Published in Nature on June 26, 2003
Neuroligins and neurexins link synaptic function to cognitive disease. Nature (2008) 9.23
Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Cell (2004) 6.08
Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet (2008) 5.04
CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell (2012) 4.81
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
Neurexin-neuroligin signaling in synapse development. Curr Opin Neurobiol (2007) 3.94
Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A (2008) 3.74
Cell adhesion molecules: signalling functions at the synapse. Nat Rev Neurosci (2007) 3.47
An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron (2009) 3.34
Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders. Trends Genet (2009) 3.25
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin. Nat Neurosci (2007) 2.90
A genomewide association study of citalopram response in major depressive disorder. Biol Psychiatry (2010) 2.77
Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol (2012) 2.42
CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila. Am J Hum Genet (2009) 2.41
Maturation of active zone assembly by Drosophila Bruchpilot. J Cell Biol (2009) 2.34
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Am J Med Genet B Neuropsychiatr Genet (2010) 2.12
Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapses. Nat Rev Neurosci (2011) 2.09
LRRTMs and neuroligins bind neurexins with a differential code to cooperate in glutamate synapse development. J Neurosci (2010) 2.00
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum Genet (2011) 1.94
How to build a central synapse: clues from cell culture. Trends Neurosci (2005) 1.94
Synaptic organizing complexes. Curr Opin Neurobiol (2010) 1.80
Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron (2012) 1.79
Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. J Neurosci (2009) 1.74
Genetics and cell biology of building specific synaptic connectivity. Annu Rev Neurosci (2010) 1.71
Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia. Neuron (2011) 1.70
Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell (2013) 1.70
Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. Ann N Y Acad Sci (2008) 1.69
Splice form dependence of beta-neurexin/neuroligin binding interactions. Neuron (2010) 1.68
Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell (2015) 1.63
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1. Cell (2011) 1.60
Silencing of neuroligin function by postsynaptic neurexins. J Neurosci (2007) 1.60
Rare deletions at the neurexin 3 locus in autism spectrum disorder. Am J Hum Genet (2011) 1.56
Alterations of GABAergic signaling in autism spectrum disorders. Neural Plast (2011) 1.56
Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond. J Physiol (2009) 1.53
Differential regulation of spontaneous and evoked neurotransmitter release at central synapses. Curr Opin Neurobiol (2011) 1.52
Gene expression in cortical interneuron precursors is prescient of their mature function. Cereb Cortex (2008) 1.51
Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. EMBO J (2009) 1.50
Induction of GABAergic postsynaptic differentiation by alpha-neurexins. J Biol Chem (2007) 1.50
β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell (2015) 1.49
Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Cell (2016) 1.48
Neurexins physically and functionally interact with GABA(A) receptors. Neuron (2010) 1.48
Molecular mechanisms of synaptic specificity in developing neural circuits. Neuron (2010) 1.46
An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J (2011) 1.45
Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proc Natl Acad Sci U S A (2004) 1.44
Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron (2007) 1.42
An intra-amygdala circuit specifically regulates social fear learning. Nat Neurosci (2017) 1.42
Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release. Annu Rev Physiol (2013) 1.41
The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo. Proc Natl Acad Sci U S A (2011) 1.39
The crystal structure of the α-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function. Structure (2011) 1.39
Rare structural variation of synapse and neurotransmission genes in autism. Mol Psychiatry (2011) 1.36
Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes Dev (2003) 1.33
The structure of neurexin 1α reveals features promoting a role as synaptic organizer. Structure (2011) 1.32
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing. J Biol Chem (2006) 1.30
Synaptic cell adhesion. Cold Spring Harb Perspect Biol (2012) 1.30
Common variants on chromosome 2 and risk of primary open-angle glaucoma in the Afro-Caribbean population of Barbados. Proc Natl Acad Sci U S A (2009) 1.30
Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components. Proc Natl Acad Sci U S A (2008) 1.28
Rapid assembly of functional presynaptic boutons triggered by adhesive contacts. J Neurosci (2009) 1.26
Unusually rapid evolution of Neuroligin-4 in mice. Proc Natl Acad Sci U S A (2008) 1.25
GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development. Curr Opin Neurobiol (2008) 1.23
High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. J Biol Chem (2012) 1.23
Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol (2005) 1.21
Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Proc Natl Acad Sci U S A (2008) 1.20
Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Endocrinology (2008) 1.19
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Front Synaptic Neurosci (2010) 1.18
Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol (2011) 1.16
Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms. Neurosci Biobehav Rev (2014) 1.14
Neurobeachin, a protein implicated in membrane protein traffic and autism, is required for the formation and functioning of central synapses. J Physiol (2009) 1.14
alpha-Latrotoxin and its receptors. Handb Exp Pharmacol (2008) 1.14
Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. Proc Natl Acad Sci U S A (2005) 1.13
Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia. Hum Mol Genet (2011) 1.10
Cell adhesion, the backbone of the synapse: "vertebrate" and "invertebrate" perspectives. Cold Spring Harb Perspect Biol (2009) 1.09
Synapse formation and clustering of neuroligin-2 in the absence of GABAA receptors. Proc Natl Acad Sci U S A (2008) 1.08
Crystal structures of beta-neurexin 1 and beta-neurexin 2 ectodomains and dynamics of splice insertion sequence 4. Structure (2008) 1.07
Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Mol Cell Biol (2005) 1.07
Sensory regulation of neuroligins and neurexin I in the honeybee brain. PLoS One (2010) 1.06
Different relationship of N- and P/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses. J Neurosci (2010) 1.06
Afadin, a Ras/Rap effector that controls cadherin function, promotes spine and excitatory synapse density in the hippocampus. J Neurosci (2012) 1.05
Dendritic spine formation and synaptic function require neurobeachin. Nat Commun (2011) 1.05
Regulation of neurexin 1beta tertiary structure and ligand binding through alternative splicing. Structure (2008) 1.04
Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases. J Biol Chem (2010) 1.03
Presenilin/γ-secretase regulates neurexin processing at synapses. PLoS One (2011) 1.03
Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses. J Comp Neurol (2010) 1.02
Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones. J Neurosci (2011) 1.02
Neurexins. Genome Biol (2013) 1.02
The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. Proc Natl Acad Sci U S A (2009) 1.02
Altered social behaviours in neurexin 1α knockout mice resemble core symptoms in neurodevelopmental disorders. PLoS One (2013) 1.00
Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses. Proc Natl Acad Sci U S A (2010) 0.99
Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse development. J Cell Biol (2013) 0.99
Synaptic proteins and receptors defects in autism spectrum disorders. Front Cell Neurosci (2014) 0.98
Bridging the synaptic gap: neuroligins and neurexin I in Apis mellifera. PLoS One (2008) 0.98
In vivo induction of postsynaptic molecular assembly by the cell adhesion molecule Fasciclin2. J Cell Biol (2007) 0.98
Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism. Transl Psychiatry (2012) 0.98
The specific α-neurexin interactor calsyntenin-3 promotes excitatory and inhibitory synapse development. Neuron (2013) 0.97
Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction. Mol Psychiatry (2013) 0.97
Human neurexin-3α antibodies associate with encephalitis and alter synapse development. Neurology (2016) 0.96
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab (2007) 9.62
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
White fat progenitor cells reside in the adipose vasculature. Science (2008) 6.49
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem (2002) 5.89
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Two supporting factors greatly improve the efficiency of human iPSC generation. Cell Stem Cell (2008) 5.04
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A (2005) 4.56
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A (2008) 4.45
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest (2002) 3.85
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest (2006) 3.54
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature (2012) 3.38
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Neuron (2005) 3.25
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A (2002) 3.09
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron (2003) 2.73
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest (2004) 2.66
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin. Neuron (2009) 2.44
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A (2002) 2.20
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Neurotrophin secretion: current facts and future prospects. Prog Neurobiol (2003) 2.12
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats. Arthritis Rheum (2012) 2.10
Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci U S A (2003) 2.07
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins. J Clin Invest (2005) 2.03
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
A neural circuit for memory specificity and generalization. Science (2013) 1.96
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91
Low blood pressure in endothelial cell-specific endothelin 1 knockout mice. Hypertension (2010) 1.91
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron (2011) 1.89
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J (2002) 1.88
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells. J Neurosci (2011) 1.87
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. J Neurosci (2005) 1.87
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J (2005) 1.86