Published in J Am Chem Soc on December 14, 2011
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Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α. Angew Chem Int Ed Engl (2012) 1.07
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A potent α/β-peptide analogue of GLP-1 with prolonged action in vivo. J Am Chem Soc (2014) 0.96
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Inhibition of nutlin-resistant HDM2 mutants by stapled peptides. PLoS One (2013) 0.85
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Targeting protein-protein interfaces using macrocyclic peptides. Biopolymers (2015) 0.83
Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion. ACS Med Chem Lett (2013) 0.82
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Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides. Nat Commun (2016) 0.78
Molecular dynamic simulation insights into the normal state and restoration of p53 function. Int J Mol Sci (2012) 0.78
Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angew Chem Int Ed Engl (2016) 0.77
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Small molecule probes to target the human Mediator complex. Isr J Chem (2013) 0.76
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Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens. Sci Rep (2016) 0.75
Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. J Phys Chem Lett (2016) 0.75
Accelerating physical simulations of proteins by leveraging external knowledge. Wiley Interdiscip Rev Comput Mol Sci (2017) 0.75
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Direct inhibition of the NOTCH transcription factor complex. Nature (2009) 4.82
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A stapled BID BH3 helix directly binds and activates BAX. Mol Cell (2006) 3.86
Structure of a repair enzyme interrogating undamaged DNA elucidates recognition of damaged DNA. Nature (2005) 3.67
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase. Nature (2004) 3.30
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine. Nature (2002) 3.05
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Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest Ophthalmol Vis Sci (2008) 3.01
The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol (2004) 2.95
Filamins: promiscuous organizers of the cytoskeleton. Trends Biochem Sci (2006) 2.79
Structure of a DNA glycosylase searching for lesions. Science (2006) 2.72
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc (2007) 2.71
Fighting fruit flies: a model system for the study of aggression. Proc Natl Acad Sci U S A (2002) 2.66
Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser. Opt Express (2011) 2.62
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The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol (2003) 2.42
Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex. Nat Struct Mol Biol (2006) 2.29
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography. Opt Express (2008) 2.24
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism. Nature (2008) 2.22
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle (2009) 2.11
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range. Opt Express (2009) 2.03
HTRA proteases: regulated proteolysis in protein quality control. Nat Rev Mol Cell Biol (2011) 2.01
Gender-selective patterns of aggressive behavior in Drosophila melanogaster. Proc Natl Acad Sci U S A (2004) 1.99
Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc Natl Acad Sci U S A (2012) 1.98
Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc (2006) 1.96
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation. Nature (2003) 1.92
Molecular machines for protein degradation. Chembiochem (2005) 1.81
Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities. EMBO J (2002) 1.79
DNA lesion recognition by the bacterial repair enzyme MutM. J Biol Chem (2003) 1.79
Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis. EMBO J (2004) 1.75
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Structure of a trapped endonuclease III-DNA covalent intermediate. EMBO J (2003) 1.72
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle (2008) 1.71
Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers. Opt Lett (2007) 1.69
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM. Nat Struct Biol (2002) 1.67
Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme. Nature (2009) 1.67
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Nat Struct Mol Biol (2006) 1.66
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Vitamin C equivalent antioxidant capacity (VCEAC) of phenolic phytochemicals. J Agric Food Chem (2002) 1.64
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K-space linear Fourier domain mode locked laser and applications for optical coherence tomography. Opt Express (2008) 1.62
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism. Proc Natl Acad Sci U S A (2003) 1.62
Enabling large-scale design, synthesis and validation of small molecule protein-protein antagonists. PLoS One (2012) 1.60
Improved spectral optical coherence tomography using optical frequency comb. Opt Express (2008) 1.58
Catalysis at a dinuclear [CuSMo(==O)OH] cluster in a CO dehydrogenase resolved at 1.1-A resolution. Proc Natl Acad Sci U S A (2002) 1.57
Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle (2007) 1.55
Aggression in invertebrates. Curr Opin Neurobiol (2003) 1.53
Direct visualization of a DNA glycosylase searching for damage. Chem Biol (2002) 1.53
A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans. Proc Natl Acad Sci U S A (2003) 1.52
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery. Cell Cycle (2010) 1.52
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell (2012) 1.50
Behavioral functions of the mesolimbic dopaminergic system: an affective neuroethological perspective. Brain Res Rev (2007) 1.50
Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell (2003) 1.49
Interplay of PDZ and protease domain of DegP ensures efficient elimination of misfolded proteins. Proc Natl Acad Sci U S A (2008) 1.48
Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease. Proc Natl Acad Sci U S A (2005) 1.47
Gene transfer and genome plasticity in Thermotoga maritima, a model hyperthermophilic species. J Bacteriol (2005) 1.45
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis. Nat Protoc (2011) 1.44
A superhelical spiral in the Escherichia coli DNA gyrase A C-terminal domain imparts unidirectional supercoiling bias. J Biol Chem (2005) 1.41
Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the catalytic mechanism and anti-malaria drug development. J Biol Chem (2003) 1.40
Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase. Biochemistry (2003) 1.40
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure (2003) 1.39
The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proc Natl Acad Sci U S A (2002) 1.38
Multi-MHz retinal OCT. Biomed Opt Express (2013) 1.36
Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach. Biochim Biophys Acta (2004) 1.36
Mechanism of the six-electron reduction of nitrite to ammonia by cytochrome c nitrite reductase. J Am Chem Soc (2002) 1.36
Expansion of the genetic code enables design of a novel "gold" class of green fluorescent proteins. J Mol Biol (2003) 1.34
Product-assisted catalysis in base-excision DNA repair. Nat Struct Biol (2003) 1.34
Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. Proc Natl Acad Sci U S A (2004) 1.32
Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem (2005) 1.32
Investigations on the maturation and regulation of archaebacterial proteasomes. J Mol Biol (2003) 1.32
High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the "tracker" program. PLoS One (2012) 1.30
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious. Angew Chem Int Ed Engl (2011) 1.30
HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues. Nat Struct Mol Biol (2010) 1.30
Practical aspects of the 2D 15N-[1h]-NOE experiment. J Biomol NMR (2002) 1.29
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Myricetin suppresses UVB-induced skin cancer by targeting Fyn. Cancer Res (2008) 1.29
Substrate access and processing by the 20S proteasome core particle. Int J Biochem Cell Biol (2003) 1.29
Protein quality control in the bacterial periplasm. Annu Rev Microbiol (2011) 1.29
Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein. Proc Natl Acad Sci U S A (2003) 1.27
Catalytic domain structures of MT-SP1/matriptase, a matrix-degrading transmembrane serine proteinase. J Biol Chem (2001) 1.27
Isoquinolin-1-one inhibitors of the MDM2-p53 interaction. ChemMedChem (2008) 1.27
Tpl2 is a key mediator of arsenite-induced signal transduction. Cancer Res (2009) 1.26
Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J Neurochem (2009) 1.25
Protein folding and stability of human CDK inhibitor p19(INK4d). J Mol Biol (2002) 1.25
Ultrahigh-speed non-invasive widefield angiography. J Biomed Opt (2012) 1.25
Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations. J Mol Biol (2005) 1.25
Crystal structure of the Bse634I restriction endonuclease: comparison of two enzymes recognizing the same DNA sequence. Nucleic Acids Res (2002) 1.24
Crystal structure of 12-oxophytodienoate reductase 3 from tomato: self-inhibition by dimerization. Proc Natl Acad Sci U S A (2006) 1.24
New isolates and physiological properties of the Aquificales and description of Thermocrinis albus sp. nov. Extremophiles (2002) 1.24
Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase. J Biol Chem (2005) 1.24