A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude.

PubWeight™: 1.38‹?› | Rank: Top 10%

🔗 View Article (PMC 165643)

Published in EMBO J on July 01, 2003

Authors

Ravi Allada1, Sebastian Kadener, Namrata Nandakumar, Michael Rosbash

Author Affiliations

1: Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA.

Articles citing this

Drosophila free-running rhythms require intercellular communication. PLoS Biol (2003) 2.42

Circadian organization of behavior and physiology in Drosophila. Annu Rev Physiol (2010) 2.36

Robustness properties of circadian clock architectures. Proc Natl Acad Sci U S A (2004) 2.31

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev (2007) 1.73

Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila. Curr Biol (2007) 1.66

Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A (2006) 1.63

A role for microRNAs in the Drosophila circadian clock. Genes Dev (2009) 1.56

Clock and cycle limit starvation-induced sleep loss in Drosophila. Curr Biol (2010) 1.55

Circadian transcription contributes to core period determination in Drosophila. PLoS Biol (2008) 1.40

Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet (2012) 1.02

An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. J Neurosci (2009) 1.01

Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proc Natl Acad Sci U S A (2006) 0.99

Dopamine acts through Cryptochrome to promote acute arousal in Drosophila. Genes Dev (2012) 0.99

Phosphorylation of the transcription activator CLOCK regulates progression through a ∼ 24-h feedback loop to influence the circadian period in Drosophila. J Biol Chem (2014) 0.91

Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol (2007) 0.91

Genetic analysis of ectopic circadian clock induction in Drosophila. J Biol Rhythms (2009) 0.90

The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Cell Metab (2012) 0.90

Regulation of oscillation dynamics in biochemical systems with dual negative feedback loops. J R Soc Interface (2012) 0.90

Adult circadian behavior in Drosophila requires developmental expression of cycle, but not period. PLoS Genet (2011) 0.86

Clk post-transcriptional control denoises circadian transcription both temporally and spatially. Nat Commun (2015) 0.84

Circadian period integrates network information through activation of the BMP signaling pathway. PLoS Biol (2013) 0.82

An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila. Nat Commun (2014) 0.81

Calcium and SOL Protease Mediate Temperature Resetting of Circadian Clocks. Cell (2015) 0.80

Synergistic interactions between the molecular and neuronal circadian networks drive robust behavioral circadian rhythms in Drosophila melanogaster. PLoS Genet (2014) 0.80

The nuclear receptor genes HR3 and E75 are required for the circadian rhythm in a primitive insect. PLoS One (2014) 0.79

A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Front Cell Neurosci (2013) 0.77

PDF Signaling Is an Integral Part of the Drosophila Circadian Molecular Oscillator. Cell Rep (2016) 0.77

Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function. PLoS Genet (2017) 0.75

Clock-Enhancing Small Molecules and Potential Applications in Chronic Diseases and Aging. Front Neurol (2017) 0.75

Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation. Proc Natl Acad Sci U S A (2016) 0.75

Articles cited by this

Positional cloning of the mouse circadian clock gene. Cell (1997) 7.79

The FlyBase database of the Drosophila genome projects and community literature. Nucleic Acids Res (2002) 7.48

Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim. Science (1998) 5.72

Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell (1997) 5.51

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Cell (1999) 5.14

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell (1998) 5.10

The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon. Cell (1998) 4.59

Microarray analysis and organization of circadian gene expression in Drosophila. Cell (2001) 4.59

CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Cell (1998) 4.22

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Cell (1998) 3.89

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Cell (1998) 3.86

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11

A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock. Cell (2001) 3.07

vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock. Cell (2003) 3.01

A role for casein kinase 2alpha in the Drosophila circadian clock. Nature (2002) 2.89

Interlocked feedback loops within the Drosophila circadian oscillator. Science (1999) 2.83

Targeted recovery of mutations in Drosophila. Genetics (2000) 2.71

Neuroanatomy of cells expressing clock genes in Drosophila: transgenic manipulation of the period and timeless genes to mark the perikarya of circadian pacemaker neurons and their projections. J Comp Neurol (2000) 2.61

Role of molecular oscillations in generating behavioral rhythms in Drosophila. Neuron (2001) 2.45

Stopping time: the genetics of fly and mouse circadian clocks. Annu Rev Neurosci (2001) 2.44

Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. EMBO J (1997) 2.38

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. Mol Cell Biol (1999) 2.29

Drosophila CRY is a deep brain circadian photoreceptor. Neuron (2000) 2.28

The Drosophila CLOCK protein undergoes daily rhythms in abundance, phosphorylation, and interactions with the PER-TIM complex. Neuron (1998) 2.20

A circadian enhancer mediates PER-dependent mRNA cycling in Drosophila melanogaster. Mol Cell Biol (1997) 2.11

VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron (2003) 2.07

Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol Cell Biol (1998) 1.96

A promoterless period gene mediates behavioral rhythmicity and cyclical per expression in a restricted subset of the Drosophila nervous system. Neuron (1994) 1.92

Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock. Neuron (2001) 1.87

Germ-line transformation involving DNA from the period locus in Drosophila melanogaster: overlapping genomic fragments that restore circadian and ultradian rhythmicity to per0 and per- mutants. J Neurogenet (1986) 1.84

Multiple circadian-regulated elements contribute to cycling period gene expression in Drosophila. EMBO J (1997) 1.82

The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit. Genetics (1997) 1.75

Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior. Cell (2001) 1.62

Novel features of drosophila period Transcription revealed by real-time luciferase reporting. Neuron (1996) 1.61

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock. Curr Biol (2000) 1.42

Wild-type circadian rhythmicity is dependent on closely spaced E boxes in the Drosophila timeless promoter. Mol Cell Biol (2001) 1.41

Drosophila CLOCK protein is under posttranscriptional control and influences light-induced activity. Neuron (2002) 1.38

Isolation and chronobiological analysis of a neuropeptide pigment-dispersing factor gene in Drosophila melanogaster. J Biol Rhythms (1998) 1.38

takeout, a novel Drosophila gene under circadian clock transcriptional regulation. Mol Cell Biol (2000) 1.30

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Neuron (1996) 1.27

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. Neuron (1991) 1.18

Circadian cycling of a PERIOD-beta-galactosidase fusion protein in Drosophila: evidence for cyclical degradation. J Biol Rhythms (1997) 1.12

Regulation of the cycling of timeless (tim) RNA. J Neurobiol (2001) 1.01

Behavioral and molecular analyses suggest that circadian output is disrupted by disconnected mutants in D. melanogaster. EMBO J (1992) 1.01

A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila. J Biol Chem (1992) 0.92

Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels. Brain Res Mol Brain Res (1996) 0.82

Articles by these authors

Coupled oscillators control morning and evening locomotor behaviour of Drosophila. Nature (2004) 4.55

A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Nature (2005) 3.35

A role for casein kinase 2alpha in the Drosophila circadian clock. Nature (2002) 2.89

PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron (2008) 2.81

The Drosophila circadian network is a seasonal timer. Cell (2007) 2.62

Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Mol Cell Biol (2002) 2.58

Transcriptional activators differ in their abilities to control alternative splicing. J Biol Chem (2002) 2.56

Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain. Proc Natl Acad Sci U S A (2008) 2.43

Drosophila free-running rhythms require intercellular communication. PLoS Biol (2003) 2.42

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science (2005) 2.29

Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Science (2004) 2.19

Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes. EMBO J (2004) 2.17

Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. J Neurosci (2002) 2.16

Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Mol Cell (2005) 2.11

Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci (2008) 2.01

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Mol Cell (2004) 1.94

The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing. Nature (2002) 1.93

Nascent-seq indicates widespread cotranscriptional pre-mRNA splicing in Drosophila. Genes Dev (2011) 1.87

Nascent-Seq reveals novel features of mouse circadian transcriptional regulation. Elife (2012) 1.82

Retracted PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. PLoS Biol (2007) 1.80

A threat to medical innovation. Science (2011) 1.76

Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Genes Dev (2007) 1.73

A genome-wide analysis indicates that yeast pre-mRNA splicing is predominantly posttranscriptional. Mol Cell (2006) 1.71

Genome-wide analysis of light- and temperature-entrained circadian transcripts in Caenorhabditis elegans. PLoS Biol (2010) 1.68

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Proc Natl Acad Sci U S A (2002) 1.61

Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA (2009) 1.59

Early formation of mRNP: license for export or quality control? Mol Cell (2003) 1.58

Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc Natl Acad Sci U S A (2010) 1.58

Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNA. Genes Dev (2010) 1.57

A role for microRNAs in the Drosophila circadian clock. Genes Dev (2009) 1.56

Drosophila clock can generate ectopic circadian clocks. Cell (2003) 1.55

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript. RNA (2004) 1.54

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. Genes Dev (2006) 1.49

Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. Genes Dev (2011) 1.49

Nascent-seq indicates widespread cotranscriptional RNA editing in Drosophila. Mol Cell (2012) 1.48

3'-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation. EMBO J (2006) 1.47

Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography. Ophthalmology (2013) 1.43

Dissecting differential gene expression within the circadian neuronal circuit of Drosophila. Nat Neurosci (2009) 1.43

Circadian transcription contributes to core period determination in Drosophila. PLoS Biol (2008) 1.40

Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. RNA (2003) 1.40

Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA (2007) 1.37

Transposition-driven genomic heterogeneity in the Drosophila brain. Science (2013) 1.35

Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine. Nat Neurosci (2011) 1.29

T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export. RNA (2002) 1.27

Ribosome components are associated with sites of transcription. Mol Cell (2002) 1.24

The coevolution of blue-light photoreception and circadian rhythms. J Mol Evol (2003) 1.20

A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization, and transcriptional repressor activity. Mol Cell Biol (2007) 1.20

Protein characterization of Saccharomyces cerevisiae RNA polymerase II after in vivo cross-linking. Proc Natl Acad Sci U S A (2007) 1.17

Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. RNA (2006) 1.15

CLOCK:BMAL1 is a pioneer-like transcription factor. Genes Dev (2014) 1.13

The nuclear exosome and adenylation regulate posttranscriptional tethering of yeast GAL genes to the nuclear periphery. Mol Cell (2008) 1.12

Cotranscriptional splicing efficiency differs dramatically between Drosophila and mouse. RNA (2012) 1.12

Short neuropeptide F is a sleep-promoting inhibitory modulator. Neuron (2013) 1.10

Nascent-Seq analysis of Drosophila cycling gene expression. Proc Natl Acad Sci U S A (2013) 1.06

Nonsense-mediated decay does not occur within the yeast nucleus. RNA (2004) 1.06

Light-mediated TIM degradation within Drosophila pacemaker neurons (s-LNvs) is neither necessary nor sufficient for delay zone phase shifts. Neuron (2010) 1.05

Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. Mol Cell (2013) 1.03

Autoreceptor control of peptide/neurotransmitter corelease from PDF neurons determines allocation of circadian activity in drosophila. Cell Rep (2012) 1.02

PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function. J Biol Rhythms (2006) 1.01

Molecular organization of Drosophila neuroendocrine cells by Dimmed. Curr Biol (2011) 1.00

Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Proc Natl Acad Sci U S A (2006) 0.99

A constant light-genetic screen identifies KISMET as a regulator of circadian photoresponses. PLoS Genet (2009) 0.98

When brain clocks lose track of time: cause or consequence of neuropsychiatric disorders. Curr Opin Neurobiol (2011) 0.97

Assaying the Drosophila negative feedback loop with RNA interference in S2 cells. Methods Enzymol (2005) 0.96

Mathematical model of the Drosophila circadian clock: loop regulation and transcriptional integration. Biophys J (2009) 0.93

A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction. Mol Cell Biol (2009) 0.93

PDF and cAMP enhance PER stability in Drosophila clock neurons. Proc Natl Acad Sci U S A (2014) 0.92

A novel plasmid-based microarray screen identifies suppressors of rrp6Delta in Saccharomyces cerevisiae. Mol Cell Biol (2006) 0.92

Ribosome components are associated with sites of transcription. Mol Cell (2002) 0.90

The oscillating miRNA 959-964 cluster impacts Drosophila feeding time and other circadian outputs. Cell Metab (2012) 0.90

NAT1/DAP5/p97 and atypical translational control in the Drosophila Circadian Oscillator. Genetics (2012) 0.89

CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Genes Dev (2012) 0.89

Circadian neuron feedback controls the Drosophila sleep--activity profile. Nature (2016) 0.88

Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation. Proc Natl Acad Sci U S A (2004) 0.87

The transcription factor Mef2 links the Drosophila core clock to Fas2, neuronal morphology, and circadian behavior. Neuron (2013) 0.87

Co-transcriptional monitoring of mRNP formation. Nat Struct Biol (2003) 0.86

Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs. Proc Biol Sci (2013) 0.86

Circadian rhythms: the cancer connection. Nature (2002) 0.86

A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics. Mol Brain (2013) 0.82

Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins. PLoS One (2012) 0.82

Accelerated degradation of perS protein provides insight into light-mediated phase shifting. J Biol Rhythms (2013) 0.81

A new twist on clock protein phosphorylation: a conformational change leads to protein degradation. Mol Cell (2011) 0.80

Sleep: hitting the reset button. Nat Neurosci (2008) 0.78

Expression of Drosophila Cabut during early embryogenesis, dorsal closure and nervous system development. Gene Expr Patterns (2010) 0.78

A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis. Front Cell Neurosci (2013) 0.77

Ronald J. Konopka (1947–2015). Cell (2015) 0.76

What can Drosophila teach us about iron-accumulation neurodegenerative disorders? J Neural Transm (Vienna) (2010) 0.76

Retraction: PER-TIM Interactions with the Photoreceptor Cryptochrome Mediate Circadian Temperature Responses in Drosophila. PLoS Biol (2016) 0.75

Life Is an N of 1. Cell (2017) 0.75

SARS-CoV-2 Nsp14 mediates the effects of viral infection on the host cell transcriptome. bioRxiv (2022) 0.75

Non-reciprocal homeostatic compensation in Drosophila potassium channel mutants. J Neurophysiol (2017) 0.75

Enhanced, near-infrared fundus reflectance for qualitative and quantitative analysis of subretinal lesions. Exp Eye Res (2012) 0.75