Published in Biochemistry on December 15, 1992
Novel insights into the genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis. Infect Immun (1996) 2.43
PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Neurogenetics (2004) 1.57
Neuron to glia signaling triggers myelin membrane exocytosis from endosomal storage sites. J Cell Biol (2006) 1.49
Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. J Cell Biol (2000) 1.47
Overexpression of the myelin proteolipid protein leads to accumulation of cholesterol and proteolipid protein in endosomes/lysosomes: implications for Pelizaeus-Merzbacher disease. J Cell Biol (2002) 1.27
A myelin proteolipid protein-LacZ fusion protein is developmentally regulated and targeted to the myelin membrane in transgenic mice. J Cell Biol (1993) 1.24
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci U S A (1994) 1.18
A common mechanism of PLP/DM20 misfolding causes cysteine-mediated endoplasmic reticulum retention in oligodendrocytes and Pelizaeus-Merzbacher disease. Proc Natl Acad Sci U S A (2007) 1.12
Lipid-modified, cysteinyl-containing peptides of diverse structures are efficiently S-acylated at the plasma membrane of mammalian cells. J Cell Biol (1996) 1.09
Molecular anatomy and genetics of myelin proteins in the peripheral nervous system. J Anat (1995) 1.02
Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein. J Clin Invest (1996) 0.98
MALDI imaging and in situ identification of integral membrane proteins from rat brain tissue sections. Anal Chem (2013) 0.98
Reverse-phase HPLC of the hydrophobic pulmonary surfactant proteins: detection of a surfactant protein C isoform containing Nepsilon-palmitoyl-lysine. Biochem J (1997) 0.97
Posttranslational modification of tubulin by palmitoylation: II. Identification of sites of palmitoylation. Mol Biol Cell (1997) 0.87
Axon-glial interaction in the CNS: what we have learned from mouse models of Pelizaeus-Merzbacher disease. J Anat (2011) 0.84
Novel alternatively spliced endoplasmic reticulum retention signal in the cytoplasmic loop of Proteolipid Protein-1. J Neurosci Res (2007) 0.83
Cysteine residues in the large extracellular loop (EC2) are essential for the function of the stress-regulated glycoprotein M6a. J Biol Chem (2009) 0.83
Unbinding-binding transition induced by molecular snaps in model membranes. Biophys J (2000) 0.83
Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein. Proc Natl Acad Sci U S A (1995) 0.83
Molecular genetic analysis of the PLP1 gene in 38 families with PLP1-related disorders: identification and functional characterization of 11 novel PLP1 mutations. Orphanet J Rare Dis (2011) 0.82
Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a. PLoS One (2011) 0.82
Tailoring of membrane proteins by alternative splicing of pre-mRNA. Biochemistry (2012) 0.80
Autopalmitoylation of tubulin. Protein Sci (2000) 0.80
The major myelin-resident protein PLP is transported to myelin membranes via a transcytotic mechanism: involvement of sulfatide. Mol Cell Biol (2014) 0.80
Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis. Curr Diab Rep (2016) 0.79
Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis. Mult Scler Int (2013) 0.78
Reconstitution of proteolipid protein: some properties and its role in interlamellar attachment. Biochem J (1994) 0.76
Oligodendroglial membrane dynamics in relation to myelin biogenesis. Cell Mol Life Sci (2016) 0.75
Correlation of in vivo and in vitro phase transitions of membrane lipids in Escherichia coli. Proc Natl Acad Sci U S A (1970) 2.93
Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci U S A (1992) 2.59
Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase. Proc Natl Acad Sci U S A (2000) 1.88
Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling? Proc Natl Acad Sci U S A (1998) 1.73
Perturbation of membrane microdomains reduces mitogenic signaling and increases susceptibility to apoptosis after T cell receptor stimulation. Cell Death Differ (2000) 1.70
Biochemical analysis of the pinocytotic process. I. Isolation and chemical composition of the lysosomal and the plasma membrane of the rat liver cell. Hoppe Seylers Z Physiol Chem (1970) 1.56
Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J (1997) 1.54
Individual exons encode the integral membrane domains of human myelin proteolipid protein. Proc Natl Acad Sci U S A (1986) 1.50
Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. J Cell Biol (2000) 1.47
Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis. Proc Natl Acad Sci U S A (1996) 1.41
Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell (1995) 1.39
Biosynthesis and composition of phosphatides in outer and inner mitochondrial membranes. Hoppe Seylers Z Physiol Chem (1968) 1.38
Studies on the occurrence and properties of lysosomal phospholipases A1 and A2 and the degradation of phosphatidic acid in rat liver lysosomes. Hoppe Seylers Z Physiol Chem (1969) 1.29
The primary structure of bovine brain myelin lipophilin (proteolipid apoprotein). Hoppe Seylers Z Physiol Chem (1983) 1.24
Structure and molecular arrangement of proteolipid protein of central nervous system myelin. Proc Natl Acad Sci U S A (1984) 1.22
PROFILEGRAPH: an interactive graphical tool for protein sequence analysis. Comput Appl Biosci (1992) 1.22
Characterization and subcellular localization of murine and human magnesium-dependent neutral sphingomyelinase. J Biol Chem (2000) 1.21
Chemical synthesis of choline-labeled lecithins and sphingomyelins. Methods Enzymol (1975) 1.19
Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice. Proc Natl Acad Sci U S A (1994) 1.18
Application of specific extracorporeal removal of low density lipoprotein in familial hypercholesterolaemia. Lancet (1981) 1.13
Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur J Biochem (1997) 1.12
Biochemical analsis of the inocytotic process. II. Comparison of some enzymes of the lysosomal nd the plasma membrane of the rat liver cel. Hoppe Seylers Z Physiol Chem (1970) 1.11
Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths. J Neurosci (1995) 1.10
Lipids with photosensitive groups as chemical probes for the structural analysis of biological membranes. On the localization of the G- and M-protein of vesicular stomatitis virus. Hoppe Seylers Z Physiol Chem (1978) 1.07
Ceramide UDPgalactosyltransferase from myelinating rat brain: purification, cloning, and expression. Proc Natl Acad Sci U S A (1993) 1.06
Enoyl-CoA hydratase and isomerase form a superfamily with a common active-site glutamate residue. Eur J Biochem (1995) 1.06
Studies in vitro on the biosynthesis of ceramide and sphingomyelin. A reevaluation of proposed pathways. Hoppe Seylers Z Physiol Chem (1980) 1.03
Galactosphingolipids and axono-glial interaction in myelin of the central nervous system. Cell Tissue Res (1998) 1.02
13C-NMR studies of the membrane structure of enveloped virions (vesicular stomatitis virus). Hoppe Seylers Z Physiol Chem (1976) 1.01
Chemical proof of lipid-protein interactions by crosslinking photosensitive lipids to apoproteins. Intermolecular cross-linkage between high-density apolipoprotein A-I and lecithins and sphingomyelins. Hoppe Seylers Z Physiol Chem (1977) 1.01
Glycosphingolipids in lysosomal membranes. Hoppe Seylers Z Physiol Chem (1973) 1.00
Studies on lipolytic activities of rat liver lysosomes. Hoppe Seylers Z Physiol Chem (1967) 1.00
A simple chemical method for labelling phosphatidylcholine and sphingomyelin in the choline moiety. Hoppe Seylers Z Physiol Chem (1971) 1.00
Sphingolipid metabolism in Bacteroideaceae. Hoppe Seylers Z Physiol Chem (1975) 0.99
Inhibition of cholesterol synthesis in cultured cells by 25-azidonorcholesterol. Hoppe Seylers Z Physiol Chem (1978) 0.98
Tumor necrosis factor alpha activates NF-kappaB in acid sphingomyelinase-deficient mouse embryonic fibroblasts. J Biol Chem (1997) 0.98
Membrane attack complex of complement: distribution of subunits between the hydrocarbon phase of target membranes and water. Proc Natl Acad Sci U S A (1981) 0.97
Functional analysis of the high affinity, Na(+)-dependent glutamate transporter GLAST-1 by site-directed mutagenesis. J Biol Chem (1995) 0.97
Lipophilin (proteolipid apoprotein) of brain white matter. Purification and amino acid sequence studies of the four tryptophan fragments. Hoppe Seylers Z Physiol Chem (1982) 0.97
Localization of N-glycosylation sites and functional role of the carbohydrate units of GLAST-1, a cloned rat brain L-glutamate/L-aspartate transporter. Eur J Biochem (1995) 0.97
Studies on the biosynthesis and degradation of sphingosine bases. Chem Phys Lipids (1970) 0.96
A facile method for the isolation and preparation of proteins and peptides for sequence analysis in the picomolar range. Biol Chem Hoppe Seyler (1990) 0.96
[Metabolism of unsaturated fatty acids. V. On the beta-oxidation of mono- and polyene-fatty acids. Mechanism of enzymatic reactions of delta-2-cis-enoyl-CoA compounds]. Hoppe Seylers Z Physiol Chem (1965) 0.96
Synthesis in vitro and translocation of apolipoprotein AI across microsomal vesicles. Eur J Biochem (1981) 0.95
Human mitochondrial 3,2-trans-enoyl-CoA isomerase (DCI): gene structure and localization to chromosome 16p13.3. Genomics (1994) 0.95
Myelin structure in proteolipid protein (PLP)-null mouse spinal cord. J Comp Neurol (1996) 0.95
Functional properties and substrate specificity of the cloned L-glutamate/L-aspartate transporter GLAST-1 from rat brain expressed in Xenopus oocytes. J Neurosci (1994) 0.94
Nature and localization of acidic groups on lysosomal membranes. Biochim Biophys Acta (1973) 0.94
The human gene CGT encoding the UDP-galactose ceramide galactosyl transferase (cerebroside synthase): cloning, characterization, and assignment to human chromosome 4, band q26. Genomics (1996) 0.94
Monolayer studies with synthetic saturated, mono- and polyunsaturated mixed 1,2-diglycerides, 1,2-diacylphosphatidylethanolamines and phosphatidylcholines at the air-water-interface. Hoppe Seylers Z Physiol Chem (1969) 0.93
Myelin-deficient rat: a point mutation in exon III (A----C, Thr75----Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death. EMBO J (1989) 0.93
Properties and specificities of sphingosine kinase from blood platelets. Hoppe Seylers Z Physiol Chem (1975) 0.93
Cloned proteolipid protein and myelin basic protein cDNA. Transcription of the two genes during myelination. Biol Chem Hoppe Seyler (1986) 0.92
Membrane topology of the high-affinity L-glutamate transporter (GLAST-1) of the central nervous system. J Cell Biol (1996) 0.90
Selective removal of apolipoprotein B-containing serum lipoproteins from blood plasma. Proc Natl Acad Sci U S A (1981) 0.90
Electrogenic L-glutamate uptake in Xenopus laevis oocytes expressing a cloned rat brain L-glutamate/L-aspartate transporter (GLAST-1). J Biol Chem (1993) 0.90
Metabolism of sphingosine bases. XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine 1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate. Hoppe Seylers Z Physiol Chem (1970) 0.90
Sphingosine kinase in blood platelets. Hoppe Seylers Z Physiol Chem (1973) 0.90
Sphingosine metabolism and its link to phospholipid biosynthesis. Mol Cell Biochem (1973) 0.90
[The metabolism of unsaturated fatty acid. 3. On the beta-oxidation of mono- and polyene-fatty acids. The mechanism of the enzymatic reaction on delta-3-cis-enoyl-CoA compounds]. Hoppe Seylers Z Physiol Chem (1964) 0.89
Light and electron microscopic analysis of the central and peripheral nervous systems of acid sphingomyelinase-deficient mice resulting from gene targeting. J Neuropathol Exp Neurol (1997) 0.89
Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products. Hoppe Seylers Z Physiol Chem (1983) 0.89
Composition and biophysical properties of myelin lipid define the neurological defects in galactocerebroside- and sulfatide-deficient mice. J Neurochem (1998) 0.88
Ceramide-independent CD28 and TCR signaling but reduced IL-2 secretion in T cells of acid sphingomyelinase-deficient mice. Eur J Immunol (1998) 0.88
Inhibition of the high-affinity brain glutamate transporter GLAST-1 via direct phosphorylation. J Neurochem (1997) 0.88
Stereospecificities in the metabolic reactions of the four isomeric sphinganines (dihydrosphingosines) in rat liver. Hoppe Seylers Z Physiol Chem (1973) 0.88
The metabolism of sphingosine bases in Tetrahymena pyriformis. Sphingosine kinase and sphingosine-1-phosphate lyase. Hoppe Seylers Z Physiol Chem (1974) 0.87
Incorporation of complete phospholipid molecules in cellular membranes of rat liver after uptake from blood serum. Hoppe Seylers Z Physiol Chem (1972) 0.87
Site-directed mutagenesis of putative active-site amino acid residues of 3,2-trans-enoyl-CoA isomerase, conserved within the low-homology isomerase/hydratase enzyme family. Biochemistry (1993) 0.87
Biosynthetic incorporation of fatty acids with photosensitive groups into membrane lipids of cells in tissue culture. Hoppe Seylers Z Physiol Chem (1976) 0.87
Mitochondrial 3-2trans-Enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of the key enzyme of unsaturated fatty acid beta-oxidation. Biol Chem Hoppe Seyler (1991) 0.87
Decompaction of CNS myelin leads to a reduction of the conduction velocity of action potentials in optic nerve. Neurosci Lett (1995) 0.87
Evolution of the myelin integral membrane proteins of the central nervous system. Biol Chem Hoppe Seyler (1991) 0.86
13C nuclear magnetic resonance spectroscopic evidence for hydrophobic lipid-protein interactions in human high density lipoproteins. Proc Natl Acad Sci U S A (1974) 0.86
UDP galactose:ceramide galactosyltransferase and glutamate/aspartate transporter. Copurification, separation and characterization of the two glycoproteins. Eur J Biochem (1995) 0.86
Enzymatic studies on the mechanism of the retroconversion of C22-polyenoic fatty acids to their C20-homologues. Hoppe Seylers Z Physiol Chem (1970) 0.86
Purification and properties of 3-cis-2-trans-enoyl-CoA isomerase (dodecenoyl-CoA delta-isomerase) from rat liver mitochondria. Hoppe Seylers Z Physiol Chem (1978) 0.86
Metabolism of sphingosine bases. 13. Enzymatic synthesis of 1-phosphate esters of 4t-sphingenine (sphingosine), sphinganine (dihydrosphingosine), 4-hydroxysphinganine (phytosphingosine) and 3-dehydrosphinganine by erythrocytes. Hoppe Seylers Z Physiol Chem (1970) 0.85
Sphingolipids. Annu Rev Biochem (1971) 0.85
Metabolism of sphingosine bases. 8. Distribution, isolation and properties of D-3-oxosphinganine reductase. Stereospecificity of the NADPH-dependent reaction of 3-oxodihydrospingosine (2-amino-1-hydroxyoctadecane-3-one). Hoppe Seylers Z Physiol Chem (1968) 0.85
Studies in vivo and in vitro on the methylation of phosphatidyl-N,N-dimethylethanolamine to phosphatidylcholine in rat liver. Hoppe Seylers Z Physiol Chem (1973) 0.85
Primary structure of the C-terminal cyanogen bromide fragments II, III and IV from bovine brain proteolipid-apoprotein. Hoppe Seylers Z Physiol Chem (1982) 0.85
Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase). Hoppe Seylers Z Physiol Chem (1969) 0.85
The organization of the human myelin basic protein gene. Comparison with the mouse gene. Biol Chem Hoppe Seyler (1989) 0.84
Functional analysis of the glycosylation of murine acid sphingomyelinase. J Biol Chem (1996) 0.84
Molecular cloning and characterization of the mouse CGT gene encoding UDP-galactose ceramide-galactosyltransferase (cerebroside synthetase). Genomics (1996) 0.84
13 C-nuclear magnetic resonance spectroscopic studies on saturated, mono-, di- and polyunsaturated fatty acids, phospho- and sphingolipids. Hoppe Seylers Z Physiol Chem (1972) 0.83
Amino-acid sequence of human and bovine brain myelin proteolipid protein (lipophilin) is completely conserved. Biol Chem Hoppe Seyler (1985) 0.83
Metabolism of sphingosine bases, 18. Degradation in vitro of phytosphingosine (4d-hydroxysphinganine). Hoppe Seylers Z Physiol Chem (1972) 0.83
Metabolism of sphingosine bases. XIV. Sphinganine (dihydrosphingosine), an effective donor of the alk-1-enyl chain of plasmalogens. Hoppe Seylers Z Physiol Chem (1970) 0.83
Serum apolipoprotein AI synthesis in rat hepatocytes and its secretion as proform. Hoppe Seylers Z Physiol Chem (1983) 0.82
Carbon-13 nuclear magnetic resonance studies on the interaction of glycophorin with lecithin in reconstituted vesicles. Biochemistry (1980) 0.82
Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice. J Neurosci (2000) 0.82
The relationship between phospholipid biosynthesis, spingosine degradation and serine metabolism. Hoppe Seylers Z Physiol Chem (1969) 0.82
Analysis of the primary structure of the strongly hydrophobic brain myelin proteolipid apoprotein (lipophilin). Isolation and amino acid sequence determination of proteolytic fragments. Hoppe Seylers Z Physiol Chem (1982) 0.82
[Pleomorphic functions of highly unsaturated phospholipids in biological membranes and serum lipoproteins]. Med Welt (1978) 0.81
The 3'-flanking region shared by the human apolipoprotein AI and CIII gene regulates gene expression in cooperation with 5'-flanking elements. Biol Chem Hoppe Seyler (1990) 0.81
A point mutation at the X-chromosomal proteolipid protein locus in Pelizaeus-Merzbacher disease leads to disruption of myelinogenesis. Biol Chem Hoppe Seyler (1990) 0.81
Biosynthesis of dihydrosphingosine in vitro. Hoppe Seylers Z Physiol Chem (1968) 0.81
Analysis of amino sugar-containing glycosphingolipids by combined gas-liquid chromatography and mass spectrometry. Hoppe Seylers Z Physiol Chem (1973) 0.81