PubRank

M J Smyth

Author PubWeight™ 92.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 NKT cells: facts, functions and fallacies. Immunol Today 2000 4.40
2 Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells. Nat Med 2001 2.74
3 The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species. Proc Natl Acad Sci U S A 2001 2.65
4 Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 2010 2.53
5 Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma. Leukemia 2009 2.50
6 Perforin and interferon-gamma activities independently control tumor initiation, growth, and metastasis. Blood 2001 2.45
7 Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proc Natl Acad Sci U S A 2007 2.10
8 NKT cells are phenotypically and functionally diverse. Eur J Immunol 1999 1.97
9 Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem 1997 1.88
10 Role of ceramide in cellular senescence. J Biol Chem 1995 1.74
11 P-glycoprotein protects leukemia cells against caspase-dependent, but not caspase-independent, cell death. Blood 1999 1.61
12 Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci 2000 1.58
13 Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A 1992 1.55
14 NKT cells and tumor immunity--a double-edged sword. Nat Immunol 2000 1.53
15 CD1-restricted T cells and tumor immunity. Curr Top Microbiol Immunol 2007 1.45
16 Interleukin 2 receptor signaling regulates the perforin gene through signal transducer and activator of transcription (Stat)5 activation of two enhancers. J Exp Med 1999 1.45
17 Targeting death-inducing receptors in cancer therapy. Oncogene 2007 1.42
18 Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol 2001 1.40
19 Efficient nuclear targeting of granzyme B and the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem 1998 1.36
20 Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction. J Immunol 1991 1.31
21 Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: implication for their cytotoxic role in vivo. J Exp Med 1990 1.24
22 Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 2001 1.19
23 Localization of granzyme B in the nucleus. A putative role in the mechanism of cytotoxic lymphocyte-mediated apoptosis. J Biol Chem 1996 1.17
24 Immunopurification of functional Asp-ase (natural killer cell granzyme B) using a monoclonal antibody. Biochem Biophys Res Commun 1993 1.14
25 Molecular mechanisms of natural killer cell activation in response to cellular stress. Cell Death Differ 2013 1.11
26 p53-dependent ceramide response to genotoxic stress. J Clin Invest 1998 1.11
27 Exploration of the Common Bile Duct for Stone. Drainage with T-Tube and Cholangiography. Br Med J 1941 1.07
28 Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma. J Immunol 2001 1.07
29 CTL granules: evolution of vesicles essential for combating virus infections. Immunol Today 1999 1.07
30 Evolution in action. Nature 1974 1.06
31 NK cells and apoptosis. Immunol Cell Biol 1999 1.04
32 Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo. Curr Opin Immunol 2000 1.02
33 Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen. Gene Ther 2010 1.00
34 HMBA induces activation of a caspase-independent cell death pathway to overcome P-glycoprotein-mediated multidrug resistance. Blood 2000 1.00
35 Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy. Cancer Res 1999 0.99
36 A role for P-glycoprotein in regulating cell death. Leuk Lymphoma 2000 0.99
37 P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation. Cell Death Differ 2002 0.97
38 Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux. Cell Death Differ 2004 0.96
39 Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines. Cell Death Differ 2013 0.95
40 Granule serine proteases are normal nuclear constituents of natural killer cells. J Biol Chem 1994 0.95
41 Redirected perforin-dependent lysis of colon carcinoma by ex vivo genetically engineered CTL. J Immunol 2000 0.94
42 Automated single-cell manipulation and sorting by light trapping. Appl Opt 1987 0.93
43 Immunoregulation in cancer-bearing hosts. Down-regulation of gene expression and cytotoxic function in CD8+ T cells. J Immunol 1992 0.92
44 Bcl-2 acts upstream of the PARP protease and prevents its activation. Cell Death Differ 1997 0.92
45 Perforin-dependent nuclear entry of granzyme B precedes apoptosis, and is not a consequence of nuclear membrane dysfunction. Cell Death Differ 1998 0.92
46 The restricted expression of granzyme M in human lymphocytes. J Immunol 2001 0.91
47 Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1. Cell Death Differ 2000 0.90
48 The subunit structure of the aliphatic amidase from Pseudomonas aeruginosa. Eur J Biochem 1973 0.90
49 Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype. Gene Ther 2010 0.89
50 Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma. Eur J Immunol 1998 0.88
51 Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity. Eur J Immunol 2001 0.88
52 Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth. Oncol Res 1998 0.87
53 Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype. J Exp Med 2000 0.87
54 The genes encoding NK cell granule serine proteases, human tryptase-2 (TRYP2) and human granzyme A (HFSP), both map to chromosome 5q11-q12 and define a new locus for cytotoxic lymphocyte granule tryptases. Immunogenetics 1994 0.86
55 m144, a murine cytomegalovirus (MCMV)-encoded major histocompatibility complex class I homologue, confers tumor resistance to natural killer cell-mediated rejection. J Exp Med 1999 0.85
56 Antitumor activity of dual-specific T cells and influenza virus. Cancer Gene Ther 2007 0.83
57 Killing by cytotoxic T cells and natural killer cells: multiple granule serine proteases as initiators of DNA fragmentation. Immunol Cell Biol 1993 0.83
58 Purification and cloning of a novel serine protease, RNK-Tryp-2, from the granules of a rat NK cell leukemia. J Immunol 1994 0.82
59 Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity. J Leukoc Biol 1993 0.82
60 Purification of a factor from the granules of a rat natural killer cell line (RNK) that reduces tumor cell growth and changes tumor morphology. Molecular identity with a granule serine protease (RNKP-1). J Immunol 1992 0.81
61 T cell lysis of murine renal cancer: multiple signaling pathways for cell death via Fas. J Leukoc Biol 2000 0.81
62 Role of CD2 in regulation of CD3- LGL function. Eur Cytokine Netw 1991 0.81
63 P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins. J Biol Chem 2001 0.81
64 Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer. Ther Immunol 1995 0.80
65 Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice. Gene Ther 2008 0.80
66 Chemoimmunoconjugates for the treatment of cancer. Adv Immunol 1994 0.80
67 Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes. Cancer Immunol Immunother 1999 0.79
68 Cloning and expression of a second human natural killer cell granule tryptase, HNK-Tryp-2/granzyme 3. J Leukoc Biol 1996 0.79
69 Generation of lymphokine-activated killer activity in T cells. Possible regulatory circuits. J Immunol 1991 0.79
70 The use of monoclonal antibody conjugates for the diagnosis and treatment of cancer. Immunol Cell Biol 1987 0.79
71 The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors. J Leukoc Biol 1996 0.78
72 Specific targeting of chlorambucil to tumors with the use of monoclonal antibodies. J Natl Cancer Inst 1986 0.78
73 Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine. Biochem Biophys Res Commun 2000 0.78
74 The mode of action of methotrexate-monoclonal antibody conjugates. Immunol Cell Biol 1987 0.77
75 The gene encoding a human natural killer cell granule serine protease, Met-ase 1, maps to chromosome 19p13.3. Immunogenetics 1994 0.76
76 The in vitro and in vivo anti-tumour activity of N-AcMEL-(Fab')2 conjugates. Br J Cancer 1987 0.75
77 Cloning and expression of the recombinant mouse natural killer cell granzyme Met-ase-1. Immunogenetics 1996 0.75
78 Selective enhancement of antitumor activity of N-acetyl melphalan upon conjugation to monoclonal antibodies. Cancer Res 1987 0.75
79 The natural killer cell serine protease gene Lmet1 maps to mouse chromosome 10. Immunogenetics 1995 0.75
80 Evidence that an anthracycline-anti-CD8 immunoconjugate, idarubicin-anti-Ly-2.1, prolongs heart allograft survival in mice. Transplantation 1993 0.75
81 Role of monoclonal antibodies in the therapy of solid tumours. Aust N Z J Surg 1988 0.75
82 The peptide loop consisting of amino acids 139-157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse. Mol Immunol 1995 0.75
83 Role of the tryptophan residue in the interaction of pancreozymin with its receptor. Biochim Biophys Acta 1980 0.75
84 Payment for medical authors. J R Soc Med 1979 0.75
85 Letter: Lincomycin and the colon. N Y State J Med 1975 0.75
86 P-4 and RNKP-7, new granzyme-like serine proteases expressed in activated rat lymphocytes. J Immunol 1997 0.75
87 The use of anthracycline-antibody complexes for specific antitumor activity. Targeted Diagn Ther 1988 0.75
88 Redirected cytotoxic effector function. Requirements for expression of chimeric single chain high affinity immunoglobulin e receptors. J Biol Chem 1996 0.75
89 Preclinical studies with immunoconjugates. Targeted Diagn Ther 1989 0.75
90 Immunochemotherapy of a murine thymoma with the use of idarubicin monoclonal antibody conjugates. Cancer Res 1988 0.75
91 cDNA cloning of granzyme J. Immunogenetics 1997 0.75
92 The question begs--what is the role of P-glycoprotein in normal physiology? Drug Resist Updat 1998 0.75
93 Differential regulation of interleukin-1 gene expression in human CD3- large granular lymphocytes. Cell Immunol 1990 0.75
94 Potentiation of the in vitro cytotoxicity of chlorambucil by monoclonal antibodies. J Immunol 1986 0.75