Published in Infect Immun on February 22, 2011
The c-Rel Transcription Factor in Development and Disease. Genes Cancer (2011) 1.01
Immune-pineal axis: nuclear factor κB (NF-kB) mediates the shift in the melatonin source from pinealocytes to immune competent cells. Int J Mol Sci (2013) 0.86
Inhibition of IKKβ in enterocytes exacerbates sepsis-induced intestinal injury and worsens mortality. Crit Care Med (2013) 0.85
Alterations of dendritic cells in sepsis: featured role in immunoparalysis. Biomed Res Int (2015) 0.82
NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm (2013) 0.81
Inhibiting IκBβ-NFκB signaling attenuates the expression of select pro-inflammatory genes. J Cell Sci (2015) 0.81
Functional imaging of Rel expression in inflammatory processes using bioluminescence imaging system in transgenic mice. PLoS One (2013) 0.78
Endotoxemia Induces IκBβ/NF-κB-Dependent Endothelin-1 Expression in Hepatic Macrophages. J Immunol (2015) 0.77
Trauma patients' elevated tumor necrosis related apoptosis inducing ligand (TRAIL) contributes to increased T cell apoptosis. Clin Immunol (2012) 0.77
Identification of haplotype tag single nucleotide polymorphisms within the nuclear factor-κB family genes and their clinical relevance in patients with major trauma. Crit Care (2015) 0.77
Treatment of low molecular weight heparin inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in rats. Inflammation (2014) 0.77
Association of REL polymorphisms and outcome of patients with septic shock. Ann Intensive Care (2016) 0.75
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A (1979) 365.71
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis. Nucleic Acids Res (1981) 35.39
The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol (1996) 22.30
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med (1992) 22.13
The pathophysiology and treatment of sepsis. N Engl J Med (2003) 21.67
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15
NF-kappaB regulation in the immune system. Nat Rev Immunol (2002) 15.80
Affinity purification of sequence-specific DNA binding proteins. Proc Natl Acad Sci U S A (1986) 14.92
Recognition of microorganisms and activation of the immune response. Nature (2007) 12.99
A network-based analysis of systemic inflammation in humans. Nature (2005) 12.60
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev (1995) 5.51
Immunotherapy for sepsis--a new approach against an ancient foe. N Engl J Med (2010) 3.62
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat Immunol (2000) 3.58
Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2005) 3.52
Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A (1999) 3.35
Modulation of NF-kappaB activity by exchange of dimers. Mol Cell (2003) 2.62
Balance of inflammatory cytokines related to severity and mortality of murine sepsis. Infect Immun (1996) 2.43
Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models. Oncogene (2006) 2.33
Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol (2002) 2.25
Role of NFkappaB in the mortality of sepsis. J Clin Invest (1997) 2.18
Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci U S A (2006) 1.96
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol (2009) 1.91
CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis. J Immunol (2005) 1.71
Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J Immunol (2007) 1.59
Disease-specific gene expression profiling in multiple models of lung disease. Am J Respir Crit Care Med (2007) 1.46
Reversal of long-term sepsis-induced immunosuppression by dendritic cells. Blood (2004) 1.44
Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel. J Immunol (2007) 1.43
Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. J Immunol (2002) 1.31
T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J Immunol (2004) 1.23
The regulatory logic of the NF-kappaB signaling system. Cold Spring Harb Perspect Biol (2010) 1.13
Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response. Int Immunol (1999) 1.07
Multiple hemopoietic defects and lymphoid hyperplasia in mice lacking the transcriptional activation domain of the c-Rel protein. J Exp Med (1998) 1.04
Dendritic cells modulate lung response to Pseudomonas aeruginosa in a murine model of sepsis-induced immune dysfunction. J Immunol (2008) 1.00
Listeria monocytogenes membrane trafficking and lifestyle: the exception or the rule? Annu Rev Cell Dev Biol (2009) 0.96
Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo. Am J Physiol Regul Integr Comp Physiol (2007) 0.92
Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays. Crit Care Med (2002) 0.92
Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes. Cell Immunol (2003) 0.92
Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells. Infect Immun (2009) 0.90
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90
High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med (2015) 10.15
A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42
High versus low blood-pressure target in patients with septic shock. N Engl J Med (2014) 7.37
Intravascular Complications of Central Venous Catheterization by Insertion Site. N Engl J Med (2015) 7.02
Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity (2010) 5.43
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med (2011) 3.63
Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome. Circulation (2002) 3.16
Outcomes of critically ill patients with hematologic malignancies: prospective multicenter data from France and Belgium--a groupe de recherche respiratoire en réanimation onco-hématologique study. J Clin Oncol (2013) 3.14
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren's syndrome. Proc Natl Acad Sci U S A (2006) 3.11
Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005-2006). Crit Care Med (2009) 3.07
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96
Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry. Circ Cardiovasc Interv (2010) 2.91
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Crit Care Med (2015) 2.81
Short- and long-term outcome in elderly patients after out-of-hospital cardiac arrest: a cohort study. Crit Care Med (2014) 2.70
Influence of overweight on ICU mortality: a prospective study. Chest (2004) 2.54
Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange. Experience of the French Thrombotic Microangiopathies Reference Center. Crit Care Med (2012) 2.51
Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol (2002) 2.27
IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med (2010) 2.21
Benefit of an early and systematic imaging procedure after cardiac arrest: insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry. Resuscitation (2012) 2.13
Cytokine cascade in sepsis. Scand J Infect Dis (2003) 2.09
Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis. Crit Care Med (2004) 2.05
Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections. Intensive Care Med (2013) 2.02
FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase. J Immunol (2008) 1.97
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med (2008) 1.89
Endotoxin tolerance: is there a clinical relevance? J Endotoxin Res (2003) 1.87
Severe imported falciparum malaria: a cohort study in 400 critically ill adults. PLoS One (2010) 1.86
c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med (2009) 1.85
Acute respiratory distress syndrome in patients with malignancies. Intensive Care Med (2014) 1.84
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A (2012) 1.83
Soluble thrombomodulin, plasma-derived unactivated protein C, and recombinant human activated protein C in sepsis. Crit Care Med (2002) 1.81
Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: the Treatment with Oscillation and an Open Lung Strategy (TOOLS) Trial pilot study. Crit Care Med (2005) 1.81
Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med (2009) 1.76
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity (2009) 1.73
Resilience to bacterial infection: difference between species could be due to proteins in serum. J Infect Dis (2010) 1.73
Prognostic value of relative adrenal insufficiency after out-of-hospital cardiac arrest. Intensive Care Med (2005) 1.71
High frequency oscillatory ventilation compared with conventional mechanical ventilation in adult respiratory distress syndrome: a randomized controlled trial [ISRCTN24242669]. Crit Care (2005) 1.69
Infectious complications in out-of-hospital cardiac arrest patients in the therapeutic hypothermia era. Crit Care Med (2011) 1.68
Outcomes in critically ill cancer patients with septic shock of pulmonary origin. Shock (2013) 1.65
IRAK1 functional genetic variant affects severity of septic shock. Crit Care Med (2010) 1.64
c-Rel is required for chromatin remodeling across the IL-2 gene promoter. J Immunol (2003) 1.64
Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients?: insights from a large registry. Circulation (2011) 1.63
Out-of-hospital cardiac arrest from brain cause: epidemiology, clinical features, and outcome in a multicenter cohort*. Crit Care Med (2015) 1.62
Early-onset pneumonia after cardiac arrest: characteristics, risk factors and influence on prognosis. Am J Respir Crit Care Med (2011) 1.62
KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Nat Genet (2011) 1.62
The combined absence of NF-kappa B1 and c-Rel reveals that overlapping roles for these transcription factors in the B cell lineage are restricted to the activation and function of mature cells. Proc Natl Acad Sci U S A (2002) 1.59
Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells. J Immunol (2007) 1.59
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A (2006) 1.58
Impact of case volume on survival of septic shock in patients with malignancies. Crit Care Med (2012) 1.58
The importance of Toll-like receptor 2 polymorphisms in severe infections. Clin Infect Dis (2005) 1.57
Plasma-induced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med (2007) 1.57
Histone dynamics on the interleukin-2 gene in response to T-cell activation. Mol Cell Biol (2005) 1.57
High-volume hemofiltration after out-of-hospital cardiac arrest: a randomized study. J Am Coll Cardiol (2005) 1.56
Outcome of severe adult thrombotic microangiopathies in the intensive care unit. Intensive Care Med (2004) 1.56
Coordinating TLR-activated signaling pathways in cells of the immune system. Immunol Cell Biol (2007) 1.52
Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era. Intensive Care Med (2014) 1.51
Testing protocols in the intensive care unit: complex trials of complex interventions for complex patients. JAMA (2008) 1.51
Lung microenvironment contributes to the resistance of alveolar macrophages to develop tolerance to endotoxin*. Crit Care Med (2012) 1.49
Nuclear outsourcing of RNA interference components to human mitochondria. PLoS One (2011) 1.49
Postresuscitation syndrome: potential role of hydroxyl radical-induced endothelial cell damage. Crit Care Med (2011) 1.47
Comparison between Flotrac-Vigileo and Bioreactance, a totally noninvasive method for cardiac output monitoring. Crit Care (2009) 1.46
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
Low titers of serum antibodies inhibiting hemagglutination predict fatal fulminant influenza A(H1N1) 2009 infection. Am J Respir Crit Care Med (2014) 1.45
The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model. J Clin Invest (2009) 1.44
Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis. Arthritis Rheumatol (2014) 1.44
Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel. J Immunol (2007) 1.43
Changes in cerebral blood flow and oxygen extraction during post-resuscitation syndrome. Resuscitation (2007) 1.42
Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction. FASEB J (2006) 1.42
Intensive care unit renal support therapy volume is not associated with patient outcome. Crit Care Med (2011) 1.42
High Level of Endotoxemia Following Out-of-Hospital Cardiac Arrest Is Associated With Severity and Duration of Postcardiac Arrest Shock. Crit Care Med (2015) 1.41
Outcome of critically ill allogeneic hematopoietic stem-cell transplantation recipients: a reappraisal of indications for organ failure supports. J Clin Oncol (2005) 1.40
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet (2011) 1.40
Acquiring procedural skills in ICUs: a prospective multicenter study*. Crit Care Med (2014) 1.40
Disulfiram ethanol reaction mimicking anaphylactic, cardiogenic, and septic shock. Am J Emerg Med (2012) 1.39
The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms. Mol Cell Biol (2004) 1.39
Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med (2014) 1.38