Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit.

Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA (2010) 10.82

Long-term cognitive impairment after critical illness. N Engl J Med (2013) 9.20

Delirium in elderly people. Lancet (2013) 6.15

Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med (2009) 4.69

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69

Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med (2013) 4.52

Delirium in the cardiovascular ICU: exploring modifiable risk factors. Crit Care Med (2013) 4.34

The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc (2008) 3.51

Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med (2014) 3.46

Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. JAMA (2015) 3.32

Immortal time bias in critical care research: application of time-varying Cox regression for observational cohort studies. Crit Care Med (2009) 2.96

Effect of Noninvasive Ventilation Delivered by Helmet vs Face Mask on the Rate of Endotracheal Intubation in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial. JAMA (2016) 2.92

Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86

Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77

Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci U S A (2010) 2.70

Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med (2011) 2.59

Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53

Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med (2009) 2.47

Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46

Randomized ICU trials do not demonstrate an association between interventions that reduce delirium duration and short-term mortality: a systematic review and meta-analysis. Crit Care Med (2014) 2.45

Delirium in the intensive care unit. Crit Care (2008) 2.34

Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med (2014) 2.33

Association of cumulative dose of haloperidol with next-day delirium in older medical ICU patients. Crit Care Med (2015) 2.33

Reducing iatrogenic risks: ICU-acquired delirium and weakness--crossing the quality chasm. Chest (2010) 2.28

Delirium after surgical and transcatheter aortic valve replacement is associated with increased mortality. J Thorac Cardiovasc Surg (2015) 2.11

Delirium epidemiology in critical care (DECCA): an international study. Crit Care (2010) 2.07

Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med (2014) 1.98

Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care (2010) 1.97

The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study*. Crit Care Med (2012) 1.97

Delirium in older emergency department patients: recognition, risk factors, and psychomotor subtypes. Acad Emerg Med (2009) 1.95

Occurrence of delirium is severely underestimated in the ICU during daily care. Intensive Care Med (2009) 1.92

Resolving postoperative neuroinflammation and cognitive decline. Ann Neurol (2011) 1.92

A research algorithm to improve detection of delirium in the intensive care unit. Crit Care (2006) 1.89

Study protocol: The Improving Care of Acute Lung Injury Patients (ICAP) study. Crit Care (2006) 1.89

Preventing ICU Subsyndromal Delirium Conversion to Delirium With Low-Dose IV Haloperidol: A Double-Blind, Placebo-Controlled Pilot Study. Crit Care Med (2016) 1.88

The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care (2012) 1.78

Association between endothelial dysfunction and acute brain dysfunction during critical illness. Anesthesiology (2013) 1.75

The Preschool Confusion Assessment Method for the ICU: Valid and Reliable Delirium Monitoring for Critically Ill Infants and Children. Crit Care Med (2016) 1.69

Intracerebral hemorrhage and delirium symptoms. Length of stay, function, and quality of life in a 114-patient cohort. Am J Respir Crit Care Med (2013) 1.68

Perioperative cognitive decline in the aging population. Mayo Clin Proc (2011) 1.66

The attributable mortality of delirium in critically ill patients: prospective cohort study. BMJ (2014) 1.65

Dexmedetomidine vs. haloperidol in delirious, agitated, intubated patients: a randomised open-label trial. Crit Care (2009) 1.65

The association between acute respiratory distress syndrome, delirium, and in-hospital mortality in intensive care unit patients. Am J Respir Crit Care Med (2015) 1.63

Evaluation Following Staggered Implementation of the "Rethinking Critical Care" ICU Care Bundle in a Multicenter Community Setting. Crit Care Med (2016) 1.61

Statins and delirium during critical illness: a multicenter, prospective cohort study. Crit Care Med (2014) 1.60

Can intensive care unit delirium be prevented and reduced? Lessons learned and future directions. Ann Am Thorac Soc (2013) 1.60

Diurnal sedative changes during intensive care: impact on liberation from mechanical ventilation and delirium. Crit Care Med (2012) 1.59

Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit. Intensive Care Med (2007) 1.57

Delirium transitions in the medical ICU: exploring the role of sleep quality and other factors. Crit Care Med (2015) 1.55

Risk factors for post-traumatic stress disorder symptoms following critical illness requiring mechanical ventilation: a prospective cohort study. Crit Care (2007) 1.53

Delirium in the emergency department: an independent predictor of death within 6 months. Ann Emerg Med (2010) 1.51

The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness*. Crit Care Med (2012) 1.51

Presence of electroencephalogram burst suppression in sedated, critically ill patients is associated with increased mortality. Crit Care Med (2008) 1.48

Length of red cell unit storage and risk for delirium after cardiac surgery. Anesth Analg (2014) 1.46

Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study. Crit Care (2014) 1.44

Intraoperative tight glucose control using hyperinsulinemic normoglycemia increases delirium after cardiac surgery. Anesthesiology (2015) 1.41

Delirium superimposed on dementia is associated with prolonged length of stay and poor outcomes in hospitalized older adults. J Hosp Med (2013) 1.39

Drug-Use Evaluation Comparing Dexmedetomidine Use at 3 Health Authority Sites Relative to Manufacturer's Recommended Directions (DECODE Study). Can J Hosp Pharm (2014) 1.38

Validity Evidence for FASTHUG-MAIDENS, a Mnemonic for Identifying Drug-Related Problems in the Intensive Care Unit. Can J Hosp Pharm (2013) 1.38

Effect of Dexmedetomidine on Mortality and Ventilator-Free Days in Patients Requiring Mechanical Ventilation With Sepsis: A Randomized Clinical Trial. JAMA (2017) 1.37

Postoperative delirium: a 76-year-old woman with delirium following surgery. JAMA (2012) 1.36

Investigating risk factors for psychological morbidity three months after intensive care: a prospective cohort study. Crit Care (2012) 1.34

Routine delirium monitoring in a UK critical care unit. Crit Care (2009) 1.31

Haloperidol prophylaxis in critically ill patients with a high risk for delirium. Crit Care (2013) 1.31

Sepsis-associated encephalopathy. Nat Rev Neurol (2012) 1.30

Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci (2010) 1.30

Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med (2011) 1.29

Clinical review: The impact of noise on patients' sleep and the effectiveness of noise reduction strategies in intensive care units. Crit Care (2009) 1.23

Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ (2015) 1.23

Liberation and animation for ventilated ICU patients: the ABCDE bundle for the back-end of critical care. Crit Care (2010) 1.23

Delirium and sedation recognition using validated instruments: reliability of bedside intensive care unit nursing assessments from 2007 to 2010. J Am Geriatr Soc (2011) 1.22

A screening, prevention, and restoration model for saving the injured brain in intensive care unit survivors. Crit Care Med (2010) 1.21

Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients. Crit Care (2011) 1.19

Combined didactic and scenario-based education improves the ability of intensive care unit staff to recognize delirium at the bedside. Crit Care (2008) 1.19

Critical care nurses' role in implementing the "ABCDE bundle" into practice. Crit Care Nurse (2012) 1.18

Antipsychotic use and diagnosis of delirium in the intensive care unit. Crit Care (2012) 1.18

Preoperative regional cerebral oxygen saturation is a predictor of postoperative delirium in on-pump cardiac surgery patients: a prospective observational trial. Crit Care (2011) 1.16

High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study. Crit Care (2010) 1.15

Factors associated with persistent delirium after intensive care unit admission in an older medical patient population. J Crit Care (2010) 1.13

Recognition of delirium in ICU patients: a diagnostic study of the NEECHAM confusion scale in ICU patients. BMC Nurs (2005) 1.12

Discomfort and factual recollection in intensive care unit patients. Crit Care (2004) 1.12

Bench-to-bedside review: delirium in ICU patients - importance of sleep deprivation. Crit Care (2009) 1.11

Delirium in the ICU: an overview. Ann Intensive Care (2012) 1.11

Implementation of a delirium assessment tool in the ICU can influence haloperidol use. Crit Care (2009) 1.10

Strategies to optimize analgesia and sedation. Crit Care (2008) 1.08

Postoperative delirium in the elderly: diagnosis and management. Clin Interv Aging (2008) 1.08

Delirium after elective surgery among elderly patients taking statins. CMAJ (2008) 1.07

Implementing delirium screening in the ICU: secrets to success. Crit Care Med (2013) 1.07

Delirium in older emergency department patients is an independent predictor of hospital length of stay. Acad Emerg Med (2011) 1.07

Predictors of in-hospital mortality among older patients. Clinics (Sao Paulo) (2009) 1.07

Prevalence and risk factors for development of delirium in burn intensive care unit patients. J Burn Care Res (2010) 1.07

Plasma tryptophan and tyrosine levels are independent risk factors for delirium in critically ill patients. Intensive Care Med (2009) 1.06

Preoperative cognitive dysfunction is related to adverse postoperative outcomes in the elderly. J Am Coll Surg (2012) 1.06

Understanding brain dysfunction in sepsis. Ann Intensive Care (2013) 1.06

Outcomes of early delirium diagnosis after general anesthesia in the elderly. Anesth Analg (2013) 1.05

The effect of window rooms on critically ill patients with subarachnoid hemorrhage admitted to intensive care. Crit Care (2011) 1.04

A combined early cognitive and physical rehabilitation program for people who are critically ill: the activity and cognitive therapy in the intensive care unit (ACT-ICU) trial. Phys Ther (2012) 1.04

Implementation, reliability testing, and compliance monitoring of the Confusion Assessment Method for the Intensive Care Unit in trauma patients. Intensive Care Med (2008) 1.04

Prolonged stay at the paediatric intensive care unit associated with paediatric delirium. Eur Child Adolesc Psychiatry (2009) 1.04

Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients. Crit Care (2011) 1.04

Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54

Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet (2008) 10.13

Criteria for evaluation of novel markers of cardiovascular risk: a scientific statement from the American Heart Association. Circulation (2009) 8.11

Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97

Using the outcome for imputation of missing predictor values was preferred. J Clin Epidemiol (2006) 7.83

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA (2007) 7.74

Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA (2003) 6.24

Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet (2007) 6.07

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med (2005) 5.76

Automated identification of postoperative complications within an electronic medical record using natural language processing. JAMA (2011) 5.40

Association of numeracy and diabetes control. Ann Intern Med (2008) 5.08

Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial. Ann Intern Med (2008) 4.85

Costs associated with delirium in mechanically ventilated patients. Crit Care Med (2004) 4.75

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med (2010) 4.69

Cognitive trajectories after postoperative delirium. N Engl J Med (2012) 4.69

Influence of patient literacy on the effectiveness of a primary care-based diabetes disease management program. JAMA (2004) 4.16

Patient understanding of food labels: the role of literacy and numeracy. Am J Prev Med (2006) 4.13

Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology (2006) 4.03

Statistical evaluation of ventilator-free days as an efficacy measure in clinical trials of treatments for acute respiratory distress syndrome. Crit Care Med (2002) 3.87

Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85

Effect of a pharmacist intervention on clinically important medication errors after hospital discharge: a randomized trial. Ann Intern Med (2012) 3.85

Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84

One-year health care costs associated with delirium in the elderly population. Arch Intern Med (2008) 3.82

Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med (2006) 3.72

Diabetes patient education: a meta-analysis and meta-regression. Patient Educ Couns (2004) 3.69

Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. N Engl J Med (2011) 3.58

The Confusion Assessment Method: a systematic review of current usage. J Am Geriatr Soc (2008) 3.51

A randomized, controlled trial of furosemide with or without albumin in hypoproteinemic patients with acute lung injury. Crit Care Med (2005) 3.44

Delirium superimposed on dementia: a systematic review. J Am Geriatr Soc (2002) 3.44

Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39

Perspectives of physicians and nurse practitioners on primary care practice. N Engl J Med (2013) 3.36

3D-CAM: derivation and validation of a 3-minute diagnostic interview for CAM-defined delirium: a cross-sectional diagnostic test study. Ann Intern Med (2014) 3.34

Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med (2010) 3.32

Delirium and Long-term Cognitive Trajectory Among Persons With Dementia. Arch Intern Med (2012) 3.27

The ethics of using quality improvement methods in health care. Ann Intern Med (2007) 3.25

Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18

Characteristics associated with delirium in older patients in a medical intensive care unit. Arch Intern Med (2007) 3.16

Slower walking speed forecasts increased postoperative morbidity and 1-year mortality across surgical specialties. Ann Surg (2013) 3.15

Increased concentration of proatherogenic inflammatory cytokines in systemic lupus erythematosus: relationship to cardiovascular risk factors. J Rheumatol (2006) 3.10

Derivation and validation of a preoperative prediction rule for delirium after cardiac surgery. Circulation (2008) 3.06

Attitudes and perceptions of patients towards methods of establishing a DNA biobank. Cell Tissue Bank (2007) 3.05

Dealing with missing outcome data in randomized trials and observational studies. Am J Epidemiol (2011) 3.03

Feasibility, efficacy, and safety of antipsychotics for intensive care unit delirium: the MIND randomized, placebo-controlled trial. Crit Care Med (2010) 2.86

Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med (2003) 2.83

Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma (2010) 2.82

Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med (2009) 2.77

Delirium in older people. BMJ (2007) 2.77

Atrial Fibrillation Is an Independent Predictor of Mortality in Critically Ill Patients. Crit Care Med (2015) 2.77

Urine neutrophil gelatinase-associated lipocalin moderately predicts acute kidney injury in critically ill adults. J Am Soc Nephrol (2009) 2.77

Findings on the portable chest radiograph correlate with fluid balance in critically ill patients. Chest (2002) 2.77

Large-scale implementation of sedation and delirium monitoring in the intensive care unit: a report from two medical centers. Crit Care Med (2005) 2.72

The association between delirium and cognitive decline: a review of the empirical literature. Neuropsychol Rev (2004) 2.72

A randomized, double-blind, placebo-controlled, Phase 2b study to evaluate the safety and efficacy of recombinant human soluble thrombomodulin, ART-123, in patients with sepsis and suspected disseminated intravascular coagulation. Crit Care Med (2013) 2.68

Albumin and furosemide therapy in hypoproteinemic patients with acute lung injury. Crit Care Med (2002) 2.62

Heart rate characteristics: novel physiomarkers to predict neonatal infection and death. Pediatrics (2005) 2.60

Early intervention improves mortality and hospitalization rates in incident hemodialysis patients: RightStart program. Clin J Am Soc Nephrol (2007) 2.60

Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med (2011) 2.59

Comparison of the SpO2/FIO2 ratio and the PaO2/FIO2 ratio in patients with acute lung injury or ARDS. Chest (2007) 2.58

Hospital at home: feasibility and outcomes of a program to provide hospital-level care at home for acutely ill older patients. Ann Intern Med (2005) 2.58

Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care (2005) 2.53

Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc (2003) 2.53

Current opinions regarding the importance, diagnosis, and management of delirium in the intensive care unit: a survey of 912 healthcare professionals. Crit Care Med (2004) 2.50

Ensuring trial validity by data quality assurance and diversification of monitoring methods. Clin Trials (2008) 2.50

Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc (2006) 2.49

Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48

Benzodiazepine and opioid use and the duration of intensive care unit delirium in an older population. Crit Care Med (2009) 2.47

Prevalence and risk factors for development of delirium in surgical and trauma intensive care unit patients. J Trauma (2008) 2.46

Delirium in elderly adults: diagnosis, prevention and treatment. Nat Rev Neurol (2009) 2.44

Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med (2003) 2.44

Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40

Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. Acad Med (2010) 2.38

Missing covariate data in medical research: to impute is better than to ignore. J Clin Epidemiol (2010) 2.37

Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure. Crit Care Med (2011) 2.36

A randomized trial of a primary care-based disease management program to improve cardiovascular risk factors and glycated hemoglobin levels in patients with diabetes. Am J Med (2005) 2.36