Published in JAMA on June 11, 2003
The MIND Study: Modifying the INcidence of Delirium | NCT00096863
Haloperidol vs Olanzapine for the Management of ICU Delirium | NCT00833300
MIND-ICU Study: Delirium and Dementia in Veterans Surviving ICU Care | NCT00400062
Loxapine and Weaning From Ventilator | NCT00122733
The PROtective Ventilation Using Open Lung Approach Or Not Trial (PROVOLON) | NCT03160144
The Effect of LBM Evaluated by US on REE Measured by Indirect Calorimetry | NCT03193632
Prediction of PACU Delirium Using EEG - German Validation Study (PACUD-EEG) | NCT03287401
Implementation of a Delirium Screening | NCT03360474
Agitation Follow up After Introduction of a New Patient Care Algorithm (SARA) | NCT04053426
Flumazenil for Hypoactive Delirium Secondary to Benzodiazepine Toxicity (FLYP) | NCT02899156
Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med (2009) 4.69
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Delirium in the cardiovascular ICU: exploring modifiable risk factors. Crit Care Med (2013) 4.34
Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med (2014) 3.46
3D-CAM: derivation and validation of a 3-minute diagnostic interview for CAM-defined delirium: a cross-sectional diagnostic test study. Ann Intern Med (2014) 3.34
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Lung protective mechanical ventilation and two year survival in patients with acute lung injury: prospective cohort study. BMJ (2012) 2.69
Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med (2011) 2.59
Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53
Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46
Delirium in the intensive care unit. Crit Care (2008) 2.34
Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med (2014) 2.33
Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm. Chest (2010) 2.28
Atypical sleep in ventilated patients: empirical electroencephalography findings and the path toward revised ICU sleep scoring criteria. Crit Care Med (2013) 2.20
Validity of a Modified Sequential Organ Failure Assessment Score Using the Richmond Agitation-Sedation Scale. Crit Care Med (2016) 2.10
The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med (2013) 2.00
Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med (2014) 1.98
Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care (2010) 1.97
The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Crit Care Med (2012) 1.97
The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study*. Crit Care Med (2012) 1.96
Depressive symptoms and impaired physical function after acute lung injury: a 2-year longitudinal study. Am J Respir Crit Care Med (2011) 1.93
Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med (2009) 1.92
A research algorithm to improve detection of delirium in the intensive care unit. Crit Care (2006) 1.89
Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study. Crit Care (2006) 1.89
Physical and cognitive performance of patients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med (2013) 1.83
Timing of low tidal volume ventilation and intensive care unit mortality in acute respiratory distress syndrome. A prospective cohort study. Am J Respir Crit Care Med (2015) 1.76
Sedation, sleep promotion, and delirium screening practices in the care of mechanically ventilated children: a wake-up call for the pediatric critical care community*. Crit Care Med (2014) 1.71
Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med (2007) 1.69
Intracerebral hemorrhage and delirium symptoms. Length of stay, function, and quality of life in a 114-patient cohort. Am J Respir Crit Care Med (2013) 1.68
Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. Crit Care (2013) 1.66
The association between acute respiratory distress syndrome, delirium, and in-hospital mortality in intensive care unit patients. Am J Respir Crit Care Med (2015) 1.63
Review articles: postoperative delirium: acute change with long-term implications. Anesth Analg (2011) 1.60
Can intensive care unit delirium be prevented and reduced? Lessons learned and future directions. Ann Am Thorac Soc (2013) 1.60
Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med (2012) 1.59
Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. Crit Care Med (2015) 1.55
Rosuvastatin versus placebo for delirium in intensive care and subsequent cognitive impairment in patients with sepsis-associated acute respiratory distress syndrome: an ancillary study to a randomised controlled trial. Lancet Respir Med (2016) 1.55
Validation of the 4AT, a new instrument for rapid delirium screening: a study in 234 hospitalised older people. Age Ageing (2014) 1.53
Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care (2007) 1.53
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*. Crit Care Med (2012) 1.51
Physical complications in acute lung injury survivors: a two-year longitudinal prospective study. Crit Care Med (2014) 1.49
Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality. Crit Care Med (2008) 1.48
Serial administration of a modified Richmond Agitation and Sedation Scale for delirium screening. J Hosp Med (2011) 1.47
Acute respiratory distress syndrome, sepsis, and cognitive decline: a review and case study. South Med J (2009) 1.46
Diagnosing delirium in older emergency department patients: validity and reliability of the delirium triage screen and the brief confusion assessment method. Ann Emerg Med (2013) 1.46
Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Crit Care (2014) 1.44
Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care (2013) 1.43
Evaluating and monitoring analgesia and sedation in the intensive care unit. Crit Care (2008) 1.38
Haloperidol prophylaxis in critically ill patients with a high risk for delirium. Crit Care (2013) 1.31
Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci (2010) 1.30
Validation of the Confusion Assessment Method for the Intensive Care Unit in older emergency department patients. Acad Emerg Med (2014) 1.29
Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey. Crit Care (2007) 1.24
Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. J Am Geriatr Soc (2011) 1.22
A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivors. Crit Care Med (2010) 1.21
High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study. Crit Care (2010) 1.15
Sedation practice in the intensive care unit: a UK national survey. Crit Care (2008) 1.14
Inter-rater reliability of the Full Outline of UnResponsiveness score and the Glasgow Coma Scale in critically ill patients: a prospective observational study. Crit Care (2010) 1.13
Clinical signs of impending death in cancer patients. Oncologist (2014) 1.10
Use of the quasi-experimental sequential cohort design in the Study of Patient-Nurse Effectiveness with Assisted Communication Strategies (SPEACS). Contemp Clin Trials (2008) 1.10
Postoperative delirium in the elderly: diagnosis and management. Clin Interv Aging (2008) 1.08
Novel use of dexmedetomidine for the treatment of anticholinergic toxidrome. J Med Toxicol (2014) 1.07
Implementing delirium screening in the ICU: secrets to success. Crit Care Med (2013) 1.07
Prevalence and risk factors for development of delirium in burn intensive care unit patients. J Burn Care Res (2010) 1.07
Closing the loop in practice to assure the desired performance. Trans Am Clin Climatol Assoc (2008) 1.07
Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med (2009) 1.06
Nurse-patient communication interactions in the intensive care unit. Am J Crit Care (2011) 1.06
A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial. Phys Ther (2012) 1.04
Diagnostic considerations regarding pediatric delirium: a review and a proposal for an algorithm for pediatric intensive care units. Intensive Care Med (2009) 1.04
Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Crit Care (2011) 1.04
Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med (2012) 1.02
Outcomes Associated With Delirium in Older Patients in Surgical ICUs. Chest (2008) 1.02
Four sensitive screening tools to detect cognitive dysfunction in geriatric emergency department patients: brief Alzheimer's Screen, Short Blessed Test, Ottawa 3DY, and the caregiver-completed AD8. Acad Emerg Med (2011) 1.01
Respiratory and haemodynamic changes during decremental open lung positive end-expiratory pressure titration in patients with acute respiratory distress syndrome. Crit Care (2009) 0.99
Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery. Crit Care (2013) 0.98
The incidence of sub-optimal sedation in the ICU: a systematic review. Crit Care (2009) 0.97
Bispectral index correlates well with Richmond agitation sedation scale in mechanically ventilated critically ill patients. J Anesth (2010) 0.96
Improving delirium care in the intensive care unit: the design of a pragmatic study. Trials (2011) 0.96
Delirium: an emerging frontier in the management of critically ill children. Crit Care Clin (2009) 0.95
Effects of positive end-expiratory pressure on respiratory function and hemodynamics in patients with acute respiratory failure with and without intra-abdominal hypertension: a pilot study. Crit Care (2009) 0.95
Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version. Ger Med Sci (2015) 0.94
Developing, implementing, and evaluating a multifaceted quality improvement intervention to promote sleep in an ICU. Am J Med Qual (2013) 0.94
Intensive care unit exposures for long-term outcomes research: development and description of exposures for 150 patients with acute lung injury. J Crit Care (2007) 0.94
Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics (2012) 0.94
Physiotherapy in critical care in australia. Cardiopulm Phys Ther J (2012) 0.93
Sedation and memories of patients subjected to mechanical ventilation in an intensive care unit. Rev Bras Ter Intensiva (2014) 0.93
Association between prescribing of anticholinergic medications and incident delirium: a cohort study. J Am Geriatr Soc (2011) 0.93
Psychometric comparison of three behavioural scales for the assessment of pain in critically ill patients unable to self-report. Crit Care (2014) 0.92
What factors are associated with the difficult-to-sedate endoscopy patient? Dig Dis Sci (2012) 0.92
Severe sepsis and septic shock in the elderly: An overview. World J Crit Care Med (2012) 0.91
Entropy and bispectral index for assessment of sedation, analgesia and the effects of unpleasant stimuli in critically ill patients: an observational study. Crit Care (2008) 0.91
Therapeutic hypothermia after nonshockable cardiac arrest: the HYPERION multicenter, randomized, controlled, assessor-blinded, superiority trial. Scand J Trauma Resusc Emerg Med (2015) 0.90
Evaluation of the depth of sedation in an intensive care unit based on the photo motor reflex variations measured by video pupillometry. Ann Intensive Care (2013) 0.90
Towards computerizing intensive care sedation guidelines: design of a rule-based architecture for automated execution of clinical guidelines. BMC Med Inform Decis Mak (2010) 0.89
Delirium in postoperative nonventilated intensive care patients: risk factors and outcomes. Ann Intensive Care (2012) 0.89
Altered mental status in older patients in the emergency department. Clin Geriatr Med (2013) 0.88
The complex interplay between delirium, sedation, and early mobility during critical illness: applications in the trauma unit. Curr Opin Anaesthesiol (2011) 0.88
Septic encephalopathy. Curr Neurol Neurosci Rep (2013) 0.88
Sedation in the intensive care setting. Clin Pharmacol (2012) 0.88
Impaired arousal at initial presentation predicts 6-month mortality: an analysis of 1084 acutely ill older patients. J Hosp Med (2014) 0.87
Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54
Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med (2013) 11.44
Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA (2004) 11.27
Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97
Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet (2007) 6.07
Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76
Automated identification of postoperative complications within an electronic medical record using natural language processing. JAMA (2011) 5.40
Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA (2011) 5.08
Association of numeracy and diabetes control. Ann Intern Med (2008) 5.08
Costs associated with delirium in mechanically ventilated patients. Crit Care Med (2004) 4.75
Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69
Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA (2012) 4.67
A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med (2009) 4.54
Influence of patient literacy on the effectiveness of a primary care-based diabetes disease management program. JAMA (2004) 4.16
Patient understanding of food labels: the role of literacy and numeracy. Am J Prev Med (2006) 4.13
Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03
Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Ann Intern Med (2012) 3.85
Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84
Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med (2006) 3.72
Diabetes patient education: a meta-analysis and meta-regression. Patient Educ Couns (2004) 3.69
Overview of the VA Quality Enhancement Research Initiative (QUERI) and QUERI theme articles: QUERI Series. Implement Sci (2008) 3.64
Chlorhexidine, toothbrushing, and preventing ventilator-associated pneumonia in critically ill adults. Am J Crit Care (2009) 3.47
A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med (2005) 3.44
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Perspectives of physicians and nurse practitioners on primary care practice. N Engl J Med (2013) 3.36
Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med (2010) 3.32
The ethics of using quality improvement methods in health care. Ann Intern Med (2007) 3.25
Group exercise, education, and combination self-management in women with fibromyalgia: a randomized trial. Arch Intern Med (2007) 3.20
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. J Rheumatol (2006) 3.10
Attitudes and perceptions of patients towards methods of establishing a DNA biobank. Cell Tissue Bank (2007) 3.05
Deviations from evidence-based clinical management guidelines increase mortality in critically injured trauma patients*. Crit Care Med (2012) 2.86
Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86
Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med (2003) 2.83
Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82
Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med (2007) 2.79
Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77
Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77
Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77
Findings on the portable chest radiograph correlate with fluid balance in critically ill patients. Chest (2002) 2.77
The rapid shallow breathing index as a predictor of failure of noninvasive ventilation for patients with acute respiratory failure. Respir Care (2012) 2.74
The learning curve for EUS-guided FNA of pancreatic cancer. Gastrointest Endosc (2004) 2.73
Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Crit Care Med (2005) 2.72
A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68
Molecular mechanisms of action of bisphosphonates: current status. Clin Cancer Res (2006) 2.67
Continuous neuromuscular blockade is associated with decreased mortality in post-cardiac arrest patients. Resuscitation (2013) 2.66
Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med (2002) 2.62
Hepatic insufficiency and mortality in 1,059 noncirrhotic patients undergoing major hepatectomy. J Am Coll Surg (2007) 2.62
Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Clin J Am Soc Nephrol (2007) 2.60
Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med (2011) 2.59
Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest (2007) 2.58
Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53
Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med (2004) 2.50
Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc (2006) 2.49
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46
Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44
Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension. Am J Respir Crit Care Med (2009) 2.40
Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40
Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. Acad Med (2010) 2.38
Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med (2011) 2.36
A randomized trial of a primary care-based disease management program to improve cardiovascular risk factors and glycated hemoglobin levels in patients with diabetes. Am J Med (2005) 2.36
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit Care Med (2010) 2.31