José C Fernández-Checa

Author PubWeight™ 37.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal 2009 2.28
2 Critical role of tumor necrosis factor receptor 1, but not 2, in hepatic stellate cell proliferation, extracellular matrix remodeling, and liver fibrogenesis. Hepatology 2011 1.73
3 Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 2003 1.58
4 Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury. J Hepatol 2010 1.51
5 Caveolin-1 deficiency causes cholesterol-dependent mitochondrial dysfunction and apoptotic susceptibility. Curr Biol 2011 1.31
6 Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity. J Neurosci 2009 1.27
7 Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. J Biol Chem 2002 1.24
8 Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. Am J Pathol 2010 1.24
9 Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential. Hepatology 2009 1.23
10 Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. J Biol Chem 2010 1.22
11 Mitochondrial cholesterol contributes to chemotherapy resistance in hepatocellular carcinoma. Cancer Res 2008 1.21
12 Reactive oxygen species mediate liver injury through parenchymal nuclear factor-kappaB inactivation in prolonged ischemia/reperfusion. Am J Pathol 2009 1.15
13 Acetaldehyde impairs mitochondrial glutathione transport in HepG2 cells through endoplasmic reticulum stress. Gastroenterology 2003 1.14
14 Sphingolipid signalling and liver diseases. Liver Int 2007 1.13
15 Redox control of liver function in health and disease. Antioxid Redox Signal 2010 1.12
16 Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta 2012 1.11
17 Cathepsin B overexpression due to acid sphingomyelinase ablation promotes liver fibrosis in Niemann-Pick disease. J Biol Chem 2011 1.07
18 Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem 2003 1.07
19 Growth arrest-specific protein 6 is hepatoprotective against murine ischemia/reperfusion injury. Hepatology 2010 1.05
20 Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation. Gastroenterology 2008 1.04
21 Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. J Clin Invest 2004 0.98
22 Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy. J Biol Chem 2002 0.93
23 Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-alpha-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3. FEBS Lett 2002 0.91
24 Redox regulation of hepatocyte apoptosis. J Gastroenterol Hepatol 2007 0.90
25 Alcohol, signaling, and ECM turnover. Alcohol Clin Exp Res 2009 0.89
26 Mitochondrial cholesterol: a connection between caveolin, metabolism, and disease. Traffic 2011 0.87
27 Neutral sphingomyelinase-induced ceramide triggers germinal vesicle breakdown and oxidant-dependent apoptosis in Xenopus laevis oocytes. J Lipid Res 2007 0.87
28 Mitochondrial S-adenosyl-L-methionine transport is insensitive to alcohol-mediated changes in membrane dynamics. Alcohol Clin Exp Res 2009 0.86
29 Mitochondria, cholesterol and amyloid beta peptide: a dangerous trio in Alzheimer disease. J Bioenerg Biomembr 2009 0.85
30 Systemic effects of cigarette smoke exposure in the guinea pig. Respir Med 2005 0.85
31 Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity. FEBS Lett 2004 0.84
32 Divergent role of ceramide generated by exogenous sphingomyelinases on NF-kappa B activation and apoptosis in human colon HT-29 cells. FEBS Lett 2002 0.81
33 Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol 2002 0.80
34 Glycosphingolipids and cell death: one aim, many ways. Apoptosis 2015 0.78
35 Differential modulation of interleukin 8 by interleukin 4 and interleukin 10 in HepG2 cells treated with acetaldehyde. Liver Int 2005 0.75