Published in J Am Chem Soc on June 11, 2003
Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels. Genome Biol (2004) 2.39
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. J Neurosci (2007) 1.45
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. J Neurosci (2008) 1.18
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proc Natl Acad Sci U S A (2010) 1.18
A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. J Gen Physiol (2006) 1.17
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. Biochemistry (2007) 1.12
Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor. Biophys J (2010) 1.08
Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes. J Biol Chem (2011) 1.08
Atypical nicotinic agonist bound conformations conferring subtype selectivity. Proc Natl Acad Sci U S A (2008) 1.07
Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. Biophys J (2009) 1.07
Synaptic neurotransmitter-gated receptors. Cold Spring Harb Perspect Biol (2012) 0.98
Molecular modeling of the GABA(C) receptor ligand-binding domain. J Mol Model (2005) 0.95
Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. J Pharmacol Exp Ther (2009) 0.93
A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Mol Pharmacol (2011) 0.92
Molecular characterization of agonists that bind to an insect GABA receptor. Biochemistry (2010) 0.88
Functional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing ground. J Med Chem (2014) 0.86
Multiple Tyrosine Residues Contribute to GABA Binding in the GABA(C) Receptor Binding Pocket. ACS Chem Neurosci (2011) 0.83
Principles of agonist recognition in Cys-loop receptors. Front Physiol (2014) 0.82
Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl. ACS Chem Biol (2014) 0.82
Probing the non-canonical interface for agonist interaction with an α5 containing nicotinic acetylcholine receptor. Neuropharmacology (2013) 0.82
Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels. Sci Rep (2015) 0.79
Using pharmacological chaperones to restore proteostasis. Pharmacol Res (2014) 0.79
Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science (2004) 5.94
A gating charge transfer center in voltage sensors. Science (2010) 3.60
Cys-loop receptors: new twists and turns. Trends Neurosci (2004) 3.58
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. Nature (2005) 3.18
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. PLoS Comput Biol (2009) 2.88
Cation-pi interactions in ligand recognition and catalysis. Trends Pharmacol Sci (2002) 2.75
In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors. Neuron (2008) 2.69
RGS9 modulates dopamine signaling in the basal ganglia. Neuron (2003) 2.61
The structural basis of function in Cys-loop receptors. Q Rev Biophys (2010) 2.45
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med (2005) 2.43
Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. J Neurosci (2007) 2.37
Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry (2002) 2.22
Nicotine binding to brain receptors requires a strong cation-pi interaction. Nature (2009) 2.21
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev (2003) 2.05
Reversible silencing of neuronal excitability in behaving mice by a genetically targeted, ivermectin-gated Cl- channel. Neuron (2007) 1.95
Neural systems governed by nicotinic acetylcholine receptors: emerging hypotheses. Neuron (2011) 1.82
D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci (2005) 1.74
Selective electrical silencing of mammalian neurons in vitro by the use of invertebrate ligand-gated chloride channels. J Neurosci (2002) 1.71
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J (2009) 1.68
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. J Biol Chem (2005) 1.61
GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. J Neurophysiol (2003) 1.60
Number, density, and surface/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. J Neurosci (2002) 1.58
A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor. Chem Biol (2005) 1.53
Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled alpha6 and beta3 subunits. Mol Pharmacol (2007) 1.52
Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res (2007) 1.50
The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron (2006) 1.46
Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol (2011) 1.46
Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. J Neurosci (2007) 1.45
Multiplexed, high density electrophysiology with nanofabricated neural probes. PLoS One (2011) 1.43
Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4* nicotinic receptors. J Neurosci (2005) 1.42
Gating transitions in bacterial ion channels measured at 3 microns resolution. J Gen Physiol (2004) 1.42
GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J Neurosci (2005) 1.41
Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors. J Neurosci (2010) 1.41
Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor. J Am Chem Soc (2005) 1.38
Codon optimization of Caenorhabditis elegans GluCl ion channel genes for mammalian cells dramatically improves expression levels. J Neurosci Methods (2003) 1.37
Structural differences determine the relative selectivity of nicotinic compounds for native alpha 4 beta 2*-, alpha 6 beta 2*-, alpha 3 beta 4*- and alpha 7-nicotine acetylcholine receptors. Neuropharmacology (2010) 1.37
Investigating lipid composition effects on the mechanosensitive channel of large conductance (MscL) using molecular dynamics simulations. Biophys J (2003) 1.36
Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis. J Neurosci (2004) 1.35
A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site. Proc Natl Acad Sci U S A (2004) 1.34
Generation and evaluation of a large mutational library from the Escherichia coli mechanosensitive channel of large conductance, MscL: implications for channel gating and evolutionary design. J Biol Chem (2003) 1.34
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists. J Biol Chem (2007) 1.31
Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. J Biol Chem (2007) 1.27
A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. J Biol Chem (2007) 1.26
Selective elimination of glutamate activation and introduction of fluorescent proteins into a Caenorhabditis elegans chloride channel. FEBS Lett (2002) 1.25
Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. J Neurosci (2009) 1.23
Voltage-dependent hydration and conduction properties of the hydrophobic pore of the mechanosensitive channel of small conductance. Biophys J (2006) 1.22
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
In vivo incorporation of multiple unnatural amino acids through nonsense and frameshift suppression. Proc Natl Acad Sci U S A (2006) 1.19
Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH. Proc Natl Acad Sci U S A (2010) 1.18
A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. J Neurosci (2008) 1.18
A cation-pi interaction between extracellular TEA and an aromatic residue in potassium channels. J Gen Physiol (2006) 1.17
Unnatural amino acid mutagenesis in mapping ion channel function. Curr Opin Neurobiol (2003) 1.16
Nicotine responses in hypersensitive and knockout alpha 4 mice account for tolerance to both hypothermia and locomotor suppression in wild-type mice. Physiol Genomics (2007) 1.16
Time course of inner ear degeneration and deafness in mice lacking the Kir4.1 potassium channel subunit. Hear Res (2003) 1.16
An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating. J Biol Chem (2008) 1.14
Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor. Biochemistry (2007) 1.12
A hydrogen bond in loop A is critical for the binding and function of the 5-HT3 receptor. Biochemistry (2008) 1.12
Five ADNFLE mutations reduce the Ca2+ dependence of the mammalian alpha4beta2 acetylcholine response. J Physiol (2003) 1.11
Intrinsic noise in cultured hippocampal neurons: experiment and modeling. J Neurosci (2004) 1.10
GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET. J Gen Physiol (2009) 1.10
CNS localization of neuronal nicotinic receptors. J Mol Neurosci (2006) 1.08
Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes. J Biol Chem (2011) 1.08
Control of P2X(2) channel permeability by the cytosolic domain. J Gen Physiol (2002) 1.08
Trafficking of alpha4* nicotinic receptors revealed by superecliptic phluorin: effects of a beta4 amyotrophic lateral sclerosis-associated mutation and chronic exposure to nicotine. J Biol Chem (2011) 1.07
Long-range coupling in an allosteric receptor revealed by mutant cycle analysis. Biophys J (2009) 1.07
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. J Gen Physiol (2014) 1.07
Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway. J Biol Chem (2007) 1.06
Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response. Alcohol Clin Exp Res (2003) 1.05
Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy. Mol Pharmacol (2009) 1.05
α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. J Neurosci (2012) 1.03
Total chemical synthesis and electrophysiological characterization of mechanosensitive channels from Escherichia coli and Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2004) 1.03
Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors. Biophys J (2009) 1.01
Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids. Proc Natl Acad Sci U S A (2009) 1.01
Improved amber and opal suppressor tRNAs for incorporation of unnatural amino acids in vivo. Part 1: minimizing misacylation. RNA (2007) 1.00