Published in Mol Cell on June 01, 2003
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol (2009) 4.53
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat Immunol (2011) 3.91
Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem J (2004) 3.01
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med (2004) 2.50
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk. Nat Immunol (2009) 2.48
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J (2006) 2.41
Sequence and chromatin determinants of cell-type-specific transcription factor binding. Genome Res (2012) 2.24
Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A (2003) 1.96
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci U S A (2006) 1.96
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci U S A (2008) 1.68
Selective C-Rel activation via Malt1 controls anti-fungal T(H)-17 immunity by dectin-1 and dectin-2. PLoS Pathog (2011) 1.62
A SILAC-based DNA protein interaction screen that identifies candidate binding proteins to functional DNA elements. Genome Res (2008) 1.60
Retracted A cell cycle regulatory network controlling NF-kappaB subunit activity and function. EMBO J (2007) 1.58
Nephrin deficiency activates NF-kappaB and promotes glomerular injury. J Am Soc Nephrol (2009) 1.57
Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. Nat Immunol (2012) 1.48
Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci U S A (2011) 1.48
IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response. J Cell Biol (2006) 1.46
NAD+-dependent SIRT1 deacetylase participates in epigenetic reprogramming during endotoxin tolerance. J Biol Chem (2011) 1.46
RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci U S A (2005) 1.45
IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression. EMBO J (2006) 1.43
Coordination of cell signaling, chromatin remodeling, histone modifications, and regulator recruitment in human matrix metalloproteinase 9 gene transcription. Mol Cell Biol (2004) 1.37
Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med (2007) 1.27
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol (2011) 1.22
TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. J Cell Biol (2005) 1.19
Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun (2010) 1.17
Cells of the synovium in rheumatoid arthritis. Dendritic cells. Arthritis Res Ther (2007) 1.16
IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo. J Exp Med (2010) 1.15
Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13
The NF-κB genomic landscape in lymphoblastoid B cells. Cell Rep (2014) 1.12
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J (2009) 1.11
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J Clin Invest (2012) 1.10
A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem (2008) 1.10
Gene network inference and visualization tools for biologists: application to new human transcriptome datasets. Nucleic Acids Res (2011) 1.08
RelB sustains IkappaBalpha expression during endotoxin tolerance. Clin Vaccine Immunol (2008) 1.07
SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther (2008) 1.04
Nuclear factor-κB1 controls the functional maturation of dendritic cells and prevents the activation of autoreactive T cells. Nat Med (2011) 1.03
p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes. Elife (2014) 1.03
X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J Mol Biol (2007) 1.01
Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus. Immunology (2008) 1.01
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. Nat Immunol (2009) 1.01
Repression of Dmp1 and Arf transcription by anthracyclins: critical roles of the NF-kappaB subunit p65. Oncogene (2007) 1.00
The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements. Cell Rep (2012) 0.99
Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts. BMC Genomics (2008) 0.99
What does tumour necrosis factor excess do to the immune system long term? Ann Rheum Dis (2005) 0.98
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes. Retrovirology (2008) 0.96
CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters. Proc Natl Acad Sci U S A (2004) 0.96
Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways. J Med Chem (2009) 0.96
Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IκBα. J Immunol (2010) 0.95
Human adenovirus type 19 infection of corneal cells induces p38 MAPK-dependent interleukin-8 expression. Virol J (2008) 0.94
Charting the NF-κB pathway interactome map. PLoS One (2012) 0.94
CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses. Proc Am Thorac Soc (2007) 0.93
Cooperation between classical and alternative NF-κB pathways regulates proinflammatory responses in epithelial cells. Am J Respir Cell Mol Biol (2012) 0.91
Non-Canonical NF-κB Signaling Initiated by BAFF Influences B Cell Biology at Multiple Junctures. Front Immunol (2014) 0.91
Nuclear receptors in inflammation control: repression by GR and beyond. Mol Cell Endocrinol (2013) 0.90
Genomic analysis reveals a novel nuclear factor-κB (NF-κB)-binding site in Alu-repetitive elements. J Biol Chem (2011) 0.90
Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production. PLoS One (2010) 0.90
Critical role of cRel subunit of NF-κB in sepsis survival. Infect Immun (2011) 0.89
NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB. Endocrinology (2006) 0.88
RelB: an outlier in leukocyte biology. J Leukoc Biol (2013) 0.88
Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells. Immunology (2006) 0.87
Frequent engagement of RelB activation is critical for cell survival in multiple myeloma. PLoS One (2013) 0.87
Notch- and transducin-like enhancer of split (TLE)-dependent histone deacetylation explain interleukin 12 (IL-12) p70 inhibition by zymosan. J Biol Chem (2011) 0.85
Regulation of Mcl-1 by constitutive activation of NF-κB contributes to cell viability in human esophageal squamous cell carcinoma cells. BMC Cancer (2014) 0.85
RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol (2008) 0.85
p65 Negatively regulates transcription of the cyclin E gene. J Biol Chem (2010) 0.85
Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine Growth Factor Rev (2015) 0.83
Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-κB. Microcirculation (2011) 0.82
Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer. Oncotarget (2014) 0.82
The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cell Mol Life Sci (2015) 0.82
The TRAF6-NF kappa B signaling pathway in autoimmunity: not just inflammation. Arthritis Res Ther (2005) 0.80
Dendritic cell maturation and survival are differentially regulated by TNFR1 and TNFR2. J Immunol (2014) 0.79
Differential utilization of NF-kappaB RELA and RELB in response to extracellular versus intracellular polyIC stimulation in HT1080 cells. BMC Immunol (2011) 0.79
Duration of alpha 1-antichymotrypsin gene activation by interleukin-1 is determined by efficiency of inhibitor of nuclear factor kappa B alpha resynthesis in primary human astrocytes. J Neurochem (2005) 0.79
DING proteins from phylogenetically different species share high degrees of sequence and structure homology and block transcription of HIV-1 LTR promoter. PLoS One (2013) 0.79
RelAp43, a member of the NF-κB family involved in innate immune response against Lyssavirus infection. PLoS Pathog (2012) 0.78
Differential requirement for the IKKβ/NF-κB signaling module in regulating TLR- versus RLR-induced type 1 IFN expression in dendritic cells. J Immunol (2014) 0.78
Classical and alternative NF-κB signaling cooperate in regulating adipocyte differentiation and function. Int J Obes (Lond) (2015) 0.78
An alternative to lung inflammation and fibrosis. Am J Pathol (2010) 0.77
IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development. J Immunol (2016) 0.77
SP110b Controls Host Immunity and Susceptibility to Tuberculosis. Am J Respir Crit Care Med (2016) 0.75
The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity. Sci Rep (2016) 0.75
The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells (2016) 0.75
Non-canonical NF-κB pathway activation predicts outcome in borderline oestrogen receptor positive breast carcinoma. Br J Cancer (2016) 0.75
Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway. Oncogene (2016) 0.75
Regulation of GTP-binding protein (Gαs) expression in human myometrial cells: a role for tumor necrosis factor in modulating Gαs promoter acetylation by transcriptional complexes. J Biol Chem (2013) 0.75
Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions. Cells (2016) 0.75
Cooperation of Rel family members in regulating Aβ1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cells. Cell Death Dis (2017) 0.75
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48
Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol (2001) 4.38
Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell (2012) 4.10
Latent enhancers activated by stimulation in differentiated cells. Cell (2013) 3.44
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol (2002) 3.07
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A (2009) 3.01
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med (2004) 2.50
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol Cell (2010) 2.43
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J (2006) 2.41
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10
Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol (2010) 2.00
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74
The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity (2012) 1.60
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS One (2008) 1.57
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A (2012) 1.53
Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell (2009) 1.48
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03
The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep (2012) 1.01
Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol (2013) 0.99
Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol (2014) 0.95
Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils. J Immunol (2013) 0.93
Transcriptional control of macrophage diversity and specialization. Eur J Immunol (2011) 0.88
Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation. Eur J Immunol (2011) 0.85
Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp Cell Res (2006) 0.85
Lineages, cell types and functional states: a genomic view. Curr Opin Cell Biol (2013) 0.84
Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data. Biol Direct (2011) 0.84
Deciphering cis-regulatory control in inflammatory cells. Philos Trans R Soc Lond B Biol Sci (2013) 0.81
A birthday gift for TRADD. Nat Immunol (2008) 0.80
Functional genomics of the inflammatory response: where are we now? Brief Funct Genomics (2013) 0.78
Non-coding transcription at cis-regulatory elements: computational and experimental approaches. Methods (2013) 0.77
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Rep (2017) 0.75
Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency. Nat Commun (2015) 0.75