66
Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J (2003) 3.06
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development (1999) 2.89
Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis (2005) 2.67
Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci U S A (1993) 2.51
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A (2003) 2.45
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med (2002) 2.20
Paracrine and autocrine regulation of epidermal growth factor-like factors in cumulus oocyte complexes and granulosa cells: key roles for prostaglandin synthase 2 and progesterone receptor. Mol Endocrinol (2006) 2.14
Luteinizing hormone-dependent activation of the epidermal growth factor network is essential for ovulation. Mol Cell Biol (2006) 2.12
Binding specificities and affinities of egf domains for ErbB receptors. FEBS Lett (1999) 2.06
Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse. Mol Endocrinol (1999) 1.84
Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. Proc Natl Acad Sci U S A (2001) 1.82
HB-EGF is a potent inducer of tumor growth and angiogenesis. Cancer Res (2004) 1.63
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus. Mol Endocrinol (1995) 1.62
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc Natl Acad Sci U S A (2004) 1.52
Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. Dev Biol (2002) 1.48
Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. Cancer Res (2004) 1.41
Dysregulation of EGF family of growth factors and COX-2 in the uterus during the preattachment and attachment reactions of the blastocyst with the luminal epithelium correlates with implantation failure in LIF-deficient mice. Mol Endocrinol (2000) 1.38
Expression of the epidermal growth factor receptor gene is regulated in mouse blastocysts during delayed implantation. Proc Natl Acad Sci U S A (1993) 1.37
Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques. J Clin Invest (1995) 1.28
Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol (2004) 1.26
Heparin-binding EGF-like growth factor interacts with mouse blastocysts independently of ErbB1: a possible role for heparan sulfate proteoglycans and ErbB4 in blastocyst implantation. Development (1999) 1.20
Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus. Mol Endocrinol (2001) 1.17
The heparin-binding domain of amphiregulin necessitates the precursor pro-region for growth factor secretion. Mol Cell Biol (1994) 1.12
Temporal and spatial regulation of expression of heparin-binding epidermal growth factor-like growth factor in the human endometrium: a possible role in blastocyst implantation. Dev Genet (1997) 1.09
Acceleration of trophoblast differentiation by heparin-binding EGF-like growth factor is dependent on the stage-specific activation of calcium influx by ErbB receptors in developing mouse blastocysts. Development (2000) 1.08
Multiple roles for heparin-binding epidermal growth factor-like growth factor are suggested by its cell-specific expression during the human endometrial cycle and early placentation. J Clin Endocrinol Metab (1999) 1.07
Heparin-binding epidermal growth factor significantly improves human blastocyst development and hatching in serum-free medium. Hum Reprod (1998) 1.07
Regulated expression of heparin-binding EGF-like growth factor (HB-EGF) in the human endometrium: a potential paracrine role during implantation. Mol Reprod Dev (2002) 1.01
Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A (2004) 1.00
Expression of betacellulin and epiregulin genes in the mouse uterus temporally by the blastocyst solely at the site of its apposition is coincident with the "window" of implantation. Dev Biol (1997) 1.00
Cell-type-specific expression of transforming growth factor-alpha in the mouse uterus during the peri-implantation period. Biol Reprod (1991) 0.96
Heparin-binding epidermal growth factor (HB-EGF) may improve embryonic development and implantation by increasing vitronectin receptor (integrin alphanubeta3) expression in peri-implantation mouse embryos. J Assist Reprod Genet (2006) 0.83
Analysis of the expression of growth factor, interleukin-1, and lactoferrin genes and the distribution of inflammatory leukocytes in the preimplantation mouse oviduct. Biol Reprod (1994) 0.82
Can mouse blastocysts stimulate a uterine response before losing the zona pellucida? J Reprod Fertil (1969) 0.80
Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet (2006) 4.92
Molecular cues to implantation. Endocr Rev (2004) 4.21
Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc Natl Acad Sci U S A (2003) 3.30
cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron (2002) 3.22
The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19
Cre-mediated recombination in cell lineages that express the progesterone receptor. Genesis (2005) 2.67
Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell (2004) 2.60
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1). Proc Natl Acad Sci U S A (2003) 2.58
Mechanisms of implantation: strategies for successful pregnancy. Nat Med (2012) 2.50
The antiproliferative action of progesterone in uterine epithelium is mediated by Hand2. Science (2011) 2.46
Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A (2003) 2.45
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med (2006) 2.30
Estrogen is a critical determinant that specifies the duration of the window of uterine receptivity for implantation. Proc Natl Acad Sci U S A (2003) 2.27
Nociceptors are interleukin-1beta sensors. J Neurosci (2008) 2.26
BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol (2007) 2.18
MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A (2007) 2.16
Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice. Cancer Res (2008) 2.15
Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod (2010) 2.12
Deciphering the cross-talk of implantation: advances and challenges. Science (2002) 2.12
Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus. Nat Genet (2006) 2.11
Bmp2 is critical for the murine uterine decidual response. Mol Cell Biol (2007) 2.09
De novo establishment of wild-type song culture in the zebra finch. Nature (2009) 2.05
Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer. Clin Cancer Res (2005) 1.99
Ligand-independent dimer formation of epidermal growth factor receptor (EGFR) is a step separable from ligand-induced EGFR signaling. Mol Biol Cell (2002) 1.95
Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human. J Biol Chem (2007) 1.91
Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A (2005) 1.91
Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Development (2002) 1.91
Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med (2004) 1.89
The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci (2006) 1.88
Fatty acid amide hydrolase deficiency limits early pregnancy events. J Clin Invest (2006) 1.86
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A (2006) 1.84
Reproductive functions of progesterone receptors. Recent Prog Horm Res (2002) 1.82
WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse. FASEB J (2010) 1.79
COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity. PLoS Genet (2007) 1.79
Canonical Wnt signaling is critical to estrogen-mediated uterine growth. Mol Endocrinol (2004) 1.76
Mutation of the androgen receptor causes oncogenic transformation of the prostate. Proc Natl Acad Sci U S A (2005) 1.73
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer. PLoS One (2008) 1.72
CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis. Cancer Cell (2013) 1.71
BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest (2013) 1.70
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res (2005) 1.68
The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev Biol (2009) 1.67
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest (2011) 1.67
Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia. Proc Natl Acad Sci U S A (2005) 1.65
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice. J Clin Invest (2010) 1.64
A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol (2002) 1.61
Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor. Endocrinology (2005) 1.59
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Res (2008) 1.58
Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J Lipid Res (2009) 1.58
Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet (2013) 1.56
Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci (2005) 1.55
Heparin-binding epidermal growth factor-like growth factor as a novel targeting molecule for cancer therapy. Cancer Sci (2006) 1.55
Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Cancer Res (2003) 1.53
Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med (2004) 1.52
Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation. Proc Natl Acad Sci U S A (2004) 1.52
NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod (2012) 1.52
Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse. Mol Cell Biol (2006) 1.52
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes. J Cell Biol (2003) 1.51
Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis. Cancer Res (2007) 1.49
Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. Dev Biol (2002) 1.48
Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model. Am J Respir Cell Mol Biol (2008) 1.44
OX40 signaling favors the induction of T(H)9 cells and airway inflammation. Nat Immunol (2012) 1.43
Heparin-binding EGF-like growth factor is a promising target for ovarian cancer therapy. Cancer Res (2004) 1.41
A repressive role for prohibitin in estrogen signaling. Mol Endocrinol (2007) 1.40
MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation. Mol Endocrinol (2014) 1.39
Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res (2008) 1.39
The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development. Mol Cell Biol (2004) 1.39
Apoptosis induced by endoplasmic reticulum stress involved in diabetic kidney disease. Biochem Biophys Res Commun (2008) 1.37
Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol (2002) 1.37
Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities. J Cell Biol (2003) 1.36
Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res (2005) 1.36
Evidence for coordinated interaction of cyclin D3 with p21 and cdk6 in directing the development of uterine stromal cell decidualization and polyploidy during implantation. Mech Dev (2002) 1.36
Variation in commercial rodent diets induces disparate molecular and physiological changes in the mouse uterus. Proc Natl Acad Sci U S A (2005) 1.34