Published in Proc Natl Acad Sci U S A on June 06, 2003
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60
The many facets of Notch ligands. Oncogene (2008) 2.57
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol (2005) 1.88
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol (2004) 1.79
From fly wings to targeted cancer therapies: a centennial for notch signaling. Cancer Cell (2014) 1.70
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med (2008) 1.68
Canonical and non-canonical Notch ligands. Curr Top Dev Biol (2010) 1.62
ADAM-17: the enzyme that does it all. Crit Rev Biochem Mol Biol (2010) 1.62
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10. Biochem J (2009) 1.49
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Trafficking of receptor tyrosine kinases to the nucleus. Exp Cell Res (2008) 1.33
GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK. Science (2013) 1.23
Proteolytic processing of delta-like 1 by ADAM proteases. J Biol Chem (2006) 1.21
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A (2008) 1.13
ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12
The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway. Nucleic Acids Res (2007) 1.11
Retracted Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Mol Cell Biol (2005) 1.10
Notch signalling in cancer progression and bone metastasis. Br J Cancer (2011) 1.09
Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture. J Cell Sci (2007) 1.08
An exo-cell assay for examining real-time gamma-secretase activity and inhibition. Mol Neurodegener (2009) 1.04
Neuralized promotes basal to apical transcytosis of delta in epithelial cells. Mol Biol Cell (2010) 1.03
The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline. Development (2010) 1.02
The role of Delta-like 1 shedding in muscle cell self-renewal and differentiation. J Cell Sci (2008) 1.02
Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One (2010) 0.99
A miniaturized 1536-well format gamma-secretase assay. Assay Drug Dev Technol (2009) 0.97
Proteolytic cleavage of Notch: "HIT and RUN". Curr Mol Med (2011) 0.95
Notching on Cancer's Door: Notch Signaling in Brain Tumors. Front Oncol (2015) 0.95
The intracellular region of Notch ligands: does the tail make the difference? Biol Direct (2007) 0.93
ADAM function in embryogenesis. Semin Cell Dev Biol (2008) 0.92
A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. PLoS One (2007) 0.90
The emergence of ADAM10 as a regulator of lymphocyte development and autoimmunity. Mol Immunol (2011) 0.88
The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways. Exp Cell Res (2011) 0.88
Differential surface expression of ADAM10 and ADAM17 on human T lymphocytes and tumor cells. PLoS One (2013) 0.87
Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS One (2008) 0.87
Prevalence of intrinsic disorder in the intracellular region of human single-pass type I proteins: the case of the notch ligand Delta-4. J Proteome Res (2008) 0.86
The role of Adams in Notch signaling. Adv Exp Med Biol (2012) 0.86
Delta activity independent of its activity as a ligand of Notch. BMC Dev Biol (2005) 0.86
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J (2011) 0.86
Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development. Br J Haematol (2010) 0.86
The expression of Delta ligands in the sponge Amphimedon queenslandica suggests an ancient role for Notch signaling in metazoan development. Evodevo (2012) 0.85
IGF-IR in neuroprotection and brain tumors. Front Biosci (Landmark Ed) (2009) 0.83
Cancer stem cells maintain a hierarchy of differentiation by creating their niche. Int J Cancer (2013) 0.82
Neurotrophin-4 (ntf4) mediates neurogenesis in mouse embryonic neural stem cells through the inhibition of the signal transducer and activator of transcription-3 (stat3) and the modulation of the activity of protein kinase B. Cell Mol Neurobiol (2010) 0.82
The very many faces of presenilins and the γ-secretase complex. Protoplasma (2013) 0.82
Notch and delta mRNAs in early-stage and mid-stage drosophila embryos exhibit complementary patterns of protein-producing potentials. Dev Dyn (2010) 0.81
γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease. Cell Mol Neurobiol (2011) 0.81
Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia. Sci Rep (2015) 0.80
Regulation of Notch1 signaling by Delta-like ligand 1 intracellular domain through physical interaction. Mol Cells (2011) 0.80
Shedding of APP limits its synaptogenic activity and cell adhesion properties. Front Cell Neurosci (2014) 0.80
GPI-AP release in cellular, developmental, and reproductive biology. J Lipid Res (2015) 0.80
No evidence for a functional role of bi-directional Notch signaling during angiogenesis. PLoS One (2012) 0.80
Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment. J Biol Chem (2010) 0.79
S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol (2014) 0.79
Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo. PLoS One (2013) 0.78
A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1. PLoS One (2013) 0.78
Lateral inhibition of Notch signaling in neoplastic cells. Oncotarget (2015) 0.77
Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development. Int Immunol (2009) 0.77
Transcriptome analysis of the zebrafish mind bomb mutant. Mol Genet Genomics (2008) 0.77
Combinatorial microenvironmental regulation of liver progenitor differentiation by Notch ligands, TGFβ, and extracellular matrix. Sci Rep (2016) 0.76
Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ. Dermatoendocrinol (2009) 0.76
Jagged1 intracellular domain-mediated inhibition of Notch1 signalling regulates cardiac homeostasis in the postnatal heart. Cardiovasc Res (2015) 0.76
The Notch pathway in the annelid Platynereis: insights into chaetogenesis and neurogenesis processes. Open Biol (2017) 0.75
Glycoprotein nonmetastatic melanoma protein B extracellular fragment shows neuroprotective effects and activates the PI3K/Akt and MEK/ERK pathways via the Na(+)/K(+)-ATPase. Sci Rep (2016) 0.75
The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol (2016) 0.75
Helicobacter pylori Infection of Gastric Epithelial Cells Affects NOTCH Pathway In Vitro. Dig Dis Sci (2016) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene Ther (2000) 12.54
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell (2000) 8.29
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature (1998) 7.43
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE. Mol Cell (2000) 5.53
gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (2001) 4.90
Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature (1999) 4.64
The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev (2003) 4.47
Retracted Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity (1999) 4.42
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Hum Mol Genet (2002) 4.19
The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A (1998) 3.99
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions. EMBO J (2002) 3.87
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell (1997) 3.47
Regulated cleavage of a contact-mediated axon repellent. Science (2000) 3.24
Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol Cell (2000) 2.98
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development (2000) 2.94
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis. Science (1996) 2.77
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science (1999) 2.71
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A (1999) 2.20
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem (2002) 1.97
Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J Biol Chem (2002) 1.83
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling. Development (1997) 1.80
kuzbanian-mediated cleavage of Drosophila Notch. Genes Dev (2002) 1.70
The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage. J Biol Chem (2003) 1.66
The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs. Development (1997) 1.63
Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem Biophys Res Commun (2003) 1.58
The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem (2002) 1.40
Autonomous and non-autonomous regulation of mammalian neurite development by Notch1 and Delta1. Curr Biol (2000) 1.38
Down-regulation of Delta by proteolytic processing. J Cell Biol (2002) 1.37
Notch-induced proteolysis and nuclear localization of the Delta ligand. J Biol Chem (2003) 1.36
Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development. Mol Biol Cell (1998) 1.33
The NOTCH receptor and its ligands. Trends Cell Biol (1997) 1.04
Delta regulates keratinocyte spreading and motility independently of differentiation. Mech Dev (2001) 0.96
A growing family of Notch ligands. Bioessays (1998) 0.88
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature (2002) 3.21
The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol (2004) 1.79
The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation. PLoS Biol (2010) 1.77
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains. EMBO Rep (2006) 1.72
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol (2006) 1.51
AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One (2008) 1.35
Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection. J Neurosci (2003) 1.28
The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation. Am J Hum Genet (2006) 1.24
Osteopetrosis, lymphedema, anhidrotic ectodermal dysplasia, and immunodeficiency in a boy and incontinentia pigmenti in his mother. Pediatrics (2002) 1.21
The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration. J Biol Chem (2004) 1.15
Notch3 and IL-1beta exert opposing effects on a vascular smooth muscle cell inflammatory pathway in which NF-kappaB drives crosstalk. J Cell Sci (2007) 1.01
Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage. Arthritis Rheum (2009) 0.97
NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus. J Allergy Clin Immunol (2011) 0.96
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus. PLoS One (2012) 0.94
The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. J Biol Chem (2012) 0.94
New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein. Blood (2011) 0.93
NF-kappaB activation during acute Helicobacter pylori infection in mice. Infect Immun (2007) 0.92
IKK connects autophagy to major stress pathways. Autophagy (2010) 0.92
Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Apoptosis (2008) 0.91
Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome. Stem Cells Transl Med (2014) 0.91
Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals. J Cell Sci (2013) 0.88
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
The implementation of novel collaborative structures for the identification and resolution of barriers to pluripotent stem cell translation. Stem Cells Dev (2013) 0.86
Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation. Blood (2004) 0.85
Ectodermal influx and cell hypertrophy provide early growth for all murine mammary rudiments, and are differentially regulated among them by Gli3. PLoS One (2011) 0.85
The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors. FASEB J (2013) 0.84
Α-arrestins - new players in Notch and GPCR signaling pathways in mammals. J Cell Sci (2014) 0.81
[Endocytosis and Notch signalling]. Med Sci (Paris) (2006) 0.75
Tracking trafficking of Notch and its ligands in mammalian cells. Methods Mol Biol (2014) 0.75
Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein. J Biol Chem (2005) 0.75