Published in Nat Immunol on December 17, 2001
Transcriptional control of the inflammatory response. Nat Rev Immunol (2009) 5.20
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1). EMBO J (2003) 4.22
Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc Natl Acad Sci U S A (2002) 3.85
Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med (2003) 3.71
Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One (2008) 3.68
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J (2003) 3.29
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways. Immunity (2008) 2.62
NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem (2006) 2.29
A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes Dev (2004) 2.16
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10
Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms. Immunol Rev (2008) 1.96
The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol (2005) 1.88
Histone modifications induced by a family of bacterial toxins. Proc Natl Acad Sci U S A (2007) 1.86
Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80
Toll-like receptor signaling in cell proliferation and survival. Cytokine (2009) 1.79
Transcriptional profiling of the LPS induced NF-kappaB response in macrophages. BMC Immunol (2007) 1.71
The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet (2011) 1.69
Control of NF-kappaB-dependent transcriptional responses by chromatin organization. Cold Spring Harb Perspect Biol (2009) 1.67
Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics (2010) 1.60
Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. Proc Natl Acad Sci U S A (2006) 1.58
NF-kappaB controls the global pro-inflammatory response in endothelial cells: evidence for the regulation of a pro-atherogenic program. Nucleic Acids Res (2005) 1.57
Epigenetics and bacterial infections. Cold Spring Harb Perspect Med (2012) 1.56
Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J Immunol (2006) 1.55
Prep1/Pbx2 complexes regulate CCL2 expression through the -2578 guanine polymorphism. Genes Immun (2008) 1.55
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling. Immunity (2013) 1.55
Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Brain Res (2009) 1.53
GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells. EMBO J (2004) 1.50
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol (2011) 1.46
Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39
The IkappaB kinase complex and NF-kappaB act as master regulators of lipopolysaccharide-induced gene expression and control subordinate activation of AP-1. Mol Cell Biol (2004) 1.39
Activation of the mouse histone deacetylase 1 gene by cooperative histone phosphorylation and acetylation. Mol Cell Biol (2002) 1.36
Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology (2007) 1.35
TNF and MAP kinase signalling pathways. Semin Immunol (2014) 1.35
Regulation of an inducible promoter by an HP1beta-HP1gamma switch. EMBO Rep (2008) 1.33
Inhibition of NF-kappaB-dependent transcription by MKP-1: transcriptional repression by glucocorticoids occurring via p38 MAPK. J Biol Chem (2009) 1.32
Transcriptional control of the TNF gene. Curr Dir Autoimmun (2010) 1.32
MAPK p38 regulates transcriptional activity of NF-kappaB in primary human astrocytes via acetylation of p65. J Immunol (2007) 1.31
Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci (2010) 1.31
Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci (2009) 1.30
WIP1 phosphatase is a negative regulator of NF-kappaB signalling. Nat Cell Biol (2009) 1.30
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc Natl Acad Sci U S A (2002) 1.30
Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab (2005) 1.29
Regulation of JNK and p38 MAPK in the immune system: signal integration, propagation and termination. Cytokine (2009) 1.28
The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes. J Exp Med (2004) 1.25
Histone H3 phosphorylation - a versatile chromatin modification for different occasions. Biochimie (2012) 1.23
Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation. J Immunol (2009) 1.22
Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx (2006) 1.21
Epigenetic regulation in alcoholic liver disease. World J Gastroenterol (2011) 1.21
Selectivity of the NF-{kappa}B response. Cold Spring Harb Perspect Biol (2009) 1.20
c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene. Mol Cell Biol (2008) 1.20
LPS-induced IL-8 activation in human intestinal epithelial cells is accompanied by specific histone H3 acetylation and methylation changes. BMC Microbiol (2010) 1.18
Common interaction surfaces of the toll-like receptor 4 cytoplasmic domain stimulate multiple nuclear targets. Mol Cell Biol (2003) 1.16
Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappaB inhibition. EMBO J (2008) 1.14
Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. Mol Cell Biol (2005) 1.14
Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem (2012) 1.13
Bordetella evades the host immune system by inducing IL-10 through a type III effector, BopN. J Exp Med (2009) 1.11
Activation of p38 mitogen-activated protein kinase attenuates Leishmania donovani infection in macrophages. Infect Immun (2002) 1.10
Modulation of acetylation: creating a pro-survival and anti-inflammatory phenotype in lethal hemorrhagic and septic shock. J Biomed Biotechnol (2011) 1.09
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4. Mol Cancer (2011) 1.08
Role of dual specificity phosphatases in biological responses to glucocorticoids. J Biol Chem (2008) 1.08
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One (2012) 1.07
Histone ADP-ribosylation facilitates gene transcription by directly remodeling nucleosomes. Mol Cell Biol (2012) 1.07
Potentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha. Mol Cell Biol (2003) 1.04
Signals for the induction of nitric oxide synthase in astrocytes. Neurochem Int (2006) 1.04
Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification. PLoS Pathog (2009) 1.04
Interleukin-37 ameliorates myocardial ischaemia/reperfusion injury in mice. Clin Exp Immunol (2014) 1.04
IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells. J Immunol (2006) 1.04
Chromatin modification and the endothelial-specific activation of the E-selectin gene. J Biol Chem (2005) 1.04
Update on staphylococcal superantigen-induced signaling pathways and therapeutic interventions. Toxins (Basel) (2013) 1.03
Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway. J Biol Chem (2008) 1.03
The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Res Ther (2006) 1.03
Dendritic cells for active anti-cancer immunotherapy: targeting activation pathways through genetic modification. Endocr Metab Immune Disord Drug Targets (2009) 1.01
RNA-binding protein AUF1 regulates lipopolysaccharide-induced IL10 expression by activating IkappaB kinase complex in monocytes. Mol Cell Biol (2010) 1.00
Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells. Respir Res (2006) 1.00
The p38 MAPK Pathway in Rheumatoid Arthritis: A Sideways Look. Open Rheumatol J (2012) 0.99
Intrinsic and extrinsic regulation of innate immune receptors. Yonsei Med J (2011) 0.98
IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Proc Natl Acad Sci U S A (2006) 0.98
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A (2011) 0.98
Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. Am J Respir Cell Mol Biol (2008) 0.97
Chromatin-mediated regulation of cytomegalovirus gene expression. Virus Res (2010) 0.97
The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation. Metabolism (2008) 0.95
Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94
Inflammation in adult and neonatal stroke. Clin Neurosci Res (2006) 0.94
Aging-dependent upregulation of IL-23p19 gene expression in dendritic cells is associated with differential transcription factor binding and histone modifications. Aging Cell (2009) 0.93
Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages. Mediators Inflamm (2010) 0.93
A mutation in Irak2c identifies IRAK-2 as a central component of the TLR regulatory network of wild-derived mice. J Exp Med (2009) 0.93
Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin. J Biol Chem (2014) 0.93
From hepatitis to hepatocellular carcinoma: a proposed model for cross-talk between inflammation and epigenetic mechanisms. Genome Med (2012) 0.93
Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes. Mol Cell Biol (2006) 0.92
Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock. Adv Exp Med Biol (2012) 0.92
The protective effect of intrasplenic transplantation of Ad-IL-18BP/IL-4 gene-modified fetal hepatocytes on ConA-induced hepatitis in mice. PLoS One (2013) 0.92
Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin. Arthritis Rheumatol (2015) 0.92
Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome (2009) 0.92
The regulation of Th1 responses by the p38 MAPK. J Immunol (2010) 0.91
Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression. Nucleic Acids Res (2009) 0.91
Pan-histone deacetylase inhibitors regulate signaling pathways involved in proliferative and pro-inflammatory mechanisms in H9c2 cells. BMC Genomics (2012) 0.90
H3S28 phosphorylation is a hallmark of the transcriptional response to cellular stress. Genome Res (2014) 0.90
The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes. Transcription (2012) 0.89
Arabinosylated lipoarabinomannan skews Th2 phenotype towards Th1 during Leishmania infection by chromatin modification: involvement of MAPK signaling. PLoS One (2011) 0.89
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. Immunity (2010) 6.48
Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell (2007) 6.07
A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol (2010) 6.01
Transcript dynamics of proinflammatory genes revealed by sequence analysis of subcellular RNA fractions. Cell (2012) 4.10
Latent enhancers activated by stimulation in differentiated cells. Cell (2013) 3.44
Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat Immunol (2002) 3.07
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB. Proc Natl Acad Sci U S A (2009) 3.01
Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J (2009) 2.72
Modulation of NF-kappaB activity by exchange of dimers. Mol Cell (2003) 2.62
Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J Exp Med (2004) 2.50
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs. Mol Cell (2010) 2.43
A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. EMBO J (2006) 2.41
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma. Cell (2013) 2.28
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev (2002) 2.10
Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol (2010) 2.00
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol (2003) 1.75
Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J (2004) 1.74
The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis. Immunity (2012) 1.60
The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PLoS One (2008) 1.57
Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A (2012) 1.53
Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell (2009) 1.48
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol (2009) 1.25
Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03
The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep (2012) 1.01
Short-term memory of danger signals and environmental stimuli in immune cells. Nat Immunol (2013) 0.99
Chromatin contributions to the regulation of innate immunity. Annu Rev Immunol (2014) 0.95
Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils. J Immunol (2013) 0.93
Transcriptional control of macrophage diversity and specialization. Eur J Immunol (2011) 0.88
Rapamycin-sensitive signals control TCR/CD28-driven Ifng, Il4 and Foxp3 transcription and promoter region methylation. Eur J Immunol (2011) 0.85
Plastic downregulation of the transcriptional repressor BCL6 during maturation of human dendritic cells. Exp Cell Res (2006) 0.85
Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data. Biol Direct (2011) 0.84
Lineages, cell types and functional states: a genomic view. Curr Opin Cell Biol (2013) 0.84
Deciphering cis-regulatory control in inflammatory cells. Philos Trans R Soc Lond B Biol Sci (2013) 0.81
A birthday gift for TRADD. Nat Immunol (2008) 0.80
Functional genomics of the inflammatory response: where are we now? Brief Funct Genomics (2013) 0.78
Non-coding transcription at cis-regulatory elements: computational and experimental approaches. Methods (2013) 0.77
Corrigendum: Massive gene amplification drives paediatric hepatocellular carcinoma caused by bile salt export pump deficiency. Nat Commun (2015) 0.75
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities. Cell Rep (2017) 0.75