Published in J Exp Med on June 28, 2004
NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev (2012) 5.77
The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol (2009) 4.61
Non-canonical NF-κB signaling pathway. Cell Res (2010) 3.03
A comprehensive map of the toll-like receptor signaling network. Mol Syst Biol (2006) 2.89
The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription. Proc Natl Acad Sci U S A (2005) 2.74
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J (2006) 2.41
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J (2006) 2.41
IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol (2006) 2.05
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. Cell Signal (2010) 1.99
Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr Rev (2009) 1.88
A single NFκB system for both canonical and non-canonical signaling. Cell Res (2010) 1.88
Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal (2011) 1.82
A pervasive role of ubiquitin conjugation in activation and termination of IkappaB kinase pathways. EMBO Rep (2005) 1.79
The nuclear signaling of NF-kappaB: current knowledge, new insights, and future perspectives. Cell Res (2009) 1.77
GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Genes Dev (2009) 1.62
Tumor necrosis factor alpha-mediated reduction of KLF2 is due to inhibition of MEF2 by NF-kappaB and histone deacetylases. Mol Cell Biol (2005) 1.57
Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep (2009) 1.54
Telomerase directly regulates NF-κB-dependent transcription. Nat Cell Biol (2012) 1.53
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA. Oncogene (2013) 1.44
Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res (2008) 1.32
WIP1 phosphatase is a negative regulator of NF-kappaB signalling. Nat Cell Biol (2009) 1.30
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Revisiting the COP9 signalosome as a transcriptional regulator. EMBO Rep (2009) 1.24
PPARγ is an E3 ligase that induces the degradation of NFκB/p65. Nat Commun (2012) 1.23
Epigenetics, bioenergetics, and microRNA coordinate gene-specific reprogramming during acute systemic inflammation. J Leukoc Biol (2011) 1.22
Proteasome-independent degradation of canonical NFkappaB complex components by the NleC protein of pathogenic Escherichia coli. J Biol Chem (2010) 1.21
Selectivity of the NF-{kappa}B response. Cold Spring Harb Perspect Biol (2009) 1.20
Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon. Nucleic Acids Res (2010) 1.20
Degradation of nuclear factor kappa B during foot-and-mouth disease virus infection. J Virol (2007) 1.20
Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation. Nat Cell Biol (2015) 1.18
Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal (2011) 1.18
Gene-specific epigenetic regulation in serious infections with systemic inflammation. J Innate Immun (2010) 1.17
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J Biol Chem (2010) 1.16
COMMD proteins: COMMing to the scene. Cell Mol Life Sci (2007) 1.15
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res (2010) 1.12
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J (2009) 1.11
NF-κB and cancer: a paradigm of Yin-Yang. Am J Cancer Res (2010) 1.08
Regulation of NF-κB by TNF family cytokines. Semin Immunol (2014) 1.06
Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A (2012) 1.06
TRAF7 protein promotes Lys-29-linked polyubiquitination of IkappaB kinase (IKKgamma)/NF-kappaB essential modulator (NEMO) and p65/RelA protein and represses NF-kappaB activation. J Biol Chem (2011) 1.05
Acetylation of p65 at lysine 314 is important for late NF-kappaB-dependent gene expression. BMC Genomics (2010) 1.05
COMMD proteins and the control of the NF kappa B pathway. Cell Cycle (2007) 1.03
Regulation of NF-κB activity by competition between RelA acetylation and ubiquitination. Oncogene (2011) 1.01
Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A (2008) 1.00
Unique aspects of transcriptional regulation in neurons--nuances in NFkappaB and Sp1-related factors. J Neuroinflammation (2009) 0.98
Human T-cell lymphotropic virus: a model of NF-κB-associated tumorigenesis. Viruses (2011) 0.97
UXT is a novel and essential cofactor in the NF-kappaB transcriptional enhanceosome. J Cell Biol (2007) 0.97
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IkappaBalpha and enhances HIV-1 replication in human T lymphocytes. Retrovirology (2008) 0.96
Gene-specific repression of proinflammatory cytokines in stimulated human macrophages by nuclear IκBα. J Immunol (2010) 0.95
Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation. J Biol Chem (2009) 0.92
Ubiquitination in the antiviral immune response. Virology (2015) 0.92
Immunological synapse: a multi-protein signalling cellular apparatus for controlling gene expression. Immunology (2010) 0.91
Diverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis. J Cancer Res Clin Oncol (2013) 0.91
Copper metabolism domain-containing 1 represses genes that promote inflammation and protects mice from colitis and colitis-associated cancer. Gastroenterology (2014) 0.90
Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targets. Cell Death Differ (2007) 0.89
Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes. Mol Immunol (2009) 0.89
TAT-mediated intracellular delivery of NPM-derived peptide induces apoptosis in leukemic cells and suppresses leukemogenesis in mice. Blood (2008) 0.89
Monoubiquitination of nuclear RelA negatively regulates NF-κB activity independent of proteasomal degradation. Cell Mol Life Sci (2012) 0.88
Proteasome inhibition increases recruitment of IκB kinase β (IKKβ), S536P-p65, and transcription factor EGR1 to interleukin-8 (IL-8) promoter, resulting in increased IL-8 production in ovarian cancer cells. J Biol Chem (2013) 0.88
Proteasome inhibition by bortezomib increases IL-8 expression in androgen-independent prostate cancer cells: the role of IKKα. J Immunol (2013) 0.88
A novel mechanism of crosstalk between the p53 and NFκB pathways: MDM2 binds and inhibits p65RelA. Cell Cycle (2013) 0.88
IKK inhibition increases bortezomib effectiveness in ovarian cancer. Oncotarget (2015) 0.87
Ubiquitin-mediated NFκB degradation pathway. Cell Mol Immunol (2014) 0.85
ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system. Nat Immunol (2012) 0.85
Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-kappaB activation. Biochem Pharmacol (2009) 0.84
HSCARG regulates NF-kappaB activation by promoting the ubiquitination of RelA or COMMD1. J Biol Chem (2009) 0.84
Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB. PLoS One (2012) 0.84
The influenza virus protein PB1-F2 interacts with IKKβ and modulates NF-κB signalling. PLoS One (2013) 0.84
A cell-type-specific role for murine Commd1 in liver inflammation. Biochim Biophys Acta (2014) 0.83
Muscle precursor cells isolated from aged rats exhibit an increased tumor necrosis factor- alpha response. Aging Cell (2009) 0.83
RelA-Induced Interferon Response Negatively Regulates Proliferation. PLoS One (2015) 0.81
Inhibition of 26S protease regulatory subunit 7 (MSS1) suppresses neuroinflammation. PLoS One (2012) 0.80
Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT). PLoS One (2012) 0.80
Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal growth factor receptor. PLoS One (2012) 0.79
Intracellular activation of interferon regulatory factor-1 by nanobodies to the multifunctional (Mf1) domain. J Biol Chem (2010) 0.78
Asymmetric arginine dimethylation of RelA provides a repressive mark to modulate TNFα/NF-κB response. Proc Natl Acad Sci U S A (2016) 0.78
Dysfunction of the ubiquitin-proteasome system in atherosclerotic cardiovascular disease. Am J Cardiovasc Dis (2015) 0.77
p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-κB subunit. J Cell Sci (2014) 0.77
N-octanoyl dopamine inhibits the expression of a subset of κB regulated genes: potential role of p65 Ser276 phosphorylation. PLoS One (2013) 0.77
PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway. Biomolecules (2015) 0.77
The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation. Nucleic Acids Res (2015) 0.75
Depletion of c-Rel from cytokine gene promoters is required for chromatin reassembly and termination of gene responses to T cell activation. PLoS One (2012) 0.75
The synthetic peptide CIGB-300 modulates CK2-dependent signaling pathways affecting the survival and chemoresistance of non-small cell lung cancer cell lines. Cancer Cell Int (2017) 0.75
Regulation and function of nuclear IκBα in inflammation and cancer. Am J Clin Exp Immunol (2012) 0.75
The Ubiquitination of NF-κB Subunits in the Control of Transcription. Cells (2016) 0.75
Dynamic phosphorylation of RelA on Ser42 and Ser45 in response to TNFα stimulation regulates DNA binding and transcription. Open Biol (2016) 0.75
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu Rev Immunol (2000) 20.70
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science (2002) 13.86
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation. Genes Dev (1995) 9.31
Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol (1994) 8.98
Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science (2001) 6.79
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev (1989) 5.61
How the ubiquitin-proteasome system controls transcription. Nat Rev Mol Cell Biol (2003) 4.90
Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice. Genes Dev (1995) 4.38
Purified human I kappa B can rapidly dissociate the complex of the NF-kappa B transcription factor with its cognate DNA. Cell (1990) 4.37
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell (2003) 4.37
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev (1993) 4.23
Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature (1998) 4.03
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities. EMBO J (2003) 3.93
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell (2003) 3.40
Regulation of transcriptional activation domain function by ubiquitin. Science (2001) 3.36
Autoregulation of I kappa B alpha activity. Proc Natl Acad Sci U S A (1994) 3.24
Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B. Mol Cell Biol (1995) 2.69
Modulation of NF-kappaB activity by exchange of dimers. Mol Cell (2003) 2.62
Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasm. J Cell Sci (1997) 2.44
Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis. Proc Natl Acad Sci U S A (2000) 2.32
I kappa B proteins: structure, function and regulation. Semin Cancer Biol (1997) 2.01
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha. Nucleic Acids Res (1994) 1.98
Proteasome-mediated degradation of transcriptional activators correlates with activation domain potency in vivo. EMBO J (1999) 1.83
Modulation of cytokine-induced HIV gene expression by competitive binding of transcription factors to the coactivator p300. EMBO J (1998) 1.56
Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta. J Exp Med (1998) 1.45
Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export. Mol Cell Biol (2000) 1.44
A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. Curr Biol (2002) 1.26
Characterization of the nuclear import and export functions of Ikappa B(epsilon). J Biol Chem (2002) 1.00
Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48
Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol (2001) 4.38
Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell (2012) 4.10
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Latent enhancers activated by stimulation in differentiated cells. Cell (2013) 3.44
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol (2002) 3.07
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A (2009) 3.01
Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. J Clin Invest (2007) 2.99
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72
Modulation of NF-kappaB activity by exchange of dimers. Mol Cell (2003) 2.62
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol Cell (2010) 2.43
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J (2006) 2.41
Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity (2002) 2.31
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nat Immunol (2005) 2.18
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10
Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells. Cancer Res (2007) 2.06
Combined deficiency of p50 and cRel in CD4+ T cells reveals an essential requirement for nuclear factor kappaB in regulating mature T cell survival and in vivo function. J Exp Med (2003) 1.93
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration. Nat Cell Biol (2011) 1.77
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74
Activation of dendritic cells via inhibition of Jak2/STAT3 signaling. J Immunol (2005) 1.61
The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity (2012) 1.60
Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J Immunol (2007) 1.59
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS One (2008) 1.57
PAK4 kinase is essential for embryonic viability and for proper neuronal development. Mol Cell Biol (2003) 1.55
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A (2012) 1.53
The Th17 immune response is controlled by the Rel-RORγ-RORγ T transcriptional axis. J Exp Med (2011) 1.50
Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell (2009) 1.48
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochem Biophys Res Commun (2002) 1.45
Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol (2010) 1.41
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J Clin Invest (2009) 1.37
NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication. J Immunol (2010) 1.33
Defining emerging roles for NF-κB in antivirus responses: revisiting the interferon-β enhanceosome paradigm. PLoS Pathog (2011) 1.27
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res (2009) 1.25
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis. Mol Cell Biol (2011) 1.25
Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses. J Virol (2011) 1.20
Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression. J Immunol (2007) 1.19
Interferons direct an effective innate response to Legionella pneumophila infection. J Biol Chem (2009) 1.19
Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury. Mol Cell Biol (2006) 1.11
Dissection of TBK1 signaling via phosphoproteomics in lung cancer cells. Proc Natl Acad Sci U S A (2013) 1.09
Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance. J Clin Invest (2013) 1.08
The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep (2012) 1.01
Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol (2013) 0.99
Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment. J Biol Chem (2010) 0.99
Pharmacologic inhibition of PKCα and PKCθ prevents GVHD while preserving GVL activity in mice. Blood (2013) 0.96
Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol (2014) 0.95
Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils. J Immunol (2013) 0.93
Regulation of developing B cell survival by RelA-containing NF-kappa B complexes. J Immunol (2003) 0.91
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. Cancer Res (2004) 0.91
Transcriptional control of macrophage diversity and specialization. Eur J Immunol (2011) 0.88
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice. Eur J Immunol (2013) 0.87
Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp Cell Res (2006) 0.85
Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation. Eur J Immunol (2011) 0.85
ComPPARtmentalizing NF-kappaB in the gut. Nat Immunol (2004) 0.84
Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data. Biol Direct (2011) 0.84
Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice. J Biol Chem (2008) 0.84
Lineages, cell types and functional states: a genomic view. Curr Opin Cell Biol (2013) 0.84
Deciphering cis-regulatory control in inflammatory cells. Philos Trans R Soc Lond B Biol Sci (2013) 0.81
Targeting PKCθ in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential. Front Immunol (2012) 0.80
A birthday gift for TRADD. Nat Immunol (2008) 0.80
Functional genomics of the inflammatory response: where are we now? Brief Funct Genomics (2013) 0.78
TNFRSF10B polymorphisms and haplotypes associated with increased risk of death in non-small cell lung cancer. Carcinogenesis (2013) 0.78
Non-canonical IKKs, IKKϵ and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer. Expert Opin Ther Targets (2013) 0.77
Non-coding transcription at cis-regulatory elements: computational and experimental approaches. Methods (2013) 0.77
Propelling Immunotherapy Combinations Into the Clinic. Oncology (Williston Park) (2015) 0.76
NF-κB is crucial in proximal T-cell signaling for calcium influx and NFAT activation. Eur J Immunol (2014) 0.76
IKKβ-induced inflammation impacts the kinetics but not the magnitude of the immune response to a viral vector. Eur J Immunol (2012) 0.75
Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency. Nat Commun (2015) 0.75
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Rep (2017) 0.75