Published in Mol Cell on June 01, 2003
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells. Cell Res (2008) 3.48
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol (2012) 2.45
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. EMBO J (2006) 2.27
Detection of damaged DNA bases by DNA glycosylase enzymes. Biochemistry (2010) 1.76
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid Redox Signal (2010) 1.65
Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG. J Biol Chem (2007) 1.46
Recent advances in the structural mechanisms of DNA glycosylases. Biochim Biophys Acta (2012) 1.30
C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases. EMBO J (2005) 1.29
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The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential. ACS Chem Biol (2011) 1.25
Base excision repair and cancer. Cancer Lett (2012) 1.23
Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms. Nucleic Acids Res (2007) 1.22
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. Nucleic Acids Res (2012) 1.13
Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. Structure (2008) 1.07
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA. Proc Natl Acad Sci U S A (2012) 1.05
Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination. Proc Natl Acad Sci U S A (2009) 1.01
Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase. Nucleic Acids Res (2004) 1.00
Mechanisms of base selection by human single-stranded selective monofunctional uracil-DNA glycosylase. J Biol Chem (2009) 0.98
DNA methylation, its mediators and genome integrity. Int J Biol Sci (2015) 0.96
Structural characterization of a mouse ortholog of human NEIL3 with a marked preference for single-stranded DNA. Structure (2013) 0.95
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Mechanisms of base selection by the Escherichia coli mispaired uracil glycosylase. J Biol Chem (2008) 0.94
Selective excision of 5-carboxylcytosine by a thymine DNA glycosylase mutant. J Mol Biol (2013) 0.89
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA. Org Biomol Chem (2014) 0.88
Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase. J Biol Chem (2010) 0.87
Activity and crystal structure of human thymine DNA glycosylase mutant N140A with 5-carboxylcytosine DNA at low pH. DNA Repair (Amst) (2013) 0.84
The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations. J Biol Chem (2015) 0.83
Twist-open mechanism of DNA damage recognition by the Rad4/XPC nucleotide excision repair complex. Proc Natl Acad Sci U S A (2016) 0.82
Stimulation of DNA Glycosylase Activities by XPC Protein Complex: Roles of Protein-Protein Interactions. J Nucleic Acids (2010) 0.82
Kinetic mechanism for the excision of hypoxanthine by Escherichia coli AlkA and evidence for binding to DNA ends. Biochemistry (2011) 0.82
A network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidis. Mol Microbiol (2012) 0.80
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res (2015) 0.80
Oxanine DNA glycosylase activities in mammalian systems. DNA Repair (Amst) (2007) 0.80
Characterization of DNA glycosylase activity by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem (2009) 0.79
Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol (2010) 0.79
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage. Chem Res Toxicol (2016) 0.78
Similarity search for local protein structures at atomic resolution by exploiting a database management system. Biophysics (Nagoya-shi) (2007) 0.78
A new conceptual framework for investigating complex genetic disease. Front Genet (2015) 0.77
Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins. Archaea (2014) 0.77
Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes. Cell Mol Life Sci (2014) 0.77
Structures of Escherichia coli DNA adenine methyltransferase (Dam) in complex with a non-GATC sequence: potential implications for methylation-independent transcriptional repression. Nucleic Acids Res (2015) 0.77
Purification, crystallization and preliminary X-ray analysis of uracil-DNA glycosylase from Sulfolobus tokodaii strain 7. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.76
The hyperthermophilic euryarchaeon Archaeoglobus fulgidus repairs uracil by single-nucleotide replacement. J Bacteriol (2010) 0.76
A unique uracil-DNA binding protein of the uracil DNA glycosylase superfamily. Nucleic Acids Res (2015) 0.76
Identification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua. DNA Repair (Amst) (2017) 0.75
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (2004) 7.63
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complex. Nature (2006) 5.42
Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA. Proc Natl Acad Sci U S A (2006) 4.60
Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. Mol Cell (2005) 4.05
Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1. Mol Cell (2002) 3.89
A stapled BID BH3 helix directly binds and activates BAX. Mol Cell (2006) 3.86
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature (2004) 3.30
Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions. Mol Cell (2003) 2.83
Structure of a DNA glycosylase searching for lesions. Science (2006) 2.72
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc (2007) 2.71
Structure of an Hsp90-Cdc37-Cdk4 complex. Mol Cell (2006) 2.62
Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair. Mol Cell (2006) 2.43
Nonspecifically bound proteins spin while diffusing along DNA. Nat Struct Mol Biol (2009) 2.43
The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Cell (2004) 2.36
Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex. EMBO J (2003) 2.33
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37. J Biol Chem (2002) 2.32
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Structural basis for uracil recognition by archaeal family B DNA polymerases. Nat Struct Biol (2002) 2.27
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the beta-clamp. EMBO J (2003) 2.25
Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Mol Cell (2010) 2.24
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J (2008) 2.12
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc Natl Acad Sci U S A (2012) 1.98
Threonine 22 phosphorylation attenuates Hsp90 interaction with cochaperones and affects its chaperone activity. Mol Cell (2011) 1.94
Molecular recognition of transcriptional repressor motifs by the WD domain of the Groucho/TLE corepressor. Mol Cell (2006) 1.91
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system. Nat Chem Biol (2013) 1.90
DNA lesion recognition by the bacterial repair enzyme MutM. J Biol Chem (2003) 1.79
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange. EMBO J (2006) 1.77
DNA glycosylase recognition and catalysis. Curr Opin Struct Biol (2004) 1.74
Structure of a trapped endonuclease III-DNA covalent intermediate. EMBO J (2003) 1.72
Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle. J Biol Chem (2004) 1.71
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem (2007) 1.67
Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature (2009) 1.67
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM. Nat Struct Biol (2002) 1.67
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Nat Struct Mol Biol (2006) 1.66
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J (2011) 1.65
Base excision repair. Adv Protein Chem (2004) 1.65
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J (2004) 1.63
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs). Structure (2005) 1.62
A two-hybrid screen of the yeast proteome for Hsp90 interactors uncovers a novel Hsp90 chaperone requirement in the activity of a stress-activated mitogen-activated protein kinase, Slt2p (Mpk1p). Eukaryot Cell (2005) 1.62
Structure and functional relationships of Hsp90. Curr Cancer Drug Targets (2003) 1.59
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37. Mol Cell (2008) 1.57
Insights into histone code syntax from structural and biochemical studies of CARM1 methyltransferase. EMBO J (2007) 1.55
Regulation of DNA replication through Sld3-Dpb11 interaction is conserved from yeast to humans. Curr Biol (2011) 1.54
Direct visualization of a DNA glycosylase searching for damage. Chem Biol (2002) 1.53
The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (2008) 1.52
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. EMBO Rep (2006) 1.50
Structural basis for recruitment of BRCA2 by PALB2. EMBO Rep (2009) 1.50
Identification of the Axin and Frat binding region of glycogen synthase kinase-3. J Biol Chem (2001) 1.49
Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Mol Cell (2006) 1.48
Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1. J Mol Biol (2003) 1.47
An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair (Amst) (2010) 1.46
Activation segment exchange: a common mechanism of kinase autophosphorylation? Trends Biochem Sci (2007) 1.45
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis. Nat Protoc (2011) 1.44
High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity. Anal Biochem (2004) 1.42
A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias. J Biol Chem (2005) 1.41
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase. Biochemistry (2003) 1.40
Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol (2003) 1.34
Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem (2005) 1.32
Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs. EMBO J (2003) 1.32
Crystal structure of the rad9-rad1-hus1 DNA damage checkpoint complex--implications for clamp loading and regulation. Mol Cell (2009) 1.31
Structure of the stapled p53 peptide bound to Mdm2. J Am Chem Soc (2011) 1.30
The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins. EMBO J (2011) 1.30
Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery. EMBO J (2004) 1.29
Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. Nucleic Acids Res (2006) 1.28
Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair. Genes Dev (2008) 1.27
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK. Nucleic Acids Res (2009) 1.25
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO J (2008) 1.24
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. J Biol Chem (2005) 1.24
Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations. J Biol Chem (2006) 1.24
A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex. Proc Natl Acad Sci U S A (2006) 1.23
Crystal structure of Bacillus stearothermophilus UvrA provides insight into ATP-modulated dimerization, UvrB interaction, and DNA binding. Mol Cell (2007) 1.21
The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine. J Biol Chem (2002) 1.19
Crystal structure of the CCTgamma apical domain: implications for substrate binding to the eukaryotic cytosolic chaperonin. J Mol Biol (2002) 1.18
Reciprocal "flipping" underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase. J Mol Biol (2002) 1.18
High-resolution footprinting of sequence-specific protein-DNA contacts. Nat Biotechnol (2002) 1.17
The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors. Bioorg Med Chem Lett (2005) 1.17
A structural model for the damage-sensing complex in bacterial nucleotide excision repair. J Biol Chem (2009) 1.16
The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). J Mol Biol (2004) 1.14
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Nucleic Acids Res (2010) 1.13
Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2. Nucleic Acids Res (2004) 1.12
Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. Structure (2002) 1.12
Structural basis of the radicicol resistance displayed by a fungal hsp90. ACS Chem Biol (2009) 1.10
All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples. J Am Chem Soc (2009) 1.10
Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine. J Am Chem Soc (2008) 1.09
Crystal structure of the retinoblastoma protein N domain provides insight into tumor suppression, ligand interaction, and holoprotein architecture. Mol Cell (2007) 1.09
Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase. Proc Natl Acad Sci U S A (2009) 1.08
Visualization of a DNA-PK/PARP1 complex. Nucleic Acids Res (2012) 1.08
Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA. Structure (2008) 1.07
Structural basis for assembly of Hsp90-Sgt1-CHORD protein complexes: implications for chaperoning of NLR innate immunity receptors. Mol Cell (2010) 1.07
Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking. Chem Biol (2002) 1.07
An iron-sulfur cluster in the family 4 uracil-DNA glycosylases. J Biol Chem (2002) 1.06
MoKCa database--mutations of kinases in cancer. Nucleic Acids Res (2008) 1.06
Structural insights into formation of an active signaling complex between Rac and phospholipase C gamma 2. Mol Cell (2009) 1.05
Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. Mol Microbiol (2005) 1.04
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. J Med Chem (2012) 1.04
CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res (2011) 1.04